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Q64406 (CP3AF_CAVPO) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 3A15

EC=1.14.14.1
Alternative name(s):
CYPIIIA15
Gene names
Name:CYP3A15
OrganismCavia porcellus (Guinea pig) [Reference proteome]
Taxonomic identifier10141 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia

Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 503503Cytochrome P450 3A15
PRO_0000051798

Sites

Metal binding4421Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q64406 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 071E187ADACDC4F9

FASTA50358,139
        10         20         30         40         50         60 
MDLIPSFSLE TWVLLALSLV LLYQYATYSH GFFKKLGIPG PKPLPLFGNV LSYRKGMWSF 

        70         80         90        100        110        120 
DIECRKKYGN MWGLYDGPQP VLAITEPDMI KAVLVKECYS VFTNRRSLVP VGFMKKSVSL 

       130        140        150        160        170        180 
SEDEEWKRIR TQLSPNFTSG KLKEMFPIIK QYGDVLVKNL RQEAEKGKPV QLKEIFGAYG 

       190        200        210        220        230        240 
MDIIIATAFG VNVDSLNNPH DPFVSKANKL FRFDFLSPFL LSTVMFPFLT QLYEMLSISI 

       250        260        270        280        290        300 
FPRDSLKFFT KFVKKTKENH LESNKKQRVN FLQMMLNSQN FKDTESHKAL SDVEILAQSI 

       310        320        330        340        350        360 
IFIFAGYETS SSTLSCIMYS LATHPDVQKK LHQEIDKTLP NKAFPTYDVM MEMEYLDMVV 

       370        380        390        400        410        420 
NETLRLYPVA NRIERMSKKD FEINGMSFPK GTLVMIPSFA LHRDSKYWPE PDEFRPERFS 

       430        440        450        460        470        480 
KKNKENIDPY IYMPFGNGPR NCIGRRMALM NLKLALIRLL QNFSFYPCKE TQIPLRLSSE 

       490        500 
ALLQPEKPLI LKVVSRDETI RGA 

« Hide

References

[1]"Regulation of CYP1A and CYP3A mRNAs by ascorbic acid in guinea pigs."
Mori T., Itoh S., Ohgiya S., Ishizaki K., Kamataki T.
Arch. Biochem. Biophys. 348:268-277(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Hartley.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D26487 mRNA. Translation: BAA05498.1.
RefSeqNP_001166588.1. NM_001173117.1.

3D structure databases

ProteinModelPortalQ64406.
SMRQ64406. Positions 30-496.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10141.ENSCPOP00000001435.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100379245.

Organism-specific databases

CTD100379245.

Phylogenomic databases

eggNOGCOG2124.
HOVERGENHBG108567.
InParanoidQ64406.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP3AF_CAVPO
AccessionPrimary (citable) accession number: Q64406
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: March 19, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families