Q64406 (CP3AF_CAVPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome P450 3A15
EC=1.14.14.1

Alternative name(s):
CYPIIIA15

Gene names

Name:

CYP3A15

Organism

Cavia porcellus (Guinea pig) [Reference proteome]

Taxonomic identifier

10141 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricognathi › Caviidae › Cavia

Protein attributes

Sequence length	503 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Induction	P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 503	503	Cytochrome P450 3A15		PRO_0000051798
Sites
	Metal binding	442	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q64406 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 071E187ADACDC4F9	FASTA	503	58,139
	10 20 30 40 50 60 MDLIPSFSLE TWVLLALSLV LLYQYATYSH GFFKKLGIPG PKPLPLFGNV LSYRKGMWSF 70 80 90 100 110 120 DIECRKKYGN MWGLYDGPQP VLAITEPDMI KAVLVKECYS VFTNRRSLVP VGFMKKSVSL 130 140 150 160 170 180 SEDEEWKRIR TQLSPNFTSG KLKEMFPIIK QYGDVLVKNL RQEAEKGKPV QLKEIFGAYG 190 200 210 220 230 240 MDIIIATAFG VNVDSLNNPH DPFVSKANKL FRFDFLSPFL LSTVMFPFLT QLYEMLSISI 250 260 270 280 290 300 FPRDSLKFFT KFVKKTKENH LESNKKQRVN FLQMMLNSQN FKDTESHKAL SDVEILAQSI 310 320 330 340 350 360 IFIFAGYETS SSTLSCIMYS LATHPDVQKK LHQEIDKTLP NKAFPTYDVM MEMEYLDMVV 370 380 390 400 410 420 NETLRLYPVA NRIERMSKKD FEINGMSFPK GTLVMIPSFA LHRDSKYWPE PDEFRPERFS 430 440 450 460 470 480 KKNKENIDPY IYMPFGNGPR NCIGRRMALM NLKLALIRLL QNFSFYPCKE TQIPLRLSSE 490 500 ALLQPEKPLI LKVVSRDETI RGA

References

[1]	"Regulation of CYP1A and CYP3A mRNAs by ascorbic acid in guinea pigs." Mori T., Itoh S., Ohgiya S., Ishizaki K., Kamataki T. Arch. Biochem. Biophys. 348:268-277(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Hartley. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D26487 mRNA. Translation: BAA05498.1.
RefSeq	NP_001166588.1. NM_001173117.1.
3D structure databases
ProteinModelPortal	Q64406.
SMR	Q64406. Positions 30-496.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100379245.
Organism-specific databases
CTD	100379245.
Phylogenomic databases
eggNOG	COG2124.
HOVERGEN	HBG108567.
InParanoid	Q64406.
Family and domain databases
Gene3D	1.10.630.10. 1 hit.
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR008072. Cyt_P450_E_CYP3A. IPR002402. Cyt_P450_E_grp-II. [Graphical view]
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00464. EP450II. PR01689. EP450IICYP3A. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CP3AF_CAVPO

Accession

Primary (citable) accession number: Q64406

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program