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Q64406

- CP3AF_CAVPO

UniProt

Q64406 - CP3AF_CAVPO

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Protein

Cytochrome P450 3A15

Gene
CYP3A15
Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi442 – 4421Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 3A15 (EC:1.14.14.1)
Alternative name(s):
CYPIIIA15
Gene namesi
Name:CYP3A15
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
ProteomesiUP000005447: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Cytochrome P450 3A15PRO_0000051798Add
BLAST

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000001435.

Structurei

3D structure databases

ProteinModelPortaliQ64406.
SMRiQ64406. Positions 30-496.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

eggNOGiCOG2124.
HOVERGENiHBG108567.
InParanoidiQ64406.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64406-1 [UniParc]FASTAAdd to Basket

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MDLIPSFSLE TWVLLALSLV LLYQYATYSH GFFKKLGIPG PKPLPLFGNV    50
LSYRKGMWSF DIECRKKYGN MWGLYDGPQP VLAITEPDMI KAVLVKECYS 100
VFTNRRSLVP VGFMKKSVSL SEDEEWKRIR TQLSPNFTSG KLKEMFPIIK 150
QYGDVLVKNL RQEAEKGKPV QLKEIFGAYG MDIIIATAFG VNVDSLNNPH 200
DPFVSKANKL FRFDFLSPFL LSTVMFPFLT QLYEMLSISI FPRDSLKFFT 250
KFVKKTKENH LESNKKQRVN FLQMMLNSQN FKDTESHKAL SDVEILAQSI 300
IFIFAGYETS SSTLSCIMYS LATHPDVQKK LHQEIDKTLP NKAFPTYDVM 350
MEMEYLDMVV NETLRLYPVA NRIERMSKKD FEINGMSFPK GTLVMIPSFA 400
LHRDSKYWPE PDEFRPERFS KKNKENIDPY IYMPFGNGPR NCIGRRMALM 450
NLKLALIRLL QNFSFYPCKE TQIPLRLSSE ALLQPEKPLI LKVVSRDETI 500
RGA 503
Length:503
Mass (Da):58,139
Last modified:November 1, 1996 - v1
Checksum:i071E187ADACDC4F9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D26487 mRNA. Translation: BAA05498.1.
RefSeqiNP_001166588.1. NM_001173117.1.

Genome annotation databases

GeneIDi100379245.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D26487 mRNA. Translation: BAA05498.1 .
RefSeqi NP_001166588.1. NM_001173117.1.

3D structure databases

ProteinModelPortali Q64406.
SMRi Q64406. Positions 30-496.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10141.ENSCPOP00000001435.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100379245.

Organism-specific databases

CTDi 100379245.

Phylogenomic databases

eggNOGi COG2124.
HOVERGENi HBG108567.
InParanoidi Q64406.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Regulation of CYP1A and CYP3A mRNAs by ascorbic acid in guinea pigs."
    Mori T., Itoh S., Ohgiya S., Ishizaki K., Kamataki T.
    Arch. Biochem. Biophys. 348:268-277(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Hartley.
    Tissue: Liver.

Entry informationi

Entry nameiCP3AF_CAVPO
AccessioniPrimary (citable) accession number: Q64406
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: March 19, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi