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Q64406

- CP3AF_CAVPO

UniProt

Q64406 - CP3AF_CAVPO

Protein

Cytochrome P450 3A15

Gene

CYP3A15

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi442 – 4421Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 3A15 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIIA15
    Gene namesi
    Name:CYP3A15
    OrganismiCavia porcellus (Guinea pig)
    Taxonomic identifieri10141 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
    ProteomesiUP000005447: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503Cytochrome P450 3A15PRO_0000051798Add
    BLAST

    Expressioni

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Interactioni

    Protein-protein interaction databases

    STRINGi10141.ENSCPOP00000001435.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64406.
    SMRiQ64406. Positions 30-496.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOVERGENiHBG108567.
    InParanoidiQ64406.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q64406-1 [UniParc]FASTAAdd to Basket

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    MDLIPSFSLE TWVLLALSLV LLYQYATYSH GFFKKLGIPG PKPLPLFGNV    50
    LSYRKGMWSF DIECRKKYGN MWGLYDGPQP VLAITEPDMI KAVLVKECYS 100
    VFTNRRSLVP VGFMKKSVSL SEDEEWKRIR TQLSPNFTSG KLKEMFPIIK 150
    QYGDVLVKNL RQEAEKGKPV QLKEIFGAYG MDIIIATAFG VNVDSLNNPH 200
    DPFVSKANKL FRFDFLSPFL LSTVMFPFLT QLYEMLSISI FPRDSLKFFT 250
    KFVKKTKENH LESNKKQRVN FLQMMLNSQN FKDTESHKAL SDVEILAQSI 300
    IFIFAGYETS SSTLSCIMYS LATHPDVQKK LHQEIDKTLP NKAFPTYDVM 350
    MEMEYLDMVV NETLRLYPVA NRIERMSKKD FEINGMSFPK GTLVMIPSFA 400
    LHRDSKYWPE PDEFRPERFS KKNKENIDPY IYMPFGNGPR NCIGRRMALM 450
    NLKLALIRLL QNFSFYPCKE TQIPLRLSSE ALLQPEKPLI LKVVSRDETI 500
    RGA 503
    Length:503
    Mass (Da):58,139
    Last modified:November 1, 1996 - v1
    Checksum:i071E187ADACDC4F9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D26487 mRNA. Translation: BAA05498.1.
    RefSeqiNP_001166588.1. NM_001173117.1.

    Genome annotation databases

    GeneIDi100379245.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D26487 mRNA. Translation: BAA05498.1 .
    RefSeqi NP_001166588.1. NM_001173117.1.

    3D structure databases

    ProteinModelPortali Q64406.
    SMRi Q64406. Positions 30-496.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10141.ENSCPOP00000001435.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100379245.

    Organism-specific databases

    CTDi 100379245.

    Phylogenomic databases

    eggNOGi COG2124.
    HOVERGENi HBG108567.
    InParanoidi Q64406.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Regulation of CYP1A and CYP3A mRNAs by ascorbic acid in guinea pigs."
      Mori T., Itoh S., Ohgiya S., Ishizaki K., Kamataki T.
      Arch. Biochem. Biophys. 348:268-277(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Hartley.
      Tissue: Liver.

    Entry informationi

    Entry nameiCP3AF_CAVPO
    AccessioniPrimary (citable) accession number: Q64406
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3