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Reviewed, UniProtKB/Swiss-Prot Q64405 (CATA_CAVPO)

Last modified June 16, 2009. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Catalase
    EC=1.11.1.6
Gene names
Name: CAT
OrganismCavia porcellus (Guinea pig)
Taxonomic identifier10141 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricognathi › Caviidae › Cavia

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Protein attributes

Sequence length527 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.

Catalytic activity

2 H2O2 = O2 + 2 H2O.

Cofactor

Heme group By similarity.

NADP By similarity.

Subunit structure

Homotetramer By similarity.

Subcellular location

Peroxisome By similarity.

Sequence similarities

Belongs to the catalase family.

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Ontologies

Keywords
   Biological processHydrogen peroxide
   Cellular componentPeroxisome
   LigandHeme
Iron
Metal-binding
NADP
   Molecular functionMitogen
Oxidoreductase
Peroxidase
   PTMPhosphoprotein
Gene Ontology (GO)
   Biological processcell proliferation

Inferred from electronic annotation. Source: UniProtKB-KW

hydrogen peroxide catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentperoxisome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioncatalase activity

Inferred from electronic annotation. Source: EC

growth factor activity

Inferred from electronic annotation. Source: UniProtKB-KW

heme binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 527526Catalase
PRO_0000084900

Sites

Active site751 By similarity
Active site1481 By similarity
Metal binding3581Iron (heme axial ligand) By similarity

Amino acid modifications

Modified residue2311Phosphotyrosine By similarity
Modified residue3081Phosphotyrosine By similarity
Modified residue5171Phosphoserine By similarity

Experimental info

Sequence conflict91Missing in AAC52717. Ref.2
Sequence conflict831A → G in AAC52717. Ref.2

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Sequences

Sequence LengthMass (Da)Tools
Q64405-1 [UniParc].

Last modified January 23, 2007. Version 4.
Checksum: 7C53CDD76255F9A8

FASTA52759,934
        10         20         30         40         50         60 
MADSRDPASD QMKHWKEERA AQKPDVLTTA GGNPVGDKLN IMTVGPRGPL LVQDVVFTDE 

        70         80         90        100        110        120 
MAHFDRERIP ERVVHAKGAG AFAYFEVTHD ITKYCKAKVF EHIGKKTPIA VRFSTVAGES 

       130        140        150        160        170        180 
GSADTVRDPR GFAVKFYTEE GIWDLVGNNT PIFFIRDALL FPSFIHSQKR NPQTHLKDPD 

       190        200        210        220        230        240 
MMWDFWSLRP ESLHQVSFLF SDRGIPDGHR HMNGYGSHTF KLVNGSGEAV YCKFHYKTDQ 

       250        260        270        280        290        300 
GIKNLSVEDA ARLSQEDPDY GLRDLFNAIA TGNYPSWTLY IQVMTFQQAQ SFPFNPFDLT 

       310        320        330        340        350        360 
KIWPHKDYPL IPVGKLVLNR NPVNYFAEVE QIAFDPSNMP PGIEPSPDKM LQGRLFAYPD 

       370        380        390        400        410        420 
THRHRLGPNY LQIPVNCPYR TRVANYQRDG PMCVTDNQGG APNYYPNSFS APVEQRQALE 

       430        440        450        460        470        480 
HTSRCSGDVG RYNSTDDDNV TQVRAFYTQV LNEEQRRRLC ENIAGHLKDA QLFIQKKAVK 

       490        500        510        520 
NFMDVHPDYG NRIQTLLDKY NVEKPKNAIH TFVQDGSHLS AKEKANL

« Hide

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References

[1]"Molecular characterization of guinea pig catalase."
Pinteric M., Baumgart E., Bulitta C., Fahimi D., Voelkl A.
Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Differential patterns of antioxidant enzyme mRNA expression in guinea pig lung and liver during development."
Yuan H.T., Bingle C.D., Kelly F.J.
Biochim. Biophys. Acta 1305:163-171(1996) [PubMed: 8597602] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-138.
Strain: Hartley.
Tissue: Lung.

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Cross-references

Sequence databases

AJ005111 mRNA. Translation: CAB57222.1.
U39841 mRNA. Translation: AAC52717.1.

3D structure databases

HSSPHSSP built from PDB template 4BLC based on UniProtKB P00432.
SMRQ64405. Positions 5-501.
ModBaseSearch...

Genome annotation databases

EnsemblENSCPOG00000012582. Cavia porcellus. [Contig view]

Phylogenomic databases

HOVERGENQ64405.

Enzyme and pathway databases

BRENDA1.11.1.6. 44.

Family and domain databases

InterProIPR002226. Catalase.
IPR010582. Catalase-rel_immune_responsive.
IPR011614. Catalase_N.
IPR018028. Catalase_rel_subgroup.
[Graphical view]
Gene3DG3DSA:2.40.180.10. Catalase_N. 1 hit.
PANTHERPTHR11465. Catalase. 1 hit.
PfamPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PRINTSPR00067. CATALASE.
ProDomPD000510. Catalase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameCATA_CAVPO
AccessionPrimary (citable) accession number: Q64405
Secondary accession number(s): Q9QZ51
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: June 16, 2009
This is version 57 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents