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Protein

Cytochrome P450 2D16

Gene

CYP2D16

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi446 – 4461Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2D16 (EC:1.14.14.1)
Alternative name(s):
CYPIID16
Gene namesi
Name:CYP2D16
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
ProteomesiUP000005447: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Cytochrome P450 2D16PRO_0000051740Add
BLAST

Expressioni

Tissue specificityi

Expressed at high levels in the inner zone of the adrenal cortex.

Structurei

3D structure databases

ProteinModelPortaliQ64403.
SMRiQ64403. Positions 37-500.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi81 – 844Poly-Val

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiQ64403.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64403-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLTGDALF SVAVAVAIFL LLVDLMHRRQ RWAARYPPGP VPVPGLGNLL
60 70 80 90 100
QVDFENMAYS CDKLRHQFGD VFSLQFVWTP VVVVNGLLAV REALVNNSTD
110 120 130 140 150
TSDRPTLPTN ALLGFGPKAQ GVIGAYYGPA WREQRRFSVS SLRNFGLGKK
160 170 180 190 200
SLEQWVTEEA ACLCAAFTNH AGQPFCPKAL LNKAVCNVIS SLIYARRFDY
210 220 230 240 250
DDPMVLRLLE FLEETLRENS SLKIQVLNSI PLLLRIPCVA AKVLSAQRSF
260 270 280 290 300
IALNDKLLAE HNTGWAPDQP PRDLTDAFLT EMHKAQGNSE SSFNDENLRL
310 320 330 340 350
LVSDLFGAGM VTTSVTLSWA LLLMILHPDV QRHVQEEIDE VIGQVRCPEM
360 370 380 390 400
ADQAHMPFTN AVIHEVQRFA DIVPMGVPHM TSRDTEVQGF LIPKGTMLFT
410 420 430 440 450
NLSSVLKDET VWEKPLHFHP GHFLDAEGRF VKREAFMPFS AGPRICLGEP
460 470 480 490 500
LARMELFLFF TSLLQRFSFS VPEGQPRPSD RGAPYLVVLP SPYQLCAVLR
Length:500
Mass (Da):55,801
Last modified:November 1, 1996 - v1
Checksum:i2429247E49BF6B24
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti123 – 1231I → V in AAB94568 (Ref. 2) Curated
Sequence conflicti127 – 1271Y → N in AAB94568 (Ref. 2) Curated
Sequence conflicti148 – 1481G → R in AAB94568 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21486 mRNA. Translation: AAA68479.1.
AF020345 Genomic DNA. Translation: AAB94568.1.
PIRiJC4153.
RefSeqiNP_001166507.1. NM_001173036.1.

Genome annotation databases

GeneIDi100169696.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21486 mRNA. Translation: AAA68479.1.
AF020345 Genomic DNA. Translation: AAB94568.1.
PIRiJC4153.
RefSeqiNP_001166507.1. NM_001173036.1.

3D structure databases

ProteinModelPortaliQ64403.
SMRiQ64403. Positions 37-500.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100169696.

Organism-specific databases

CTDi100169696.

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiQ64403.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and sequencing of a guinea pig cytochrome P4502D (CYP2D16): high level expression in adrenal microsomes."
    Jiang Q., Voigt J.M., Colby H.D.
    Biochem. Biophys. Res. Commun. 209:1149-1156(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 1-38.
    Strain: 13.
    Tissue: Adrenal cortex.
  2. "The gene sequence of a xenobiotic metabolism-related cytochrome P450 isozyme (CYP2D16) in guinea pig adrenal gland."
    Sun Y., Voigt J.M., Pierce J.C., Colby H.D.
    Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Hartley.
    Tissue: Adrenal gland.

Entry informationi

Entry nameiCP2DG_CAVPO
AccessioniPrimary (citable) accession number: Q64403
Secondary accession number(s): O54866
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: January 7, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.