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Q64403

- CP2DG_CAVPO

UniProt

Q64403 - CP2DG_CAVPO

Protein

Cytochrome P450 2D16

Gene

CYP2D16

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi446 – 4461Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2D16 (EC:1.14.14.1)
    Alternative name(s):
    CYPIID16
    Gene namesi
    Name:CYP2D16
    OrganismiCavia porcellus (Guinea pig)
    Taxonomic identifieri10141 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
    ProteomesiUP000005447: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 500500Cytochrome P450 2D16PRO_0000051740Add
    BLAST

    Expressioni

    Tissue specificityi

    Expressed at high levels in the inner zone of the adrenal cortex.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64403.
    SMRiQ64403. Positions 37-500.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi81 – 844Poly-Val

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000036991.
    HOVERGENiHBG015789.
    InParanoidiQ64403.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01686. EP450ICYP2D.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q64403-1 [UniParc]FASTAAdd to Basket

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    MGLLTGDALF SVAVAVAIFL LLVDLMHRRQ RWAARYPPGP VPVPGLGNLL    50
    QVDFENMAYS CDKLRHQFGD VFSLQFVWTP VVVVNGLLAV REALVNNSTD 100
    TSDRPTLPTN ALLGFGPKAQ GVIGAYYGPA WREQRRFSVS SLRNFGLGKK 150
    SLEQWVTEEA ACLCAAFTNH AGQPFCPKAL LNKAVCNVIS SLIYARRFDY 200
    DDPMVLRLLE FLEETLRENS SLKIQVLNSI PLLLRIPCVA AKVLSAQRSF 250
    IALNDKLLAE HNTGWAPDQP PRDLTDAFLT EMHKAQGNSE SSFNDENLRL 300
    LVSDLFGAGM VTTSVTLSWA LLLMILHPDV QRHVQEEIDE VIGQVRCPEM 350
    ADQAHMPFTN AVIHEVQRFA DIVPMGVPHM TSRDTEVQGF LIPKGTMLFT 400
    NLSSVLKDET VWEKPLHFHP GHFLDAEGRF VKREAFMPFS AGPRICLGEP 450
    LARMELFLFF TSLLQRFSFS VPEGQPRPSD RGAPYLVVLP SPYQLCAVLR 500
    Length:500
    Mass (Da):55,801
    Last modified:November 1, 1996 - v1
    Checksum:i2429247E49BF6B24
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti123 – 1231I → V in AAB94568. 1 PublicationCurated
    Sequence conflicti127 – 1271Y → N in AAB94568. 1 PublicationCurated
    Sequence conflicti148 – 1481G → R in AAB94568. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U21486 mRNA. Translation: AAA68479.1.
    AF020345 Genomic DNA. Translation: AAB94568.1.
    PIRiJC4153.
    RefSeqiNP_001166507.1. NM_001173036.1.

    Genome annotation databases

    GeneIDi100169696.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U21486 mRNA. Translation: AAA68479.1 .
    AF020345 Genomic DNA. Translation: AAB94568.1 .
    PIRi JC4153.
    RefSeqi NP_001166507.1. NM_001173036.1.

    3D structure databases

    ProteinModelPortali Q64403.
    SMRi Q64403. Positions 37-500.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100169696.

    Organism-specific databases

    CTDi 100169696.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000036991.
    HOVERGENi HBG015789.
    InParanoidi Q64403.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01686. EP450ICYP2D.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and sequencing of a guinea pig cytochrome P4502D (CYP2D16): high level expression in adrenal microsomes."
      Jiang Q., Voigt J.M., Colby H.D.
      Biochem. Biophys. Res. Commun. 209:1149-1156(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 1-38.
      Strain: 13.
      Tissue: Adrenal cortex.
    2. "The gene sequence of a xenobiotic metabolism-related cytochrome P450 isozyme (CYP2D16) in guinea pig adrenal gland."
      Sun Y., Voigt J.M., Pierce J.C., Colby H.D.
      Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Hartley.
      Tissue: Adrenal gland.

    Entry informationi

    Entry nameiCP2DG_CAVPO
    AccessioniPrimary (citable) accession number: Q64403
    Secondary accession number(s): O54866
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3