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Q64403

- CP2DG_CAVPO

UniProt

Q64403 - CP2DG_CAVPO

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Protein
Cytochrome P450 2D16
Gene
CYP2D16
Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi446 – 4461Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2D16 (EC:1.14.14.1)
Alternative name(s):
CYPIID16
Gene namesi
Name:CYP2D16
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
ProteomesiUP000005447: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Cytochrome P450 2D16
PRO_0000051740Add
BLAST

Expressioni

Tissue specificityi

Expressed at high levels in the inner zone of the adrenal cortex.

Structurei

3D structure databases

ProteinModelPortaliQ64403.
SMRiQ64403. Positions 37-500.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi81 – 844Poly-Val

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiQ64403.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64403-1 [UniParc]FASTAAdd to Basket

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MGLLTGDALF SVAVAVAIFL LLVDLMHRRQ RWAARYPPGP VPVPGLGNLL    50
QVDFENMAYS CDKLRHQFGD VFSLQFVWTP VVVVNGLLAV REALVNNSTD 100
TSDRPTLPTN ALLGFGPKAQ GVIGAYYGPA WREQRRFSVS SLRNFGLGKK 150
SLEQWVTEEA ACLCAAFTNH AGQPFCPKAL LNKAVCNVIS SLIYARRFDY 200
DDPMVLRLLE FLEETLRENS SLKIQVLNSI PLLLRIPCVA AKVLSAQRSF 250
IALNDKLLAE HNTGWAPDQP PRDLTDAFLT EMHKAQGNSE SSFNDENLRL 300
LVSDLFGAGM VTTSVTLSWA LLLMILHPDV QRHVQEEIDE VIGQVRCPEM 350
ADQAHMPFTN AVIHEVQRFA DIVPMGVPHM TSRDTEVQGF LIPKGTMLFT 400
NLSSVLKDET VWEKPLHFHP GHFLDAEGRF VKREAFMPFS AGPRICLGEP 450
LARMELFLFF TSLLQRFSFS VPEGQPRPSD RGAPYLVVLP SPYQLCAVLR 500
Length:500
Mass (Da):55,801
Last modified:November 1, 1996 - v1
Checksum:i2429247E49BF6B24
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti123 – 1231I → V in AAB94568. 1 Publication
Sequence conflicti127 – 1271Y → N in AAB94568. 1 Publication
Sequence conflicti148 – 1481G → R in AAB94568. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U21486 mRNA. Translation: AAA68479.1.
AF020345 Genomic DNA. Translation: AAB94568.1.
PIRiJC4153.
RefSeqiNP_001166507.1. NM_001173036.1.

Genome annotation databases

GeneIDi100169696.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U21486 mRNA. Translation: AAA68479.1 .
AF020345 Genomic DNA. Translation: AAB94568.1 .
PIRi JC4153.
RefSeqi NP_001166507.1. NM_001173036.1.

3D structure databases

ProteinModelPortali Q64403.
SMRi Q64403. Positions 37-500.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100169696.

Organism-specific databases

CTDi 100169696.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000036991.
HOVERGENi HBG015789.
InParanoidi Q64403.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and sequencing of a guinea pig cytochrome P4502D (CYP2D16): high level expression in adrenal microsomes."
    Jiang Q., Voigt J.M., Colby H.D.
    Biochem. Biophys. Res. Commun. 209:1149-1156(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 1-38.
    Strain: 13.
    Tissue: Adrenal cortex.
  2. "The gene sequence of a xenobiotic metabolism-related cytochrome P450 isozyme (CYP2D16) in guinea pig adrenal gland."
    Sun Y., Voigt J.M., Pierce J.C., Colby H.D.
    Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Hartley.
    Tissue: Adrenal gland.

Entry informationi

Entry nameiCP2DG_CAVPO
AccessioniPrimary (citable) accession number: Q64403
Secondary accession number(s): O54866
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: December 11, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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