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Q64403 (CP2DG_CAVPO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2D16

EC=1.14.14.1
Alternative name(s):
CYPIID16
Gene names
Name:CYP2D16
OrganismCavia porcellus (Guinea pig) [Reference proteome]
Taxonomic identifier10141 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia

Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Tissue specificity

Expressed at high levels in the inner zone of the adrenal cortex.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 500500Cytochrome P450 2D16
PRO_0000051740

Regions

Compositional bias81 – 844Poly-Val

Sites

Metal binding4461Iron (heme axial ligand) By similarity

Experimental info

Sequence conflict1231I → V in AAB94568. Ref.2
Sequence conflict1271Y → N in AAB94568. Ref.2
Sequence conflict1481G → R in AAB94568. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q64403 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 2429247E49BF6B24

FASTA50055,801
        10         20         30         40         50         60 
MGLLTGDALF SVAVAVAIFL LLVDLMHRRQ RWAARYPPGP VPVPGLGNLL QVDFENMAYS 

        70         80         90        100        110        120 
CDKLRHQFGD VFSLQFVWTP VVVVNGLLAV REALVNNSTD TSDRPTLPTN ALLGFGPKAQ 

       130        140        150        160        170        180 
GVIGAYYGPA WREQRRFSVS SLRNFGLGKK SLEQWVTEEA ACLCAAFTNH AGQPFCPKAL 

       190        200        210        220        230        240 
LNKAVCNVIS SLIYARRFDY DDPMVLRLLE FLEETLRENS SLKIQVLNSI PLLLRIPCVA 

       250        260        270        280        290        300 
AKVLSAQRSF IALNDKLLAE HNTGWAPDQP PRDLTDAFLT EMHKAQGNSE SSFNDENLRL 

       310        320        330        340        350        360 
LVSDLFGAGM VTTSVTLSWA LLLMILHPDV QRHVQEEIDE VIGQVRCPEM ADQAHMPFTN 

       370        380        390        400        410        420 
AVIHEVQRFA DIVPMGVPHM TSRDTEVQGF LIPKGTMLFT NLSSVLKDET VWEKPLHFHP 

       430        440        450        460        470        480 
GHFLDAEGRF VKREAFMPFS AGPRICLGEP LARMELFLFF TSLLQRFSFS VPEGQPRPSD 

       490        500 
RGAPYLVVLP SPYQLCAVLR 

« Hide

References

[1]"Molecular cloning and sequencing of a guinea pig cytochrome P4502D (CYP2D16): high level expression in adrenal microsomes."
Jiang Q., Voigt J.M., Colby H.D.
Biochem. Biophys. Res. Commun. 209:1149-1156(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 1-38.
Strain: 13.
Tissue: Adrenal cortex.
[2]"The gene sequence of a xenobiotic metabolism-related cytochrome P450 isozyme (CYP2D16) in guinea pig adrenal gland."
Sun Y., Voigt J.M., Pierce J.C., Colby H.D.
Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Hartley.
Tissue: Adrenal gland.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U21486 mRNA. Translation: AAA68479.1.
AF020345 Genomic DNA. Translation: AAB94568.1.
PIRJC4153.
RefSeqNP_001166507.1. NM_001173036.1.

3D structure databases

ProteinModelPortalQ64403.
SMRQ64403. Positions 37-500.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100169696.

Organism-specific databases

CTD100169696.

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000036991.
HOVERGENHBG015789.
InParanoidQ64403.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP2DG_CAVPO
AccessionPrimary (citable) accession number: Q64403
Secondary accession number(s): O54866
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: December 11, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families