Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

HCTP4

Gene

HCTP4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
HCTP4Imported
Submitted name:
TPX2, microtubule-associated, homolog (Xenopus laevis), isoform CRA_bImported
Submitted name:
cDNA, FLJ92922Imported
Gene namesi
Name:HCTP4Imported
Synonyms:TPX2Imported
ORF Names:hCG_38821Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25638.

Expressioni

Gene expression databases

BgeeiENSG00000088325.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GOLGA2Q083793EBI-10248808,EBI-618309

Protein-protein interaction databases

STRINGi9606.ENSP00000300403.

Structurei

3D structure databases

SMRiQ643R0. Positions 6-42.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 6868Aurora-A_bindInterPro annotationAdd
BLAST
Domaini366 – 489124TPX2_importinInterPro annotationAdd
BLAST
Domaini662 – 71857TPX2InterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili662 – 71453Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410IIEY. Eukaryota.
ENOG4110SQ6. LUCA.
HOVERGENiHBG057334.
KOiK16812.
PhylomeDBiQ643R0.

Family and domain databases

InterProiIPR015128. Aurora-A-bd.
IPR027329. TPX2_C.
IPR027330. TPX2_central_dom.
IPR009675. TPX2_fam.
[Graphical view]
PANTHERiPTHR14326. PTHR14326. 1 hit.
PfamiPF09041. Aurora-A_bind. 1 hit.
PF06886. TPX2. 1 hit.
PF12214. TPX2_importin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q643R0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQVKSSYSY DAPSDFINFS SLDDEGDTQN IDSWFEEKAN LENKLLGKNG
60 70 80 90 100
TGGLFQGKTP LRKANLQQAI VTPLKPVDNT YYKEAEKENL VEQSIPSNAC
110 120 130 140 150
SSLEVEAAIS RKTPAQPQRR SLRLSAQKDL EQKEKHHVKM KAKRCATPVI
160 170 180 190 200
IDEILPSKKM KVSNNKKKPE EEGSAHQDTA EKNASSPEKA KGRHTVPCMP
210 220 230 240 250
PAKQKFLKST EEQELEKSMK MQQEVVEMRK KNEEFKKLAL AGIGQPVKKS
260 270 280 290 300
VSQVTKSVDF HFRTDERIKQ HPKNQEEYKE VNFTSELRKH PSSPARVTKG
310 320 330 340 350
CTIVKPFNLS QGKKRTFDET VSTYVPLAQQ VEDFHKRTPN RYHLRSKKDD
360 370 380 390 400
INLLPSKSSV TKICRDPQTP VLQTKHRARA VTCKSTAELE AEELEKLQQY
410 420 430 440 450
KFKARELDPR ILEGGPILPK KPPVKPPTEP IGFDLEIEKR IQERESKKKT
460 470 480 490 500
EDEHFEFHSR PCPTKILEDV VGVPEKKVLP ITVPKSPAFA LKNRIRMPTK
510 520 530 540 550
EDEEEDEPVV IKAQPVPHYG VPFKPQIPEA RTVEICPFSF DSRDKERQLQ
560 570 580 590 600
KEKKIKELQK GEVPKFKALP LPHFDTINLP EKKVKNVTQI EPFCLETDRR
610 620 630 640 650
GALKAQTWKH QLEEELRQQK EAACFKARPN TVISQEPFVP KKEKKSVAEG
660 670 680 690 700
LSGSLVQEPF QLATEKRAKE RQELEKRMAE VEAQKAQQLE EARLQEEEQK
710 720 730 740
KEELARLRRE LVHKANPIRK YQGLEIKSSD QPLTVPVSPK FSTRFHC
Length:747
Mass (Da):85,653
Last modified:May 10, 2005 - v1
Checksum:iE028E0BB50BBCA0F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY734680 mRNA. Translation: AAU29203.1.
AK312549 mRNA. Translation: BAG35446.1.
CH471077 Genomic DNA. Translation: EAW76419.1.
CH471077 Genomic DNA. Translation: EAW76421.1.
RefSeqiNP_036244.2. NM_012112.4.
XP_011526999.1. XM_011528697.2.
XP_011527001.1. XM_011528699.2.
UniGeneiHs.244580.

Genome annotation databases

GeneIDi22974.
KEGGihsa:22974.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY734680 mRNA. Translation: AAU29203.1.
AK312549 mRNA. Translation: BAG35446.1.
CH471077 Genomic DNA. Translation: EAW76419.1.
CH471077 Genomic DNA. Translation: EAW76421.1.
RefSeqiNP_036244.2. NM_012112.4.
XP_011526999.1. XM_011528697.2.
XP_011527001.1. XM_011528699.2.
UniGeneiHs.244580.

3D structure databases

SMRiQ643R0. Positions 6-42.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000300403.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi22974.
KEGGihsa:22974.

Organism-specific databases

CTDi22974.
PharmGKBiPA25638.

Phylogenomic databases

eggNOGiENOG410IIEY. Eukaryota.
ENOG4110SQ6. LUCA.
HOVERGENiHBG057334.
KOiK16812.
PhylomeDBiQ643R0.

Miscellaneous databases

ChiTaRSiTPX2. human.
GenomeRNAii22974.

Gene expression databases

BgeeiENSG00000088325.

Family and domain databases

InterProiIPR015128. Aurora-A-bd.
IPR027329. TPX2_C.
IPR027330. TPX2_central_dom.
IPR009675. TPX2_fam.
[Graphical view]
PANTHERiPTHR14326. PTHR14326. 1 hit.
PfamiPF09041. Aurora-A_bind. 1 hit.
PF06886. TPX2. 1 hit.
PF12214. TPX2_importin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ643R0_HUMAN
AccessioniPrimary (citable) accession number: Q643R0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: September 7, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.