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Protein
Submitted name:

HCTP4

Gene

HCTP4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
HCTP4Imported
Submitted name:
TPX2, microtubule-associated, homolog (Xenopus laevis), isoform CRA_bImported
Submitted name:
cDNA, FLJ92922Imported
Gene namesi
Name:HCTP4Imported
Synonyms:TPX2Imported
ORF Names:hCG_38821Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000088325.15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25638

Expressioni

Gene expression databases

BgeeiENSG00000088325

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GOLGA2Q083793EBI-10248808,EBI-618309

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ643R0, 1 interactor

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 68Aurora-A_bindInterPro annotationAdd BLAST68
Domaini366 – 489TPX2_importinInterPro annotationAdd BLAST124
Domaini662 – 718TPX2InterPro annotationAdd BLAST57

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili218 – 238Sequence analysisAdd BLAST21
Coiled coili662 – 714Sequence analysisAdd BLAST53

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410IIEY Eukaryota
ENOG4110SQ6 LUCA
HOVERGENiHBG057334
KOiK16812

Family and domain databases

InterProiView protein in InterPro
IPR015128 Aurora-A-bd
IPR027329 TPX2_C
IPR027330 TPX2_central_dom
IPR009675 TPX2_fam
PANTHERiPTHR14326 PTHR14326, 1 hit
PfamiView protein in Pfam
PF09041 Aurora-A_bind, 1 hit
PF06886 TPX2, 1 hit
PF12214 TPX2_importin, 1 hit

Sequencei

Sequence statusi: Complete.

Q643R0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQVKSSYSY DAPSDFINFS SLDDEGDTQN IDSWFEEKAN LENKLLGKNG
60 70 80 90 100
TGGLFQGKTP LRKANLQQAI VTPLKPVDNT YYKEAEKENL VEQSIPSNAC
110 120 130 140 150
SSLEVEAAIS RKTPAQPQRR SLRLSAQKDL EQKEKHHVKM KAKRCATPVI
160 170 180 190 200
IDEILPSKKM KVSNNKKKPE EEGSAHQDTA EKNASSPEKA KGRHTVPCMP
210 220 230 240 250
PAKQKFLKST EEQELEKSMK MQQEVVEMRK KNEEFKKLAL AGIGQPVKKS
260 270 280 290 300
VSQVTKSVDF HFRTDERIKQ HPKNQEEYKE VNFTSELRKH PSSPARVTKG
310 320 330 340 350
CTIVKPFNLS QGKKRTFDET VSTYVPLAQQ VEDFHKRTPN RYHLRSKKDD
360 370 380 390 400
INLLPSKSSV TKICRDPQTP VLQTKHRARA VTCKSTAELE AEELEKLQQY
410 420 430 440 450
KFKARELDPR ILEGGPILPK KPPVKPPTEP IGFDLEIEKR IQERESKKKT
460 470 480 490 500
EDEHFEFHSR PCPTKILEDV VGVPEKKVLP ITVPKSPAFA LKNRIRMPTK
510 520 530 540 550
EDEEEDEPVV IKAQPVPHYG VPFKPQIPEA RTVEICPFSF DSRDKERQLQ
560 570 580 590 600
KEKKIKELQK GEVPKFKALP LPHFDTINLP EKKVKNVTQI EPFCLETDRR
610 620 630 640 650
GALKAQTWKH QLEEELRQQK EAACFKARPN TVISQEPFVP KKEKKSVAEG
660 670 680 690 700
LSGSLVQEPF QLATEKRAKE RQELEKRMAE VEAQKAQQLE EARLQEEEQK
710 720 730 740
KEELARLRRE LVHKANPIRK YQGLEIKSSD QPLTVPVSPK FSTRFHC
Length:747
Mass (Da):85,653
Last modified:May 10, 2005 - v1
Checksum:iE028E0BB50BBCA0F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY734680 mRNA Translation: AAU29203.1
AK312549 mRNA Translation: BAG35446.1
CH471077 Genomic DNA Translation: EAW76419.1
CH471077 Genomic DNA Translation: EAW76421.1
RefSeqiNP_036244.2, NM_012112.4
XP_011526999.1, XM_011528697.2
XP_011527001.1, XM_011528699.2
UniGeneiHs.244580

Genome annotation databases

GeneIDi22974
KEGGihsa:22974

Similar proteinsi

Entry informationi

Entry nameiQ643R0_HUMAN
AccessioniPrimary (citable) accession number: Q643R0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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