Reviewed, UniProtKB/Swiss-Prot Q64395 (PDE1B_CRIGR)

Names and origin

Protein names

Recommended name:
    Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
      Short name=Cam-PDE 1B
    EC=3.1.4.17

Gene names

Name:

PDE1B1

Organism

Cricetulus griseus (Chinese hamster)

Taxonomic identifier

10029 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Cricetidae › Cricetinae › Cricetulus

Protein attributes

Sequence length	199 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.
Enzyme regulation	Type I PDE are activated by the binding of calmodulin in the presence of Ca2+.
Subunit structure	Homodimer.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the cyclic nucleotide phosphodiesterase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	cAMP cGMP
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3',5'-cyclic-nucleotide phosphodiesterase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›199	›199	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B		PRO_0000198788
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	199	1

Sequences

	Sequence		Length	Mass (Da)
	Q64395-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 17AD1392C727BB5F	FASTA	199	22,904
	10 20 30 40 50 60 LISRFKIPTV FLMSFLEALE TGYGKYKNPY HNQIHAADVT QTVHCFLLRT GMVHCLSEIE 70 80 90 100 110 120 VLAIIFAAAI HDYEHTGTTN SFHIQTKSEC AILYNDRSVL ENHHISSVFR MMQDDEMNIF 130 140 150 160 170 180 INLTKDEFVE LRALVIEMVL ATDMSCHFQQ VKSMKTALQQ LERIDKSKAL SLLLHAADIS 190 HPTKQWSVHS HWTKALMEE

References

[1]

"Receptor-mediated stimulation of lipid signalling pathways in CHO cells elicits the rapid transient induction of the PDE1B isoform of Ca2+/calmodulin-stimulated cAMP phosphodiesterase." Spence S., Rena G., Sullivan M., Erdogan S., Houslay M.D. Biochem. J. 321:157-163(1997) [PubMed: 9003415] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	U40585 mRNA. Translation: AAB50017.1.
3D structure databases
HSSP	HSSP built from PDB template 1OYN based on UniProtKB Q08499.
SMR	Q64395. Positions 1-199.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q64395.
Enzyme and pathway databases
BRENDA	3.1.4.17. 18.
Family and domain databases
InterPro	IPR003607. Met-dep_phosphohydro_HD. IPR002073. PDEase. [Graphical view]
Pfam	PF00233. PDEase_I. 1 hit. [Graphical view]
PRINTS	PR00387. PDIESTERASE1.
SMART	SM00471. HDc. 1 hit. [Graphical view]
PROSITE	PS00126. PDEASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PDE1B_CRIGR

Accession

Primary (citable) accession number: Q64395

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2004
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)