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Protein

Sialidase-2

Gene

NEU2

Organism
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins, oligosaccharides and gangliosides.1 Publication

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei21SubstrateBy similarity1
Binding sitei41SubstrateBy similarity1
Active sitei46Proton acceptorBy similarity1
Binding sitei179SubstrateBy similarity1
Binding sitei181SubstrateBy similarity1
Binding sitei218SubstrateBy similarity1
Binding sitei237SubstrateSequence analysis1
Binding sitei303SubstrateBy similarity1
Active sitei333NucleophileBy similarity1
Active sitei354Sequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Lipid degradation, Lipid metabolism

Protein family/group databases

CAZyiGH33 Glycoside Hydrolase Family 33

Names & Taxonomyi

Protein namesi
Recommended name:
Sialidase-2 (EC:3.2.1.18)
Alternative name(s):
Cytosolic sialidase
N-acetyl-alpha-neuraminidase 2
Gene namesi
Name:NEU2
OrganismiCricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Taxonomic identifieri10029 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeCricetinaeCricetulus

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002088981 – 379Sialidase-2Add BLAST379

Proteomic databases

PRIDEiQ64393

Structurei

3D structure databases

ProteinModelPortaliQ64393
SMRiQ64393
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati127 – 138BNR 1Add BLAST12
Repeati197 – 208BNR 2Add BLAST12

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi20 – 23FRIP motif4

Sequence similaritiesi

Belongs to the glycosyl hydrolase 33 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG052608
KOiK12357

Family and domain databases

InterProiView protein in InterPro
IPR011040 Sialidase
IPR026945 Sialidase-2
IPR026856 Sialidase_fam
IPR036278 Sialidase_sf
PANTHERiPTHR10628 PTHR10628, 1 hit
PTHR10628:SF6 PTHR10628:SF6, 1 hit
PfamiView protein in Pfam
PF13088 BNR_2, 1 hit
SUPFAMiSSF50939 SSF50939, 1 hit

Sequencei

Sequence statusi: Complete.

Q64393-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATCPVLQKE TLFQTGDYAY RIPALIYLSK QKTLLAFAEK RLTKTDEHAD
60 70 80 90 100
LFVLRRGSYN ADTHQVQWQA EEVVTQAYLE GHRSMSPCPL YDKQTRTLFL
110 120 130 140 150
FFIAVRGQIS EHHQLQTGVN VTRLCHITST DHGKTWSAVQ DLTDTTIGST
160 170 180 190 200
HQDWATFGVG PGHCLQLRNT AGSLLVPAYA YRKQPPIHAP APSAFCFLSH
210 220 230 240 250
DHGSTWELGH FVSQNSLECQ VAEVGTGAER VVYLNARSCL GARVQAQSPN
260 270 280 290 300
SGLDFQDNQV VSKLVEPPKG CHGSVIAFPN PTSKADALDV WLLYTHPTDS
310 320 330 340 350
RKRTNLGVYL NQKPLDPTTW SAPTLLATGI CAYSDLQNMG HGPDGSPQFG
360 370
CLYESNNYEE IVFLMFTLKQ AFPAVFGAQ
Length:379
Mass (Da):41,962
Last modified:November 1, 1996 - v1
Checksum:iB5AFFBC6B6BE88B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06143 mRNA Translation: AAA19746.1
PIRiA54961
RefSeqiNP_001233664.1, NM_001246735.2

Genome annotation databases

EnsembliENSCGRT00001030356; ENSCGRP00001026110; ENSCGRG00001023529
GeneIDi100689301
KEGGicge:100689301

Similar proteinsi

Entry informationi

Entry nameiNEUR2_CRIGR
AccessioniPrimary (citable) accession number: Q64393
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

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