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Protein

Potassium-transporting ATPase alpha chain 2

Gene

ATP12A

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane. Responsible for potassium absorption in various tissues.

Catalytic activityi

ATP + H2O + H+(In) + K+(Out) = ADP + phosphate + H+(Out) + K+(In).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3854-aspartylphosphate intermediateBy similarity1
Metal bindingi726MagnesiumBy similarity1
Metal bindingi730MagnesiumBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processHydrogen ion transport, Ion transport, Potassium transport, Transport
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium-transporting ATPase alpha chain 2 (EC:3.6.3.10)
Alternative name(s):
Non-gastric H(+)/K(+) ATPase subunit alpha
Proton pump
Gene namesi
Name:ATP12A
Synonyms:ATP1AL1
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 96CytoplasmicSequence analysisAdd BLAST96
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Topological domaini118 – 140LumenalSequence analysisAdd BLAST23
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Topological domaini162 – 297CytoplasmicSequence analysisAdd BLAST136
Transmembranei298 – 317HelicalSequence analysisAdd BLAST20
Topological domaini318 – 329LumenalSequence analysisAdd BLAST12
Transmembranei330 – 347HelicalSequence analysisAdd BLAST18
Topological domaini348 – 781CytoplasmicSequence analysisAdd BLAST434
Transmembranei782 – 801HelicalSequence analysisAdd BLAST20
Topological domaini802 – 811LumenalSequence analysis10
Transmembranei812 – 832HelicalSequence analysisAdd BLAST21
Topological domaini833 – 852CytoplasmicSequence analysisAdd BLAST20
Transmembranei853 – 875HelicalSequence analysisAdd BLAST23
Topological domaini876 – 927LumenalSequence analysisAdd BLAST52
Transmembranei928 – 947HelicalSequence analysisAdd BLAST20
Topological domaini948 – 961CytoplasmicSequence analysisAdd BLAST14
Transmembranei962 – 980HelicalSequence analysisAdd BLAST19
Topological domaini981 – 995LumenalSequence analysisAdd BLAST15
Transmembranei996 – 1016HelicalSequence analysisAdd BLAST21
Topological domaini1017 – 1033CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000462591 – 1033Potassium-transporting ATPase alpha chain 2Add BLAST1033

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei952Phosphoserine; by PKABy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ64392

Expressioni

Tissue specificityi

Found in skin, kidney and distal colon.1 Publication

Interactioni

Subunit structurei

Composed of two subunits: alpha (catalytic) and beta.

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000003081

Structurei

3D structure databases

ProteinModelPortaliQ64392
SMRiQ64392
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0203 Eukaryota
COG0474 LUCA
GeneTreeiENSGT00890000139334
HOGENOMiHOG000265622
HOVERGENiHBG004298
InParanoidiQ64392
OMAiPHAILIW
OrthoDBiEOG091G01BB
TreeFamiTF312838

Family and domain databases

CDDicd02608 P-type_ATPase_Na-K_like, 1 hit
Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR030318 Atp12a
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR005775 P-type_ATPase_IIC
IPR001757 P_typ_ATPase
PANTHERiPTHR43294:SF1 PTHR43294:SF1, 1 hit
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01106 ATPase-IIC_X-K, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequencei

Sequence statusi: Complete.

Q64392-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRKTLEIYS VELDGTKDTK QLGQEEGKKC NELDLKKSSQ KEELKKELDL
60 70 80 90 100
DDHKLTSEEL EQKYGTNIIR GLSSTRAAEL LARDGPNALS PPKQTPEIIK
110 120 130 140 150
FLKQMIGGFS ILLWVGAILC WIAYGIQYAS NQSGSLDNVY LGVVLALVVI
160 170 180 190 200
LTGIFAYYQE AKSTNIMSSF SKMIPQEALV TRDAEKKVIP AEQLVVGDIV
210 220 230 240 250
EIKGGDQIPA DIRLLFSQGC KVDNSSLTGE SEPQPRSAEF THENPLETKN
260 270 280 290 300
IAFYSTTCLE GTATGMVINT GDRTIIGRIA SLASGVGNEK TPIATEIEHF
310 320 330 340 350
VHIVAGVAVS IGILFFIIAV SLKYRVLDSI IFLIGIIVAN VPEGLLATVT
360 370 380 390 400
VTLSLTAKRM AKKNCLVKNL EAVETLGSTS VICSDKTGTL TQNRMTVAHL
410 420 430 440 450
WFDSQIFTAD TSESQSNQAF DQSSGTWASL SKIIALCNRA EFRPGQENVP
460 470 480 490 500
IMKRVVVGDA SETALLKFSE VILGDVMEIR KRNRKVAEIP FNSTNKFQLS
510 520 530 540 550
IHETEDPGDP RFLMVMKGAP ERILEKCSTI MINGQEQPLD KNNANAFHTA
560 570 580 590 600
YMELGGMGER VLGFCHLYLP AHEFPENYSF DVDTMNFPTS NLCFVGLLSM
610 620 630 640 650
IDPPRSTVPD AVAKCRSAGI KVIMVTGDHP ITAKAIAKSV GIISANSETV
660 670 680 690 700
EDIAKRCNIA VEQVNKQDAR AAVVTGMELK DMTPEQLDEI LANYPEIVFA
710 720 730 740 750
RTSPQQKLII VEGCQRQNAV VAVTGDGVND SPALKKADIG IAMGIAGSDA
760 770 780 790 800
AKNAADMVLL DDNFASIVTG VEEGRLIFDN LKKTIAYTLT KNIAELCPFL
810 820 830 840 850
VYIIVGLPLP IGTITILFID LGTDIIPSIA LAYEKVESDI MNRKPRHKKK
860 870 880 890 900
DRLVNHQLAI YSYLHIGLMQ ALGAFLVYFT VYAQQGFWPT SLIQLRVKWE
910 920 930 940 950
QDYVNDLEDS YGQQWTRYQR KYLEWTGYTA FFVGIMVQQI ADLIIRKTRR
960 970 980 990 1000
NSIFQQGLFR NKVIWVGITS QIIVALILSC GLGSITALNF TMLRVQYWFV
1010 1020 1030
AVPHAILIWV YDEVRKLFLR LYPGSWWDKN MYY
Length:1,033
Mass (Da):114,557
Last modified:November 1, 1996 - v1
Checksum:iC4EEE72D83C1F40C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D21854 mRNA Translation: BAA04880.1
RefSeqiNP_001166387.1, NM_001172916.1

Genome annotation databases

EnsembliENSCPOT00000003451; ENSCPOP00000003081; ENSCPOG00000003407
GeneIDi100135482

Similar proteinsi

Entry informationi

Entry nameiAT12A_CAVPO
AccessioniPrimary (citable) accession number: Q64392
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health