Q64391 (CP1A2_CAVPO) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 91.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Cytochrome P450 1A2 EC=1.14.14.1 Alternative name(s): CYPIA2 | ||
| Gene names |
| ||
| Organism | Cavia porcellus (Guinea pig) [Reference proteome] | ||
| Taxonomic identifier | 10141 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricognathi › Caviidae › Cavia![]() |
Protein attributes
| Sequence length | 515 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation By similarity. |
| Catalytic activity | RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O. |
| Cofactor | Heme group By similarity. |
| Subcellular location | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
| Sequence similarities | Belongs to the cytochrome P450 family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | ||||||
| Chain | 2 – 515 | 514 | Cytochrome P450 1A2 | PRO_0000051650 | |||||
Sites | |||||||||
| Metal binding | 458 | 1 | Iron (heme axial ligand) By similarity | ||||||
| Binding site | 226 | 1 | Substrate By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 289 | 1 | N6-acetyllysine By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 149 | 1 | V → L in AAB70866. Ref.2 | ||||||
Sequences
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References
| [1] | "Regulation of CYP1A and CYP3A mRNAs by ascorbic acid in guinea pigs." Mori T., Itoh S., Ohgiya S., Ishizaki K., Kamataki T. Arch. Biochem. Biophys. 348:268-277(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Hartley. Tissue: Liver. |
| [2] | Black V.H. Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Hartley. Tissue: Liver. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | D50457 mRNA. Translation: BAA09048.1. U23501 mRNA. Translation: AAB70866.1. |
| RefSeq | NP_001166165.1. NM_001172694.1. |
3D structure databases | |
| ProteinModelPortal | Q64391. |
| SMR | Q64391. Positions 34-514. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 10141.ENSCPOP00000017610. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSCPOT00000001250; ENSCPOP00000017610; ENSCPOG00000001235. |
| GeneID | 100135513. |
Organism-specific databases | |
| CTD | 1544. |
Phylogenomic databases | |
| eggNOG | COG2124. |
| GeneTree | ENSGT00680000099714. |
| HOGENOM | HOG000036991. |
| HOVERGEN | HBG106944. |
| InParanoid | Q64391. |
| OrthoDB | EOG4WSW9D. |
Family and domain databases | |
| Gene3D | 1.10.630.10. 1 hit. |
| InterPro | IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. IPR008066. Cyt_P450_E_grp-I_CYP1. [Graphical view] |
| Pfam | PF00067. p450. 1 hit. [Graphical view] |
| PRINTS | PR00463. EP450I. PR01683. EP450ICYP1A. PR00385. P450. |
| SUPFAM | SSF48264. Cytochrome_P450. 1 hit. |
| PROSITE | PS00086. CYTOCHROME_P450. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CP1A2_CAVPO | ||||||||
| Accession | Primary (citable) accession number: Q64391 Secondary accession number(s): Q64404 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

Clusters with
