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Q64391

- CP1A2_CAVPO

UniProt

Q64391 - CP1A2_CAVPO

Protein

Cytochrome P450 1A2

Gene

CYP1A2

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation By similarity.By similarity

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei226 – 2261SubstrateBy similarity
    Metal bindingi458 – 4581Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. caffeine oxidase activity Source: Ensembl
    3. demethylase activity Source: Ensembl
    4. heme binding Source: UniProtKB
    5. iron ion binding Source: InterPro

    GO - Biological processi

    1. alkaloid metabolic process Source: Ensembl
    2. cellular respiration Source: Ensembl
    3. cellular response to cadmium ion Source: Ensembl
    4. dibenzo-p-dioxin metabolic process Source: Ensembl
    5. exogenous drug catabolic process Source: Ensembl
    6. hydrogen peroxide biosynthetic process Source: Ensembl
    7. lung development Source: Ensembl
    8. monocarboxylic acid metabolic process Source: Ensembl
    9. monoterpenoid metabolic process Source: Ensembl
    10. oxidative deethylation Source: Ensembl
    11. oxidative demethylation Source: Ensembl
    12. porphyrin-containing compound metabolic process Source: Ensembl
    13. post-embryonic development Source: Ensembl
    14. regulation of gene expression Source: Ensembl
    15. steroid catabolic process Source: Ensembl
    16. toxin biosynthetic process Source: Ensembl

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 1A2 (EC:1.14.14.1)
    Alternative name(s):
    CYPIA2
    Gene namesi
    Name:CYP1A2
    OrganismiCavia porcellus (Guinea pig)
    Taxonomic identifieri10141 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
    ProteomesiUP000005447: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 515514Cytochrome P450 1A2PRO_0000051650Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi69 – 691O-linked (GlcNAc)By similarity

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi10141.ENSCPOP00000017610.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64391.
    SMRiQ64391. Positions 34-514.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00750000117317.
    HOGENOMiHOG000036991.
    HOVERGENiHBG106944.
    InParanoidiQ64391.
    OrthoDBiEOG7RBZ85.
    TreeFamiTF105095.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q64391-1 [UniParc]FASTAAdd to Basket

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    MPLSWLLPFS AMELLLTATI FYLVLWVVKA FRLQVPKGLK SPPGPWGWPL    50
    IGHVLTLGKN PHLALTRLSA RYGDVLQIRI GSTPVVVLSG LDTIRQALVR 100
    QSDDFKGRPD LYSSTFISDG QSMIFNPDSG PVWAARRRLA QSALQSFSVA 150
    SDPASVSSCY LEEHVSREAE HLVTKLLDLM AGPGCFEPSS QIVGSVANVI 200
    GAMCFGKNFP QTSEEMLQIV NTSKEFTEFA SSGNPVDFFP ILRYLPNPML 250
    QQFKDFNKRF LQFLQKTVQE HYQDFDKNHV QDIASALFKH SEESPHVNGD 300
    LIPRKKIVNL VNDIFGAGFD TVTTAISWSL LYLVTKPEIQ KKIHKELDAV 350
    IGRDRKPRLA DRPQLPYMEA FILEVFRYSS FLPFTIPHCT TRDTILNGFY 400
    IPKDRCVFIN QWQVNHDPKQ WEDPFEFRPE RFLLANNTAV DKTLSDKILL 450
    FGLGKRRCIG ETLGRWEVFL FLAILLQQLE FSVPPGVKVD LTPVYGLTMK 500
    PPHCQHVQAR PRFSK 515
    Length:515
    Mass (Da):58,423
    Last modified:November 1, 1996 - v1
    Checksum:iE5EDF0B9D33151A8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti149 – 1491V → L in AAB70866. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50457 mRNA. Translation: BAA09048.1.
    U23501 mRNA. Translation: AAB70866.1.
    RefSeqiNP_001166165.1. NM_001172694.1.

    Genome annotation databases

    EnsembliENSCPOT00000001250; ENSCPOP00000017610; ENSCPOG00000001235.
    GeneIDi100135513.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50457 mRNA. Translation: BAA09048.1 .
    U23501 mRNA. Translation: AAB70866.1 .
    RefSeqi NP_001166165.1. NM_001172694.1.

    3D structure databases

    ProteinModelPortali Q64391.
    SMRi Q64391. Positions 34-514.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10141.ENSCPOP00000017610.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCPOT00000001250 ; ENSCPOP00000017610 ; ENSCPOG00000001235 .
    GeneIDi 100135513.

    Organism-specific databases

    CTDi 1544.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00750000117317.
    HOGENOMi HOG000036991.
    HOVERGENi HBG106944.
    InParanoidi Q64391.
    OrthoDBi EOG7RBZ85.
    TreeFami TF105095.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Regulation of CYP1A and CYP3A mRNAs by ascorbic acid in guinea pigs."
      Mori T., Itoh S., Ohgiya S., Ishizaki K., Kamataki T.
      Arch. Biochem. Biophys. 348:268-277(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Hartley.
      Tissue: Liver.
    2. Black V.H.
      Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Hartley.
      Tissue: Liver.

    Entry informationi

    Entry nameiCP1A2_CAVPO
    AccessioniPrimary (citable) accession number: Q64391
    Secondary accession number(s): Q64404
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3