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Protein

CAMPATH-1 antigen

Gene

Cd52

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in carrying and orienting carbohydrate, as well as having a more specific role.

Names & Taxonomyi

Protein namesi
Recommended name:
CAMPATH-1 antigen
Alternative name(s):
Lymphocyte differentiation antigen B7
CD_antigen: CD52
Gene namesi
Name:Cd52
Synonyms:Cdw52, Mb7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1346088. Cd52.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
  • sperm midpiece Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PeptideiPRO_000002090824 – 47CAMPATH-1 antigenAdd BLAST24
PropeptideiPRO_000002090948 – 74Removed in mature formSequence analysisAdd BLAST27

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi36N-linked (GlcNAc...)Sequence analysis1
Lipidationi47GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ64389.
PRIDEiQ64389.

Expressioni

Tissue specificityi

Expressed on lymphohematopoietic tissues, including thymus, spleen, and bone marrow, but not in liver, kidney, and brain.

Gene expression databases

BgeeiENSMUSG00000000682.
CleanExiMM_CD52.
GenevisibleiQ64389. MM.

Interactioni

Protein-protein interaction databases

IntActiQ64389. 2 interactors.
STRINGi10090.ENSMUSP00000000696.

Structurei

3D structure databases

ProteinModelPortaliQ64389.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00520000062107.
HOGENOMiHOG000111489.
HOVERGENiHBG005283.
InParanoidiQ64389.
KOiK06488.
OMAiFFANTLM.
OrthoDBiEOG091G1D4N.
TreeFamiTF338573.

Family and domain databases

InterProiIPR026643. CAMPATH-1.
[Graphical view]
PANTHERiPTHR15029. PTHR15029. 1 hit.
PfamiPF15116. CD52. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64389-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSFLLFLTI ILLVVIQIQT GSLGQATTAA SGTNKNSTST KKTPLKSGAS
60 70
SIIDAGACSF LFFANTLMCL FYLS
Length:74
Mass (Da):7,798
Last modified:November 1, 1996 - v1
Checksum:iE106F479AC481925
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55561 mRNA. Translation: AAA39889.1.
X76696 mRNA. Translation: CAA54125.1.
AK088161 mRNA. Translation: BAC40183.1.
BC027495 mRNA. Translation: AAH27495.1.
CCDSiCCDS38909.1.
PIRiI48263.
RefSeqiNP_038734.1. NM_013706.2.
UniGeneiMm.24130.

Genome annotation databases

EnsembliENSMUST00000000696; ENSMUSP00000000696; ENSMUSG00000000682.
GeneIDi23833.
KEGGimmu:23833.
UCSCiuc008vea.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55561 mRNA. Translation: AAA39889.1.
X76696 mRNA. Translation: CAA54125.1.
AK088161 mRNA. Translation: BAC40183.1.
BC027495 mRNA. Translation: AAH27495.1.
CCDSiCCDS38909.1.
PIRiI48263.
RefSeqiNP_038734.1. NM_013706.2.
UniGeneiMm.24130.

3D structure databases

ProteinModelPortaliQ64389.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ64389. 2 interactors.
STRINGi10090.ENSMUSP00000000696.

Proteomic databases

PaxDbiQ64389.
PRIDEiQ64389.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000696; ENSMUSP00000000696; ENSMUSG00000000682.
GeneIDi23833.
KEGGimmu:23833.
UCSCiuc008vea.2. mouse.

Organism-specific databases

CTDi1043.
MGIiMGI:1346088. Cd52.

Phylogenomic databases

GeneTreeiENSGT00520000062107.
HOGENOMiHOG000111489.
HOVERGENiHBG005283.
InParanoidiQ64389.
KOiK06488.
OMAiFFANTLM.
OrthoDBiEOG091G1D4N.
TreeFamiTF338573.

Miscellaneous databases

PROiQ64389.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000682.
CleanExiMM_CD52.
GenevisibleiQ64389. MM.

Family and domain databases

InterProiIPR026643. CAMPATH-1.
[Graphical view]
PANTHERiPTHR15029. PTHR15029. 1 hit.
PfamiPF15116. CD52. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD52_MOUSE
AccessioniPrimary (citable) accession number: Q64389
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.