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Protein

CAMPATH-1 antigen

Gene

Cd52

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in carrying and orienting carbohydrate, as well as having a more specific role.

Names & Taxonomyi

Protein namesi
Recommended name:
CAMPATH-1 antigen
Alternative name(s):
Lymphocyte differentiation antigen B7
CD_antigen: CD52
Gene namesi
Name:Cd52
Synonyms:Cdw52, Mb7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1346088. Cd52.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
  • sperm midpiece Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Peptidei24 – 4724CAMPATH-1 antigenPRO_0000020908Add
BLAST
Propeptidei48 – 7427Removed in mature formSequence analysisPRO_0000020909Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence analysis
Lipidationi47 – 471GPI-anchor amidated serineSequence analysis

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ64389.
PRIDEiQ64389.

Expressioni

Tissue specificityi

Expressed on lymphohematopoietic tissues, including thymus, spleen, and bone marrow, but not in liver, kidney, and brain.

Gene expression databases

BgeeiQ64389.
CleanExiMM_CD52.
GenevisibleiQ64389. MM.

Interactioni

Protein-protein interaction databases

IntActiQ64389. 2 interactions.
STRINGi10090.ENSMUSP00000000696.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00520000062107.
HOGENOMiHOG000111489.
HOVERGENiHBG005283.
InParanoidiQ64389.
KOiK06488.
OMAiFFANTLM.
OrthoDBiEOG7673JK.
TreeFamiTF338573.

Family and domain databases

InterProiIPR026643. CAMPATH-1.
[Graphical view]
PANTHERiPTHR15029. PTHR15029. 1 hit.
PfamiPF15116. CD52. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64389-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSFLLFLTI ILLVVIQIQT GSLGQATTAA SGTNKNSTST KKTPLKSGAS
60 70
SIIDAGACSF LFFANTLMCL FYLS
Length:74
Mass (Da):7,798
Last modified:November 1, 1996 - v1
Checksum:iE106F479AC481925
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55561 mRNA. Translation: AAA39889.1.
X76696 mRNA. Translation: CAA54125.1.
AK088161 mRNA. Translation: BAC40183.1.
BC027495 mRNA. Translation: AAH27495.1.
CCDSiCCDS38909.1.
PIRiI48263.
RefSeqiNP_038734.1. NM_013706.2.
UniGeneiMm.24130.

Genome annotation databases

EnsembliENSMUST00000000696; ENSMUSP00000000696; ENSMUSG00000000682.
GeneIDi23833.
KEGGimmu:23833.
UCSCiuc008vea.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55561 mRNA. Translation: AAA39889.1.
X76696 mRNA. Translation: CAA54125.1.
AK088161 mRNA. Translation: BAC40183.1.
BC027495 mRNA. Translation: AAH27495.1.
CCDSiCCDS38909.1.
PIRiI48263.
RefSeqiNP_038734.1. NM_013706.2.
UniGeneiMm.24130.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ64389. 2 interactions.
STRINGi10090.ENSMUSP00000000696.

Proteomic databases

PaxDbiQ64389.
PRIDEiQ64389.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000696; ENSMUSP00000000696; ENSMUSG00000000682.
GeneIDi23833.
KEGGimmu:23833.
UCSCiuc008vea.2. mouse.

Organism-specific databases

CTDi1043.
MGIiMGI:1346088. Cd52.

Phylogenomic databases

GeneTreeiENSGT00520000062107.
HOGENOMiHOG000111489.
HOVERGENiHBG005283.
InParanoidiQ64389.
KOiK06488.
OMAiFFANTLM.
OrthoDBiEOG7673JK.
TreeFamiTF338573.

Miscellaneous databases

PROiQ64389.
SOURCEiSearch...

Gene expression databases

BgeeiQ64389.
CleanExiMM_CD52.
GenevisibleiQ64389. MM.

Family and domain databases

InterProiIPR026643. CAMPATH-1.
[Graphical view]
PANTHERiPTHR15029. PTHR15029. 1 hit.
PfamiPF15116. CD52. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and gene cloning of a new phosphatidylinositol-linked antigen expressed on mature lymphocytes. Down-regulation by lymphocyte activation."
    Kubota H., Okazaki H., Onuma M., Kano S., Hattori M., Minato N.
    J. Immunol. 145:3924-3931(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "A major messenger ribonucleic acid of the rodent epididymis encodes a small glycosylphosphatidylinositol-anchored lymphocyte surface antigen."
    Kirchhoff C.
    Biol. Reprod. 50:896-902(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Epididymis.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Thymus.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.

Entry informationi

Entry nameiCD52_MOUSE
AccessioniPrimary (citable) accession number: Q64389
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.