Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interleukin-11 receptor subunit alpha-1

Gene

Il11ra1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth.
A soluble form (sIL11RA) can act as an antagonist of IL11-dependent cell differentiation in cells where both transmembrane IL11RA and IL6ST are present.

GO - Molecular functioni

  • interleukin-11 binding Source: MGI
  • interleukin-11 receptor activity Source: MGI

GO - Biological processi

  • cytokine-mediated signaling pathway Source: MGI
  • decidualization Source: MGI
  • developmental process Source: UniProtKB
  • head development Source: UniProtKB
  • interleukin-11-mediated signaling pathway Source: GOC
  • maternal process involved in female pregnancy Source: MGI
  • natural killer cell differentiation Source: MGI
  • placenta development Source: MGI
  • positive regulation of cell proliferation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-6788467. IL-6-type cytokine receptor ligand interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-11 receptor subunit alpha-1
Short name:
IL-11 receptor subunit alpha-1
Short name:
IL-11R subunit alpha-1
Short name:
IL-11R-alpha-1
Short name:
IL-11RA1
Alternative name(s):
Enhancer trap locus homolog 2
Short name:
Etl-2
Novel cytokine receptor 1
Short name:
NR-1
Short name:
NR1
Gene namesi
Name:Il11ra1
Synonyms:Etl2, Il11ra
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:107426. Il11ra1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 372349ExtracellularSequence analysisAdd
BLAST
Transmembranei373 – 39321HelicalSequence analysisAdd
BLAST
Topological domaini394 – 43239CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Mice have disturbed cranial growth and suture activity.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 432409Interleukin-11 receptor subunit alpha-1PRO_0000010914Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi48 ↔ 94PROSITE-ProRule annotation
Disulfide bondi120 ↔ 130PROSITE-ProRule annotation
Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence analysis
Disulfide bondi170 ↔ 180PROSITE-ProRule annotation
Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ64385.
PRIDEiQ64385.

PTM databases

iPTMnetiQ64385.
PhosphoSiteiQ64385.

Expressioni

Tissue specificityi

Widely expressed in all adult tissues and in embryos. Highest levels in kidney, skeletal muscle and embryo.1 Publication

Developmental stagei

First detected at low levels at 10.5 dpc in cranofacial mesenchyme and in parts of the nervous system. At 12.5 dpc, high expression found in heart, diaphragm, bronchi and in the mesenchyme surrounding precartilage condensations. At later stages, expressed in dental papilla, dermis, hair follicles and in the perichondrium and in regions containing chondro and osteo progenitor cells.1 Publication

Gene expression databases

BgeeiQ64385.
CleanExiMM_IL11RA1.
GenevisibleiQ64385. MM.

Interactioni

Subunit structurei

On ligand binding, forms a multimer complex with IL6ST/gp130.By similarity

GO - Molecular functioni

  • interleukin-11 binding Source: MGI

Protein-protein interaction databases

DIPiDIP-5781N.
MINTiMINT-4997379.
STRINGi10090.ENSMUSP00000095736.

Structurei

3D structure databases

ProteinModelPortaliQ64385.
SMRiQ64385. Positions 26-317.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 11084Ig-like C2-typeAdd
BLAST
Domaini112 – 219108Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini220 – 31798Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi304 – 3085WSXWS motif

Sequence similaritiesi

Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ7D. Eukaryota.
ENOG4111N1H. LUCA.
GeneTreeiENSGT00530000063103.
HOGENOMiHOG000231670.
HOVERGENiHBG063427.
InParanoidiQ64385.
KOiK05056.
OMAiWFRDGET.
OrthoDBiEOG72NRQF.
PhylomeDBiQ64385.
TreeFamiTF331210.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
PS01354. HEMATOPO_REC_L_F3. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64385-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSCSGLTR VLVAVATALV SSSSPCPQAW GPPGVQYGQP GRPVMLCCPG
60 70 80 90 100
VSAGTPVSWF RDGDSRLLQG PDSGLGHRLV LAQVDSPDEG TYVCQTLDGV
110 120 130 140 150
SGGMVTLKLG FPPARPEVSC QAVDYENFSC TWSPGQVSGL PTRYLTSYRK
160 170 180 190 200
KTLPGAESQR ESPSTGPWPC PQDPLEASRC VVHGAEFWSE YRINVTEVNP
210 220 230 240 250
LGASTCLLDV RLQSILRPDP PQGLRVESVP GYPRRLHASW TYPASWRRQP
260 270 280 290 300
HFLLKFRLQY RPAQHPAWST VEPIGLEEVI TDAVAGLPHA VRVSARDFLD
310 320 330 340 350
AGTWSAWSPE AWGTPSTGPL QDEIPDWSQG HGQQLEAVVA QEDSPAPARP
360 370 380 390 400
SLQPDPRPLD HRDPLEQVAV LASLGIFSCL GLAVGALALG LWLRLRRSGK
410 420 430
DGPQKPGLLA PMIPVEKLPG IPNLQRTPEN FS
Length:432
Mass (Da):46,655
Last modified:November 1, 1996 - v1
Checksum:i068389943502BBFC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti93 – 931V → I in AAH57664 (PubMed:15489334).Curated
Sequence conflicti93 – 931V → I in AAH69984 (PubMed:15489334).Curated
Sequence conflicti332 – 3321G → R in AAH57664 (PubMed:15489334).Curated
Sequence conflicti332 – 3321G → R in AAH69984 (PubMed:15489334).Curated
Sequence conflicti368 – 3681V → I in AAH57664 (PubMed:15489334).Curated
Sequence conflicti368 – 3681V → I in AAH69984 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74953 mRNA. Translation: CAA52908.1.
U14412 mRNA. Translation: AAA53248.1.
X94162, X94163 Genomic DNA. Translation: CAA63873.1.
AL807796 Genomic DNA. Translation: CAM16061.1.
BC004619 mRNA. Translation: AAH04619.1.
BC057664 mRNA. Translation: AAH57664.1.
BC069984 mRNA. Translation: AAH69984.1.
CCDSiCCDS18071.1.
PIRiI48343.
RefSeqiNP_001156873.1. NM_001163401.1.
NP_001165525.1. NM_001172054.1.
NP_034679.1. NM_010549.3.
UniGeneiMm.193451.

Genome annotation databases

EnsembliENSMUST00000098132; ENSMUSP00000095736; ENSMUSG00000073889.
ENSMUST00000108040; ENSMUSP00000103675; ENSMUSG00000073889.
ENSMUST00000108041; ENSMUSP00000103676; ENSMUSG00000073889.
ENSMUST00000108042; ENSMUSP00000103677; ENSMUSG00000073889.
GeneIDi16157.
KEGGimmu:16157.
UCSCiuc008sjr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74953 mRNA. Translation: CAA52908.1.
U14412 mRNA. Translation: AAA53248.1.
X94162, X94163 Genomic DNA. Translation: CAA63873.1.
AL807796 Genomic DNA. Translation: CAM16061.1.
BC004619 mRNA. Translation: AAH04619.1.
BC057664 mRNA. Translation: AAH57664.1.
BC069984 mRNA. Translation: AAH69984.1.
CCDSiCCDS18071.1.
PIRiI48343.
RefSeqiNP_001156873.1. NM_001163401.1.
NP_001165525.1. NM_001172054.1.
NP_034679.1. NM_010549.3.
UniGeneiMm.193451.

3D structure databases

ProteinModelPortaliQ64385.
SMRiQ64385. Positions 26-317.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-5781N.
MINTiMINT-4997379.
STRINGi10090.ENSMUSP00000095736.

PTM databases

iPTMnetiQ64385.
PhosphoSiteiQ64385.

Proteomic databases

PaxDbiQ64385.
PRIDEiQ64385.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098132; ENSMUSP00000095736; ENSMUSG00000073889.
ENSMUST00000108040; ENSMUSP00000103675; ENSMUSG00000073889.
ENSMUST00000108041; ENSMUSP00000103676; ENSMUSG00000073889.
ENSMUST00000108042; ENSMUSP00000103677; ENSMUSG00000073889.
GeneIDi16157.
KEGGimmu:16157.
UCSCiuc008sjr.2. mouse.

Organism-specific databases

CTDi16157.
MGIiMGI:107426. Il11ra1.

Phylogenomic databases

eggNOGiENOG410IJ7D. Eukaryota.
ENOG4111N1H. LUCA.
GeneTreeiENSGT00530000063103.
HOGENOMiHOG000231670.
HOVERGENiHBG063427.
InParanoidiQ64385.
KOiK05056.
OMAiWFRDGET.
OrthoDBiEOG72NRQF.
PhylomeDBiQ64385.
TreeFamiTF331210.

Enzyme and pathway databases

ReactomeiR-MMU-6788467. IL-6-type cytokine receptor ligand interactions.

Miscellaneous databases

PROiQ64385.
SOURCEiSearch...

Gene expression databases

BgeeiQ64385.
CleanExiMM_IL11RA1.
GenevisibleiQ64385. MM.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
PS01354. HEMATOPO_REC_L_F3. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "etl2, a novel putative type-1 cytokine receptor expressed during mouse embryogenesis at high levels in skin and cells with skeletogenic potential."
    Neuhaus H., Bettenhausen B., Bilinski P., Simon-Chazottes D., Guenet J.-L., Gossler A.
    Dev. Biol. 166:531-542(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
    Strain: BALB/cJ.
  2. "Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction."
    Hilton D.J., Hilton A.A., Raicevic A., Rakar S., Harrison-Smith M., Gough N.M., Begley C.G., Metcalf D., Nicola N.A., Willson T.A.
    EMBO J. 13:4765-4775(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X CBA.
    Tissue: Liver.
  3. "Two differentially expressed interleukin-11 receptor genes in the mouse genome."
    Bilinski P., Hall M.A., Neuhaus H., Gissel C., Heath J.K., Gossler A.
    Biochem. J. 320:359-363(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  4. "Structural analysis of the gene encoding the murine interleukin-11 receptor alpha-chain and a related locus."
    Robb L., Hilton D.J., Willson T.A., Begley C.G.
    J. Biol. Chem. 271:13754-13761(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    Strain: 129/Sv.
    Tissue: Testis.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Limb and Mammary tumor.
  7. "Recombinant soluble interleukin-11 (IL-11) receptor alpha-chain can act as an IL-11 antagonist."
    Curtis D.J., Hilton D.J., Roberts B., Murray L., Nicola N., Begley C.G.
    Blood 90:4403-4412(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-38, FUNCTION OF SOLUBLE FORM.
  8. Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiI11RA_MOUSE
AccessioniPrimary (citable) accession number: Q64385
Secondary accession number(s): A2AMS4, Q6NSQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.