SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q64378

- FKBP5_MOUSE

UniProt

Q64378 - FKBP5_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Peptidyl-prolyl cis-trans isomerase FKBP5

Gene
Fkbp5, Fkbp51
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Inhibited by both FK506 and rapamycin.

GO - Molecular functioni

  1. FK506 binding Source: RefGenome
  2. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB
  3. protein binding Source: IntAct

GO - Biological processi

  1. chaperone-mediated protein folding Source: UniProtKB
  2. peptidyl-proline modification Source: RefGenome
  3. protein peptidyl-prolyl isomerization Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Isomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP5 (EC:5.2.1.8)
Short name:
PPIase FKBP5
Alternative name(s):
51 kDa FK506-binding protein
Short name:
51 kDa FKBP
Short name:
FKBP-51
FK506-binding protein 5
Short name:
FKBP-5
Rotamase
Gene namesi
Name:Fkbp5
Synonyms:Fkbp51
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:104670. Fkbp5.

Subcellular locationi

Cytoplasm. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. membrane Source: RefGenome
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456Peptidyl-prolyl cis-trans isomerase FKBP5PRO_0000075325Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Modified residuei444 – 4441Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ64378.
PaxDbiQ64378.
PRIDEiQ64378.

PTM databases

PhosphoSiteiQ64378.

Expressioni

Tissue specificityi

Widely expressed, highest levels found in the liver, skeletal muscle, kidney and thymus. Expression is regulated during adipocyte differentiation.

Gene expression databases

ArrayExpressiQ64378.
BgeeiQ64378.
CleanExiMM_FKBP5.
GenevestigatoriQ64378.

Interactioni

Subunit structurei

Part of a heteromultimeric cytoplasmic complex with HSP90AA1, HSPA1A/HSPA1B and steroid receptors. Upon ligand binding dissociates from the complex and FKBP4 takes its place. Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Nr3c1P065372EBI-492796,EBI-492753

Protein-protein interaction databases

IntActiQ64378. 6 interactions.
MINTiMINT-1576439.

Structurei

3D structure databases

ProteinModelPortaliQ64378.
SMRiQ64378. Positions 13-412.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 13889PPIase FKBP-type 1Add
BLAST
Domaini165 – 25187PPIase FKBP-type 2Add
BLAST
Repeati268 – 30134TPR 1Add
BLAST
Repeati317 – 35034TPR 2Add
BLAST
Repeati351 – 38434TPR 3Add
BLAST

Sequence similaritiesi

Contains 3 TPR repeats.

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiCOG0545.
GeneTreeiENSGT00550000074272.
HOGENOMiHOG000256916.
HOVERGENiHBG051624.
InParanoidiQ64378.
KOiK09571.
OMAiHLEGCCG.
OrthoDBiEOG725DHH.
PhylomeDBiQ64378.

Family and domain databases

Gene3Di1.10.150.160. 1 hit.
1.25.40.10. 1 hit.
InterProiIPR023114. Elongated_TPR_rpt_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 2 hits.
PF00515. TPR_1. 2 hits.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 2 hits.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64378-1 [UniParc]FASTAAdd to Basket

« Hide

MTTDEGTSNN GENPAATMTE QGEDITTKKD RGVLKIVKRV GTSDEAPMFG    50
DKVYVHYKGM LSDGKKFDSS HDRKKPFAFS LGQGQVIKAW DIGVSTMKKG 100
EICHLLCKPE YAYGSAGHLQ KIPSNATLFF EIELLDFKGE DLFEDSGVIR 150
RIKRKGEGYS NPNEGATVKV HLEGCCGGRT FDCRDVVFVV GEGEDHDIPI 200
GIDKALVKMQ REEQCILYLG PRYGFGEAGK PKFGIDPNAE LMYEVTLKSF 250
EKAKESWEMD TKEKLTQAAI VKEKGTVYFK GGKYTQAVIQ YRKIVSWLEM 300
EYGLSEKESK ASESFLLAAF LNLAMCYLKL REYNKAVECC DKALGLDSAN 350
EKGLYRRGEA QLLMNDFESA KGDFEKVLAV NPQNRAARLQ ISMCQRKAKE 400
HNERDRRVYA NMFKKFAERD AKEEASKAGS KKAVEGAAGK QHESQAMEEG 450
KAKGHV 456
Length:456
Mass (Da):50,966
Last modified:November 1, 1996 - v1
Checksum:i8FD0C9B61478EB46
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U36220 mRNA. Translation: AAA89162.1.
U16959 mRNA. Translation: AAA86983.1.
BC015260 mRNA. Translation: AAH15260.1.
CCDSiCCDS37528.1.
RefSeqiNP_034350.1. NM_010220.4.
UniGeneiMm.276405.

Genome annotation databases

EnsembliENSMUST00000079413; ENSMUSP00000078382; ENSMUSG00000024222.
ENSMUST00000114792; ENSMUSP00000110440; ENSMUSG00000024222.
ENSMUST00000177939; ENSMUSP00000136245; ENSMUSG00000024222.
GeneIDi14229.
KEGGimmu:14229.
UCSCiuc008bqz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U36220 mRNA. Translation: AAA89162.1 .
U16959 mRNA. Translation: AAA86983.1 .
BC015260 mRNA. Translation: AAH15260.1 .
CCDSi CCDS37528.1.
RefSeqi NP_034350.1. NM_010220.4.
UniGenei Mm.276405.

3D structure databases

ProteinModelPortali Q64378.
SMRi Q64378. Positions 13-412.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q64378. 6 interactions.
MINTi MINT-1576439.

PTM databases

PhosphoSitei Q64378.

Proteomic databases

MaxQBi Q64378.
PaxDbi Q64378.
PRIDEi Q64378.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000079413 ; ENSMUSP00000078382 ; ENSMUSG00000024222 .
ENSMUST00000114792 ; ENSMUSP00000110440 ; ENSMUSG00000024222 .
ENSMUST00000177939 ; ENSMUSP00000136245 ; ENSMUSG00000024222 .
GeneIDi 14229.
KEGGi mmu:14229.
UCSCi uc008bqz.2. mouse.

Organism-specific databases

CTDi 2289.
MGIi MGI:104670. Fkbp5.

Phylogenomic databases

eggNOGi COG0545.
GeneTreei ENSGT00550000074272.
HOGENOMi HOG000256916.
HOVERGENi HBG051624.
InParanoidi Q64378.
KOi K09571.
OMAi HLEGCCG.
OrthoDBi EOG725DHH.
PhylomeDBi Q64378.

Miscellaneous databases

NextBioi 285495.
PROi Q64378.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q64378.
Bgeei Q64378.
CleanExi MM_FKBP5.
Genevestigatori Q64378.

Family and domain databases

Gene3Di 1.10.150.160. 1 hit.
1.25.40.10. 1 hit.
InterProi IPR023114. Elongated_TPR_rpt_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view ]
PANTHERi PTHR10516. PTHR10516. 1 hit.
Pfami PF00254. FKBP_C. 2 hits.
PF00515. TPR_1. 2 hits.
[Graphical view ]
SMARTi SM00028. TPR. 3 hits.
[Graphical view ]
PROSITEi PS50059. FKBP_PPIASE. 2 hits.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of an immunophilin expressed during the clonal expansion phase of adipocyte differentiation."
    Yeh W.-C., Li T.-K., Bierer B.E., McKnight S.L.
    Proc. Natl. Acad. Sci. U.S.A. 92:11081-11085(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "FKBP51, a novel T-cell-specific immunophilin capable of calcineurin inhibition."
    Baughman G., Wiederrecht G.J., Campbell N.F., Martin M.M., Bourgeois S.
    Mol. Cell. Biol. 15:4395-4402(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.
  4. "A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins."
    Davies T.H., Ning Y.M., Sanchez E.R.
    J. Biol. Chem. 277:4597-4600(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH HSP90AA1 AND NR3C1, SUBCELLULAR LOCATION.
  5. "Protein phosphatase 5 mediates lipid metabolism through reciprocal control of glucocorticoid receptor and peroxisome proliferator-activated receptor-? (PPAR?)."
    Hinds T.D. Jr., Stechschulte L.A., Cash H.A., Whisler D., Banerjee A., Yong W., Khuder S.S., Kaw M.K., Shou W., Najjar S.M., Sanchez E.R.
    J. Biol. Chem. 286:42911-42922(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NR3C1.

Entry informationi

Entry nameiFKBP5_MOUSE
AccessioniPrimary (citable) accession number: Q64378
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi