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Protein

Peptidyl-prolyl cis-trans isomerase FKBP5

Gene

Fkbp5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Inhibited by both FK506 and rapamycin.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone, Isomerase, Rotamase

Enzyme and pathway databases

ReactomeiR-MMU-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-MMU-8939211 ESR-mediated signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP5 (EC:5.2.1.8)
Short name:
PPIase FKBP5
Alternative name(s):
51 kDa FK506-binding protein
Short name:
51 kDa FKBP
Short name:
FKBP-51
FK506-binding protein 5
Short name:
FKBP-5
Rotamase
Gene namesi
Name:Fkbp5
Synonyms:Fkbp51
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:104670 Fkbp5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3792270

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000753251 – 456Peptidyl-prolyl cis-trans isomerase FKBP5Add BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei444PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ64378
MaxQBiQ64378
PaxDbiQ64378
PRIDEiQ64378

PTM databases

iPTMnetiQ64378
PhosphoSitePlusiQ64378

Expressioni

Tissue specificityi

Widely expressed, highest levels found in the liver, skeletal muscle, kidney and thymus. Expression is regulated during adipocyte differentiation.

Gene expression databases

BgeeiENSMUSG00000024222
CleanExiMM_FKBP5
ExpressionAtlasiQ64378 baseline and differential
GenevisibleiQ64378 MM

Interactioni

Subunit structurei

Part of a heteromultimeric cytoplasmic complex with HSP90AA1, HSPA1A/HSPA1B and steroid receptors. Upon ligand binding dissociates from the complex and FKBP4 takes its place. Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Nr3c1P065372EBI-492796,EBI-492753

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199686, 1 interactor
IntActiQ64378, 6 interactors
MINTiQ64378
STRINGi10090.ENSMUSP00000078382

Structurei

3D structure databases

ProteinModelPortaliQ64378
SMRiQ64378
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 138PPIase FKBP-type 1PROSITE-ProRule annotationAdd BLAST89
Domaini165 – 251PPIase FKBP-type 2PROSITE-ProRule annotationAdd BLAST87
Repeati268 – 301TPR 1Add BLAST34
Repeati317 – 350TPR 2Add BLAST34
Repeati351 – 384TPR 3Add BLAST34

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0543 Eukaryota
COG0545 LUCA
GeneTreeiENSGT00760000119159
HOGENOMiHOG000256916
HOVERGENiHBG051624
InParanoidiQ64378
KOiK09571
OMAiNSEETPM
OrthoDBiEOG091G07OA
PhylomeDBiQ64378

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR031210 FKBP5
IPR023566 PPIase_FKBP
IPR001179 PPIase_FKBP_dom
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat
PANTHERiPTHR10516 PTHR10516, 1 hit
PTHR10516:SF26 PTHR10516:SF26, 1 hit
PfamiView protein in Pfam
PF00254 FKBP_C, 2 hits
PF00515 TPR_1, 1 hit
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50059 FKBP_PPIASE, 2 hits
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q64378-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTDEGTSNN GENPAATMTE QGEDITTKKD RGVLKIVKRV GTSDEAPMFG
60 70 80 90 100
DKVYVHYKGM LSDGKKFDSS HDRKKPFAFS LGQGQVIKAW DIGVSTMKKG
110 120 130 140 150
EICHLLCKPE YAYGSAGHLQ KIPSNATLFF EIELLDFKGE DLFEDSGVIR
160 170 180 190 200
RIKRKGEGYS NPNEGATVKV HLEGCCGGRT FDCRDVVFVV GEGEDHDIPI
210 220 230 240 250
GIDKALVKMQ REEQCILYLG PRYGFGEAGK PKFGIDPNAE LMYEVTLKSF
260 270 280 290 300
EKAKESWEMD TKEKLTQAAI VKEKGTVYFK GGKYTQAVIQ YRKIVSWLEM
310 320 330 340 350
EYGLSEKESK ASESFLLAAF LNLAMCYLKL REYNKAVECC DKALGLDSAN
360 370 380 390 400
EKGLYRRGEA QLLMNDFESA KGDFEKVLAV NPQNRAARLQ ISMCQRKAKE
410 420 430 440 450
HNERDRRVYA NMFKKFAERD AKEEASKAGS KKAVEGAAGK QHESQAMEEG

KAKGHV
Length:456
Mass (Da):50,966
Last modified:November 1, 1996 - v1
Checksum:i8FD0C9B61478EB46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36220 mRNA Translation: AAA89162.1
U16959 mRNA Translation: AAA86983.1
BC015260 mRNA Translation: AAH15260.1
CCDSiCCDS37528.1
RefSeqiNP_034350.1, NM_010220.4
UniGeneiMm.276405

Genome annotation databases

EnsembliENSMUST00000079413; ENSMUSP00000078382; ENSMUSG00000024222
ENSMUST00000114792; ENSMUSP00000110440; ENSMUSG00000024222
ENSMUST00000177939; ENSMUSP00000136245; ENSMUSG00000024222
GeneIDi14229
KEGGimmu:14229
UCSCiuc008bqz.3 mouse

Similar proteinsi

Entry informationi

Entry nameiFKBP5_MOUSE
AccessioniPrimary (citable) accession number: Q64378
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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