Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q64362

- AKTIP_MOUSE

UniProt

Q64362 - AKTIP_MOUSE

Protein

AKT-interacting protein

Gene

Aktip

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade By similarity.By similarity

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. early endosome to late endosome transport Source: UniProtKB
    3. endosome organization Source: UniProtKB
    4. endosome to lysosome transport Source: UniProtKB
    5. lysosome organization Source: UniProtKB
    6. positive regulation of protein binding Source: MGI
    7. positive regulation of protein phosphorylation Source: MGI
    8. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Apoptosis, Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AKT-interacting protein
    Alternative name(s):
    FT1
    Fused toes protein
    Gene namesi
    Name:Aktip
    Synonyms:Fif, Ft1, Fts
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:3693832. Aktip.

    Subcellular locationi

    Cytoplasm By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity

    GO - Cellular componenti

    1. FHF complex Source: UniProtKB
    2. Golgi apparatus Source: Ensembl
    3. HOPS complex Source: Ensembl
    4. nucleolus Source: Ensembl
    5. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Defects in Aktip are a cause of embryonic death in homozygous animals. Death occurs at about 10 days of development. Symptoms include loss of left-right asymmetry, malformation of the developing brain and of the spinal cord, syndactyly and polydactyly. Heterozygous animals are characterized by polydactyly and thymic hyperplasia.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 292292AKT-interacting proteinPRO_0000082610Add
    BLAST

    Proteomic databases

    PaxDbiQ64362.
    PRIDEiQ64362.

    PTM databases

    PhosphoSiteiQ64362.

    Expressioni

    Tissue specificityi

    Ubiquitous. Highest expression in kidney, testis and brain and lowest in spleen and liver.1 Publication

    Gene expression databases

    ArrayExpressiQ64362.
    BgeeiQ64362.
    GenevestigatoriQ64362.

    Interactioni

    Subunit structurei

    Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. May interact directly with HOOK1, HOOK2 and HOOK3. The FHF complex associates with the homotypic vesicular sorting complex (the HOPS complex). Also interacts with AKT1 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ64362.
    SMRiQ64362. Positions 77-223.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family. FTS subfamily.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG285076.
    GeneTreeiENSGT00390000010125.
    HOGENOMiHOG000033885.
    HOVERGENiHBG095637.
    InParanoidiQ3TYE3.
    OMAiSPWNPAV.
    PhylomeDBiQ64362.
    TreeFamiTF314386.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q64362-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNPLWSMSAG SVRKRAEGEE KTLAGDVKTS PPRSAPKKQL PSIPKNALPI    50
    AKPTSPAPAA QSTNGTHASY GPFYLEYSLL AEFTLVVKQK LPGVYVQPSY 100
    RSALVWFGVI FIRHGLYQDG VFKFTVYIPD NYPDGDCPRL LFDIPVFHPL 150
    VDPTSGELDV KRAFAKWRRN HNHIWQVLMY ARRVFYKIDT TSPLNPEAAV 200
    LYEKDIQLFK SKVVDSVKVC TARLFDQPKI EDPYAISFSP WNPSVHDEAR 250
    EKMLTQKKPD EQHNKSVHVA GLSWVKPGSV QPFSKEEKTV AT 292
    Length:292
    Mass (Da):32,942
    Last modified:November 1, 1996 - v1
    Checksum:iA5FFC7F9053B1E3B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z67963 mRNA. Translation: CAA91902.1.
    X71978 mRNA. Translation: CAA50800.1.
    AK146459 mRNA. Translation: BAE27187.1.
    AK158704 mRNA. Translation: BAE34620.1.
    CH466525 Genomic DNA. Translation: EDL11072.1.
    CH466525 Genomic DNA. Translation: EDL11073.1.
    BC008130 mRNA. Translation: AAH08130.1.
    CCDSiCCDS22519.1.
    PIRiS33513.
    RefSeqiNP_034371.1. NM_010241.4.
    XP_006530733.1. XM_006530670.1.
    XP_006530734.1. XM_006530671.1.
    XP_006530735.1. XM_006530672.1.
    UniGeneiMm.324588.

    Genome annotation databases

    EnsembliENSMUST00000109609; ENSMUSP00000105238; ENSMUSG00000031667.
    ENSMUST00000120213; ENSMUSP00000112375; ENSMUSG00000031667.
    ENSMUST00000120349; ENSMUSP00000113769; ENSMUSG00000031667.
    GeneIDi14339.
    KEGGimmu:14339.
    UCSCiuc009msl.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z67963 mRNA. Translation: CAA91902.1 .
    X71978 mRNA. Translation: CAA50800.1 .
    AK146459 mRNA. Translation: BAE27187.1 .
    AK158704 mRNA. Translation: BAE34620.1 .
    CH466525 Genomic DNA. Translation: EDL11072.1 .
    CH466525 Genomic DNA. Translation: EDL11073.1 .
    BC008130 mRNA. Translation: AAH08130.1 .
    CCDSi CCDS22519.1.
    PIRi S33513.
    RefSeqi NP_034371.1. NM_010241.4.
    XP_006530733.1. XM_006530670.1.
    XP_006530734.1. XM_006530671.1.
    XP_006530735.1. XM_006530672.1.
    UniGenei Mm.324588.

    3D structure databases

    ProteinModelPortali Q64362.
    SMRi Q64362. Positions 77-223.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q64362.

    Proteomic databases

    PaxDbi Q64362.
    PRIDEi Q64362.

    Protocols and materials databases

    DNASUi 14339.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000109609 ; ENSMUSP00000105238 ; ENSMUSG00000031667 .
    ENSMUST00000120213 ; ENSMUSP00000112375 ; ENSMUSG00000031667 .
    ENSMUST00000120349 ; ENSMUSP00000113769 ; ENSMUSG00000031667 .
    GeneIDi 14339.
    KEGGi mmu:14339.
    UCSCi uc009msl.1. mouse.

    Organism-specific databases

    CTDi 64400.
    MGIi MGI:3693832. Aktip.

    Phylogenomic databases

    eggNOGi NOG285076.
    GeneTreei ENSGT00390000010125.
    HOGENOMi HOG000033885.
    HOVERGENi HBG095637.
    InParanoidi Q3TYE3.
    OMAi SPWNPAV.
    PhylomeDBi Q64362.
    TreeFami TF314386.

    Miscellaneous databases

    NextBioi 285777.
    PROi Q64362.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q64362.
    Bgeei Q64362.
    Genevestigatori Q64362.

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Ft1, a novel gene related to ubiquitin conjugating enzymes, is deleted in the Fused toes mouse mutation."
      Lesche R., Peetz A., van der Hoeven F., Ruether U.
      Mamm. Genome 8:879-883(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: C57BL/6.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Amnion and Visual cortex.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    5. "Programmed cell death is affected in the novel mouse mutant Fused toes (Ft)."
      van der Hoeven F., Schimmang T., Volkmann A., Mattei M.-G., Kyewski B., Ruether U.
      Development 120:2601-2607(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISEASE.

    Entry informationi

    Entry nameiAKTIP_MOUSE
    AccessioniPrimary (citable) accession number: Q64362
    Secondary accession number(s): Q3TYE3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    Lacks the conserved Cys residue necessary for ubiquitin-conjugating enzyme E2 activity.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3