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Q64362

- AKTIP_MOUSE

UniProt

Q64362 - AKTIP_MOUSE

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Protein

AKT-interacting protein

Gene

Aktip

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade (By similarity).By similarity

GO - Molecular functioni

  1. acid-amino acid ligase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. early endosome to late endosome transport Source: UniProtKB
  3. endosome organization Source: UniProtKB
  4. endosome to lysosome transport Source: UniProtKB
  5. lysosome organization Source: UniProtKB
  6. positive regulation of protein binding Source: MGI
  7. positive regulation of protein phosphorylation Source: MGI
  8. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
AKT-interacting protein
Alternative name(s):
FT1
Fused toes protein
Gene namesi
Name:Aktip
Synonyms:Fif, Ft1, Fts
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:3693832. Aktip.

Subcellular locationi

Cytoplasm By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. FHF complex Source: UniProtKB
  2. HOPS complex Source: Ensembl
  3. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Aktip are a cause of embryonic death in homozygous animals. Death occurs at about 10 days of development. Symptoms include loss of left-right asymmetry, malformation of the developing brain and of the spinal cord, syndactyly and polydactyly. Heterozygous animals are characterized by polydactyly and thymic hyperplasia.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292AKT-interacting proteinPRO_0000082610Add
BLAST

Proteomic databases

MaxQBiQ64362.
PaxDbiQ64362.
PRIDEiQ64362.

PTM databases

PhosphoSiteiQ64362.

Expressioni

Tissue specificityi

Ubiquitous. Highest expression in kidney, testis and brain and lowest in spleen and liver.1 Publication

Gene expression databases

BgeeiQ64362.
ExpressionAtlasiQ64362. baseline and differential.
GenevestigatoriQ64362.

Interactioni

Subunit structurei

Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. May interact directly with HOOK1, HOOK2 and HOOK3. The FHF complex associates with the homotypic vesicular sorting complex (the HOPS complex). Also interacts with AKT1 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ64362.
SMRiQ64362. Positions 107-223.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family. FTS subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG285076.
GeneTreeiENSGT00390000010125.
HOGENOMiHOG000033885.
HOVERGENiHBG095637.
InParanoidiQ64362.
OMAiSPWNPAV.
PhylomeDBiQ64362.
TreeFamiTF314386.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64362-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNPLWSMSAG SVRKRAEGEE KTLAGDVKTS PPRSAPKKQL PSIPKNALPI
60 70 80 90 100
AKPTSPAPAA QSTNGTHASY GPFYLEYSLL AEFTLVVKQK LPGVYVQPSY
110 120 130 140 150
RSALVWFGVI FIRHGLYQDG VFKFTVYIPD NYPDGDCPRL LFDIPVFHPL
160 170 180 190 200
VDPTSGELDV KRAFAKWRRN HNHIWQVLMY ARRVFYKIDT TSPLNPEAAV
210 220 230 240 250
LYEKDIQLFK SKVVDSVKVC TARLFDQPKI EDPYAISFSP WNPSVHDEAR
260 270 280 290
EKMLTQKKPD EQHNKSVHVA GLSWVKPGSV QPFSKEEKTV AT
Length:292
Mass (Da):32,942
Last modified:November 1, 1996 - v1
Checksum:iA5FFC7F9053B1E3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z67963 mRNA. Translation: CAA91902.1.
X71978 mRNA. Translation: CAA50800.1.
AK146459 mRNA. Translation: BAE27187.1.
AK158704 mRNA. Translation: BAE34620.1.
CH466525 Genomic DNA. Translation: EDL11072.1.
CH466525 Genomic DNA. Translation: EDL11073.1.
BC008130 mRNA. Translation: AAH08130.1.
CCDSiCCDS22519.1.
PIRiS33513.
RefSeqiNP_034371.1. NM_010241.5.
UniGeneiMm.324588.

Genome annotation databases

EnsembliENSMUST00000109609; ENSMUSP00000105238; ENSMUSG00000031667.
ENSMUST00000120213; ENSMUSP00000112375; ENSMUSG00000031667.
ENSMUST00000120349; ENSMUSP00000113769; ENSMUSG00000031667.
GeneIDi14339.
KEGGimmu:14339.
UCSCiuc009msl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z67963 mRNA. Translation: CAA91902.1 .
X71978 mRNA. Translation: CAA50800.1 .
AK146459 mRNA. Translation: BAE27187.1 .
AK158704 mRNA. Translation: BAE34620.1 .
CH466525 Genomic DNA. Translation: EDL11072.1 .
CH466525 Genomic DNA. Translation: EDL11073.1 .
BC008130 mRNA. Translation: AAH08130.1 .
CCDSi CCDS22519.1.
PIRi S33513.
RefSeqi NP_034371.1. NM_010241.5.
UniGenei Mm.324588.

3D structure databases

ProteinModelPortali Q64362.
SMRi Q64362. Positions 107-223.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q64362.

Proteomic databases

MaxQBi Q64362.
PaxDbi Q64362.
PRIDEi Q64362.

Protocols and materials databases

DNASUi 14339.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000109609 ; ENSMUSP00000105238 ; ENSMUSG00000031667 .
ENSMUST00000120213 ; ENSMUSP00000112375 ; ENSMUSG00000031667 .
ENSMUST00000120349 ; ENSMUSP00000113769 ; ENSMUSG00000031667 .
GeneIDi 14339.
KEGGi mmu:14339.
UCSCi uc009msl.1. mouse.

Organism-specific databases

CTDi 64400.
MGIi MGI:3693832. Aktip.

Phylogenomic databases

eggNOGi NOG285076.
GeneTreei ENSGT00390000010125.
HOGENOMi HOG000033885.
HOVERGENi HBG095637.
InParanoidi Q64362.
OMAi SPWNPAV.
PhylomeDBi Q64362.
TreeFami TF314386.

Miscellaneous databases

NextBioi 285777.
PROi Q64362.
SOURCEi Search...

Gene expression databases

Bgeei Q64362.
ExpressionAtlasi Q64362. baseline and differential.
Genevestigatori Q64362.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Ft1, a novel gene related to ubiquitin conjugating enzymes, is deleted in the Fused toes mouse mutation."
    Lesche R., Peetz A., van der Hoeven F., Ruether U.
    Mamm. Genome 8:879-883(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: C57BL/6.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Amnion and Visual cortex.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  5. "Programmed cell death is affected in the novel mouse mutant Fused toes (Ft)."
    van der Hoeven F., Schimmang T., Volkmann A., Mattei M.-G., Kyewski B., Ruether U.
    Development 120:2601-2607(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISEASE.

Entry informationi

Entry nameiAKTIP_MOUSE
AccessioniPrimary (citable) accession number: Q64362
Secondary accession number(s): Q3TYE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Lacks the conserved Cys residue necessary for ubiquitin-conjugating enzyme E2 activity.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3