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Protein

Latexin

Gene

Lxn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Metalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor

Keywords - Biological processi

Inflammatory response

Keywords - Ligandi

Heparin-binding

Protein family/group databases

MEROPSiI47.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Latexin
Alternative name(s):
Endogenous carboxypeptidase inhibitor
Short name:
ECI
Tissue carboxypeptidase inhibitor
Short name:
TCI
Gene namesi
Name:Lxn
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi68361. Lxn.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223LatexinPRO_0000191345Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei56 – 561N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ64361.
PRIDEiQ64361.

PTM databases

iPTMnetiQ64361.
PhosphoSiteiQ64361.

Expressioni

Gene expression databases

BgeeiENSRNOG00000013572.
GenevisibleiQ64361. RN.

Interactioni

Protein-protein interaction databases

IntActiQ64361. 1 interaction.
STRINGi10116.ENSRNOP00000018402.

Structurei

3D structure databases

ProteinModelPortaliQ64361.
SMRiQ64361. Positions 3-218.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9797Cystatin-like fold 1By similarityAdd
BLAST
Regioni98 – 11821Alpha-helical linkerBy similarityAdd
BLAST
Regioni119 – 223105Cystatin-like fold 2By similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IHYK. Eukaryota.
ENOG4111KGW. LUCA.
GeneTreeiENSGT00530000063813.
HOGENOMiHOG000113410.
HOVERGENiHBG052373.
InParanoidiQ64361.
OMAiCLKFSVE.
OrthoDBiEOG091G0I8X.
PhylomeDBiQ64361.
TreeFamiTF332787.

Family and domain databases

InterProiIPR009684. Prot_inh_latexin.
[Graphical view]
PfamiPF06907. Latexin. 1 hit.
[Graphical view]
PIRSFiPIRSF011132. Prot_inh_latexin. 1 hit.
ProDomiPD023134. Prot_inh_latexin. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q64361-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEIPPTHYA ASRAASVAEN CINYQQGTPN KVFKVQTVQQ ASKEDIPGRG
60 70 80 90 100
HKYHLKFSVE EIIQKQVTVS CTAEVLYPRM GQGSAPEVNF TFEGEIGKNP
110 120 130 140 150
DEEDNTFYQR LMSMKEPLQA QNIPDNFGNV SPQMKPVHHL AWVACGYVMW
160 170 180 190 200
QNSTEDTWYK MAKIQTVKQV QRNDDFIELD YTVLLHDVAS QEIIPWQMQV
210 220
LWHPQYGTKV KHNSRLPKEA PAE
Length:223
Mass (Da):25,580
Last modified:November 1, 1996 - v1
Checksum:i763E10679A9F0F8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76985 mRNA. Translation: CAA54290.1.
U40260 mRNA. Translation: AAC52381.1.
Y18435 Genomic DNA. Translation: CAA77175.2.
BC081763 mRNA. Translation: AAH81763.1.
PIRiS41286.
RefSeqiNP_113843.1. NM_031655.1.
UniGeneiRn.11404.

Genome annotation databases

EnsembliENSRNOT00000018402; ENSRNOP00000018402; ENSRNOG00000013572.
GeneIDi59073.
KEGGirno:59073.
UCSCiRGD:68361. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76985 mRNA. Translation: CAA54290.1.
U40260 mRNA. Translation: AAC52381.1.
Y18435 Genomic DNA. Translation: CAA77175.2.
BC081763 mRNA. Translation: AAH81763.1.
PIRiS41286.
RefSeqiNP_113843.1. NM_031655.1.
UniGeneiRn.11404.

3D structure databases

ProteinModelPortaliQ64361.
SMRiQ64361. Positions 3-218.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ64361. 1 interaction.
STRINGi10116.ENSRNOP00000018402.

Protein family/group databases

MEROPSiI47.001.

PTM databases

iPTMnetiQ64361.
PhosphoSiteiQ64361.

Proteomic databases

PaxDbiQ64361.
PRIDEiQ64361.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018402; ENSRNOP00000018402; ENSRNOG00000013572.
GeneIDi59073.
KEGGirno:59073.
UCSCiRGD:68361. rat.

Organism-specific databases

CTDi56925.
RGDi68361. Lxn.

Phylogenomic databases

eggNOGiENOG410IHYK. Eukaryota.
ENOG4111KGW. LUCA.
GeneTreeiENSGT00530000063813.
HOGENOMiHOG000113410.
HOVERGENiHBG052373.
InParanoidiQ64361.
OMAiCLKFSVE.
OrthoDBiEOG091G0I8X.
PhylomeDBiQ64361.
TreeFamiTF332787.

Miscellaneous databases

PROiQ64361.

Gene expression databases

BgeeiENSRNOG00000013572.
GenevisibleiQ64361. RN.

Family and domain databases

InterProiIPR009684. Prot_inh_latexin.
[Graphical view]
PfamiPF06907. Latexin. 1 hit.
[Graphical view]
PIRSFiPIRSF011132. Prot_inh_latexin. 1 hit.
ProDomiPD023134. Prot_inh_latexin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiLXN_RAT
AccessioniPrimary (citable) accession number: Q64361
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.