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Protein

Myelin and lymphocyte protein

Gene

Mal

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function.

GO - Molecular functioni

  • structural constituent of myelin sheath Source: RGD

GO - Biological processi

  • intracellular protein transport Source: RGD
  • myelination Source: RGD
  • positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin and lymphocyte protein
Alternative name(s):
17 kDa myelin vesicular protein
Short name:
MVP17
NS 3
T-lymphocyte maturation-associated protein
Gene namesi
Name:Mal
Synonyms:Mvp17
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi3037. Mal.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24CytoplasmicSequence analysisAdd BLAST24
Transmembranei25 – 46HelicalSequence analysisAdd BLAST22
Topological domaini47 – 53ExtracellularSequence analysis7
Transmembranei54 – 75HelicalSequence analysisAdd BLAST22
Topological domaini76 – 92CytoplasmicSequence analysisAdd BLAST17
Transmembranei93 – 114HelicalSequence analysisAdd BLAST22
Topological domaini115 – 125ExtracellularSequence analysisAdd BLAST11
Transmembranei126 – 147HelicalSequence analysisAdd BLAST22
Topological domaini148 – 153CytoplasmicSequence analysis6

GO - Cellular componenti

  • endoplasmic reticulum Source: Ensembl
  • extrinsic component of membrane Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • membrane raft Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001568071 – 153Myelin and lymphocyte proteinAdd BLAST153

Post-translational modificationi

Lipoprotein.By similarity

Keywords - PTMi

Lipoprotein

Proteomic databases

PaxDbiQ64349.

Expressioni

Tissue specificityi

Exclusively expressed in white and gray matter oligodendrocytes in the CNS and in myelinating Schwann cells in peripheral nerves. Higher levels are found in the PNS than in the CNS or spinal cord, in the gray matter than in the white. Weak expression also found in spleen and kidney.

Developmental stagei

Detected just before birth in Schwann cells and after birth in oligodendrocytes of brainstem and spinal cord.

Inductioni

Up-regulated during myelination.

Gene expression databases

BgeeiENSRNOG00000015445.
GenevisibleiQ64349. RN.

Interactioni

Protein-protein interaction databases

DIPiDIP-46222N.
STRINGi10116.ENSRNOP00000020870.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 151MARVELPROSITE-ProRule annotationAdd BLAST134

Sequence similaritiesi

Belongs to the MAL family.Curated
Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00730000110762.
HOGENOMiHOG000231752.
HOVERGENiHBG000925.
InParanoidiQ64349.
OMAiVPIPLIQ.
OrthoDBiEOG091G0OS1.
PhylomeDBiQ64349.
TreeFamiTF316174.

Family and domain databases

InterProiIPR013295. MAL.
IPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR01884. MALPROTEIN.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64349-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPAAASGGS TLPSGFSVFV TFPDLLFIFE FIFGGLVWIL IASSLVPMPL
60 70 80 90 100
VQGWVMFVSV FCFLATTSLM VMYIIGTHGG ETSWITLDAA YHCVAALFYL
110 120 130 140 150
SASVLEALAT ITMFDGFTYR HYHENIAAVV FAYVATLLYV IHAVFSLIRW

KSS
Length:153
Mass (Da):16,758
Last modified:November 1, 1996 - v1
Checksum:iC98996D2C3612494
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31367 mRNA. Translation: AAC52366.1.
X82557 mRNA. Translation: CAA57903.1.
BC085755 mRNA. Translation: AAH85755.1.
RefSeqiNP_036930.1. NM_012798.1.
UniGeneiRn.10174.

Genome annotation databases

EnsembliENSRNOT00000020870; ENSRNOP00000020870; ENSRNOG00000015445.
GeneIDi25263.
KEGGirno:25263.
UCSCiRGD:3037. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31367 mRNA. Translation: AAC52366.1.
X82557 mRNA. Translation: CAA57903.1.
BC085755 mRNA. Translation: AAH85755.1.
RefSeqiNP_036930.1. NM_012798.1.
UniGeneiRn.10174.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46222N.
STRINGi10116.ENSRNOP00000020870.

Proteomic databases

PaxDbiQ64349.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020870; ENSRNOP00000020870; ENSRNOG00000015445.
GeneIDi25263.
KEGGirno:25263.
UCSCiRGD:3037. rat.

Organism-specific databases

CTDi4118.
RGDi3037. Mal.

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00730000110762.
HOGENOMiHOG000231752.
HOVERGENiHBG000925.
InParanoidiQ64349.
OMAiVPIPLIQ.
OrthoDBiEOG091G0OS1.
PhylomeDBiQ64349.
TreeFamiTF316174.

Miscellaneous databases

PROiQ64349.

Gene expression databases

BgeeiENSRNOG00000015445.
GenevisibleiQ64349. RN.

Family and domain databases

InterProiIPR013295. MAL.
IPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR01884. MALPROTEIN.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMAL_RAT
AccessioniPrimary (citable) accession number: Q64349
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.