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Protein
Submitted name:

Amyloid beta (A4)-like protein 2, isoform CRA_b

Gene

Aplp2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Amyloid beta (A4)-like protein 2, isoform CRA_bImported
Submitted name:
CDE1-binding protein CDEBPImported
Gene namesi
Name:Aplp2Imported
Synonyms:CdebpImported
ORF Names:mCG_14974Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88047. Aplp2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei626 – 648HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_501014117832 – 695Sequence analysisAdd BLAST664

Proteomic databases

MaxQBiQ64348.

Expressioni

Gene expression databases

ExpressionAtlasiQ64348. baseline and differential.

Structurei

3D structure databases

SMRiQ64348.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 204A4_EXTRAInterPro annotationAdd BLAST163

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

HOVERGENiHBG000051.

Family and domain databases

Gene3Di3.30.1490.140. 1 hit.
3.90.570.10. 1 hit.
InterProiView protein in InterPro
IPR008155. Amyloid_glyco.
IPR011178. Amyloid_glyco_Cu-bd.
IPR024329. Amyloid_glyco_E2_domain.
IPR008154. Amyloid_glyco_extra.
IPR019744. Amyloid_glyco_extracell_CS.
IPR015849. Amyloid_glyco_heparin-bd.
IPR019745. Amyloid_glyco_intracell_CS.
IPR019543. APP_amyloid_C.
PfamiView protein in Pfam
PF10515. APP_amyloid. 1 hit.
PF12924. APP_Cu_bd. 1 hit.
PF12925. APP_E2. 1 hit.
PF02177. APP_N. 1 hit.
PRINTSiPR00203. AMYLOIDA4.
SMARTiView protein in SMART
SM00006. A4_EXTRA. 1 hit.
SUPFAMiSSF109843. SSF109843. 1 hit.
SSF56491. SSF56491. 1 hit.
SSF89811. SSF89811. 1 hit.
PROSITEiView protein in PROSITE
PS00319. A4_EXTRA. 1 hit.
PS00320. A4_INTRA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q64348-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATGTAAAA ATGKLLVLLL LGLTAPAAAL AGYIEALAAN AGTGFAVAEP
60 70 80 90 100
QIAMFCGKLN MHVNIQTGKW EPDPTGTKSC LGTKEEVLQY CQEIYPELQI
110 120 130 140 150
TNVMEANQPV NIDSWCRRDK RQCKSHIVIP FKCLVGEFVS DVLLVPDNCQ
160 170 180 190 200
FFHQERMEVC EKHQRWHTLV KEACLTEGLT LYSYGMLLPC GVDQFHGTEY
210 220 230 240 250
VCCPQTKTVD SDSTMSKEEE EEEEDEEDEE EDYDLDKSEF PTEADLEDFT
260 270 280 290 300
EAAADEEEED EEEGEEVVED RDYYYDPFKG DDYNEENPTE PSSEGTISDK
310 320 330 340 350
EIVHDVKVPP TPLPTNDVDV YFETSADDNE HARFQKAKEQ LEIRHRNRMD
360 370 380 390 400
RVKKEWEEAE LQAKNLPKTE RQTLIQHFQA MVKALEKEAA SEKQQLVETH
410 420 430 440 450
LARVEAMLND RRRIALENYL AALQSDPPRP HRILQALRRY VRAENKDRLH
460 470 480 490 500
TIRHYQHVLA VDPEKAAQMK SQVMTHLHVI EERRNQSLSL LYKVPYVAQE
510 520 530 540 550
IQEEIDELLQ EQRADMDQFT SSISENPVDV RVSSEESEEI PPFHPLHPFP
560 570 580 590 600
SLSENEGSGM AEQDGGLIGA EEKVINSKNK MDENMVIDET LDVKEMIFNA
610 620 630 640 650
ERVGGLEEEP ESVGPLREDF SLSSNALIGL LVIAVAIATV IVISLVMLRK
660 670 680 690
RQYGTISHGI VEVDPMLTPE ERHLNKMQNH GYENPTYKYL EQMQI
Length:695
Mass (Da):78,998
Last modified:November 1, 1996 - v1
Checksum:iADB62430849EF6AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AH004870
, U37468, U37469, U37470, U37471, U37472, U37473, U37476, U37477, U37478, U37479, U37480, U37482, U37483, U37484 Genomic DNA. Translation: AAB38115.1.
Z27070 mRNA. Translation: CAA81583.1.
CH466522 Genomic DNA. Translation: EDL25340.1.
RefSeqiNP_033821.1. NM_009691.2.
UniGeneiMm.19133.

Genome annotation databases

GeneIDi11804.
UCSCiuc009orn.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiQ64348_MOUSE
AccessioniPrimary (citable) accession number: Q64348
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: August 30, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)