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Q64346

- DUS6_RAT

UniProt

Q64346 - DUS6_RAT

Protein

Dual specificity protein phosphatase 6

Gene

Dusp6

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Inactivates MAP kinases. Has a specificity for the ERK family. Implicated in muscle and neuronal differentiation.

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei293 – 2931Phosphocysteine intermediateBy similarity

    GO - Molecular functioni

    1. MAP kinase tyrosine/serine/threonine phosphatase activity Source: Ensembl
    2. protein tyrosine/serine/threonine phosphatase activity Source: RGD
    3. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell differentiation Source: RGD
    2. dorsal/ventral pattern formation Source: RefGenome
    3. negative regulation of ERK1 and ERK2 cascade Source: RGD
    4. positive regulation of apoptotic process Source: RefGenome
    5. positive regulation of cell death Source: RGD
    6. protein dephosphorylation Source: RefGenome
    7. regulation of endodermal cell fate specification Source: RefGenome
    8. regulation of fibroblast growth factor receptor signaling pathway Source: RefGenome
    9. regulation of heart growth Source: RefGenome
    10. response to drug Source: RGD
    11. response to growth factor Source: RGD
    12. response to nitrosative stress Source: Ensembl
    13. response to organic cyclic compound Source: RGD
    14. response to organic substance Source: RGD

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity protein phosphatase 6 (EC:3.1.3.16, EC:3.1.3.48)
    Alternative name(s):
    Mitogen-activated protein kinase phosphatase 3
    Short name:
    MAP kinase phosphatase 3
    Short name:
    MKP-3
    Gene namesi
    Name:Dusp6
    Synonyms:Mkp3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi70978. Dusp6.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RGD
    2. cytosol Source: RGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 381381Dual specificity protein phosphatase 6PRO_0000094806Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriQ64346.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000032969.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2FYSX-ray2.50C/D60-76[»]
    ProteinModelPortaliQ64346.
    SMRiQ64346. Positions 1-154, 205-347.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ64346.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 148119RhodanesePROSITE-ProRule annotationAdd
    BLAST
    Domaini206 – 381176Tyrosine-protein phosphataseAdd
    BLAST

    Sequence similaritiesi

    Contains 1 rhodanese domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG2453.
    GeneTreeiENSGT00750000117282.
    HOGENOMiHOG000294079.
    HOVERGENiHBG007347.
    KOiK04459.
    OMAiSEWNENT.
    OrthoDBiEOG793B7W.
    PhylomeDBiQ64346.
    TreeFamiTF105122.

    Family and domain databases

    Gene3Di3.40.250.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR008343. MKP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR001763. Rhodanese-like_dom.
    IPR000387. Tyr/Dual-sp_Pase.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    PF00581. Rhodanese. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000939. MAPK_Ptase. 1 hit.
    PRINTSiPR01764. MAPKPHPHTASE.
    SMARTiSM00195. DSPc. 1 hit.
    SM00450. RHOD. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    SSF52821. SSF52821. 1 hit.
    PROSITEiPS50206. RHODANESE_3. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q64346-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIDTLRPVPF ASEMAISKTV AWLNEQLELG NEQLLLMDCR PQELYESSHI    50
    ESAINVAIPG IMLRRLQKGN LPVRALFTRC EDRDRFTRRC GTDTVVLYDE 100
    NSSDWNENTG GESVLGLLLK KLKDEGCRAF YLEGGFSKFQ AEFALHCETN 150
    LDGSCSSSSP PLPVLGLGGL RISSDSSSDI ESDLDRDPNS ATDSDGSPLS 200
    NSQPSFPVEI LPFLYLGCAK DSTNLDVLEE FGIKYILNVT PNLPNLFENA 250
    GEFKYKQIPI SDHWSQNLSQ FFPEAISFID EARGKNCGVL VHCLAGISRS 300
    VTVTVAYLMQ KLNLSMNDAY DIVKMKKSNI SPNFNFMGQL LDFERTLGLS 350
    SPCDNRVPAQ QLYFTAPSNQ NVYQVDSLQS T 381
    Length:381
    Mass (Da):42,319
    Last modified:November 1, 1996 - v1
    Checksum:iC511E00CB68F2888
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X94185 mRNA. Translation: CAA63895.1.
    U42627 mRNA. Translation: AAB06202.1.
    BC087003 mRNA. Translation: AAH87003.1.
    RefSeqiNP_446335.1. NM_053883.2.
    UniGeneiRn.4313.

    Genome annotation databases

    EnsembliENSRNOT00000037844; ENSRNOP00000032969; ENSRNOG00000023896.
    GeneIDi116663.
    KEGGirno:116663.
    UCSCiRGD:70978. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X94185 mRNA. Translation: CAA63895.1 .
    U42627 mRNA. Translation: AAB06202.1 .
    BC087003 mRNA. Translation: AAH87003.1 .
    RefSeqi NP_446335.1. NM_053883.2.
    UniGenei Rn.4313.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2FYS X-ray 2.50 C/D 60-76 [» ]
    ProteinModelPortali Q64346.
    SMRi Q64346. Positions 1-154, 205-347.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000032969.

    Chemistry

    BindingDBi Q64346.
    ChEMBLi CHEMBL5511.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000037844 ; ENSRNOP00000032969 ; ENSRNOG00000023896 .
    GeneIDi 116663.
    KEGGi rno:116663.
    UCSCi RGD:70978. rat.

    Organism-specific databases

    CTDi 1848.
    RGDi 70978. Dusp6.

    Phylogenomic databases

    eggNOGi COG2453.
    GeneTreei ENSGT00750000117282.
    HOGENOMi HOG000294079.
    HOVERGENi HBG007347.
    KOi K04459.
    OMAi SEWNENT.
    OrthoDBi EOG793B7W.
    PhylomeDBi Q64346.
    TreeFami TF105122.

    Miscellaneous databases

    EvolutionaryTracei Q64346.
    NextBioi 619455.
    PROi Q64346.

    Gene expression databases

    Genevestigatori Q64346.

    Family and domain databases

    Gene3Di 3.40.250.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR008343. MKP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR001763. Rhodanese-like_dom.
    IPR000387. Tyr/Dual-sp_Pase.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    PF00581. Rhodanese. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000939. MAPK_Ptase. 1 hit.
    PRINTSi PR01764. MAPKPHPHTASE.
    SMARTi SM00195. DSPc. 1 hit.
    SM00450. RHOD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    SSF52821. SSF52821. 1 hit.
    PROSITEi PS50206. RHODANESE_3. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase."
      Muda M., Boschert U., Dickinson R., Martinou J.-C., Martinou I., Camps M., Schlegel W., Arkinstall S.
      J. Biol. Chem. 271:4319-4326(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Neuron.
    2. "A novel cytoplasmic dual specificity protein tyrosine phosphatase implicated in muscle and neuronal differentiation."
      Mourey R.J., Vega Q.C., Campbell J.S., Wenderoth M.P., Hauschka S.D., Krebs E.G., Dixon J.E.
      J. Biol. Chem. 271:3795-3802(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiDUS6_RAT
    AccessioniPrimary (citable) accession number: Q64346
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3