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Protein

Dual specificity protein phosphatase 6

Gene

Dusp6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inactivates MAP kinases. Has a specificity for the ERK family (PubMed:8626780). Implicated in muscle and neuronal differentiation (PubMed:8631996). Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity).By similarity2 Publications

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei293Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: RGD
  • dorsal/ventral pattern formation Source: GO_Central
  • negative regulation of ERK1 and ERK2 cascade Source: RGD
  • positive regulation of apoptotic process Source: GO_Central
  • positive regulation of cell death Source: RGD
  • regulation of endodermal cell fate specification Source: GO_Central
  • regulation of fibroblast growth factor receptor signaling pathway Source: GO_Central
  • regulation of heart growth Source: GO_Central
  • response to drug Source: RGD
  • response to growth factor Source: RGD
  • response to nitrosative stress Source: Ensembl
  • response to organic cyclic compound Source: RGD
  • response to organic substance Source: RGD

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiR-RNO-112409 RAF-independent MAPK1/3 activation
R-RNO-202670 ERKs are inactivated
R-RNO-5675221 Negative regulation of MAPK pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 6 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
Mitogen-activated protein kinase phosphatase 3
Short name:
MAP kinase phosphatase 3
Short name:
MKP-3
Gene namesi
Name:Dusp6
Synonyms:Mkp3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi70978 Dusp6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5511

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000948061 – 381Dual specificity protein phosphatase 6Add BLAST381

Proteomic databases

PaxDbiQ64346

PTM databases

iPTMnetiQ64346
PhosphoSitePlusiQ64346

Expressioni

Tissue specificityi

Expressed in lung, heart, brain, and kidney, but not significantly in skeletal muscle or testis.1 Publication

Gene expression databases

BgeeiENSRNOG00000023896
GenevisibleiQ64346 RN

Interactioni

Protein-protein interaction databases

DIPiDIP-61143N
IntActiQ64346, 1 interactor
STRINGi10116.ENSRNOP00000032969

Chemistry databases

BindingDBiQ64346

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FYSX-ray2.50C/D60-76[»]
ProteinModelPortaliQ64346
SMRiQ64346
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ64346

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 148RhodanesePROSITE-ProRule annotationAdd BLAST119
Domaini206 – 381Tyrosine-protein phosphataseAdd BLAST176

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1717 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000118902
HOGENOMiHOG000294079
HOVERGENiHBG007347
InParanoidiQ64346
KOiK21946
OMAiLLVMDCR
OrthoDBiEOG091G0249
PhylomeDBiQ64346
TreeFamiTF105122

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.40.250.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR008343 MKP
IPR029021 Prot-tyrosine_phosphatase-like
IPR001763 Rhodanese-like_dom
IPR036873 Rhodanese-like_dom_sf
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PF00581 Rhodanese, 1 hit
PIRSFiPIRSF000939 MAPK_Ptase, 1 hit
PRINTSiPR01764 MAPKPHPHTASE
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SM00450 RHOD, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
SSF52821 SSF52821, 1 hit
PROSITEiView protein in PROSITE
PS50206 RHODANESE_3, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

Sequencei

Sequence statusi: Complete.

Q64346-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDTLRPVPF ASEMAISKTV AWLNEQLELG NEQLLLMDCR PQELYESSHI
60 70 80 90 100
ESAINVAIPG IMLRRLQKGN LPVRALFTRC EDRDRFTRRC GTDTVVLYDE
110 120 130 140 150
NSSDWNENTG GESVLGLLLK KLKDEGCRAF YLEGGFSKFQ AEFALHCETN
160 170 180 190 200
LDGSCSSSSP PLPVLGLGGL RISSDSSSDI ESDLDRDPNS ATDSDGSPLS
210 220 230 240 250
NSQPSFPVEI LPFLYLGCAK DSTNLDVLEE FGIKYILNVT PNLPNLFENA
260 270 280 290 300
GEFKYKQIPI SDHWSQNLSQ FFPEAISFID EARGKNCGVL VHCLAGISRS
310 320 330 340 350
VTVTVAYLMQ KLNLSMNDAY DIVKMKKSNI SPNFNFMGQL LDFERTLGLS
360 370 380
SPCDNRVPAQ QLYFTAPSNQ NVYQVDSLQS T
Length:381
Mass (Da):42,319
Last modified:November 1, 1996 - v1
Checksum:iC511E00CB68F2888
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94185 mRNA Translation: CAA63895.1
U42627 mRNA Translation: AAB06202.1
BC087003 mRNA Translation: AAH87003.1
RefSeqiNP_446335.1, NM_053883.2
UniGeneiRn.4313

Genome annotation databases

EnsembliENSRNOT00000037844; ENSRNOP00000032969; ENSRNOG00000023896
GeneIDi116663
KEGGirno:116663
UCSCiRGD:70978 rat

Similar proteinsi

Entry informationi

Entry nameiDUS6_RAT
AccessioniPrimary (citable) accession number: Q64346
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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