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Protein

Interferon-induced protein with tetratricopeptide repeats 3

Gene

Ifit3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiviral defense, Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced protein with tetratricopeptide repeats 3
Short name:
IFIT-3
Alternative name(s):
Glucocorticoid-attenuated response gene 49 protein
Short name:
GARG-49
Short name:
P49
IRG2
Gene namesi
Name:Ifit3
Synonyms:Garg49, Ifi49, Isg49
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1101055. Ifit3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 403403Interferon-induced protein with tetratricopeptide repeats 3PRO_0000106350Add
BLAST

Proteomic databases

MaxQBiQ64345.
PaxDbiQ64345.
PRIDEiQ64345.

PTM databases

iPTMnetiQ64345.
PhosphoSiteiQ64345.

Expressioni

Gene expression databases

BgeeiENSMUSG00000074896.
ExpressionAtlasiQ64345. baseline and differential.
GenevisibleiQ64345. MM.

Interactioni

Subunit structurei

Component of an interferon-dependent multiprotein complex, at least composed of IFIT1, IFIT2 and IFIT3. Interacts with IFIT1 and IFIT2 (By similarity). Interacts (via N-terminus) with MAVS, TBK1, TRAF6 and DDX58 (By similarity). Interacts with COPS5 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200527. 1 interaction.
IntActiQ64345. 1 interaction.
MINTiMINT-1563374.
STRINGi10090.ENSMUSP00000099889.

Structurei

3D structure databases

ProteinModelPortaliQ64345.
SMRiQ64345. Positions 6-402.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati94 – 12734TPR 1Add
BLAST
Repeati136 – 16934TPR 2Add
BLAST
Repeati172 – 20635TPR 3Add
BLAST
Repeati241 – 27434TPR 4Add
BLAST

Sequence similaritiesi

Belongs to the IFIT family.Curated
Contains 4 TPR repeats.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1124. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00390000013876.
HOGENOMiHOG000001558.
HOVERGENiHBG066330.
InParanoidiQ64345.
OMAiCTEIRTF.
OrthoDBiEOG091G06GX.
PhylomeDBiQ64345.
TreeFamiTF342671.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR024122. Interferon-induced_IFIT3.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10271:SF3. PTHR10271:SF3. 1 hit.
PfamiPF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 5 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64345-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEVNRESLE AILPQLKCHF TWNLFREGSM SSHMEDRVCN QVEHLNSEEK
60 70 80 90 100
ATMYDLLAYI KHLDGESKAA LECLGQAEDL RKSEHNDQSE IRRLVTWGNY
110 120 130 140 150
AWIYYHMGRL SEAQAYVDKV RQVCQKFANP YSMECPELEC EEGWTRLKCG
160 170 180 190 200
RNERAKMCFE KALEEKPKDP ECSSGMAIAM FRLEEKPEKQ FSVDALKQAM
210 220 230 240 250
ELNPQNQYLK VLLALKLLRM GEEAEGERLI KDALGKAPNQ TDVLQKAAQF
260 270 280 290 300
YKKKGNLDRA IELLGKALRS TVNNSPLYSL VMCRYREILE QLQNKGDADS
310 320 330 340 350
SERRQRMAEL RRLTMEFMQK TLQRRRSPLN SYSDLIDFPE VERCYQMVIS
360 370 380 390 400
KESPDVEEED LYERYCNLQE YHRKSEDLAA LECLLQFPRN ERSIEKEEVK

EQT
Length:403
Mass (Da):47,223
Last modified:November 1, 1996 - v1
Checksum:iAE5F5ED42F4F8F60
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti158 – 1581C → Y in AAH03804 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43086 Genomic DNA. Translation: AAC52627.1.
L32974 mRNA. Translation: AAA39329.1.
BC003804 mRNA. Translation: AAH03804.1.
CCDSiCCDS29762.1.
PIRiS71356.
RefSeqiNP_034631.1. NM_010501.2.
UniGeneiMm.426079.

Genome annotation databases

EnsembliENSMUST00000102825; ENSMUSP00000099889; ENSMUSG00000074896.
GeneIDi15959.
KEGGimmu:15959.
UCSCiuc008hgo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43086 Genomic DNA. Translation: AAC52627.1.
L32974 mRNA. Translation: AAA39329.1.
BC003804 mRNA. Translation: AAH03804.1.
CCDSiCCDS29762.1.
PIRiS71356.
RefSeqiNP_034631.1. NM_010501.2.
UniGeneiMm.426079.

3D structure databases

ProteinModelPortaliQ64345.
SMRiQ64345. Positions 6-402.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200527. 1 interaction.
IntActiQ64345. 1 interaction.
MINTiMINT-1563374.
STRINGi10090.ENSMUSP00000099889.

PTM databases

iPTMnetiQ64345.
PhosphoSiteiQ64345.

Proteomic databases

MaxQBiQ64345.
PaxDbiQ64345.
PRIDEiQ64345.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102825; ENSMUSP00000099889; ENSMUSG00000074896.
GeneIDi15959.
KEGGimmu:15959.
UCSCiuc008hgo.1. mouse.

Organism-specific databases

CTDi3437.
MGIiMGI:1101055. Ifit3.

Phylogenomic databases

eggNOGiKOG1124. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00390000013876.
HOGENOMiHOG000001558.
HOVERGENiHBG066330.
InParanoidiQ64345.
OMAiCTEIRTF.
OrthoDBiEOG091G06GX.
PhylomeDBiQ64345.
TreeFamiTF342671.

Miscellaneous databases

PROiQ64345.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000074896.
ExpressionAtlasiQ64345. baseline and differential.
GenevisibleiQ64345. MM.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR024122. Interferon-induced_IFIT3.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10271:SF3. PTHR10271:SF3. 1 hit.
PfamiPF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 5 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIFIT3_MOUSE
AccessioniPrimary (citable) accession number: Q64345
Secondary accession number(s): Q99L62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.