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Q64343

- ABCG1_MOUSE

UniProt

Q64343 - ABCG1_MOUSE

Protein

ATP-binding cassette sub-family G member 1

Gene

Abcg1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi118 – 1258ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ADP binding Source: Ensembl
    2. ATP binding Source: UniProtKB-KW
    3. cholesterol transporter activity Source: Ensembl
    4. glycoprotein transporter activity Source: Ensembl
    5. phospholipid transporter activity Source: Ensembl
    6. sterol-transporting ATPase activity Source: Ensembl
    7. toxin transporter activity Source: Ensembl

    GO - Biological processi

    1. amyloid precursor protein catabolic process Source: Ensembl
    2. cholesterol efflux Source: BHF-UCL
    3. cholesterol homeostasis Source: Ensembl
    4. cholesterol metabolic process Source: Ensembl
    5. cholesterol transport Source: MGI
    6. high-density lipoprotein particle remodeling Source: BHF-UCL
    7. intracellular cholesterol transport Source: Ensembl
    8. low-density lipoprotein particle remodeling Source: BHF-UCL
    9. negative regulation of lipid storage Source: BHF-UCL
    10. negative regulation of macrophage derived foam cell differentiation Source: BHF-UCL
    11. phospholipid efflux Source: Ensembl
    12. phospholipid homeostasis Source: Ensembl
    13. positive regulation of cholesterol biosynthetic process Source: BHF-UCL
    14. positive regulation of cholesterol efflux Source: BHF-UCL
    15. regulation of cholesterol esterification Source: BHF-UCL
    16. regulation of transcription, DNA-templated Source: BHF-UCL
    17. response to high density lipoprotein particle Source: BHF-UCL
    18. response to lipid Source: Ensembl
    19. reverse cholesterol transport Source: BHF-UCL

    Keywords - Biological processi

    Lipid transport, Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_197984. ABCA transporters in lipid homeostasis.
    REACT_213857. HDL-mediated lipid transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-binding cassette sub-family G member 1
    Alternative name(s):
    ATP-binding cassette transporter 8
    White protein homolog
    Gene namesi
    Name:Abcg1
    Synonyms:Abc8, Wht1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:107704. Abcg1.

    Subcellular locationi

    GO - Cellular componenti

    1. endosome Source: BHF-UCL
    2. external side of plasma membrane Source: BHF-UCL
    3. Golgi apparatus Source: Ensembl
    4. integral component of membrane Source: UniProtKB-KW
    5. mitochondrion Source: Ensembl
    6. recycling endosome Source: BHF-UCL

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 666666ATP-binding cassette sub-family G member 1PRO_0000093385Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi30 – 301S-palmitoyl cysteineBy similarity
    Lipidationi154 – 1541S-palmitoyl cysteineBy similarity
    Lipidationi315 – 3151S-palmitoyl cysteineBy similarity
    Lipidationi394 – 3941S-palmitoyl cysteineBy similarity

    Post-translational modificationi

    Palmitoylation at Cys-315 seems important for trafficking from the endoplasmic reticulum.By similarity

    Keywords - PTMi

    Lipoprotein, Palmitate

    Proteomic databases

    MaxQBiQ64343.
    PaxDbiQ64343.
    PRIDEiQ64343.

    PTM databases

    PhosphoSiteiQ64343.

    Expressioni

    Tissue specificityi

    Expressed mainly in brain, thymus, lung, adrenals, spleen and placenta. Little or no expression in liver, kidney, heart, muscle or testes.

    Inductioni

    Strongly induced in macrophage cell line RAW 264.7 during cholesterol influx. Induction is mediated by the liver X receptor/retinoid X receptor (LXR/RXR) pathway. Down-regulated by endotoxins or cytokines (TNF and IL1) in J-774 macrophages.1 Publication

    Gene expression databases

    ArrayExpressiQ64343.
    BgeeiQ64343.
    GenevestigatoriQ64343.

    Interactioni

    Protein-protein interaction databases

    BioGridi197904. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64343.
    SMRiQ64343. Positions 2-323.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 414414CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini434 – 44411ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini466 – 49429CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini514 – 5218ExtracellularSequence Analysis
    Topological domaini544 – 55512CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini575 – 63763ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini658 – 6669CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei415 – 43319HelicalSequence AnalysisAdd
    BLAST
    Transmembranei445 – 46521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei495 – 51319HelicalSequence AnalysisAdd
    BLAST
    Transmembranei522 – 54322HelicalSequence AnalysisAdd
    BLAST
    Transmembranei556 – 57419HelicalSequence AnalysisAdd
    BLAST
    Transmembranei638 – 65720HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini77 – 317241ABC transporterPROSITE-ProRule annotationAdd
    BLAST
    Domaini403 – 661259ABC transmembrane type-2Add
    BLAST

    Sequence similaritiesi

    Contains 1 ABC transporter domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1131.
    GeneTreeiENSGT00740000114855.
    HOGENOMiHOG000236364.
    HOVERGENiHBG103052.
    InParanoidiQ64343.
    KOiK05679.
    OMAiRERICDT.
    OrthoDBiEOG7KWSGT.
    PhylomeDBiQ64343.
    TreeFamiTF105210.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR013525. ABC_2_trans.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR020064. ABCG1.
    IPR027417. P-loop_NTPase.
    IPR005284. Pigment_permease.
    [Graphical view]
    PANTHERiPTHR19241:SF177. PTHR19241:SF177. 1 hit.
    PfamiPF01061. ABC2_membrane. 1 hit.
    PF00005. ABC_tran. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00955. 3a01204. 1 hit.
    PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q64343-1 [UniParc]FASTAAdd to Basket

    « Hide

    MACLMAAFSV GTAMNASSYS AAMTEPKSVC VSVDEVVSSN VDEVETDLLN    50
    GHLKKVDNNF TEAQRFSSLP RRAAVNIEFK DLSYSVPEGP WWKKKGYKTL 100
    LKGISGKFNS GELVAIMGPS GAGKSTLMNI LAGYRETGMK GAVLINGMPR 150
    DLRCFRKVSC YIMQDDMLLP HLTVQEAMMV SAHLKLQEKD EGRREMVKEI 200
    LTALGLLPCA NTRTGSLSGG QRKRLAIALE LVNNPPVMFF DEPTSGLDSA 250
    SCFQVVSLMK GLAQGGRSIV CTIHQPSAKL FELFDQLYVL SQGQCVYRGK 300
    VSNLVPYLRD LGLNCPTYHN PADFVMEVAS GEYGDQNSRL VRAVREGMCD 350
    ADYKRDLGGD TDVNPFLWHR PAEEDSASME GCHSFSASCL TQFCILFKRT 400
    FLSIMRDSVL THLRITSHIG IGLLIGLLYL GIGNEAKKVL SNSGFLFFSM 450
    LFLMFAALMP TVLTFPLEMS VFLREHLNYW YSLKAYYLAK TMADVPFQIM 500
    FPVAYCSIVY WMTSQPSDAV RFVLFAALGT MTSLVAQSLG LLIGAASTSL 550
    QVATFVGPVT AIPVLLFSGF FVSFDTIPAY LQWMSYISYV RYGFEGVILS 600
    IYGLDREDLH CDIAETCHFQ KSEAILRELD VENAKLYLDF IVLGIFFISL 650
    RLIAYFVLRY KIRAER 666
    Length:666
    Mass (Da):74,033
    Last modified:November 1, 1997 - v1
    Checksum:iEDDC6AFBD43950B6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U34920 mRNA. Translation: AAB47738.1.
    Z48745 mRNA. Translation: CAA88636.1.
    AF323659 mRNA. Translation: AAK27442.1.
    CCDSiCCDS28602.1.
    RefSeqiNP_033723.1. NM_009593.2.
    UniGeneiMm.15691.
    Mm.470747.

    Genome annotation databases

    EnsembliENSMUST00000024829; ENSMUSP00000024829; ENSMUSG00000024030.
    GeneIDi11307.
    KEGGimmu:11307.
    UCSCiuc008buj.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U34920 mRNA. Translation: AAB47738.1 .
    Z48745 mRNA. Translation: CAA88636.1 .
    AF323659 mRNA. Translation: AAK27442.1 .
    CCDSi CCDS28602.1.
    RefSeqi NP_033723.1. NM_009593.2.
    UniGenei Mm.15691.
    Mm.470747.

    3D structure databases

    ProteinModelPortali Q64343.
    SMRi Q64343. Positions 2-323.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 197904. 1 interaction.

    PTM databases

    PhosphoSitei Q64343.

    Proteomic databases

    MaxQBi Q64343.
    PaxDbi Q64343.
    PRIDEi Q64343.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000024829 ; ENSMUSP00000024829 ; ENSMUSG00000024030 .
    GeneIDi 11307.
    KEGGi mmu:11307.
    UCSCi uc008buj.2. mouse.

    Organism-specific databases

    CTDi 9619.
    MGIi MGI:107704. Abcg1.

    Phylogenomic databases

    eggNOGi COG1131.
    GeneTreei ENSGT00740000114855.
    HOGENOMi HOG000236364.
    HOVERGENi HBG103052.
    InParanoidi Q64343.
    KOi K05679.
    OMAi RERICDT.
    OrthoDBi EOG7KWSGT.
    PhylomeDBi Q64343.
    TreeFami TF105210.

    Enzyme and pathway databases

    Reactomei REACT_197984. ABCA transporters in lipid homeostasis.
    REACT_213857. HDL-mediated lipid transport.

    Miscellaneous databases

    NextBioi 278604.
    PROi Q64343.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q64343.
    Bgeei Q64343.
    Genevestigatori Q64343.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR013525. ABC_2_trans.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR020064. ABCG1.
    IPR027417. P-loop_NTPase.
    IPR005284. Pigment_permease.
    [Graphical view ]
    PANTHERi PTHR19241:SF177. PTHR19241:SF177. 1 hit.
    Pfami PF01061. ABC2_membrane. 1 hit.
    PF00005. ABC_tran. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00955. 3a01204. 1 hit.
    PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of a mammalian homolog of the Drosophila white gene."
      Croop J.M., Tiller G.E., Fletcher J.A., Lux M.L., Raab E., Goldenson D., Son D., Arciniegas S., Wu R.
      Gene 185:77-85(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Molecular cloning of a mammalian ABC transporter homologous to Drosophila white gene."
      Savary S., Denizot F., Luciani M.-F., Mattei M.-G., Chimini G.
      Mamm. Genome 7:673-676(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: DBA/2.
    3. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols."
      Venkateswaran A., Repa J.J., Lobaccaro J.-M.A., Bronson A., Mangelsdorf D.J., Edwards P.A.
      J. Biol. Chem. 275:14700-14707(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION, PROBABLE FUNCTION.
    5. "Role of ABCG1 and other ABCG family members in lipid metabolism."
      Schmitz G., Langmann T., Heimerl S.
      J. Lipid Res. 42:1513-1520(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    6. "Physiological function of ABCG1."
      Ito T.
      Drug News Perspect. 16:490-492(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Endotoxin down-regulates ABCG5 and ABCG8 in mouse liver and ABCA1 and ABCG1 in J774 murine macrophages: differential role of LXR."
      Khovidhunkit W., Moser A.H., Shigenaga J.K., Grunfeld C., Feingold K.R.
      J. Lipid Res. 44:1728-1736(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: DOWN-REGULATION BY ENDOTOXIN.
    8. "Characterization of palmitoylation of ATP binding cassette transporter G1: Effect on protein trafficking and function."
      Gu H.M., Li G., Gao X., Berthiaume L.G., Zhang D.W.
      Biochim. Biophys. Acta 1831:1067-1078(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: PALMITOYLATION.

    Entry informationi

    Entry nameiABCG1_MOUSE
    AccessioniPrimary (citable) accession number: Q64343
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 132 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3