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Protein

ATP-binding cassette sub-family G member 1

Gene

Abcg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi118 – 125ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • amyloid precursor protein catabolic process Source: MGI
  • cholesterol efflux Source: BHF-UCL
  • cholesterol homeostasis Source: MGI
  • cholesterol metabolic process Source: MGI
  • cholesterol transport Source: MGI
  • glycoprotein transport Source: MGI
  • high-density lipoprotein particle remodeling Source: BHF-UCL
  • intracellular cholesterol transport Source: MGI
  • low-density lipoprotein particle remodeling Source: BHF-UCL
  • negative regulation of lipid storage Source: BHF-UCL
  • negative regulation of macrophage derived foam cell differentiation Source: BHF-UCL
  • phospholipid efflux Source: MGI
  • phospholipid homeostasis Source: MGI
  • positive regulation of cholesterol biosynthetic process Source: BHF-UCL
  • positive regulation of cholesterol efflux Source: BHF-UCL
  • regulation of cholesterol esterification Source: BHF-UCL
  • regulation of transcription, DNA-templated Source: BHF-UCL
  • response to high density lipoprotein particle Source: BHF-UCL
  • response to lipid Source: MGI
  • response to organic substance Source: MGI
  • reverse cholesterol transport Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-1369062. ABC transporters in lipid homeostasis.
R-MMU-194223. HDL-mediated lipid transport.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family G member 1
Alternative name(s):
ATP-binding cassette transporter 8
White protein homolog
Gene namesi
Name:Abcg1
Synonyms:Abc8, Wht1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:107704. Abcg1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 414CytoplasmicSequence analysisAdd BLAST414
Transmembranei415 – 433HelicalSequence analysisAdd BLAST19
Topological domaini434 – 444ExtracellularSequence analysisAdd BLAST11
Transmembranei445 – 465HelicalSequence analysisAdd BLAST21
Topological domaini466 – 494CytoplasmicSequence analysisAdd BLAST29
Transmembranei495 – 513HelicalSequence analysisAdd BLAST19
Topological domaini514 – 521ExtracellularSequence analysis8
Transmembranei522 – 543HelicalSequence analysisAdd BLAST22
Topological domaini544 – 555CytoplasmicSequence analysisAdd BLAST12
Transmembranei556 – 574HelicalSequence analysisAdd BLAST19
Topological domaini575 – 637ExtracellularSequence analysisAdd BLAST63
Transmembranei638 – 657HelicalSequence analysisAdd BLAST20
Topological domaini658 – 666CytoplasmicSequence analysis9

GO - Cellular componenti

  • endosome Source: BHF-UCL
  • external side of plasma membrane Source: BHF-UCL
  • Golgi apparatus Source: MGI
  • integral component of membrane Source: GO_Central
  • intracellular membrane-bounded organelle Source: MGI
  • mitochondrion Source: MGI
  • nucleoplasm Source: MGI
  • plasma membrane Source: MGI
  • recycling endosome Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933851 – 666ATP-binding cassette sub-family G member 1Add BLAST666

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi30S-palmitoyl cysteineBy similarity1
Lipidationi154S-palmitoyl cysteineBy similarity1
Lipidationi315S-palmitoyl cysteineBy similarity1
Lipidationi394S-palmitoyl cysteineBy similarity1

Post-translational modificationi

Palmitoylation at Cys-315 seems important for trafficking from the endoplasmic reticulum.By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

MaxQBiQ64343.
PaxDbiQ64343.
PRIDEiQ64343.

PTM databases

iPTMnetiQ64343.
PhosphoSitePlusiQ64343.

Expressioni

Tissue specificityi

Expressed mainly in brain, thymus, lung, adrenals, spleen and placenta. Little or no expression in liver, kidney, heart, muscle or testes.

Inductioni

Strongly induced in macrophage cell line RAW 264.7 during cholesterol influx. Induction is mediated by the liver X receptor/retinoid X receptor (LXR/RXR) pathway. Down-regulated by endotoxins or cytokines (TNF and IL1) in J-774 macrophages.1 Publication

Gene expression databases

BgeeiENSMUSG00000024030.
ExpressionAtlasiQ64343. baseline and differential.
GenevisibleiQ64343. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024829.

Structurei

3D structure databases

ProteinModelPortaliQ64343.
SMRiQ64343.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini77 – 317ABC transporterPROSITE-ProRule annotationAdd BLAST241
Domaini403 – 661ABC transmembrane type-2Add BLAST259

Sequence similaritiesi

Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0061. Eukaryota.
COG1131. LUCA.
GeneTreeiENSGT00740000114855.
HOGENOMiHOG000236364.
HOVERGENiHBG103052.
InParanoidiQ64343.
KOiK05679.
OMAiASMEGCH.
OrthoDBiEOG091G050S.
PhylomeDBiQ64343.
TreeFamiTF105210.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR020064. ABCG1.
IPR027417. P-loop_NTPase.
IPR005284. Pigment_permease.
[Graphical view]
PANTHERiPTHR19241:SF177. PTHR19241:SF177. 1 hit.
PfamiPF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00955. 3a01204. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64343-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACLMAAFSV GTAMNASSYS AAMTEPKSVC VSVDEVVSSN VDEVETDLLN
60 70 80 90 100
GHLKKVDNNF TEAQRFSSLP RRAAVNIEFK DLSYSVPEGP WWKKKGYKTL
110 120 130 140 150
LKGISGKFNS GELVAIMGPS GAGKSTLMNI LAGYRETGMK GAVLINGMPR
160 170 180 190 200
DLRCFRKVSC YIMQDDMLLP HLTVQEAMMV SAHLKLQEKD EGRREMVKEI
210 220 230 240 250
LTALGLLPCA NTRTGSLSGG QRKRLAIALE LVNNPPVMFF DEPTSGLDSA
260 270 280 290 300
SCFQVVSLMK GLAQGGRSIV CTIHQPSAKL FELFDQLYVL SQGQCVYRGK
310 320 330 340 350
VSNLVPYLRD LGLNCPTYHN PADFVMEVAS GEYGDQNSRL VRAVREGMCD
360 370 380 390 400
ADYKRDLGGD TDVNPFLWHR PAEEDSASME GCHSFSASCL TQFCILFKRT
410 420 430 440 450
FLSIMRDSVL THLRITSHIG IGLLIGLLYL GIGNEAKKVL SNSGFLFFSM
460 470 480 490 500
LFLMFAALMP TVLTFPLEMS VFLREHLNYW YSLKAYYLAK TMADVPFQIM
510 520 530 540 550
FPVAYCSIVY WMTSQPSDAV RFVLFAALGT MTSLVAQSLG LLIGAASTSL
560 570 580 590 600
QVATFVGPVT AIPVLLFSGF FVSFDTIPAY LQWMSYISYV RYGFEGVILS
610 620 630 640 650
IYGLDREDLH CDIAETCHFQ KSEAILRELD VENAKLYLDF IVLGIFFISL
660
RLIAYFVLRY KIRAER
Length:666
Mass (Da):74,033
Last modified:November 1, 1997 - v1
Checksum:iEDDC6AFBD43950B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34920 mRNA. Translation: AAB47738.1.
Z48745 mRNA. Translation: CAA88636.1.
AF323659 mRNA. Translation: AAK27442.1.
CCDSiCCDS28602.1.
RefSeqiNP_033723.1. NM_009593.2.
UniGeneiMm.15691.
Mm.470747.

Genome annotation databases

EnsembliENSMUST00000024829; ENSMUSP00000024829; ENSMUSG00000024030.
GeneIDi11307.
KEGGimmu:11307.
UCSCiuc008buj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34920 mRNA. Translation: AAB47738.1.
Z48745 mRNA. Translation: CAA88636.1.
AF323659 mRNA. Translation: AAK27442.1.
CCDSiCCDS28602.1.
RefSeqiNP_033723.1. NM_009593.2.
UniGeneiMm.15691.
Mm.470747.

3D structure databases

ProteinModelPortaliQ64343.
SMRiQ64343.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024829.

PTM databases

iPTMnetiQ64343.
PhosphoSitePlusiQ64343.

Proteomic databases

MaxQBiQ64343.
PaxDbiQ64343.
PRIDEiQ64343.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024829; ENSMUSP00000024829; ENSMUSG00000024030.
GeneIDi11307.
KEGGimmu:11307.
UCSCiuc008buj.2. mouse.

Organism-specific databases

CTDi9619.
MGIiMGI:107704. Abcg1.

Phylogenomic databases

eggNOGiKOG0061. Eukaryota.
COG1131. LUCA.
GeneTreeiENSGT00740000114855.
HOGENOMiHOG000236364.
HOVERGENiHBG103052.
InParanoidiQ64343.
KOiK05679.
OMAiASMEGCH.
OrthoDBiEOG091G050S.
PhylomeDBiQ64343.
TreeFamiTF105210.

Enzyme and pathway databases

ReactomeiR-MMU-1369062. ABC transporters in lipid homeostasis.
R-MMU-194223. HDL-mediated lipid transport.

Miscellaneous databases

PROiQ64343.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024030.
ExpressionAtlasiQ64343. baseline and differential.
GenevisibleiQ64343. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR020064. ABCG1.
IPR027417. P-loop_NTPase.
IPR005284. Pigment_permease.
[Graphical view]
PANTHERiPTHR19241:SF177. PTHR19241:SF177. 1 hit.
PfamiPF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00955. 3a01204. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiABCG1_MOUSE
AccessioniPrimary (citable) accession number: Q64343
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 153 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.