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Q64343

- ABCG1_MOUSE

UniProt

Q64343 - ABCG1_MOUSE

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Protein

ATP-binding cassette sub-family G member 1

Gene
Abcg1, Abc8, Wht1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi118 – 1258ATP Reviewed prediction

GO - Molecular functioni

  1. ADP binding Source: Ensembl
  2. ATP binding Source: UniProtKB-KW
  3. cholesterol transporter activity Source: Ensembl
  4. glycoprotein transporter activity Source: Ensembl
  5. phospholipid transporter activity Source: Ensembl
  6. sterol-transporting ATPase activity Source: Ensembl
  7. toxin transporter activity Source: Ensembl

GO - Biological processi

  1. amyloid precursor protein catabolic process Source: Ensembl
  2. cholesterol efflux Source: BHF-UCL
  3. cholesterol homeostasis Source: Ensembl
  4. cholesterol metabolic process Source: Ensembl
  5. cholesterol transport Source: MGI
  6. high-density lipoprotein particle remodeling Source: BHF-UCL
  7. intracellular cholesterol transport Source: Ensembl
  8. low-density lipoprotein particle remodeling Source: BHF-UCL
  9. negative regulation of lipid storage Source: BHF-UCL
  10. negative regulation of macrophage derived foam cell differentiation Source: BHF-UCL
  11. phospholipid efflux Source: Ensembl
  12. phospholipid homeostasis Source: Ensembl
  13. positive regulation of cholesterol biosynthetic process Source: BHF-UCL
  14. positive regulation of cholesterol efflux Source: BHF-UCL
  15. regulation of cholesterol esterification Source: BHF-UCL
  16. regulation of transcription, DNA-templated Source: BHF-UCL
  17. response to high density lipoprotein particle Source: BHF-UCL
  18. response to lipid Source: Ensembl
  19. reverse cholesterol transport Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_197984. ABCA transporters in lipid homeostasis.
REACT_213857. HDL-mediated lipid transport.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family G member 1
Alternative name(s):
ATP-binding cassette transporter 8
White protein homolog
Gene namesi
Name:Abcg1
Synonyms:Abc8, Wht1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:107704. Abcg1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 414414Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei415 – 43319Helical; Reviewed predictionAdd
BLAST
Topological domaini434 – 44411Extracellular Reviewed predictionAdd
BLAST
Transmembranei445 – 46521Helical; Reviewed predictionAdd
BLAST
Topological domaini466 – 49429Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei495 – 51319Helical; Reviewed predictionAdd
BLAST
Topological domaini514 – 5218Extracellular Reviewed prediction
Transmembranei522 – 54322Helical; Reviewed predictionAdd
BLAST
Topological domaini544 – 55512Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei556 – 57419Helical; Reviewed predictionAdd
BLAST
Topological domaini575 – 63763Extracellular Reviewed predictionAdd
BLAST
Transmembranei638 – 65720Helical; Reviewed predictionAdd
BLAST
Topological domaini658 – 6669Cytoplasmic Reviewed prediction

GO - Cellular componenti

  1. endosome Source: BHF-UCL
  2. external side of plasma membrane Source: BHF-UCL
  3. Golgi apparatus Source: Ensembl
  4. integral component of membrane Source: UniProtKB-KW
  5. mitochondrion Source: Ensembl
  6. recycling endosome Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 666666ATP-binding cassette sub-family G member 1PRO_0000093385Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi30 – 301S-palmitoyl cysteine By similarity
Lipidationi154 – 1541S-palmitoyl cysteine By similarity
Lipidationi315 – 3151S-palmitoyl cysteine By similarity
Lipidationi394 – 3941S-palmitoyl cysteine By similarity

Post-translational modificationi

Palmitoylation at Cys-315 seems important for trafficking from the endoplasmic reticulum By similarity.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

MaxQBiQ64343.
PaxDbiQ64343.
PRIDEiQ64343.

PTM databases

PhosphoSiteiQ64343.

Expressioni

Tissue specificityi

Expressed mainly in brain, thymus, lung, adrenals, spleen and placenta. Little or no expression in liver, kidney, heart, muscle or testes.

Inductioni

Strongly induced in macrophage cell line RAW 264.7 during cholesterol influx. Induction is mediated by the liver X receptor/retinoid X receptor (LXR/RXR) pathway. Down-regulated by endotoxins or cytokines (TNF and IL1) in J-774 macrophages.2 Publications

Gene expression databases

ArrayExpressiQ64343.
BgeeiQ64343.
GenevestigatoriQ64343.

Interactioni

Protein-protein interaction databases

BioGridi197904. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ64343.
SMRiQ64343. Positions 2-323.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini77 – 317241ABC transporterAdd
BLAST
Domaini403 – 661259ABC transmembrane type-2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1131.
GeneTreeiENSGT00740000114855.
HOGENOMiHOG000236364.
HOVERGENiHBG103052.
InParanoidiQ64343.
KOiK05679.
OMAiRERICDT.
OrthoDBiEOG7KWSGT.
PhylomeDBiQ64343.
TreeFamiTF105210.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR020064. ABCG1.
IPR027417. P-loop_NTPase.
IPR005284. Pigment_permease.
[Graphical view]
PANTHERiPTHR19241:SF177. PTHR19241:SF177. 1 hit.
PfamiPF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00955. 3a01204. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64343-1 [UniParc]FASTAAdd to Basket

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MACLMAAFSV GTAMNASSYS AAMTEPKSVC VSVDEVVSSN VDEVETDLLN    50
GHLKKVDNNF TEAQRFSSLP RRAAVNIEFK DLSYSVPEGP WWKKKGYKTL 100
LKGISGKFNS GELVAIMGPS GAGKSTLMNI LAGYRETGMK GAVLINGMPR 150
DLRCFRKVSC YIMQDDMLLP HLTVQEAMMV SAHLKLQEKD EGRREMVKEI 200
LTALGLLPCA NTRTGSLSGG QRKRLAIALE LVNNPPVMFF DEPTSGLDSA 250
SCFQVVSLMK GLAQGGRSIV CTIHQPSAKL FELFDQLYVL SQGQCVYRGK 300
VSNLVPYLRD LGLNCPTYHN PADFVMEVAS GEYGDQNSRL VRAVREGMCD 350
ADYKRDLGGD TDVNPFLWHR PAEEDSASME GCHSFSASCL TQFCILFKRT 400
FLSIMRDSVL THLRITSHIG IGLLIGLLYL GIGNEAKKVL SNSGFLFFSM 450
LFLMFAALMP TVLTFPLEMS VFLREHLNYW YSLKAYYLAK TMADVPFQIM 500
FPVAYCSIVY WMTSQPSDAV RFVLFAALGT MTSLVAQSLG LLIGAASTSL 550
QVATFVGPVT AIPVLLFSGF FVSFDTIPAY LQWMSYISYV RYGFEGVILS 600
IYGLDREDLH CDIAETCHFQ KSEAILRELD VENAKLYLDF IVLGIFFISL 650
RLIAYFVLRY KIRAER 666
Length:666
Mass (Da):74,033
Last modified:November 1, 1997 - v1
Checksum:iEDDC6AFBD43950B6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U34920 mRNA. Translation: AAB47738.1.
Z48745 mRNA. Translation: CAA88636.1.
AF323659 mRNA. Translation: AAK27442.1.
CCDSiCCDS28602.1.
RefSeqiNP_033723.1. NM_009593.2.
UniGeneiMm.15691.
Mm.470747.

Genome annotation databases

EnsembliENSMUST00000024829; ENSMUSP00000024829; ENSMUSG00000024030.
GeneIDi11307.
KEGGimmu:11307.
UCSCiuc008buj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U34920 mRNA. Translation: AAB47738.1 .
Z48745 mRNA. Translation: CAA88636.1 .
AF323659 mRNA. Translation: AAK27442.1 .
CCDSi CCDS28602.1.
RefSeqi NP_033723.1. NM_009593.2.
UniGenei Mm.15691.
Mm.470747.

3D structure databases

ProteinModelPortali Q64343.
SMRi Q64343. Positions 2-323.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 197904. 1 interaction.

PTM databases

PhosphoSitei Q64343.

Proteomic databases

MaxQBi Q64343.
PaxDbi Q64343.
PRIDEi Q64343.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000024829 ; ENSMUSP00000024829 ; ENSMUSG00000024030 .
GeneIDi 11307.
KEGGi mmu:11307.
UCSCi uc008buj.2. mouse.

Organism-specific databases

CTDi 9619.
MGIi MGI:107704. Abcg1.

Phylogenomic databases

eggNOGi COG1131.
GeneTreei ENSGT00740000114855.
HOGENOMi HOG000236364.
HOVERGENi HBG103052.
InParanoidi Q64343.
KOi K05679.
OMAi RERICDT.
OrthoDBi EOG7KWSGT.
PhylomeDBi Q64343.
TreeFami TF105210.

Enzyme and pathway databases

Reactomei REACT_197984. ABCA transporters in lipid homeostasis.
REACT_213857. HDL-mediated lipid transport.

Miscellaneous databases

NextBioi 278604.
PROi Q64343.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q64343.
Bgeei Q64343.
Genevestigatori Q64343.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR020064. ABCG1.
IPR027417. P-loop_NTPase.
IPR005284. Pigment_permease.
[Graphical view ]
PANTHERi PTHR19241:SF177. PTHR19241:SF177. 1 hit.
Pfami PF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00955. 3a01204. 1 hit.
PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of a mammalian homolog of the Drosophila white gene."
    Croop J.M., Tiller G.E., Fletcher J.A., Lux M.L., Raab E., Goldenson D., Son D., Arciniegas S., Wu R.
    Gene 185:77-85(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning of a mammalian ABC transporter homologous to Drosophila white gene."
    Savary S., Denizot F., Luciani M.-F., Mattei M.-G., Chimini G.
    Mamm. Genome 7:673-676(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: DBA/2.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols."
    Venkateswaran A., Repa J.J., Lobaccaro J.-M.A., Bronson A., Mangelsdorf D.J., Edwards P.A.
    J. Biol. Chem. 275:14700-14707(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, PROBABLE FUNCTION.
  5. "Role of ABCG1 and other ABCG family members in lipid metabolism."
    Schmitz G., Langmann T., Heimerl S.
    J. Lipid Res. 42:1513-1520(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  6. "Physiological function of ABCG1."
    Ito T.
    Drug News Perspect. 16:490-492(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Endotoxin down-regulates ABCG5 and ABCG8 in mouse liver and ABCA1 and ABCG1 in J774 murine macrophages: differential role of LXR."
    Khovidhunkit W., Moser A.H., Shigenaga J.K., Grunfeld C., Feingold K.R.
    J. Lipid Res. 44:1728-1736(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOWN-REGULATION BY ENDOTOXIN.
  8. "Characterization of palmitoylation of ATP binding cassette transporter G1: Effect on protein trafficking and function."
    Gu H.M., Li G., Gao X., Berthiaume L.G., Zhang D.W.
    Biochim. Biophys. Acta 1831:1067-1078(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PALMITOYLATION.

Entry informationi

Entry nameiABCG1_MOUSE
AccessioniPrimary (citable) accession number: Q64343
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi