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Q64338

- PDE1C_MOUSE

UniProt

Q64338 - PDE1C_MOUSE

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Protein

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

Gene
Pde1c
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP.

Catalytic activityi

Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.

Cofactori

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.

Enzyme regulationi

Type I PDE are activated by the binding of calmodulin in the presence of Ca2+.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei228 – 2281Proton donor By similarity
Metal bindingi232 – 2321Divalent metal cation 1 By similarity
Metal bindingi268 – 2681Divalent metal cation 1 By similarity
Metal bindingi269 – 2691Divalent metal cation 1 By similarity
Metal bindingi269 – 2691Divalent metal cation 2 By similarity
Metal bindingi376 – 3761Divalent metal cation 1 By similarity

GO - Molecular functioni

  1. calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity Source: MGI
  2. calmodulin-dependent cyclic-nucleotide phosphodiesterase activity Source: MGI
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. metabolic process Source: GOC
  2. response to calcium ion Source: MGI
  3. sensory perception of smell Source: MGI
  4. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calmodulin-binding, cAMP, cGMP, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_227001. Cam-PDE 1 activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC:3.1.4.17)
Short name:
Cam-PDE 1C
Gene namesi
Name:Pde1c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:108413. Pde1c.

Subcellular locationi

GO - Cellular componenti

  1. cilium Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 706706Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CPRO_0000198793Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ64338.
PRIDEiQ64338.

PTM databases

PhosphoSiteiQ64338.

Expressioni

Tissue specificityi

Isoform 1 is highly expressed in testis. Isoform 2 is highly expressed in heart and testis, and detected at lower levels in olfactory epithelium and cerebellum.

Gene expression databases

ArrayExpressiQ64338.
BgeeiQ64338.
CleanExiMM_PDE1C.
GenevestigatoriQ64338.

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ64338.
SMRiQ64338. Positions 151-450.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni202 – 521320Catalytic By similarityAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG139098.
GeneTreeiENSGT00660000095451.
HOGENOMiHOG000231888.
HOVERGENiHBG056120.
InParanoidiQ64338.
KOiK13755.
OMAiNPRGKNS.
OrthoDBiEOG7X9G6J.
PhylomeDBiQ64338.
TreeFamiTF314638.

Family and domain databases

Gene3Di1.10.1300.10. 2 hits.
InterProiIPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
IPR013706. PDEase_N.
[Graphical view]
PfamiPF00233. PDEase_I. 1 hit.
PF08499. PDEase_I_N. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00471. HDc. 1 hit.
[Graphical view]
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 3 (identifier: Q64338-3) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MESPTKEIEE FESNSLKHLQ PEQIEKIWLR LRGLRKYKKT SQRLRSLVKQ    50
LERGEASVVD LKKNLEYAAT VLESVYIDET RRLLDTEDEL SDIQSDAVPS 100
EVRDWLASTF TRQMGMMLRR SDEKPRFKSI VHAVQAGIFV ERMYRRTSNM 150
VGLSYPPAVI DALKDVDTWS FDVFSLNEAS GDHALKFIFY ELLTRYDLIS 200
RFKIPISALV SFVEALEVGY SKHKNPYHNL MHAADVTQTV HYLLYKTGVA 250
NWLTELEIFA IIFSAAIHDY EHTGTTNNFH IQTRSDPAIL YNDRSVLENH 300
HLSAAYRLLQ EDEEMNILVN LSKDDWREFR TLVIEMVMAT DMSCHFQQIK 350
AMKTALQQPE AIEKPKALSL MLHTADISHP AKAWDLHHRW TMSLLEEFFR 400
QGDREAELGL PFSPLCDRKS TMVAQSQVGF IDFIVEPTFT VLTDMTEKIV 450
SPLIDESSQT GGTGQRRSSL NSINSSDAKR SGVKSSGSDG SAPINNSVIP 500
VDYKSFKATW TEVVQINRER WRAKVPKEEK AKKEAEEKAR LAAEEKQKEM 550
EAKSQAEQGT TSKGEKKTSG EAKSQVNGTR KGDNPRGKNS KGEKAGEKQQ 600
NGDLKDGKNK ADKKDHSNTG NESKKTDGTK KRSHGSPAPS TSSTSRITLP 650
VIKPPLRHFK RPAYASSSYA PSVPKKTDDH PVRYKMLDQR IKMKKIQNIS 700
HHWNKK 706
Length:706
Mass (Da):80,290
Last modified:January 4, 2005 - v2
Checksum:i1F58533E1259801F
GO
Isoform 1 (identifier: Q64338-1) [UniParc]FASTAAdd to Basket

Also known as: PDE1C4, PDE1C5

The sequence of this isoform differs from the canonical sequence as follows:
     651-654: VIKP → GDYG
     655-706: Missing.

Show »
Length:654
Mass (Da):74,004
Checksum:iEEDFFCF64FB08F39
GO
Isoform 2 (identifier: Q64338-2) [UniParc]FASTAAdd to Basket

Also known as: PDE1C1

The sequence of this isoform differs from the canonical sequence as follows:
     628-631: GTKK → DPEE
     632-706: Missing.

Show »
Length:631
Mass (Da):71,746
Checksum:iDE0C171B61B6F176
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei628 – 6314GTKK → DPEE in isoform 2. VSP_004554
Alternative sequencei632 – 70675Missing in isoform 2. VSP_012380Add
BLAST
Alternative sequencei651 – 6544VIKP → GDYG in isoform 1. VSP_012381
Alternative sequencei655 – 70652Missing in isoform 1. VSP_012382Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L76947 mRNA. Translation: AAC37702.1.
L76946 mRNA. Translation: AAC37703.1.
L76944 mRNA. Translation: AAC37701.1.
AK030423 mRNA. Translation: BAC26956.1.
CCDSiCCDS20170.1. [Q64338-1]
CCDS51784.1. [Q64338-3]
CCDS51785.1. [Q64338-2]
RefSeqiNP_001020739.1. NM_001025568.2. [Q64338-2]
NP_001153424.1. NM_001159952.1.
NP_001153425.1. NM_001159953.1. [Q64338-3]
NP_001153427.1. NM_001159955.1. [Q64338-1]
NP_001153432.1. NM_001159960.1. [Q64338-2]
NP_035184.1. NM_011054.4. [Q64338-1]
UniGeneiMm.5145.

Genome annotation databases

EnsembliENSMUST00000044505; ENSMUSP00000046601; ENSMUSG00000004347. [Q64338-3]
ENSMUST00000114327; ENSMUSP00000109966; ENSMUSG00000004347. [Q64338-1]
ENSMUST00000164752; ENSMUSP00000129185; ENSMUSG00000004347. [Q64338-2]
ENSMUST00000166102; ENSMUSP00000131350; ENSMUSG00000004347. [Q64338-2]
ENSMUST00000168944; ENSMUSP00000128364; ENSMUSG00000004347. [Q64338-1]
GeneIDi18575.
KEGGimmu:18575.
UCSCiuc009caz.2. mouse. [Q64338-3]
uc009cbb.2. mouse. [Q64338-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L76947 mRNA. Translation: AAC37702.1 .
L76946 mRNA. Translation: AAC37703.1 .
L76944 mRNA. Translation: AAC37701.1 .
AK030423 mRNA. Translation: BAC26956.1 .
CCDSi CCDS20170.1. [Q64338-1 ]
CCDS51784.1. [Q64338-3 ]
CCDS51785.1. [Q64338-2 ]
RefSeqi NP_001020739.1. NM_001025568.2. [Q64338-2 ]
NP_001153424.1. NM_001159952.1.
NP_001153425.1. NM_001159953.1. [Q64338-3 ]
NP_001153427.1. NM_001159955.1. [Q64338-1 ]
NP_001153432.1. NM_001159960.1. [Q64338-2 ]
NP_035184.1. NM_011054.4. [Q64338-1 ]
UniGenei Mm.5145.

3D structure databases

ProteinModelPortali Q64338.
SMRi Q64338. Positions 151-450.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q64338.

Proteomic databases

PaxDbi Q64338.
PRIDEi Q64338.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000044505 ; ENSMUSP00000046601 ; ENSMUSG00000004347 . [Q64338-3 ]
ENSMUST00000114327 ; ENSMUSP00000109966 ; ENSMUSG00000004347 . [Q64338-1 ]
ENSMUST00000164752 ; ENSMUSP00000129185 ; ENSMUSG00000004347 . [Q64338-2 ]
ENSMUST00000166102 ; ENSMUSP00000131350 ; ENSMUSG00000004347 . [Q64338-2 ]
ENSMUST00000168944 ; ENSMUSP00000128364 ; ENSMUSG00000004347 . [Q64338-1 ]
GeneIDi 18575.
KEGGi mmu:18575.
UCSCi uc009caz.2. mouse. [Q64338-3 ]
uc009cbb.2. mouse. [Q64338-1 ]

Organism-specific databases

CTDi 5137.
MGIi MGI:108413. Pde1c.

Phylogenomic databases

eggNOGi NOG139098.
GeneTreei ENSGT00660000095451.
HOGENOMi HOG000231888.
HOVERGENi HBG056120.
InParanoidi Q64338.
KOi K13755.
OMAi NPRGKNS.
OrthoDBi EOG7X9G6J.
PhylomeDBi Q64338.
TreeFami TF314638.

Enzyme and pathway databases

Reactomei REACT_227001. Cam-PDE 1 activation.

Miscellaneous databases

NextBioi 294428.
PROi Q64338.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q64338.
Bgeei Q64338.
CleanExi MM_PDE1C.
Genevestigatori Q64338.

Family and domain databases

Gene3Di 1.10.1300.10. 2 hits.
InterProi IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
IPR013706. PDEase_N.
[Graphical view ]
Pfami PF00233. PDEase_I. 1 hit.
PF08499. PDEase_I_N. 1 hit.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00471. HDc. 1 hit.
[Graphical view ]
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The calmodulin-dependent phosphodiesterase gene PDE1C encodes several functionally different splice variants in a tissue-specific manner."
    Yan C., Zhao A.Z., Bentley J.K., Beavo J.A.
    J. Biol. Chem. 271:25699-25706(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Strain: BALB/c.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: C57BL/6J.
    Tissue: Pituitary.

Entry informationi

Entry nameiPDE1C_MOUSE
AccessioniPrimary (citable) accession number: Q64338
Secondary accession number(s): Q62045, Q8BSV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 4, 2005
Last modified: September 3, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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