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Protein

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

Gene

Pde1c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP.

Catalytic activityi

Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.By similarity

Enzyme regulationi

Type I PDE are activated by the binding of calmodulin in the presence of Ca2+.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei228 – 2281Proton donorBy similarity
Metal bindingi232 – 2321Divalent metal cation 1By similarity
Metal bindingi268 – 2681Divalent metal cation 1By similarity
Metal bindingi269 – 2691Divalent metal cation 1By similarity
Metal bindingi269 – 2691Divalent metal cation 2By similarity
Metal bindingi376 – 3761Divalent metal cation 1By similarity

GO - Molecular functioni

GO - Biological processi

  • metabolic process Source: GOC
  • response to calcium ion Source: MGI
  • sensory perception of smell Source: MGI
  • signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calmodulin-binding, cAMP, cGMP, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_309030. Cam-PDE 1 activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC:3.1.4.17)
Short name:
Cam-PDE 1C
Gene namesi
Name:Pde1c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:108413. Pde1c.

Subcellular locationi

GO - Cellular componenti

  • cilium Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 706706Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CPRO_0000198793Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ64338.
PaxDbiQ64338.
PRIDEiQ64338.

PTM databases

PhosphoSiteiQ64338.

Expressioni

Tissue specificityi

Isoform 1 is highly expressed in testis. Isoform 2 is highly expressed in heart and testis, and detected at lower levels in olfactory epithelium and cerebellum.

Gene expression databases

BgeeiQ64338.
CleanExiMM_PDE1C.
ExpressionAtlasiQ64338. baseline and differential.
GenevisibleiQ64338. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046601.

Structurei

3D structure databases

ProteinModelPortaliQ64338.
SMRiQ64338. Positions 155-524.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni202 – 521320CatalyticBy similarityAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG139098.
GeneTreeiENSGT00760000118889.
HOGENOMiHOG000231888.
HOVERGENiHBG056120.
InParanoidiQ64338.
KOiK13755.
OMAiNPRGKNS.
OrthoDBiEOG7X9G6J.
PhylomeDBiQ64338.
TreeFamiTF314638.

Family and domain databases

Gene3Di1.10.1300.10. 2 hits.
InterProiIPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
IPR013706. PDEase_N.
[Graphical view]
PfamiPF00233. PDEase_I. 1 hit.
PF08499. PDEase_I_N. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00471. HDc. 1 hit.
[Graphical view]
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.

Isoform 3 (identifier: Q64338-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESPTKEIEE FESNSLKHLQ PEQIEKIWLR LRGLRKYKKT SQRLRSLVKQ
60 70 80 90 100
LERGEASVVD LKKNLEYAAT VLESVYIDET RRLLDTEDEL SDIQSDAVPS
110 120 130 140 150
EVRDWLASTF TRQMGMMLRR SDEKPRFKSI VHAVQAGIFV ERMYRRTSNM
160 170 180 190 200
VGLSYPPAVI DALKDVDTWS FDVFSLNEAS GDHALKFIFY ELLTRYDLIS
210 220 230 240 250
RFKIPISALV SFVEALEVGY SKHKNPYHNL MHAADVTQTV HYLLYKTGVA
260 270 280 290 300
NWLTELEIFA IIFSAAIHDY EHTGTTNNFH IQTRSDPAIL YNDRSVLENH
310 320 330 340 350
HLSAAYRLLQ EDEEMNILVN LSKDDWREFR TLVIEMVMAT DMSCHFQQIK
360 370 380 390 400
AMKTALQQPE AIEKPKALSL MLHTADISHP AKAWDLHHRW TMSLLEEFFR
410 420 430 440 450
QGDREAELGL PFSPLCDRKS TMVAQSQVGF IDFIVEPTFT VLTDMTEKIV
460 470 480 490 500
SPLIDESSQT GGTGQRRSSL NSINSSDAKR SGVKSSGSDG SAPINNSVIP
510 520 530 540 550
VDYKSFKATW TEVVQINRER WRAKVPKEEK AKKEAEEKAR LAAEEKQKEM
560 570 580 590 600
EAKSQAEQGT TSKGEKKTSG EAKSQVNGTR KGDNPRGKNS KGEKAGEKQQ
610 620 630 640 650
NGDLKDGKNK ADKKDHSNTG NESKKTDGTK KRSHGSPAPS TSSTSRITLP
660 670 680 690 700
VIKPPLRHFK RPAYASSSYA PSVPKKTDDH PVRYKMLDQR IKMKKIQNIS

HHWNKK
Length:706
Mass (Da):80,290
Last modified:January 4, 2005 - v2
Checksum:i1F58533E1259801F
GO
Isoform 1 (identifier: Q64338-1) [UniParc]FASTAAdd to basket

Also known as: PDE1C4, PDE1C5

The sequence of this isoform differs from the canonical sequence as follows:
     651-654: VIKP → GDYG
     655-706: Missing.

Show »
Length:654
Mass (Da):74,004
Checksum:iEEDFFCF64FB08F39
GO
Isoform 2 (identifier: Q64338-2) [UniParc]FASTAAdd to basket

Also known as: PDE1C1

The sequence of this isoform differs from the canonical sequence as follows:
     628-631: GTKK → DPEE
     632-706: Missing.

Show »
Length:631
Mass (Da):71,746
Checksum:iDE0C171B61B6F176
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei628 – 6314GTKK → DPEE in isoform 2. 1 PublicationVSP_004554
Alternative sequencei632 – 70675Missing in isoform 2. 1 PublicationVSP_012380Add
BLAST
Alternative sequencei651 – 6544VIKP → GDYG in isoform 1. 1 PublicationVSP_012381
Alternative sequencei655 – 70652Missing in isoform 1. 1 PublicationVSP_012382Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76947 mRNA. Translation: AAC37702.1.
L76946 mRNA. Translation: AAC37703.1.
L76944 mRNA. Translation: AAC37701.1.
AK030423 mRNA. Translation: BAC26956.1.
CCDSiCCDS20170.1. [Q64338-1]
CCDS51784.1. [Q64338-3]
CCDS51785.1. [Q64338-2]
RefSeqiNP_001020739.1. NM_001025568.2. [Q64338-2]
NP_001153424.1. NM_001159952.1.
NP_001153425.1. NM_001159953.1. [Q64338-3]
NP_001153427.1. NM_001159955.1. [Q64338-1]
NP_001153432.1. NM_001159960.1. [Q64338-2]
NP_035184.1. NM_011054.4. [Q64338-1]
XP_011239552.1. XM_011241250.1. [Q64338-1]
UniGeneiMm.5145.

Genome annotation databases

EnsembliENSMUST00000044505; ENSMUSP00000046601; ENSMUSG00000004347. [Q64338-3]
ENSMUST00000114327; ENSMUSP00000109966; ENSMUSG00000004347. [Q64338-1]
ENSMUST00000168944; ENSMUSP00000128364; ENSMUSG00000004347. [Q64338-1]
GeneIDi18575.
KEGGimmu:18575.
UCSCiuc009caz.2. mouse. [Q64338-3]
uc009cbb.2. mouse. [Q64338-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76947 mRNA. Translation: AAC37702.1.
L76946 mRNA. Translation: AAC37703.1.
L76944 mRNA. Translation: AAC37701.1.
AK030423 mRNA. Translation: BAC26956.1.
CCDSiCCDS20170.1. [Q64338-1]
CCDS51784.1. [Q64338-3]
CCDS51785.1. [Q64338-2]
RefSeqiNP_001020739.1. NM_001025568.2. [Q64338-2]
NP_001153424.1. NM_001159952.1.
NP_001153425.1. NM_001159953.1. [Q64338-3]
NP_001153427.1. NM_001159955.1. [Q64338-1]
NP_001153432.1. NM_001159960.1. [Q64338-2]
NP_035184.1. NM_011054.4. [Q64338-1]
XP_011239552.1. XM_011241250.1. [Q64338-1]
UniGeneiMm.5145.

3D structure databases

ProteinModelPortaliQ64338.
SMRiQ64338. Positions 155-524.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046601.

PTM databases

PhosphoSiteiQ64338.

Proteomic databases

MaxQBiQ64338.
PaxDbiQ64338.
PRIDEiQ64338.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044505; ENSMUSP00000046601; ENSMUSG00000004347. [Q64338-3]
ENSMUST00000114327; ENSMUSP00000109966; ENSMUSG00000004347. [Q64338-1]
ENSMUST00000168944; ENSMUSP00000128364; ENSMUSG00000004347. [Q64338-1]
GeneIDi18575.
KEGGimmu:18575.
UCSCiuc009caz.2. mouse. [Q64338-3]
uc009cbb.2. mouse. [Q64338-1]

Organism-specific databases

CTDi5137.
MGIiMGI:108413. Pde1c.

Phylogenomic databases

eggNOGiNOG139098.
GeneTreeiENSGT00760000118889.
HOGENOMiHOG000231888.
HOVERGENiHBG056120.
InParanoidiQ64338.
KOiK13755.
OMAiNPRGKNS.
OrthoDBiEOG7X9G6J.
PhylomeDBiQ64338.
TreeFamiTF314638.

Enzyme and pathway databases

ReactomeiREACT_309030. Cam-PDE 1 activation.

Miscellaneous databases

NextBioi294428.
PROiQ64338.
SOURCEiSearch...

Gene expression databases

BgeeiQ64338.
CleanExiMM_PDE1C.
ExpressionAtlasiQ64338. baseline and differential.
GenevisibleiQ64338. MM.

Family and domain databases

Gene3Di1.10.1300.10. 2 hits.
InterProiIPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
IPR013706. PDEase_N.
[Graphical view]
PfamiPF00233. PDEase_I. 1 hit.
PF08499. PDEase_I_N. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00471. HDc. 1 hit.
[Graphical view]
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The calmodulin-dependent phosphodiesterase gene PDE1C encodes several functionally different splice variants in a tissue-specific manner."
    Yan C., Zhao A.Z., Bentley J.K., Beavo J.A.
    J. Biol. Chem. 271:25699-25706(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Strain: BALB/c.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: C57BL/6J.
    Tissue: Pituitary.

Entry informationi

Entry nameiPDE1C_MOUSE
AccessioniPrimary (citable) accession number: Q64338
Secondary accession number(s): Q62045, Q8BSV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 4, 2005
Last modified: July 22, 2015
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.