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Q64338

- PDE1C_MOUSE

UniProt

Q64338 - PDE1C_MOUSE

Protein

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

Gene

Pde1c

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 2 (04 Jan 2005)
      Previous versions | rss
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    Functioni

    Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP.

    Catalytic activityi

    Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.

    Cofactori

    Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.By similarity

    Enzyme regulationi

    Type I PDE are activated by the binding of calmodulin in the presence of Ca2+.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei228 – 2281Proton donorBy similarity
    Metal bindingi232 – 2321Divalent metal cation 1By similarity
    Metal bindingi268 – 2681Divalent metal cation 1By similarity
    Metal bindingi269 – 2691Divalent metal cation 1By similarity
    Metal bindingi269 – 2691Divalent metal cation 2By similarity
    Metal bindingi376 – 3761Divalent metal cation 1By similarity

    GO - Molecular functioni

    1. calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity Source: MGI
    2. calmodulin-dependent cyclic-nucleotide phosphodiesterase activity Source: MGI
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. metabolic process Source: GOC
    2. response to calcium ion Source: MGI
    3. sensory perception of smell Source: MGI
    4. signal transduction Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Calmodulin-binding, cAMP, cGMP, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_227001. Cam-PDE 1 activation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC:3.1.4.17)
    Short name:
    Cam-PDE 1C
    Gene namesi
    Name:Pde1c
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:108413. Pde1c.

    Subcellular locationi

    GO - Cellular componenti

    1. cilium Source: MGI

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 706706Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CPRO_0000198793Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ64338.
    PRIDEiQ64338.

    PTM databases

    PhosphoSiteiQ64338.

    Expressioni

    Tissue specificityi

    Isoform 1 is highly expressed in testis. Isoform 2 is highly expressed in heart and testis, and detected at lower levels in olfactory epithelium and cerebellum.

    Gene expression databases

    ArrayExpressiQ64338.
    BgeeiQ64338.
    CleanExiMM_PDE1C.
    GenevestigatoriQ64338.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ64338.
    SMRiQ64338. Positions 151-450.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni202 – 521320CatalyticBy similarityAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG139098.
    GeneTreeiENSGT00660000095451.
    HOGENOMiHOG000231888.
    HOVERGENiHBG056120.
    InParanoidiQ64338.
    KOiK13755.
    OMAiNPRGKNS.
    OrthoDBiEOG7X9G6J.
    PhylomeDBiQ64338.
    TreeFamiTF314638.

    Family and domain databases

    Gene3Di1.10.1300.10. 2 hits.
    InterProiIPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    IPR013706. PDEase_N.
    [Graphical view]
    PfamiPF00233. PDEase_I. 1 hit.
    PF08499. PDEase_I_N. 1 hit.
    [Graphical view]
    PRINTSiPR00387. PDIESTERASE1.
    SMARTiSM00471. HDc. 1 hit.
    [Graphical view]
    PROSITEiPS00126. PDEASE_I. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 3 (identifier: Q64338-3) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MESPTKEIEE FESNSLKHLQ PEQIEKIWLR LRGLRKYKKT SQRLRSLVKQ    50
    LERGEASVVD LKKNLEYAAT VLESVYIDET RRLLDTEDEL SDIQSDAVPS 100
    EVRDWLASTF TRQMGMMLRR SDEKPRFKSI VHAVQAGIFV ERMYRRTSNM 150
    VGLSYPPAVI DALKDVDTWS FDVFSLNEAS GDHALKFIFY ELLTRYDLIS 200
    RFKIPISALV SFVEALEVGY SKHKNPYHNL MHAADVTQTV HYLLYKTGVA 250
    NWLTELEIFA IIFSAAIHDY EHTGTTNNFH IQTRSDPAIL YNDRSVLENH 300
    HLSAAYRLLQ EDEEMNILVN LSKDDWREFR TLVIEMVMAT DMSCHFQQIK 350
    AMKTALQQPE AIEKPKALSL MLHTADISHP AKAWDLHHRW TMSLLEEFFR 400
    QGDREAELGL PFSPLCDRKS TMVAQSQVGF IDFIVEPTFT VLTDMTEKIV 450
    SPLIDESSQT GGTGQRRSSL NSINSSDAKR SGVKSSGSDG SAPINNSVIP 500
    VDYKSFKATW TEVVQINRER WRAKVPKEEK AKKEAEEKAR LAAEEKQKEM 550
    EAKSQAEQGT TSKGEKKTSG EAKSQVNGTR KGDNPRGKNS KGEKAGEKQQ 600
    NGDLKDGKNK ADKKDHSNTG NESKKTDGTK KRSHGSPAPS TSSTSRITLP 650
    VIKPPLRHFK RPAYASSSYA PSVPKKTDDH PVRYKMLDQR IKMKKIQNIS 700
    HHWNKK 706
    Length:706
    Mass (Da):80,290
    Last modified:January 4, 2005 - v2
    Checksum:i1F58533E1259801F
    GO
    Isoform 1 (identifier: Q64338-1) [UniParc]FASTAAdd to Basket

    Also known as: PDE1C4, PDE1C5

    The sequence of this isoform differs from the canonical sequence as follows:
         651-654: VIKP → GDYG
         655-706: Missing.

    Show »
    Length:654
    Mass (Da):74,004
    Checksum:iEEDFFCF64FB08F39
    GO
    Isoform 2 (identifier: Q64338-2) [UniParc]FASTAAdd to Basket

    Also known as: PDE1C1

    The sequence of this isoform differs from the canonical sequence as follows:
         628-631: GTKK → DPEE
         632-706: Missing.

    Show »
    Length:631
    Mass (Da):71,746
    Checksum:iDE0C171B61B6F176
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei628 – 6314GTKK → DPEE in isoform 2. 1 PublicationVSP_004554
    Alternative sequencei632 – 70675Missing in isoform 2. 1 PublicationVSP_012380Add
    BLAST
    Alternative sequencei651 – 6544VIKP → GDYG in isoform 1. 1 PublicationVSP_012381
    Alternative sequencei655 – 70652Missing in isoform 1. 1 PublicationVSP_012382Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L76947 mRNA. Translation: AAC37702.1.
    L76946 mRNA. Translation: AAC37703.1.
    L76944 mRNA. Translation: AAC37701.1.
    AK030423 mRNA. Translation: BAC26956.1.
    CCDSiCCDS20170.1. [Q64338-1]
    CCDS51784.1. [Q64338-3]
    CCDS51785.1. [Q64338-2]
    RefSeqiNP_001020739.1. NM_001025568.2. [Q64338-2]
    NP_001153424.1. NM_001159952.1.
    NP_001153425.1. NM_001159953.1. [Q64338-3]
    NP_001153427.1. NM_001159955.1. [Q64338-1]
    NP_001153432.1. NM_001159960.1. [Q64338-2]
    NP_035184.1. NM_011054.4. [Q64338-1]
    UniGeneiMm.5145.

    Genome annotation databases

    EnsembliENSMUST00000044505; ENSMUSP00000046601; ENSMUSG00000004347. [Q64338-3]
    ENSMUST00000114327; ENSMUSP00000109966; ENSMUSG00000004347. [Q64338-1]
    ENSMUST00000164752; ENSMUSP00000129185; ENSMUSG00000004347. [Q64338-2]
    ENSMUST00000166102; ENSMUSP00000131350; ENSMUSG00000004347. [Q64338-2]
    ENSMUST00000168944; ENSMUSP00000128364; ENSMUSG00000004347. [Q64338-1]
    GeneIDi18575.
    KEGGimmu:18575.
    UCSCiuc009caz.2. mouse. [Q64338-3]
    uc009cbb.2. mouse. [Q64338-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L76947 mRNA. Translation: AAC37702.1 .
    L76946 mRNA. Translation: AAC37703.1 .
    L76944 mRNA. Translation: AAC37701.1 .
    AK030423 mRNA. Translation: BAC26956.1 .
    CCDSi CCDS20170.1. [Q64338-1 ]
    CCDS51784.1. [Q64338-3 ]
    CCDS51785.1. [Q64338-2 ]
    RefSeqi NP_001020739.1. NM_001025568.2. [Q64338-2 ]
    NP_001153424.1. NM_001159952.1.
    NP_001153425.1. NM_001159953.1. [Q64338-3 ]
    NP_001153427.1. NM_001159955.1. [Q64338-1 ]
    NP_001153432.1. NM_001159960.1. [Q64338-2 ]
    NP_035184.1. NM_011054.4. [Q64338-1 ]
    UniGenei Mm.5145.

    3D structure databases

    ProteinModelPortali Q64338.
    SMRi Q64338. Positions 151-450.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q64338.

    Proteomic databases

    PaxDbi Q64338.
    PRIDEi Q64338.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000044505 ; ENSMUSP00000046601 ; ENSMUSG00000004347 . [Q64338-3 ]
    ENSMUST00000114327 ; ENSMUSP00000109966 ; ENSMUSG00000004347 . [Q64338-1 ]
    ENSMUST00000164752 ; ENSMUSP00000129185 ; ENSMUSG00000004347 . [Q64338-2 ]
    ENSMUST00000166102 ; ENSMUSP00000131350 ; ENSMUSG00000004347 . [Q64338-2 ]
    ENSMUST00000168944 ; ENSMUSP00000128364 ; ENSMUSG00000004347 . [Q64338-1 ]
    GeneIDi 18575.
    KEGGi mmu:18575.
    UCSCi uc009caz.2. mouse. [Q64338-3 ]
    uc009cbb.2. mouse. [Q64338-1 ]

    Organism-specific databases

    CTDi 5137.
    MGIi MGI:108413. Pde1c.

    Phylogenomic databases

    eggNOGi NOG139098.
    GeneTreei ENSGT00660000095451.
    HOGENOMi HOG000231888.
    HOVERGENi HBG056120.
    InParanoidi Q64338.
    KOi K13755.
    OMAi NPRGKNS.
    OrthoDBi EOG7X9G6J.
    PhylomeDBi Q64338.
    TreeFami TF314638.

    Enzyme and pathway databases

    Reactomei REACT_227001. Cam-PDE 1 activation.

    Miscellaneous databases

    NextBioi 294428.
    PROi Q64338.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q64338.
    Bgeei Q64338.
    CleanExi MM_PDE1C.
    Genevestigatori Q64338.

    Family and domain databases

    Gene3Di 1.10.1300.10. 2 hits.
    InterProi IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    IPR013706. PDEase_N.
    [Graphical view ]
    Pfami PF00233. PDEase_I. 1 hit.
    PF08499. PDEase_I_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00387. PDIESTERASE1.
    SMARTi SM00471. HDc. 1 hit.
    [Graphical view ]
    PROSITEi PS00126. PDEASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The calmodulin-dependent phosphodiesterase gene PDE1C encodes several functionally different splice variants in a tissue-specific manner."
      Yan C., Zhao A.Z., Bentley J.K., Beavo J.A.
      J. Biol. Chem. 271:25699-25706(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Strain: BALB/c.
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Strain: C57BL/6J.
      Tissue: Pituitary.

    Entry informationi

    Entry nameiPDE1C_MOUSE
    AccessioniPrimary (citable) accession number: Q64338
    Secondary accession number(s): Q62045, Q8BSV6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3