Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

T-box brain protein 1

Gene

Tbr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable transcriptional regulator involved in developmental processes. Required for normal brain development.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi213 – 393T-boxPROSITE-ProRule annotationAdd BLAST181

GO - Molecular functioni

GO - Biological processi

  • amygdala development Source: MGI
  • cerebral cortex development Source: Ensembl
  • commitment of neuronal cell to specific neuron type in forebrain Source: MGI
  • conditioned taste aversion Source: MGI
  • hindbrain development Source: MGI
  • neuron differentiation Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • regulation of axon guidance Source: MGI
  • regulation of gene expression Source: MGI
  • regulation of neuron projection development Source: MGI
  • specification of animal organ identity Source: MGI

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
T-box brain protein 1
Short name:
T-brain-1
Short name:
TBR-1
Alternative name(s):
TES-56
Gene namesi
Name:Tbr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:107404 Tbr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001844581 – 681T-box brain protein 1Add BLAST681

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei408PhosphothreonineCombined sources1
Modified residuei410PhosphoserineCombined sources1
Modified residuei594PhosphoserineCombined sources1
Modified residuei640PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ64336
PRIDEiQ64336

PTM databases

iPTMnetiQ64336
PhosphoSitePlusiQ64336

Expressioni

Tissue specificityi

Expressed in specific lamina in the developing and adult brain.

Developmental stagei

First detected around day 10 of embryonic development in the preplate, at day 12.5, in the cortical plate and intermediate zone, and from day 16.5 to 18.5, in a rostro-caudal gradient in the subplate. In the thalamus, expression is first observed at postnatal stage, P7, and weak expression continues in later postnatal and adult stages.

Gene expression databases

BgeeiENSMUSG00000035033
CleanExiMM_TBR1
ExpressionAtlasiQ64336 baseline and differential
GenevisibleiQ64336 MM

Interactioni

Subunit structurei

Part of a complex containing CASK, TBR1 and TSPYL2; may modulate gene expression in response to neuronal synaptic activity.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046787

Structurei

3D structure databases

ProteinModelPortaliQ64336
SMRiQ64336
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi569 – 573Poly-Ala5

Phylogenomic databases

eggNOGiKOG3585 Eukaryota
ENOG410XSTS LUCA
GeneTreeiENSGT00900000140847
HOGENOMiHOG000218633
HOVERGENiHBG000578
InParanoidiQ64336
KOiK10174
OMAiGCDIDRL
OrthoDBiEOG091G0PQQ
TreeFamiTF106341

Family and domain databases

CDDicd00182 TBOX, 1 hit
Gene3Di2.60.40.820, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR032385 T-box_assoc
IPR036960 T-box_sf
IPR001699 TF_T-box
IPR018186 TF_T-box_CS
PANTHERiPTHR11267 PTHR11267, 1 hit
PfamiView protein in Pfam
PF00907 T-box, 1 hit
PF16176 T-box_assoc, 1 hit
PRINTSiPR00937 TBOX
SMARTiView protein in SMART
SM00425 TBOX, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS01283 TBOX_1, 1 hit
PS01264 TBOX_2, 1 hit
PS50252 TBOX_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q64336-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLEHCLSPS IMLSKKFLNV SSSYPHSGGS ELVLHDHPII STTDNLERSS
60 70 80 90 100
PLKKITRGMT NQSDTDNFPD SKDSPGDVQR SKLSPVLDGV SELRHSFDGS
110 120 130 140 150
AADRYLLSQS SQPQSAATAP SAMFPYPSQH GPAHPAFSIG SPSRYMAHHP
160 170 180 190 200
VITNGAYNSL LSNSSPQGYP TAGYPYPQQY GHSYQGAPFY QFSSTQPGLV
210 220 230 240 250
PGKAQVYLCN RPLWLKFHRH QTEMIITKQG RRMFPFLSFN ISGLDPTAHY
260 270 280 290 300
NIFVDVILAD PNHWRFQGGK WVPCGKADTN VQGNRVYMHP DSPNTGAHWM
310 320 330 340 350
RQEISFGKLK LTNNKGASNN NGQMVVLQSL HKYQPRLHVV EVNEDGTEDT
360 370 380 390 400
SQPGRVQTFT FPETQFIAVT AYQNTDITQL KIDHNPFAKG FRDNYDTIYT
410 420 430 440 450
GCDMDRLTPS PNDSPRSQIV PGARYAMAGS FLQDQFVSNY AKARFHPGAG
460 470 480 490 500
AGPGPGTDRS VPHTNGLLSP QQAEDPGAPS PQRWFVTPAN NRLDFAASAY
510 520 530 540 550
DTATDFAGNA ATLLSYAAAG VKALPLQAAG CTGRPLGYYA DPSGWGARSP
560 570 580 590 600
PQYCGAKSGS VLPCWPNSAA AAARMAGANP YLGEEAEGLA AERSPLAPAA
610 620 630 640 650
EDAKPKDLSD SSWIETPSSI KSIDSSDSGI YEQAKRRRIS PADTPVSESS
660 670 680
SPLKSEVLAQ RDCEKNCAKD IGGYYGFYSH S
Length:681
Mass (Da):73,940
Last modified:July 27, 2011 - v2
Checksum:i6932EDE5412D97BF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53K → E in AAA92011 (PubMed:7619531).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49251 mRNA Translation: AAA92011.1
AL845291 Genomic DNA Translation: CAM17335.1
CH466519 Genomic DNA Translation: EDL26982.1
BC052737 mRNA Translation: AAH52737.1
BC058399 mRNA Translation: AAH58399.1
CCDSiCCDS16063.1
RefSeqiNP_033348.2, NM_009322.3
XP_006499161.1, XM_006499098.3
UniGeneiMm.308525
Mm.404741

Genome annotation databases

EnsembliENSMUST00000048934; ENSMUSP00000046787; ENSMUSG00000035033
GeneIDi21375
KEGGimmu:21375
UCSCiuc008jvd.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTBR1_MOUSE
AccessioniPrimary (citable) accession number: Q64336
Secondary accession number(s): Q7TSY9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health