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Q64336

- TBR1_MOUSE

UniProt

Q64336 - TBR1_MOUSE

Protein

T-box brain protein 1

Gene

Tbr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Probable transcriptional regulator involved in developmental processes. Required for normal brain development.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi213 – 393181T-boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. RNA polymerase II core promoter sequence-specific DNA binding Source: MGI
    3. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. axon guidance Source: MGI
    2. commitment of neuronal cell to specific neuron type in forebrain Source: MGI
    3. hindbrain development Source: MGI
    4. neuron differentiation Source: MGI
    5. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    6. regulation of gene expression Source: MGI
    7. regulation of neuron projection development Source: MGI
    8. specification of organ identity Source: MGI
    9. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-box brain protein 1
    Short name:
    T-brain-1
    Short name:
    TBR-1
    Alternative name(s):
    TES-56
    Gene namesi
    Name:Tbr1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:107404. Tbr1.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. intracellular Source: MGI
    2. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 681681T-box brain protein 1PRO_0000184458Add
    BLAST

    Proteomic databases

    PaxDbiQ64336.
    PRIDEiQ64336.

    PTM databases

    PhosphoSiteiQ64336.

    Expressioni

    Tissue specificityi

    Expressed in specific lamina in the developing and adult brain.

    Developmental stagei

    First detected around day 10 of embryonic development in the preplate, at day 12.5, in the cortical plate and intermediate zone, and from day 16.5 to 18.5, in a rostro-caudal gradient in the subplate. In the thalamus, expression is first observed at postnatal stage, P7, and weak expression continues in later postnatal and adult stages.

    Gene expression databases

    BgeeiQ64336.
    CleanExiMM_TBR1.
    GenevestigatoriQ64336.

    Interactioni

    Subunit structurei

    Part of a complex containing CASK, TBR1 and TSPYL2; may modulate gene expression in response to neuronal synaptic activity.1 Publication

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000046787.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64336.
    SMRiQ64336. Positions 205-392.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi569 – 5735Poly-Ala

    Sequence similaritiesi

    Contains 1 T-box DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG245070.
    GeneTreeiENSGT00740000115029.
    HOGENOMiHOG000218633.
    HOVERGENiHBG000578.
    InParanoidiQ7TSY9.
    KOiK10174.
    OMAiMFPYPSQ.
    OrthoDBiEOG7C2R14.
    TreeFamiTF106341.

    Family and domain databases

    Gene3Di2.60.40.820. 1 hit.
    InterProiIPR008967. p53-like_TF_DNA-bd.
    IPR001699. TF_T-box.
    IPR018186. TF_T-box_CS.
    [Graphical view]
    PANTHERiPTHR11267. PTHR11267. 1 hit.
    PfamiPF00907. T-box. 1 hit.
    [Graphical view]
    PRINTSiPR00937. TBOX.
    SMARTiSM00425. TBOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF49417. SSF49417. 1 hit.
    PROSITEiPS01283. TBOX_1. 1 hit.
    PS01264. TBOX_2. 1 hit.
    PS50252. TBOX_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q64336-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQLEHCLSPS IMLSKKFLNV SSSYPHSGGS ELVLHDHPII STTDNLERSS    50
    PLKKITRGMT NQSDTDNFPD SKDSPGDVQR SKLSPVLDGV SELRHSFDGS 100
    AADRYLLSQS SQPQSAATAP SAMFPYPSQH GPAHPAFSIG SPSRYMAHHP 150
    VITNGAYNSL LSNSSPQGYP TAGYPYPQQY GHSYQGAPFY QFSSTQPGLV 200
    PGKAQVYLCN RPLWLKFHRH QTEMIITKQG RRMFPFLSFN ISGLDPTAHY 250
    NIFVDVILAD PNHWRFQGGK WVPCGKADTN VQGNRVYMHP DSPNTGAHWM 300
    RQEISFGKLK LTNNKGASNN NGQMVVLQSL HKYQPRLHVV EVNEDGTEDT 350
    SQPGRVQTFT FPETQFIAVT AYQNTDITQL KIDHNPFAKG FRDNYDTIYT 400
    GCDMDRLTPS PNDSPRSQIV PGARYAMAGS FLQDQFVSNY AKARFHPGAG 450
    AGPGPGTDRS VPHTNGLLSP QQAEDPGAPS PQRWFVTPAN NRLDFAASAY 500
    DTATDFAGNA ATLLSYAAAG VKALPLQAAG CTGRPLGYYA DPSGWGARSP 550
    PQYCGAKSGS VLPCWPNSAA AAARMAGANP YLGEEAEGLA AERSPLAPAA 600
    EDAKPKDLSD SSWIETPSSI KSIDSSDSGI YEQAKRRRIS PADTPVSESS 650
    SPLKSEVLAQ RDCEKNCAKD IGGYYGFYSH S 681
    Length:681
    Mass (Da):73,940
    Last modified:July 27, 2011 - v2
    Checksum:i6932EDE5412D97BF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti53 – 531K → E in AAA92011. (PubMed:7619531)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U49251 mRNA. Translation: AAA92011.1.
    AL845291 Genomic DNA. Translation: CAM17335.1.
    CH466519 Genomic DNA. Translation: EDL26982.1.
    BC052737 mRNA. Translation: AAH52737.1.
    BC058399 mRNA. Translation: AAH58399.1.
    CCDSiCCDS16063.1.
    RefSeqiNP_033348.2. NM_009322.3.
    XP_006499161.1. XM_006499098.1.
    UniGeneiMm.308525.
    Mm.404741.

    Genome annotation databases

    EnsembliENSMUST00000048934; ENSMUSP00000046787; ENSMUSG00000035033.
    GeneIDi21375.
    KEGGimmu:21375.
    UCSCiuc008jvd.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U49251 mRNA. Translation: AAA92011.1 .
    AL845291 Genomic DNA. Translation: CAM17335.1 .
    CH466519 Genomic DNA. Translation: EDL26982.1 .
    BC052737 mRNA. Translation: AAH52737.1 .
    BC058399 mRNA. Translation: AAH58399.1 .
    CCDSi CCDS16063.1.
    RefSeqi NP_033348.2. NM_009322.3.
    XP_006499161.1. XM_006499098.1.
    UniGenei Mm.308525.
    Mm.404741.

    3D structure databases

    ProteinModelPortali Q64336.
    SMRi Q64336. Positions 205-392.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000046787.

    PTM databases

    PhosphoSitei Q64336.

    Proteomic databases

    PaxDbi Q64336.
    PRIDEi Q64336.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000048934 ; ENSMUSP00000046787 ; ENSMUSG00000035033 .
    GeneIDi 21375.
    KEGGi mmu:21375.
    UCSCi uc008jvd.1. mouse.

    Organism-specific databases

    CTDi 10716.
    MGIi MGI:107404. Tbr1.

    Phylogenomic databases

    eggNOGi NOG245070.
    GeneTreei ENSGT00740000115029.
    HOGENOMi HOG000218633.
    HOVERGENi HBG000578.
    InParanoidi Q7TSY9.
    KOi K10174.
    OMAi MFPYPSQ.
    OrthoDBi EOG7C2R14.
    TreeFami TF106341.

    Miscellaneous databases

    ChiTaRSi TBR1. mouse.
    NextBioi 300596.
    PROi Q64336.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q64336.
    CleanExi MM_TBR1.
    Genevestigatori Q64336.

    Family and domain databases

    Gene3Di 2.60.40.820. 1 hit.
    InterProi IPR008967. p53-like_TF_DNA-bd.
    IPR001699. TF_T-box.
    IPR018186. TF_T-box_CS.
    [Graphical view ]
    PANTHERi PTHR11267. PTHR11267. 1 hit.
    Pfami PF00907. T-box. 1 hit.
    [Graphical view ]
    PRINTSi PR00937. TBOX.
    SMARTi SM00425. TBOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49417. SSF49417. 1 hit.
    PROSITEi PS01283. TBOX_1. 1 hit.
    PS01264. TBOX_2. 1 hit.
    PS50252. TBOX_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "T-brain-1: a homolog of Brachyury whose expression defines molecularly distinct domains within the cerebral cortex."
      Bulfone A., Smiga S.M., Shimamura K., Peterson A., Puelles L., Rubenstein J.L.R.
      Neuron 15:63-78(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Fetal brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    5. "Transcriptional modification by a CASK-interacting nucleosome assembly protein."
      Wang G.-S., Hong C.-J., Yen T.-Y., Huang H.-Y., Ou Y., Huang T.-N., Jung W.-G., Kuo T.-Y., Sheng M., Wang T.-F., Hsueh Y.-P.
      Neuron 42:113-128(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN COMPLEX WITH CASK AND TBR1.
      Strain: C57BL/6.
    6. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.

    Entry informationi

    Entry nameiTBR1_MOUSE
    AccessioniPrimary (citable) accession number: Q64336
    Secondary accession number(s): Q7TSY9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3