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Q64336

- TBR1_MOUSE

UniProt

Q64336 - TBR1_MOUSE

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Protein

T-box brain protein 1

Gene

Tbr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Probable transcriptional regulator involved in developmental processes. Required for normal brain development.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi213 – 393181T-boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. RNA polymerase II core promoter sequence-specific DNA binding Source: MGI
  3. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. axon guidance Source: MGI
  2. commitment of neuronal cell to specific neuron type in forebrain Source: MGI
  3. hindbrain development Source: MGI
  4. neuron differentiation Source: MGI
  5. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  6. regulation of gene expression Source: MGI
  7. regulation of neuron projection development Source: MGI
  8. specification of organ identity Source: MGI
  9. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-box brain protein 1
Short name:
T-brain-1
Short name:
TBR-1
Alternative name(s):
TES-56
Gene namesi
Name:Tbr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:107404. Tbr1.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. intracellular Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 681681T-box brain protein 1PRO_0000184458Add
BLAST

Proteomic databases

PaxDbiQ64336.
PRIDEiQ64336.

PTM databases

PhosphoSiteiQ64336.

Expressioni

Tissue specificityi

Expressed in specific lamina in the developing and adult brain.

Developmental stagei

First detected around day 10 of embryonic development in the preplate, at day 12.5, in the cortical plate and intermediate zone, and from day 16.5 to 18.5, in a rostro-caudal gradient in the subplate. In the thalamus, expression is first observed at postnatal stage, P7, and weak expression continues in later postnatal and adult stages.

Gene expression databases

BgeeiQ64336.
CleanExiMM_TBR1.
ExpressionAtlasiQ64336. baseline and differential.
GenevestigatoriQ64336.

Interactioni

Subunit structurei

Part of a complex containing CASK, TBR1 and TSPYL2; may modulate gene expression in response to neuronal synaptic activity.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046787.

Structurei

3D structure databases

ProteinModelPortaliQ64336.
SMRiQ64336. Positions 205-392.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi569 – 5735Poly-Ala

Sequence similaritiesi

Contains 1 T-box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG245070.
GeneTreeiENSGT00740000115029.
HOGENOMiHOG000218633.
HOVERGENiHBG000578.
InParanoidiQ64336.
KOiK10174.
OMAiMFPYPSQ.
OrthoDBiEOG7C2R14.
TreeFamiTF106341.

Family and domain databases

Gene3Di2.60.40.820. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERiPTHR11267. PTHR11267. 1 hit.
PfamiPF00907. T-box. 1 hit.
[Graphical view]
PRINTSiPR00937. TBOX.
SMARTiSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64336-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQLEHCLSPS IMLSKKFLNV SSSYPHSGGS ELVLHDHPII STTDNLERSS
60 70 80 90 100
PLKKITRGMT NQSDTDNFPD SKDSPGDVQR SKLSPVLDGV SELRHSFDGS
110 120 130 140 150
AADRYLLSQS SQPQSAATAP SAMFPYPSQH GPAHPAFSIG SPSRYMAHHP
160 170 180 190 200
VITNGAYNSL LSNSSPQGYP TAGYPYPQQY GHSYQGAPFY QFSSTQPGLV
210 220 230 240 250
PGKAQVYLCN RPLWLKFHRH QTEMIITKQG RRMFPFLSFN ISGLDPTAHY
260 270 280 290 300
NIFVDVILAD PNHWRFQGGK WVPCGKADTN VQGNRVYMHP DSPNTGAHWM
310 320 330 340 350
RQEISFGKLK LTNNKGASNN NGQMVVLQSL HKYQPRLHVV EVNEDGTEDT
360 370 380 390 400
SQPGRVQTFT FPETQFIAVT AYQNTDITQL KIDHNPFAKG FRDNYDTIYT
410 420 430 440 450
GCDMDRLTPS PNDSPRSQIV PGARYAMAGS FLQDQFVSNY AKARFHPGAG
460 470 480 490 500
AGPGPGTDRS VPHTNGLLSP QQAEDPGAPS PQRWFVTPAN NRLDFAASAY
510 520 530 540 550
DTATDFAGNA ATLLSYAAAG VKALPLQAAG CTGRPLGYYA DPSGWGARSP
560 570 580 590 600
PQYCGAKSGS VLPCWPNSAA AAARMAGANP YLGEEAEGLA AERSPLAPAA
610 620 630 640 650
EDAKPKDLSD SSWIETPSSI KSIDSSDSGI YEQAKRRRIS PADTPVSESS
660 670 680
SPLKSEVLAQ RDCEKNCAKD IGGYYGFYSH S
Length:681
Mass (Da):73,940
Last modified:July 27, 2011 - v2
Checksum:i6932EDE5412D97BF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti53 – 531K → E in AAA92011. (PubMed:7619531)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U49251 mRNA. Translation: AAA92011.1.
AL845291 Genomic DNA. Translation: CAM17335.1.
CH466519 Genomic DNA. Translation: EDL26982.1.
BC052737 mRNA. Translation: AAH52737.1.
BC058399 mRNA. Translation: AAH58399.1.
CCDSiCCDS16063.1.
RefSeqiNP_033348.2. NM_009322.3.
XP_006499161.1. XM_006499098.1.
UniGeneiMm.308525.
Mm.404741.

Genome annotation databases

EnsembliENSMUST00000048934; ENSMUSP00000046787; ENSMUSG00000035033.
GeneIDi21375.
KEGGimmu:21375.
UCSCiuc008jvd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U49251 mRNA. Translation: AAA92011.1 .
AL845291 Genomic DNA. Translation: CAM17335.1 .
CH466519 Genomic DNA. Translation: EDL26982.1 .
BC052737 mRNA. Translation: AAH52737.1 .
BC058399 mRNA. Translation: AAH58399.1 .
CCDSi CCDS16063.1.
RefSeqi NP_033348.2. NM_009322.3.
XP_006499161.1. XM_006499098.1.
UniGenei Mm.308525.
Mm.404741.

3D structure databases

ProteinModelPortali Q64336.
SMRi Q64336. Positions 205-392.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000046787.

PTM databases

PhosphoSitei Q64336.

Proteomic databases

PaxDbi Q64336.
PRIDEi Q64336.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000048934 ; ENSMUSP00000046787 ; ENSMUSG00000035033 .
GeneIDi 21375.
KEGGi mmu:21375.
UCSCi uc008jvd.1. mouse.

Organism-specific databases

CTDi 10716.
MGIi MGI:107404. Tbr1.

Phylogenomic databases

eggNOGi NOG245070.
GeneTreei ENSGT00740000115029.
HOGENOMi HOG000218633.
HOVERGENi HBG000578.
InParanoidi Q64336.
KOi K10174.
OMAi MFPYPSQ.
OrthoDBi EOG7C2R14.
TreeFami TF106341.

Miscellaneous databases

ChiTaRSi TBR1. mouse.
NextBioi 300596.
PROi Q64336.
SOURCEi Search...

Gene expression databases

Bgeei Q64336.
CleanExi MM_TBR1.
ExpressionAtlasi Q64336. baseline and differential.
Genevestigatori Q64336.

Family and domain databases

Gene3Di 2.60.40.820. 1 hit.
InterProi IPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view ]
PANTHERi PTHR11267. PTHR11267. 1 hit.
Pfami PF00907. T-box. 1 hit.
[Graphical view ]
PRINTSi PR00937. TBOX.
SMARTi SM00425. TBOX. 1 hit.
[Graphical view ]
SUPFAMi SSF49417. SSF49417. 1 hit.
PROSITEi PS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "T-brain-1: a homolog of Brachyury whose expression defines molecularly distinct domains within the cerebral cortex."
    Bulfone A., Smiga S.M., Shimamura K., Peterson A., Puelles L., Rubenstein J.L.R.
    Neuron 15:63-78(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Fetal brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  5. "Transcriptional modification by a CASK-interacting nucleosome assembly protein."
    Wang G.-S., Hong C.-J., Yen T.-Y., Huang H.-Y., Ou Y., Huang T.-N., Jung W.-G., Kuo T.-Y., Sheng M., Wang T.-F., Hsueh Y.-P.
    Neuron 42:113-128(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN COMPLEX WITH CASK AND TBR1.
    Strain: C57BL/6.
  6. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiTBR1_MOUSE
AccessioniPrimary (citable) accession number: Q64336
Secondary accession number(s): Q7TSY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3