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Q64336 (TBR1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
T-box brain protein 1

Short name=T-brain-1
Short name=TBR-1
Alternative name(s):
TES-56
Gene names
Name:Tbr1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length681 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable transcriptional regulator involved in developmental processes. Required for normal brain development.

Subunit structure

Part of a complex containing CASK, TBR1 and TSPYL2; may modulate gene expression in response to neuronal synaptic activity. Ref.5

Subcellular location

Nucleus Potential.

Tissue specificity

Expressed in specific lamina in the developing and adult brain.

Developmental stage

First detected around day 10 of embryonic development in the preplate, at day 12.5, in the cortical plate and intermediate zone, and from day 16.5 to 18.5, in a rostro-caudal gradient in the subplate. In the thalamus, expression is first observed at postnatal stage, P7, and weak expression continues in later postnatal and adult stages.

Sequence similarities

Contains 1 T-box DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 681681T-box brain protein 1
PRO_0000184458

Regions

DNA binding213 – 393181T-box
Compositional bias569 – 5735Poly-Ala

Experimental info

Sequence conflict531K → E in AAA92011. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q64336 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 6932EDE5412D97BF

FASTA68173,940
        10         20         30         40         50         60 
MQLEHCLSPS IMLSKKFLNV SSSYPHSGGS ELVLHDHPII STTDNLERSS PLKKITRGMT 

        70         80         90        100        110        120 
NQSDTDNFPD SKDSPGDVQR SKLSPVLDGV SELRHSFDGS AADRYLLSQS SQPQSAATAP 

       130        140        150        160        170        180 
SAMFPYPSQH GPAHPAFSIG SPSRYMAHHP VITNGAYNSL LSNSSPQGYP TAGYPYPQQY 

       190        200        210        220        230        240 
GHSYQGAPFY QFSSTQPGLV PGKAQVYLCN RPLWLKFHRH QTEMIITKQG RRMFPFLSFN 

       250        260        270        280        290        300 
ISGLDPTAHY NIFVDVILAD PNHWRFQGGK WVPCGKADTN VQGNRVYMHP DSPNTGAHWM 

       310        320        330        340        350        360 
RQEISFGKLK LTNNKGASNN NGQMVVLQSL HKYQPRLHVV EVNEDGTEDT SQPGRVQTFT 

       370        380        390        400        410        420 
FPETQFIAVT AYQNTDITQL KIDHNPFAKG FRDNYDTIYT GCDMDRLTPS PNDSPRSQIV 

       430        440        450        460        470        480 
PGARYAMAGS FLQDQFVSNY AKARFHPGAG AGPGPGTDRS VPHTNGLLSP QQAEDPGAPS 

       490        500        510        520        530        540 
PQRWFVTPAN NRLDFAASAY DTATDFAGNA ATLLSYAAAG VKALPLQAAG CTGRPLGYYA 

       550        560        570        580        590        600 
DPSGWGARSP PQYCGAKSGS VLPCWPNSAA AAARMAGANP YLGEEAEGLA AERSPLAPAA 

       610        620        630        640        650        660 
EDAKPKDLSD SSWIETPSSI KSIDSSDSGI YEQAKRRRIS PADTPVSESS SPLKSEVLAQ 

       670        680 
RDCEKNCAKD IGGYYGFYSH S 

« Hide

References

« Hide 'large scale' references
[1]"T-brain-1: a homolog of Brachyury whose expression defines molecularly distinct domains within the cerebral cortex."
Bulfone A., Smiga S.M., Shimamura K., Peterson A., Puelles L., Rubenstein J.L.R.
Neuron 15:63-78(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Fetal brain.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[5]"Transcriptional modification by a CASK-interacting nucleosome assembly protein."
Wang G.-S., Hong C.-J., Yen T.-Y., Huang H.-Y., Ou Y., Huang T.-N., Jung W.-G., Kuo T.-Y., Sheng M., Wang T.-F., Hsueh Y.-P.
Neuron 42:113-128(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN COMPLEX WITH CASK AND TBR1.
Strain: C57BL/6.
[6]"Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U49251 mRNA. Translation: AAA92011.1.
AL845291 Genomic DNA. Translation: CAM17335.1.
CH466519 Genomic DNA. Translation: EDL26982.1.
BC052737 mRNA. Translation: AAH52737.1.
BC058399 mRNA. Translation: AAH58399.1.
CCDSCCDS16063.1.
RefSeqNP_033348.2. NM_009322.3.
XP_006499161.1. XM_006499098.1.
UniGeneMm.308525.
Mm.404741.

3D structure databases

ProteinModelPortalQ64336.
SMRQ64336. Positions 205-392.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000046787.

PTM databases

PhosphoSiteQ64336.

Proteomic databases

PaxDbQ64336.
PRIDEQ64336.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000048934; ENSMUSP00000046787; ENSMUSG00000035033.
GeneID21375.
KEGGmmu:21375.
UCSCuc008jvd.1. mouse.

Organism-specific databases

CTD10716.
MGIMGI:107404. Tbr1.

Phylogenomic databases

eggNOGNOG245070.
GeneTreeENSGT00740000115029.
HOGENOMHOG000218633.
HOVERGENHBG000578.
InParanoidQ7TSY9.
KOK10174.
OMAMFPYPSQ.
OrthoDBEOG7C2R14.
TreeFamTF106341.

Gene expression databases

BgeeQ64336.
CleanExMM_TBR1.
GenevestigatorQ64336.

Family and domain databases

Gene3D2.60.40.820. 1 hit.
InterProIPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERPTHR11267. PTHR11267. 1 hit.
PfamPF00907. T-box. 1 hit.
[Graphical view]
PRINTSPR00937. TBOX.
SMARTSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMSSF49417. SSF49417. 1 hit.
PROSITEPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTBR1. mouse.
NextBio300596.
PROQ64336.
SOURCESearch...

Entry information

Entry nameTBR1_MOUSE
AccessionPrimary (citable) accession number: Q64336
Secondary accession number(s): Q7TSY9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot