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Protein

Killer cell lectin-like receptor subfamily G member 1

Gene

Klrg1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells (By similarity).By similarity

GO - Molecular functioni

  • carbohydrate binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Innate immunity

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell lectin-like receptor subfamily G member 1
Alternative name(s):
Mast cell function-associated antigen
Gene namesi
Name:Klrg1
Synonyms:Mafa
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi61978. Klrg1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434CytoplasmicSequence analysisAdd
BLAST
Transmembranei35 – 5521Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini56 – 188133ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188Killer cell lectin-like receptor subfamily G member 1PRO_0000331258Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi75 ↔ 86PROSITE-ProRule annotation
Glycosylationi82 – 821N-linked (GlcNAc...)Sequence analysis
Glycosylationi97 – 971N-linked (GlcNAc...)Sequence analysis
Disulfide bondi103 ↔ 183PROSITE-ProRule annotation
Disulfide bondi162 ↔ 175PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated in response to monoclonal antibody G63 binding and antigenic stimulation.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ64335.
PRIDEiQ64335.

Expressioni

Tissue specificityi

Expressed in lung mast cells.2 Publications

Gene expression databases

GenevisibleiQ64335. RN.

Interactioni

Subunit structurei

Forms a monomer and homodimer; disulfide-linked. Interacts (via ITIM motif) with PTPN11 and INPP5D (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020094.

Structurei

3D structure databases

ProteinModelPortaliQ64335.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini82 – 184103C-type lectinPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi5 – 106ITIM motif

Domaini

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00840000129990.
HOGENOMiHOG000082429.
HOVERGENiHBG103557.
InParanoidiQ64335.
KOiK10076.
OMAiMADNSIY.
OrthoDBiEOG70KGR1.
PhylomeDBiQ64335.
TreeFamiTF336674.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64335-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADNSIYSTL ELPAAPRVQD DSRWKVKAVL HRPCVSYLVM VALGLLTVIL
60 70 80 90 100
MSLLLYQRTL CCGSKGFMCS QCSRCPNLWM RNGSHCYYFS MEKRDWNSSL
110 120 130 140 150
KFCADKGSHL LTFPDNQGVN LFQEYVGEDF YWIGLRDIDG WRWEDGPALS
160 170 180
LSILSNSVVQ KCGTIHRCGL HASSCEVALQ WICEKVLP
Length:188
Mass (Da):21,356
Last modified:November 1, 1996 - v1
Checksum:i2CC8032D4D020B15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79812 mRNA. Translation: CAA56208.1.
X97191
, X97192, X97193, X97194, X97195 Genomic DNA. Translation: CAA65829.1.
PIRiI59421.
RefSeqiNP_113837.1. NM_031649.2.
UniGeneiRn.10256.

Genome annotation databases

EnsembliENSRNOT00000020094; ENSRNOP00000020094; ENSRNOG00000014918.
GeneIDi58975.
KEGGirno:58975.
UCSCiRGD:61978. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79812 mRNA. Translation: CAA56208.1.
X97191
, X97192, X97193, X97194, X97195 Genomic DNA. Translation: CAA65829.1.
PIRiI59421.
RefSeqiNP_113837.1. NM_031649.2.
UniGeneiRn.10256.

3D structure databases

ProteinModelPortaliQ64335.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020094.

Proteomic databases

PaxDbiQ64335.
PRIDEiQ64335.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020094; ENSRNOP00000020094; ENSRNOG00000014918.
GeneIDi58975.
KEGGirno:58975.
UCSCiRGD:61978. rat.

Organism-specific databases

CTDi10219.
RGDi61978. Klrg1.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00840000129990.
HOGENOMiHOG000082429.
HOVERGENiHBG103557.
InParanoidiQ64335.
KOiK10076.
OMAiMADNSIY.
OrthoDBiEOG70KGR1.
PhylomeDBiQ64335.
TreeFamiTF336674.

Miscellaneous databases

PROiQ64335.

Gene expression databases

GenevisibleiQ64335. RN.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A secretion inhibitory signal transduction molecule on mast cells is another C-type lectin."
    Guthmann M.D., Tal M., Pecht I.
    Proc. Natl. Acad. Sci. U.S.A. 92:9397-9401(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT, TISSUE SPECIFICITY, PHOSPHORYLATION.
  2. "Analysis of the genes encoding the mast cell function-associated antigen and its alternatively spliced transcripts."
    Bocek P. Jr., Guthmann M.D., Pecht I.
    J. Immunol. 158:3235-3243(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Testis.

Entry informationi

Entry nameiKLRG1_RAT
AccessioniPrimary (citable) accession number: Q64335
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.