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Q64332

- SYN2_MOUSE

UniProt

Q64332 - SYN2_MOUSE

Protein

Synapsin-2

Gene

Syn2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (30 Aug 2005)
      Previous versions | rss
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    Functioni

    Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons.1 Publication

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. catalytic activity Source: InterPro
    3. protein dimerization activity Source: MGI

    GO - Biological processi

    1. neurotransmitter secretion Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Synapsin-2
    Alternative name(s):
    Synapsin II
    Gene namesi
    Name:Syn2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:103020. Syn2.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. synapse Source: MGI
    3. synaptic vesicle membrane Source: MGI

    Keywords - Cellular componenti

    Cell junction, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 586586Synapsin-2PRO_0000183022Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei10 – 101Phosphoserine; by PKA and CaMK1By similarity
    Modified residuei426 – 4261Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylation at Ser-10 dissociates synapsins from synaptic vesicles By similarity. Phosphorylation at Ser-426 by MAPK1/ERK2 and/or MAPK3/ERK1 may play a role in noradrenaline secretion by sympathetic neurons.By similarity1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ64332.
    PaxDbiQ64332.
    PRIDEiQ64332.

    PTM databases

    PhosphoSiteiQ64332.

    Expressioni

    Tissue specificityi

    Expressed exclusively in neuronal cells. Isoform IIb is enriched in sympathetic cervical ganglion.1 Publication

    Gene expression databases

    BgeeiQ64332.
    CleanExiMM_SYN2.
    GenevestigatoriQ64332.

    Interactioni

    Subunit structurei

    Interacts with CAPON.By similarity

    Protein-protein interaction databases

    BioGridi203601. 5 interactions.
    IntActiQ64332. 8 interactions.
    MINTiMINT-215012.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64332.
    SMRiQ64332. Positions 113-420.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2929AAdd
    BLAST
    Regioni33 – 11381B; linkerAdd
    BLAST
    Regioni114 – 421308C; actin-binding and synaptic-vesicle bindingAdd
    BLAST
    Regioni422 – 45837G; Pro-rich linkerAdd
    BLAST
    Regioni459 – 53779H; Pro/Ser-rich linkerAdd
    BLAST
    Regioni538 – 58649EAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi486 – 49914Poly-SerAdd
    BLAST
    Compositional biasi515 – 5206Poly-Ser

    Domaini

    The A region binds phospholipids with a preference for negatively charged species.By similarity

    Sequence similaritiesi

    Belongs to the synapsin family.Curated

    Phylogenomic databases

    eggNOGiNOG284201.
    GeneTreeiENSGT00530000063319.
    HOGENOMiHOG000231323.
    HOVERGENiHBG016354.
    InParanoidiQ64332.
    OMAiQGMQPPG.
    OrthoDBiEOG793B7G.
    PhylomeDBiQ64332.
    TreeFamiTF319919.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 2 hits.
    3.40.50.20. 1 hit.
    InterProiIPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR016185. PreATP-grasp_dom.
    IPR001359. Synapsin.
    IPR020898. Synapsin_ATP-bd_dom.
    IPR019735. Synapsin_CS.
    IPR019736. Synapsin_P_site.
    IPR020897. Synapsin_pre-ATP-grasp_dom.
    [Graphical view]
    PANTHERiPTHR10841. PTHR10841. 1 hit.
    PfamiPF02078. Synapsin. 1 hit.
    PF02750. Synapsin_C. 1 hit.
    PF10581. Synapsin_N. 1 hit.
    [Graphical view]
    PRINTSiPR01368. SYNAPSIN.
    SUPFAMiSSF52440. SSF52440. 1 hit.
    PROSITEiPS00415. SYNAPSIN_1. 1 hit.
    PS00416. SYNAPSIN_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform IIa (identifier: Q64332-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMNFLRRRLS DSSFIANLPN GYMTDLQRPE PQQPPPAPGP GAATASAATS    50
    AASPGPERRP PPAQAPAPQP APQPAPTPSV GSSFFSSLSQ AVKQTAASAG 100
    LVDAPAPSAA SRKAKVLLVV DEPHTDWAKC FRGKKILGDY DIKVEQAEFS 150
    ELNLVAHADG TYAVDMQVLR NGTKVVRSFR PDFVLIRQHA FGMAENEDFR 200
    HLVIGMQYAG LPSINSLESI YNFCDKPWVF AQMVAIFKTL GGEKFPLIEQ 250
    TYYPNHREML TLPTFPVVVK IGHAHSGMGK VKVENHYDFQ DIASVVALTQ 300
    TYATAEPFID AKYDIRVQKI GNNYKAYMRT SISGNWKTNT GSAMLEQIAM 350
    SDRYKLWVDA CSEMFGGLDI CAVKAVHGKD GKDYIFEVMD CSMPLIGEHQ 400
    VEDRQLITDL VISKMNQLLS RTPALSPQRP LTTQQPQSGT LKEPDSSKTP 450
    PQRPPPQGGP GQPQGMQPPG KVLPPRRLPS GPSLPSSSSS SSSSSSSSSA 500
    PQRPGGPTTT HGDASSSSNS LAEAQAPQAA PAQKPQPHPQ LNKSQSLTNA 550
    FSFSESSFFR SSANEDEAKA ETIRSLRKSF ASLFSD 586
    Length:586
    Mass (Da):63,373
    Last modified:August 30, 2005 - v2
    Checksum:i2B1B6A7453E286FC
    GO
    Isoform IIb (identifier: Q64332-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         459-479: GPGQPQGMQPPGKVLPPRRLP → CLQYILDCNGIAVGPKQVQAS
         480-586: Missing.

    Show »
    Length:479
    Mass (Da):52,452
    Checksum:i21EF91B466D08BB5
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei459 – 47921GPGQP…PRRLP → CLQYILDCNGIAVGPKQVQA S in isoform IIb. 1 PublicationVSP_015203Add
    BLAST
    Alternative sequencei480 – 586107Missing in isoform IIb. 1 PublicationVSP_015204Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF096867 mRNA. Translation: AAC72966.1.
    L32026 Genomic DNA. Translation: AAA79964.1.
    BC066004 mRNA. Translation: AAH66004.1.
    BC085129 mRNA. Translation: AAH85129.1.
    CCDSiCCDS51874.1. [Q64332-1]
    CCDS51875.1. [Q64332-2]
    PIRiI61260.
    RefSeqiNP_001104485.1. NM_001111015.1. [Q64332-1]
    NP_038709.1. NM_013681.3. [Q64332-2]
    UniGeneiMm.441431.
    Mm.466323.

    Genome annotation databases

    EnsembliENSMUST00000009538; ENSMUSP00000009538; ENSMUSG00000009394. [Q64332-1]
    ENSMUST00000169345; ENSMUSP00000133121; ENSMUSG00000009394. [Q64332-2]
    GeneIDi20965.
    KEGGimmu:20965.
    UCSCiuc009dim.2. mouse. [Q64332-2]
    uc009din.2. mouse. [Q64332-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF096867 mRNA. Translation: AAC72966.1 .
    L32026 Genomic DNA. Translation: AAA79964.1 .
    BC066004 mRNA. Translation: AAH66004.1 .
    BC085129 mRNA. Translation: AAH85129.1 .
    CCDSi CCDS51874.1. [Q64332-1 ]
    CCDS51875.1. [Q64332-2 ]
    PIRi I61260.
    RefSeqi NP_001104485.1. NM_001111015.1. [Q64332-1 ]
    NP_038709.1. NM_013681.3. [Q64332-2 ]
    UniGenei Mm.441431.
    Mm.466323.

    3D structure databases

    ProteinModelPortali Q64332.
    SMRi Q64332. Positions 113-420.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203601. 5 interactions.
    IntActi Q64332. 8 interactions.
    MINTi MINT-215012.

    PTM databases

    PhosphoSitei Q64332.

    Proteomic databases

    MaxQBi Q64332.
    PaxDbi Q64332.
    PRIDEi Q64332.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000009538 ; ENSMUSP00000009538 ; ENSMUSG00000009394 . [Q64332-1 ]
    ENSMUST00000169345 ; ENSMUSP00000133121 ; ENSMUSG00000009394 . [Q64332-2 ]
    GeneIDi 20965.
    KEGGi mmu:20965.
    UCSCi uc009dim.2. mouse. [Q64332-2 ]
    uc009din.2. mouse. [Q64332-1 ]

    Organism-specific databases

    CTDi 6854.
    MGIi MGI:103020. Syn2.

    Phylogenomic databases

    eggNOGi NOG284201.
    GeneTreei ENSGT00530000063319.
    HOGENOMi HOG000231323.
    HOVERGENi HBG016354.
    InParanoidi Q64332.
    OMAi QGMQPPG.
    OrthoDBi EOG793B7G.
    PhylomeDBi Q64332.
    TreeFami TF319919.

    Miscellaneous databases

    NextBioi 299926.
    PROi Q64332.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q64332.
    CleanExi MM_SYN2.
    Genevestigatori Q64332.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 2 hits.
    3.40.50.20. 1 hit.
    InterProi IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR016185. PreATP-grasp_dom.
    IPR001359. Synapsin.
    IPR020898. Synapsin_ATP-bd_dom.
    IPR019735. Synapsin_CS.
    IPR019736. Synapsin_P_site.
    IPR020897. Synapsin_pre-ATP-grasp_dom.
    [Graphical view ]
    PANTHERi PTHR10841. PTHR10841. 1 hit.
    Pfami PF02078. Synapsin. 1 hit.
    PF02750. Synapsin_C. 1 hit.
    PF10581. Synapsin_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01368. SYNAPSIN.
    SUPFAMi SSF52440. SSF52440. 1 hit.
    PROSITEi PS00415. SYNAPSIN_1. 1 hit.
    PS00416. SYNAPSIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of mouse synapsin IIb."
      Han S.J.
      Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IIB).
      Strain: H129.
      Tissue: Brain.
    2. "Neuron-specific expression of the synapsin II gene is directed by a specific core promoter and upstream regulatory elements."
      Chin L.S., Li L., Greengard P.
      J. Biol. Chem. 269:18507-18513(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-126, TISSUE SPECIFICITY.
      Strain: 129/Sv.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-586 (ISOFORM IIA).
      Strain: C57BL/6.
      Tissue: Brain.
    4. Lubec G., Klug S., Kang S.U., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 59-112; 116-129; 136-143; 178-213; 245-270; 338-353 AND 405-414, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6 and OF1.
      Tissue: Brain and Hippocampus.
    5. "Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation."
      Inoue D., Kimura I., Wakabayashi M., Tsumoto H., Ozawa K., Hara T., Takei Y., Hirasawa A., Ishihama Y., Tsujimoto G.
      FEBS Lett. 586:1547-1554(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, PHOSPHORYLATION AT SER-426, TISSUE SPECIFICITY (ISOFORM IIB).

    Entry informationi

    Entry nameiSYN2_MOUSE
    AccessioniPrimary (citable) accession number: Q64332
    Secondary accession number(s): Q6NZR0, Q9QWV7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3