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Q64332 (SYN2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Synapsin-2
Alternative name(s):
Synapsin II
Gene names
Name:Syn2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length586 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release By similarity.

Subunit structure

Interacts with CAPON By similarity.

Subcellular location

Cell junction › synapse.

Tissue specificity

Expressed exclusively in neuronal cells. Ref.3

Domain

The A region binds phospholipids with a preference for negatively charged species By similarity.

Post-translational modification

Phosphorylation at Ser-10 dissociates synapsins from synaptic vesicles By similarity.

Sequence similarities

Belongs to the synapsin family.

Sequence caution

The sequence AAH66004.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAH85129.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform IIa (identifier: Q64332-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform IIb (identifier: Q64332-2)

The sequence of this isoform differs from the canonical sequence as follows:
     459-479: GPGQPQGMQPPGKVLPPRRLP → CLQYILDCNGIAVGPKQVQAS
     480-586: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 586586Synapsin-2
PRO_0000183022

Regions

Region1 – 2929A
Region33 – 11381B; linker
Region114 – 421308C; actin-binding and synaptic-vesicle binding
Region422 – 45837G; Pro-rich linker
Region459 – 53779H; Pro/Ser-rich linker
Region538 – 58649E
Compositional bias486 – 49914Poly-Ser
Compositional bias515 – 5206Poly-Ser

Amino acid modifications

Modified residue101Phosphoserine; by PKA and CaMK1 By similarity
Modified residue4221Phosphothreonine Ref.5
Modified residue4261Phosphoserine Ref.5

Natural variations

Alternative sequence459 – 47921GPGQP…PRRLP → CLQYILDCNGIAVGPKQVQA S in isoform IIb.
VSP_015203
Alternative sequence480 – 586107Missing in isoform IIb.
VSP_015204

Sequences

Sequence LengthMass (Da)Tools
Isoform IIa [UniParc].

Last modified August 30, 2005. Version 2.
Checksum: 2B1B6A7453E286FC

FASTA58663,373
        10         20         30         40         50         60 
MMNFLRRRLS DSSFIANLPN GYMTDLQRPE PQQPPPAPGP GAATASAATS AASPGPERRP 

        70         80         90        100        110        120 
PPAQAPAPQP APQPAPTPSV GSSFFSSLSQ AVKQTAASAG LVDAPAPSAA SRKAKVLLVV 

       130        140        150        160        170        180 
DEPHTDWAKC FRGKKILGDY DIKVEQAEFS ELNLVAHADG TYAVDMQVLR NGTKVVRSFR 

       190        200        210        220        230        240 
PDFVLIRQHA FGMAENEDFR HLVIGMQYAG LPSINSLESI YNFCDKPWVF AQMVAIFKTL 

       250        260        270        280        290        300 
GGEKFPLIEQ TYYPNHREML TLPTFPVVVK IGHAHSGMGK VKVENHYDFQ DIASVVALTQ 

       310        320        330        340        350        360 
TYATAEPFID AKYDIRVQKI GNNYKAYMRT SISGNWKTNT GSAMLEQIAM SDRYKLWVDA 

       370        380        390        400        410        420 
CSEMFGGLDI CAVKAVHGKD GKDYIFEVMD CSMPLIGEHQ VEDRQLITDL VISKMNQLLS 

       430        440        450        460        470        480 
RTPALSPQRP LTTQQPQSGT LKEPDSSKTP PQRPPPQGGP GQPQGMQPPG KVLPPRRLPS 

       490        500        510        520        530        540 
GPSLPSSSSS SSSSSSSSSA PQRPGGPTTT HGDASSSSNS LAEAQAPQAA PAQKPQPHPQ 

       550        560        570        580 
LNKSQSLTNA FSFSESSFFR SSANEDEAKA ETIRSLRKSF ASLFSD

« Hide

Isoform IIb [UniParc].

Checksum: 21EF91B466D08BB5
Show »

FASTA47952,452

References

« Hide 'large scale' references
[1]"Identification of mouse synapsin IIb."
Han S.J.
Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IIB).
Strain: H129.
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM IIA).
Strain: C57BL/6.
Tissue: Brain.
[3]"Neuron-specific expression of the synapsin II gene is directed by a specific core promoter and upstream regulatory elements."
Chin L.S., Li L., Greengard P.
J. Biol. Chem. 269:18507-18513(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-126, TISSUE SPECIFICITY.
Strain: 129/Sv.
[4]Lubec G., Klug S., Kang S.U., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 59-112; 116-129; 136-143; 178-213; 245-270; 338-353 AND 405-414, MASS SPECTROMETRY.
Strain: C57BL/6 and OF1.
Tissue: Brain and Hippocampus.
[5]"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-422 AND SER-426, MASS SPECTROMETRY.
Tissue: Brain cortex.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF096867 mRNA. Translation: AAC72966.1.
BC066004 mRNA. Translation: AAH66004.1. Different initiation.
BC085129 mRNA. Translation: AAH85129.1. Different initiation.
L32026 Genomic DNA. Translation: AAA79964.1.
IPIIPI00134492.
IPI00469548.
PIRI61260.
RefSeqNP_001104485.1. NM_001111015.1.
NP_038709.1. NM_013681.2.
UniGeneMm.441431.
Mm.466323.

3D structure databases

ProteinModelPortalQ64332.
SMRQ64332. Positions 113-420.
ModBaseSearch...

Protein-protein interaction databases

IntActQ64332. 6 interactions.

PTM databases

PhosphoSiteQ64332.

Proteomic databases

PaxDbQ64332.
PRIDEQ64332.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000009538; ENSMUSP00000009538; ENSMUSG00000009394.
ENSMUST00000169345; ENSMUSP00000133121; ENSMUSG00000009394.
GeneID20965.
KEGGmmu:20965.
UCSCuc009dim.2. mouse.
uc009din.2. mouse.

Organism-specific databases

CTD6854.
MGIMGI:103020. Syn2.

Phylogenomic databases

eggNOGNOG284201.
GeneTreeENSGT00530000063319.
HOGENOMHOG000231323.
HOVERGENHBG016354.
InParanoidQ64332.
OMAQGMQPPG.

Gene expression databases

BgeeQ64332.
CleanExMM_SYN2.
GenevestigatorQ64332.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
InterProIPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR001359. Synapsin.
IPR020898. Synapsin_ATP-bd_dom.
IPR019735. Synapsin_CS.
IPR019736. Synapsin_P_site.
IPR020897. Synapsin_pre-ATP-grasp_dom.
[Graphical view]
PfamPF02078. Synapsin. 1 hit.
PF02750. Synapsin_C. 1 hit.
PF10581. Synapsin_N. 1 hit.
[Graphical view]
PRINTSPR01368. SYNAPSIN.
SUPFAMSSF52440. PreATP-grasp-like. 1 hit.
PROSITEPS00415. SYNAPSIN_1. 1 hit.
PS00416. SYNAPSIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio299926.
SOURCESearch...

Entry information

Entry nameSYN2_MOUSE
AccessionPrimary (citable) accession number: Q64332
Secondary accession number(s): Q6NZR0, Q9QWV7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 30, 2005
Last modified: April 3, 2013
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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