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Protein

Adrenocorticotropic hormone receptor

Gene

Mc2r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Adrenocorticotropic hormone receptor
Short name:
ACTH receptor
Short name:
ACTH-R
Alternative name(s):
Adrenocorticotropin receptor
Melanocortin receptor 2
Short name:
MC2-R
Gene namesi
Name:Mc2r
Synonyms:Acthr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:96928 Mc2r

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularBy similarityAdd BLAST23
Transmembranei24 – 49Helical; Name=1By similarityAdd BLAST26
Topological domaini50 – 58CytoplasmicBy similarity9
Transmembranei59 – 79Helical; Name=2By similarityAdd BLAST21
Topological domaini80 – 104ExtracellularBy similarityAdd BLAST25
Transmembranei105 – 126Helical; Name=3By similarityAdd BLAST22
Topological domaini127 – 147CytoplasmicBy similarityAdd BLAST21
Transmembranei148 – 168Helical; Name=4By similarityAdd BLAST21
Topological domaini169 – 180ExtracellularBy similarityAdd BLAST12
Transmembranei181 – 199Helical; Name=5By similarityAdd BLAST19
Topological domaini200 – 217CytoplasmicBy similarityAdd BLAST18
Transmembranei218 – 244Helical; Name=6By similarityAdd BLAST27
Topological domaini245 – 256ExtracellularBy similarityAdd BLAST12
Transmembranei257 – 278Helical; Name=7By similarityAdd BLAST22
Topological domaini279 – 296CytoplasmicBy similarityAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2279
GuidetoPHARMACOLOGYi283

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690561 – 296Adrenocorticotropic hormone receptorAdd BLAST296

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi12N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi17N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi293S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ64326
PRIDEiQ64326

PTM databases

iPTMnetiQ64326
PhosphoSitePlusiQ64326

Expressioni

Gene expression databases

BgeeiENSMUSG00000045569
CleanExiMM_MC2R
ExpressionAtlasiQ64326 baseline and differential
GenevisibleiQ64326 MM

Interactioni

Subunit structurei

Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH) (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058691

Chemistry databases

BindingDBiQ64326

Structurei

3D structure databases

ProteinModelPortaliQ64326
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00770000120529
HOGENOMiHOG000246927
HOVERGENiHBG108148
InParanoidiQ64326
KOiK04200
OMAiFHALQYH
OrthoDBiEOG091G0BVW
PhylomeDBiQ64326
TreeFamiTF332646

Family and domain databases

InterProiView protein in InterPro
IPR001168 ACTH_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001671 Melcrt_ACTH_rcpt
PANTHERiPTHR22750:SF3 PTHR22750:SF3, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00520 ACTROPHINR
PR00237 GPCRRHODOPSN
PR00534 MCRFAMILY
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q64326-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHIINSYEH TNDTARNNSD CPDVVLPEEI FFTISVIGIL ENLIVLLAVI
60 70 80 90 100
KNKNLQSPMY FFICSLAISD MLGSLYKILE NILIMFRNMG YLKPRGSFES
110 120 130 140 150
TADDIIDCMF ILSLLGSIFS LSVIAADRYI TIFHALQYHS IVTMRRTIIT
160 170 180 190 200
LTIIWMFCTG SGITMVIFSH HIPTVLTFTS LFPLMLVFIL CLYIHMFLLA
210 220 230 240 250
RSHARKISTL PRTNMKGAMT LTILLGVFIF CWAPFVLHVL LMTFCPNNPY
260 270 280 290
CVCYMSLFQV NGMLIMCNAV IDPFIYAFRS PELRDAFKRM LFCNRY
Length:296
Mass (Da):33,982
Last modified:November 1, 1996 - v1
Checksum:i8ECB3D9A028CB9B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31952 Genomic DNA Translation: BAA06722.1
S78985 Genomic DNA Translation: AAB34919.1
CCDSiCCDS29328.1
PIRiJC4046
RefSeqiNP_001258645.1, NM_001271716.1
NP_001258646.1, NM_001271717.1
NP_001288301.1, NM_001301372.1
NP_032586.1, NM_008560.3
UniGeneiMm.426053

Genome annotation databases

EnsembliENSMUST00000052347; ENSMUSP00000058691; ENSMUSG00000045569
GeneIDi17200
KEGGimmu:17200
UCSCiuc008fnm.2 mouse

Entry informationi

Entry nameiACTHR_MOUSE
AccessioniPrimary (citable) accession number: Q64326
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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