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Protein

Adrenocorticotropic hormone receptor

Gene

Mc2r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Adrenocorticotropic hormone receptor
Short name:
ACTH receptor
Short name:
ACTH-R
Alternative name(s):
Adrenocorticotropin receptor
Melanocortin receptor 2
Short name:
MC2-R
Gene namesi
Name:Mc2r
Synonyms:Acthr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:96928. Mc2r.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularBy similarityAdd
BLAST
Transmembranei24 – 4926Helical; Name=1By similarityAdd
BLAST
Topological domaini50 – 589CytoplasmicBy similarity
Transmembranei59 – 7921Helical; Name=2By similarityAdd
BLAST
Topological domaini80 – 10425ExtracellularBy similarityAdd
BLAST
Transmembranei105 – 12622Helical; Name=3By similarityAdd
BLAST
Topological domaini127 – 14721CytoplasmicBy similarityAdd
BLAST
Transmembranei148 – 16821Helical; Name=4By similarityAdd
BLAST
Topological domaini169 – 18012ExtracellularBy similarityAdd
BLAST
Transmembranei181 – 19919Helical; Name=5By similarityAdd
BLAST
Topological domaini200 – 21718CytoplasmicBy similarityAdd
BLAST
Transmembranei218 – 24427Helical; Name=6By similarityAdd
BLAST
Topological domaini245 – 25612ExtracellularBy similarityAdd
BLAST
Transmembranei257 – 27822Helical; Name=7By similarityAdd
BLAST
Topological domaini279 – 29618CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2279.
GuidetoPHARMACOLOGYi283.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 296296Adrenocorticotropic hormone receptorPRO_0000069056Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi12 – 121N-linked (GlcNAc...)Sequence analysis
Glycosylationi17 – 171N-linked (GlcNAc...)Sequence analysis
Lipidationi293 – 2931S-palmitoyl cysteineSequence analysis

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ64326.
PRIDEiQ64326.

PTM databases

PhosphoSiteiQ64326.

Expressioni

Gene expression databases

BgeeiQ64326.
CleanExiMM_MC2R.
ExpressionAtlasiQ64326. baseline and differential.
GenevisibleiQ64326. MM.

Interactioni

Subunit structurei

Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH) (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058691.

Chemistry

BindingDBiQ64326.

Structurei

3D structure databases

ProteinModelPortaliQ64326.
SMRiQ64326. Positions 26-293.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00770000120529.
HOGENOMiHOG000246927.
HOVERGENiHBG108148.
InParanoidiQ64326.
KOiK04200.
OMAiAVIWTFC.
OrthoDBiEOG7327PD.
PhylomeDBiQ64326.
TreeFamiTF332646.

Family and domain databases

InterProiIPR001168. ACTH_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001671. Melcrt_ACTH_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF3. PTHR22750:SF3. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00520. ACTROPHINR.
PR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64326-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHIINSYEH TNDTARNNSD CPDVVLPEEI FFTISVIGIL ENLIVLLAVI
60 70 80 90 100
KNKNLQSPMY FFICSLAISD MLGSLYKILE NILIMFRNMG YLKPRGSFES
110 120 130 140 150
TADDIIDCMF ILSLLGSIFS LSVIAADRYI TIFHALQYHS IVTMRRTIIT
160 170 180 190 200
LTIIWMFCTG SGITMVIFSH HIPTVLTFTS LFPLMLVFIL CLYIHMFLLA
210 220 230 240 250
RSHARKISTL PRTNMKGAMT LTILLGVFIF CWAPFVLHVL LMTFCPNNPY
260 270 280 290
CVCYMSLFQV NGMLIMCNAV IDPFIYAFRS PELRDAFKRM LFCNRY
Length:296
Mass (Da):33,982
Last modified:November 1, 1996 - v1
Checksum:i8ECB3D9A028CB9B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31952 Genomic DNA. Translation: BAA06722.1.
S78985 Genomic DNA. Translation: AAB34919.1.
CCDSiCCDS29328.1.
PIRiJC4046.
RefSeqiNP_001258645.1. NM_001271716.1.
NP_001258646.1. NM_001271717.1.
NP_001288301.1. NM_001301372.1.
NP_032586.1. NM_008560.3.
UniGeneiMm.426053.

Genome annotation databases

EnsembliENSMUST00000052347; ENSMUSP00000058691; ENSMUSG00000045569.
GeneIDi17200.
KEGGimmu:17200.
UCSCiuc008fnm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31952 Genomic DNA. Translation: BAA06722.1.
S78985 Genomic DNA. Translation: AAB34919.1.
CCDSiCCDS29328.1.
PIRiJC4046.
RefSeqiNP_001258645.1. NM_001271716.1.
NP_001258646.1. NM_001271717.1.
NP_001288301.1. NM_001301372.1.
NP_032586.1. NM_008560.3.
UniGeneiMm.426053.

3D structure databases

ProteinModelPortaliQ64326.
SMRiQ64326. Positions 26-293.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058691.

Chemistry

BindingDBiQ64326.
ChEMBLiCHEMBL2279.
GuidetoPHARMACOLOGYi283.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ64326.

Proteomic databases

PaxDbiQ64326.
PRIDEiQ64326.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052347; ENSMUSP00000058691; ENSMUSG00000045569.
GeneIDi17200.
KEGGimmu:17200.
UCSCiuc008fnm.2. mouse.

Organism-specific databases

CTDi4158.
MGIiMGI:96928. Mc2r.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00770000120529.
HOGENOMiHOG000246927.
HOVERGENiHBG108148.
InParanoidiQ64326.
KOiK04200.
OMAiAVIWTFC.
OrthoDBiEOG7327PD.
PhylomeDBiQ64326.
TreeFamiTF332646.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418555. G alpha (s) signalling events.

Miscellaneous databases

NextBioi291578.
PROiQ64326.
SOURCEiSearch...

Gene expression databases

BgeeiQ64326.
CleanExiMM_MC2R.
ExpressionAtlasiQ64326. baseline and differential.
GenevisibleiQ64326. MM.

Family and domain databases

InterProiIPR001168. ACTH_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001671. Melcrt_ACTH_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF3. PTHR22750:SF3. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00520. ACTROPHINR.
PR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of a mouse adrenocorticotropin receptor-encoding gene."
    Kubo M., Ishizuka T., Kijima H., Kakinuma M., Koike T.
    Gene 153:279-280(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Cloning, characterization and expression of a functional mouse ACTH receptor."
    Cammas F.M., Kapas S., Barker S., Clark A.J.
    Biochem. Biophys. Res. Commun. 212:912-918(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiACTHR_MOUSE
AccessioniPrimary (citable) accession number: Q64326
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.