ID   STXB2_MOUSE             Reviewed;         593 AA.
AC   Q64324;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   24-JAN-2024, entry version 146.
DE   RecName: Full=Syntaxin-binding protein 2;
DE   AltName: Full=MUSEC1;
DE   AltName: Full=Protein unc-18 homolog 2;
DE            Short=Munc18-2;
DE            Short=Unc18-2;
DE   AltName: Full=Protein unc-18 homolog B;
DE            Short=Unc-18B;
GN   Name=Stxbp2; Synonyms=Unc18b;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7890715; DOI=10.1074/jbc.270.11.5857;
RA   Tellam J.T., McIntosh S., James D.E.;
RT   "Molecular identification of two novel Munc-18 isoforms expressed in non-
RT   neuronal tissues.";
RL   J. Biol. Chem. 270:5857-5863(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Pancreatic islet;
RX   PubMed=7890599; DOI=10.1074/jbc.270.10.4963;
RA   Katagiri H., Terasaki J., Murata T., Ishihara H., Ogihara T., Inukai K.,
RA   Fukushima Y., Anai M., Kikuchi M., Miyazaki J., Yazaki Y., Oka Y.;
RT   "A novel isoform of syntaxin-binding protein homologous to yeast Sec1
RT   expressed ubiquitously in mammalian cells.";
RL   J. Biol. Chem. 270:4963-4966(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brown adipose tissue, Kidney, Liver, Lung, Pancreas, Spleen,
RC   and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Involved in intracellular vesicle trafficking and vesicle
CC       fusion with membranes. Contributes to the granule exocytosis machinery
CC       through interaction with soluble N-ethylmaleimide-sensitive factor
CC       attachment protein receptor (SNARE) proteins that regulate membrane
CC       fusion. Regulates cytotoxic granule exocytosis in natural killer (NK)
CC       cells (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with STX1A, STX2 and STX3. Interacts with STX11.
CC       {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in testis, intestine, kidney, rat adipose
CC       tissue and 3T3-L1 cells.
CC   -!- SIMILARITY: Belongs to the STXBP/unc-18/SEC1 family. {ECO:0000305}.
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DR   EMBL; U19520; AAA69912.1; -; mRNA.
DR   EMBL; D42068; BAA07666.1; -; mRNA.
DR   EMBL; BC008102; AAH08102.1; -; mRNA.
DR   CCDS; CCDS22067.1; -.
DR   PIR; A55931; A55931.
DR   RefSeq; NP_035633.1; NM_011503.4.
DR   AlphaFoldDB; Q64324; -.
DR   SMR; Q64324; -.
DR   BioGRID; 203565; 14.
DR   STRING; 10090.ENSMUSP00000125405; -.
DR   iPTMnet; Q64324; -.
DR   PhosphoSitePlus; Q64324; -.
DR   EPD; Q64324; -.
DR   jPOST; Q64324; -.
DR   MaxQB; Q64324; -.
DR   PaxDb; 10090-ENSMUSP00000125405; -.
DR   ProteomicsDB; 254772; -.
DR   Antibodypedia; 2787; 244 antibodies from 29 providers.
DR   DNASU; 20911; -.
DR   Ensembl; ENSMUST00000160708.8; ENSMUSP00000125405.2; ENSMUSG00000004626.15.
DR   GeneID; 20911; -.
DR   KEGG; mmu:20911; -.
DR   UCSC; uc009kse.1; mouse.
DR   AGR; MGI:107370; -.
DR   CTD; 6813; -.
DR   MGI; MGI:107370; Stxbp2.
DR   VEuPathDB; HostDB:ENSMUSG00000004626; -.
DR   eggNOG; KOG1300; Eukaryota.
DR   GeneTree; ENSGT00940000160045; -.
DR   HOGENOM; CLU_009210_2_0_1; -.
DR   InParanoid; Q64324; -.
DR   OMA; KQWPFVS; -.
DR   OrthoDB; 4609640at2759; -.
DR   PhylomeDB; Q64324; -.
DR   TreeFam; TF313242; -.
DR   Reactome; R-MMU-114608; Platelet degranulation.
DR   Reactome; R-MMU-449836; Other interleukin signaling.
DR   BioGRID-ORCS; 20911; 5 hits in 77 CRISPR screens.
DR   ChiTaRS; Stxbp2; mouse.
DR   PRO; PR:Q64324; -.
DR   Proteomes; UP000000589; Chromosome 8.
DR   RNAct; Q64324; Protein.
DR   Bgee; ENSMUSG00000004626; Expressed in granulocyte and 209 other cell types or tissues.
DR   ExpressionAtlas; Q64324; baseline and differential.
DR   GO; GO:0016324; C:apical plasma membrane; IDA:MGI.
DR   GO; GO:0042582; C:azurophil granule; ISO:MGI.
DR   GO; GO:0044194; C:cytolytic granule; ISO:MGI.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0030027; C:lamellipodium; ISO:MGI.
DR   GO; GO:0045335; C:phagocytic vesicle; IDA:MGI.
DR   GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR   GO; GO:0098793; C:presynapse; IEA:GOC.
DR   GO; GO:0032991; C:protein-containing complex; ISO:MGI.
DR   GO; GO:0030141; C:secretory granule; IBA:GO_Central.
DR   GO; GO:0042581; C:specific granule; ISO:MGI.
DR   GO; GO:0070820; C:tertiary granule; ISO:MGI.
DR   GO; GO:0042589; C:zymogen granule membrane; IDA:MGI.
DR   GO; GO:0019905; F:syntaxin binding; ISO:MGI.
DR   GO; GO:0017075; F:syntaxin-1 binding; IPI:MGI.
DR   GO; GO:0030348; F:syntaxin-3 binding; IPI:MGI.
DR   GO; GO:0071346; P:cellular response to type II interferon; IDA:MGI.
DR   GO; GO:0006887; P:exocytosis; IMP:MGI.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0001909; P:leukocyte mediated cytotoxicity; ISO:MGI.
DR   GO; GO:0007269; P:neurotransmitter secretion; IBA:GO_Central.
DR   GO; GO:0043306; P:positive regulation of mast cell degranulation; ISO:MGI.
DR   GO; GO:0043304; P:regulation of mast cell degranulation; ISO:MGI.
DR   GO; GO:0006904; P:vesicle docking involved in exocytosis; IBA:GO_Central.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   Gene3D; 1.25.40.60; -; 1.
DR   Gene3D; 3.40.50.1910; -; 1.
DR   Gene3D; 3.40.50.2060; -; 1.
DR   InterPro; IPR043154; Sec-1-like_dom1.
DR   InterPro; IPR043127; Sec-1-like_dom3a.
DR   InterPro; IPR001619; Sec1-like.
DR   InterPro; IPR027482; Sec1-like_dom2.
DR   InterPro; IPR036045; Sec1-like_sf.
DR   PANTHER; PTHR11679:SF27; SYNTAXIN-BINDING PROTEIN 2; 1.
DR   PANTHER; PTHR11679; VESICLE PROTEIN SORTING-ASSOCIATED; 1.
DR   Pfam; PF00995; Sec1; 1.
DR   PIRSF; PIRSF005715; VPS45_Sec1; 1.
DR   SUPFAM; SSF56815; Sec1/munc18-like (SM) proteins; 1.
DR   Genevisible; Q64324; MM.
PE   1: Evidence at protein level;
KW   Exocytosis; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..593
FT                   /note="Syntaxin-binding protein 2"
FT                   /id="PRO_0000206282"
SQ   SEQUENCE   593 AA;  66357 MW;  1A7735C0566BDC8F CRC64;
     MAPLGLKAVV GEKILSGVIR SVKKDGEWKV LIMDHPSMRI LSSCCKMSDI LAEGITIVED
     INKRREPIPS LEAIYLLSPT EKSVQALIAD FQGTPTFTYK AAHIFFTDTC PEPLFSELGR
     SRLAKAVKTL KEIHLAFLPY EAQVFSLDAP HSTYNLYCPF RAGERGRQLD ALAQQIATLC
     ATLQEYPSIR YRKGPEDTAQ LAHAVLAKLN AFKADTPSLG EGPEKTRSQL LIMDRAADPV
     SPLLHELTFQ AMAYDLLDIE QDTYRYETTG LSESREKAVL LDEDDDLWVE LRHMHIADVS
     KKVTELLKTF CESKRLTTDK ANIKDLSHIL KKMPQYQKEL NKYSTHLHLA DDCMKHFKGS
     VEKLCSVEQD LAMGSDAEGE KIKDAMKLIV PVLLDASVPP YDKIRVLLLY ILLRNGVSEE
     NLAKLIQHAN VQSYSSLIRN LEQLGGTVTN SAGSGTSSRL ERRERMEPTY QLSRWSPVIK
     DVMEDVVEDR LDRKLWPFVS DPAPVPSSQA AVSARFGHWH KNKAGVEARA GPRLIVYIVG
     GVAMSEMRAA YEVTRATEGK WEVLIGSSHI LTPTRFLDDL KTLDQKLEGV ALP
//