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Q64324 (STXB2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Syntaxin-binding protein 2
Alternative name(s):
MUSEC1
Protein unc-18 homolog 2
Short name=Munc18-2
Short name=Unc18-2
Protein unc-18 homolog B
Short name=Unc-18B
Gene names
Name:Stxbp2
Synonyms:Unc18b
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length593 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells By similarity.

Subunit structure

Interacts with STX1A, STX2 and STX3 By similarity. Interacts with STX11 By similarity.

Tissue specificity

Expressed in testis, intestine, kidney, rat adipose tissue and 3T3-L1 cells.

Sequence similarities

Belongs to the STXBP/unc-18/SEC1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 593593Syntaxin-binding protein 2
PRO_0000206282

Sequences

Sequence LengthMass (Da)Tools
Q64324 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 1A7735C0566BDC8F

FASTA59366,357
        10         20         30         40         50         60 
MAPLGLKAVV GEKILSGVIR SVKKDGEWKV LIMDHPSMRI LSSCCKMSDI LAEGITIVED 

        70         80         90        100        110        120 
INKRREPIPS LEAIYLLSPT EKSVQALIAD FQGTPTFTYK AAHIFFTDTC PEPLFSELGR 

       130        140        150        160        170        180 
SRLAKAVKTL KEIHLAFLPY EAQVFSLDAP HSTYNLYCPF RAGERGRQLD ALAQQIATLC 

       190        200        210        220        230        240 
ATLQEYPSIR YRKGPEDTAQ LAHAVLAKLN AFKADTPSLG EGPEKTRSQL LIMDRAADPV 

       250        260        270        280        290        300 
SPLLHELTFQ AMAYDLLDIE QDTYRYETTG LSESREKAVL LDEDDDLWVE LRHMHIADVS 

       310        320        330        340        350        360 
KKVTELLKTF CESKRLTTDK ANIKDLSHIL KKMPQYQKEL NKYSTHLHLA DDCMKHFKGS 

       370        380        390        400        410        420 
VEKLCSVEQD LAMGSDAEGE KIKDAMKLIV PVLLDASVPP YDKIRVLLLY ILLRNGVSEE 

       430        440        450        460        470        480 
NLAKLIQHAN VQSYSSLIRN LEQLGGTVTN SAGSGTSSRL ERRERMEPTY QLSRWSPVIK 

       490        500        510        520        530        540 
DVMEDVVEDR LDRKLWPFVS DPAPVPSSQA AVSARFGHWH KNKAGVEARA GPRLIVYIVG 

       550        560        570        580        590 
GVAMSEMRAA YEVTRATEGK WEVLIGSSHI LTPTRFLDDL KTLDQKLEGV ALP 

« Hide

References

« Hide 'large scale' references
[1]"Molecular identification of two novel Munc-18 isoforms expressed in non-neuronal tissues."
Tellam J.T., McIntosh S., James D.E.
J. Biol. Chem. 270:5857-5863(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"A novel isoform of syntaxin-binding protein homologous to yeast Sec1 expressed ubiquitously in mammalian cells."
Katagiri H., Terasaki J., Murata T., Ishihara H., Ogihara T., Inukai K., Fukushima Y., Anai M., Kikuchi M., Miyazaki J., Yazaki Y., Oka Y.
J. Biol. Chem. 270:4963-4966(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
Tissue: Pancreatic islet.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U19520 mRNA. Translation: AAA69912.1.
D42068 mRNA. Translation: BAA07666.1.
BC008102 mRNA. Translation: AAH08102.1.
CCDSCCDS22067.1.
PIRA55931.
RefSeqNP_035633.1. NM_011503.4.
UniGeneMm.7247.

3D structure databases

ProteinModelPortalQ64324.
SMRQ64324. Positions 5-593.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid203565. 4 interactions.

PTM databases

PhosphoSiteQ64324.

Proteomic databases

MaxQBQ64324.
PaxDbQ64324.
PRIDEQ64324.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000160708; ENSMUSP00000125405; ENSMUSG00000004626.
GeneID20911.
KEGGmmu:20911.
UCSCuc009kse.1. mouse.

Organism-specific databases

CTD6813.
MGIMGI:107370. Stxbp2.

Phylogenomic databases

eggNOGCOG5158.
GeneTreeENSGT00390000005206.
HOVERGENHBG052710.
InParanoidQ64324.
KOK15300.
OrthoDBEOG78PV8M.
PhylomeDBQ64324.
TreeFamTF313242.

Gene expression databases

ArrayExpressQ64324.
BgeeQ64324.
CleanExMM_STXBP2.
GenevestigatorQ64324.

Family and domain databases

Gene3D3.40.50.1910. 2 hits.
InterProIPR027482. Sec-1-like_dom2.
IPR001619. Sec1-like.
[Graphical view]
PANTHERPTHR11679. PTHR11679. 1 hit.
PfamPF00995. Sec1. 1 hit.
[Graphical view]
PIRSFPIRSF005715. VPS45_Sec1. 1 hit.
SUPFAMSSF56815. SSF56815. 1 hit.
ProtoNetSearch...

Other

ChiTaRSSTXBP2. mouse.
NextBio299801.
PROQ64324.
SOURCESearch...

Entry information

Entry nameSTXB2_MOUSE
AccessionPrimary (citable) accession number: Q64324
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot