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Q64324

- STXB2_MOUSE

UniProt

Q64324 - STXB2_MOUSE

Protein

Syntaxin-binding protein 2

Gene

Stxbp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells By similarity.By similarity

    GO - Molecular functioni

    1. syntaxin-1 binding Source: MGI
    2. syntaxin-3 binding Source: MGI
    3. syntaxin binding Source: MGI

    GO - Biological processi

    1. exocytosis Source: MGI
    2. leukocyte mediated cytotoxicity Source: Ensembl
    3. neutrophil degranulation Source: Ensembl
    4. protein transport Source: UniProtKB-KW
    5. vesicle docking involved in exocytosis Source: InterPro

    Keywords - Biological processi

    Exocytosis, Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Syntaxin-binding protein 2
    Alternative name(s):
    MUSEC1
    Protein unc-18 homolog 2
    Short name:
    Munc18-2
    Short name:
    Unc18-2
    Protein unc-18 homolog B
    Short name:
    Unc-18B
    Gene namesi
    Name:Stxbp2
    Synonyms:Unc18b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:107370. Stxbp2.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: MGI
    2. azurophil granule Source: Ensembl
    3. cytolytic granule Source: Ensembl
    4. cytosol Source: Ensembl
    5. extracellular vesicular exosome Source: Ensembl
    6. SNARE complex Source: Ensembl
    7. specific granule Source: Ensembl
    8. tertiary granule Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 593593Syntaxin-binding protein 2PRO_0000206282Add
    BLAST

    Proteomic databases

    MaxQBiQ64324.
    PaxDbiQ64324.
    PRIDEiQ64324.

    PTM databases

    PhosphoSiteiQ64324.

    Expressioni

    Tissue specificityi

    Expressed in testis, intestine, kidney, rat adipose tissue and 3T3-L1 cells.

    Gene expression databases

    ArrayExpressiQ64324.
    BgeeiQ64324.
    CleanExiMM_STXBP2.
    GenevestigatoriQ64324.

    Interactioni

    Subunit structurei

    Interacts with STX1A, STX2 and STX3. Interacts with STX11.By similarity

    Protein-protein interaction databases

    BioGridi203565. 4 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64324.
    SMRiQ64324. Positions 5-593.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the STXBP/unc-18/SEC1 family.Curated

    Phylogenomic databases

    eggNOGiCOG5158.
    GeneTreeiENSGT00390000005206.
    HOVERGENiHBG052710.
    InParanoidiQ64324.
    KOiK15300.
    OrthoDBiEOG78PV8M.
    PhylomeDBiQ64324.
    TreeFamiTF313242.

    Family and domain databases

    Gene3Di3.40.50.1910. 2 hits.
    InterProiIPR027482. Sec-1-like_dom2.
    IPR001619. Sec1-like.
    [Graphical view]
    PANTHERiPTHR11679. PTHR11679. 1 hit.
    PfamiPF00995. Sec1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005715. VPS45_Sec1. 1 hit.
    SUPFAMiSSF56815. SSF56815. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q64324-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPLGLKAVV GEKILSGVIR SVKKDGEWKV LIMDHPSMRI LSSCCKMSDI    50
    LAEGITIVED INKRREPIPS LEAIYLLSPT EKSVQALIAD FQGTPTFTYK 100
    AAHIFFTDTC PEPLFSELGR SRLAKAVKTL KEIHLAFLPY EAQVFSLDAP 150
    HSTYNLYCPF RAGERGRQLD ALAQQIATLC ATLQEYPSIR YRKGPEDTAQ 200
    LAHAVLAKLN AFKADTPSLG EGPEKTRSQL LIMDRAADPV SPLLHELTFQ 250
    AMAYDLLDIE QDTYRYETTG LSESREKAVL LDEDDDLWVE LRHMHIADVS 300
    KKVTELLKTF CESKRLTTDK ANIKDLSHIL KKMPQYQKEL NKYSTHLHLA 350
    DDCMKHFKGS VEKLCSVEQD LAMGSDAEGE KIKDAMKLIV PVLLDASVPP 400
    YDKIRVLLLY ILLRNGVSEE NLAKLIQHAN VQSYSSLIRN LEQLGGTVTN 450
    SAGSGTSSRL ERRERMEPTY QLSRWSPVIK DVMEDVVEDR LDRKLWPFVS 500
    DPAPVPSSQA AVSARFGHWH KNKAGVEARA GPRLIVYIVG GVAMSEMRAA 550
    YEVTRATEGK WEVLIGSSHI LTPTRFLDDL KTLDQKLEGV ALP 593
    Length:593
    Mass (Da):66,357
    Last modified:November 1, 1996 - v1
    Checksum:i1A7735C0566BDC8F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19520 mRNA. Translation: AAA69912.1.
    D42068 mRNA. Translation: BAA07666.1.
    BC008102 mRNA. Translation: AAH08102.1.
    CCDSiCCDS22067.1.
    PIRiA55931.
    RefSeqiNP_035633.1. NM_011503.4.
    UniGeneiMm.7247.

    Genome annotation databases

    EnsembliENSMUST00000160708; ENSMUSP00000125405; ENSMUSG00000004626.
    GeneIDi20911.
    KEGGimmu:20911.
    UCSCiuc009kse.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19520 mRNA. Translation: AAA69912.1 .
    D42068 mRNA. Translation: BAA07666.1 .
    BC008102 mRNA. Translation: AAH08102.1 .
    CCDSi CCDS22067.1.
    PIRi A55931.
    RefSeqi NP_035633.1. NM_011503.4.
    UniGenei Mm.7247.

    3D structure databases

    ProteinModelPortali Q64324.
    SMRi Q64324. Positions 5-593.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203565. 4 interactions.

    PTM databases

    PhosphoSitei Q64324.

    Proteomic databases

    MaxQBi Q64324.
    PaxDbi Q64324.
    PRIDEi Q64324.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000160708 ; ENSMUSP00000125405 ; ENSMUSG00000004626 .
    GeneIDi 20911.
    KEGGi mmu:20911.
    UCSCi uc009kse.1. mouse.

    Organism-specific databases

    CTDi 6813.
    MGIi MGI:107370. Stxbp2.

    Phylogenomic databases

    eggNOGi COG5158.
    GeneTreei ENSGT00390000005206.
    HOVERGENi HBG052710.
    InParanoidi Q64324.
    KOi K15300.
    OrthoDBi EOG78PV8M.
    PhylomeDBi Q64324.
    TreeFami TF313242.

    Miscellaneous databases

    ChiTaRSi STXBP2. mouse.
    NextBioi 299801.
    PROi Q64324.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q64324.
    Bgeei Q64324.
    CleanExi MM_STXBP2.
    Genevestigatori Q64324.

    Family and domain databases

    Gene3Di 3.40.50.1910. 2 hits.
    InterProi IPR027482. Sec-1-like_dom2.
    IPR001619. Sec1-like.
    [Graphical view ]
    PANTHERi PTHR11679. PTHR11679. 1 hit.
    Pfami PF00995. Sec1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005715. VPS45_Sec1. 1 hit.
    SUPFAMi SSF56815. SSF56815. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular identification of two novel Munc-18 isoforms expressed in non-neuronal tissues."
      Tellam J.T., McIntosh S., James D.E.
      J. Biol. Chem. 270:5857-5863(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "A novel isoform of syntaxin-binding protein homologous to yeast Sec1 expressed ubiquitously in mammalian cells."
      Katagiri H., Terasaki J., Murata T., Ishihara H., Ogihara T., Inukai K., Fukushima Y., Anai M., Kikuchi M., Miyazaki J., Yazaki Y., Oka Y.
      J. Biol. Chem. 270:4963-4966(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Pancreatic islet.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiSTXB2_MOUSE
    AccessioniPrimary (citable) accession number: Q64324
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3