Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Syntaxin-binding protein 2

Gene

Stxbp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells (By similarity).By similarity

GO - Molecular functioni

  1. syntaxin-1 binding Source: MGI
  2. syntaxin-3 binding Source: MGI
  3. syntaxin binding Source: MGI

GO - Biological processi

  1. exocytosis Source: MGI
  2. leukocyte mediated cytotoxicity Source: MGI
  3. protein transport Source: UniProtKB-KW
  4. vesicle docking involved in exocytosis Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Exocytosis, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-binding protein 2
Alternative name(s):
MUSEC1
Protein unc-18 homolog 2
Short name:
Munc18-2
Short name:
Unc18-2
Protein unc-18 homolog B
Short name:
Unc-18B
Gene namesi
Name:Stxbp2
Synonyms:Unc18b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:107370. Stxbp2.

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: MGI
  2. azurophil granule Source: MGI
  3. cytolytic granule Source: MGI
  4. cytosol Source: MGI
  5. extracellular vesicular exosome Source: MGI
  6. plasma membrane Source: MGI
  7. specific granule Source: MGI
  8. tertiary granule Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 593593Syntaxin-binding protein 2PRO_0000206282Add
BLAST

Proteomic databases

MaxQBiQ64324.
PaxDbiQ64324.
PRIDEiQ64324.

PTM databases

PhosphoSiteiQ64324.

Expressioni

Tissue specificityi

Expressed in testis, intestine, kidney, rat adipose tissue and 3T3-L1 cells.

Gene expression databases

BgeeiQ64324.
CleanExiMM_STXBP2.
ExpressionAtlasiQ64324. baseline and differential.
GenevestigatoriQ64324.

Interactioni

Subunit structurei

Interacts with STX1A, STX2 and STX3. Interacts with STX11.By similarity

Protein-protein interaction databases

BioGridi203565. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ64324.
SMRiQ64324. Positions 5-593.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the STXBP/unc-18/SEC1 family.Curated

Phylogenomic databases

eggNOGiCOG5158.
GeneTreeiENSGT00390000005206.
HOVERGENiHBG052710.
InParanoidiQ64324.
KOiK15300.
OrthoDBiEOG78PV8M.
PhylomeDBiQ64324.
TreeFamiTF313242.

Family and domain databases

Gene3Di3.40.50.1910. 2 hits.
InterProiIPR027482. Sec-1-like_dom2.
IPR001619. Sec1-like.
[Graphical view]
PANTHERiPTHR11679. PTHR11679. 1 hit.
PfamiPF00995. Sec1. 1 hit.
[Graphical view]
PIRSFiPIRSF005715. VPS45_Sec1. 1 hit.
SUPFAMiSSF56815. SSF56815. 1 hit.

Sequencei

Sequence statusi: Complete.

Q64324-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPLGLKAVV GEKILSGVIR SVKKDGEWKV LIMDHPSMRI LSSCCKMSDI
60 70 80 90 100
LAEGITIVED INKRREPIPS LEAIYLLSPT EKSVQALIAD FQGTPTFTYK
110 120 130 140 150
AAHIFFTDTC PEPLFSELGR SRLAKAVKTL KEIHLAFLPY EAQVFSLDAP
160 170 180 190 200
HSTYNLYCPF RAGERGRQLD ALAQQIATLC ATLQEYPSIR YRKGPEDTAQ
210 220 230 240 250
LAHAVLAKLN AFKADTPSLG EGPEKTRSQL LIMDRAADPV SPLLHELTFQ
260 270 280 290 300
AMAYDLLDIE QDTYRYETTG LSESREKAVL LDEDDDLWVE LRHMHIADVS
310 320 330 340 350
KKVTELLKTF CESKRLTTDK ANIKDLSHIL KKMPQYQKEL NKYSTHLHLA
360 370 380 390 400
DDCMKHFKGS VEKLCSVEQD LAMGSDAEGE KIKDAMKLIV PVLLDASVPP
410 420 430 440 450
YDKIRVLLLY ILLRNGVSEE NLAKLIQHAN VQSYSSLIRN LEQLGGTVTN
460 470 480 490 500
SAGSGTSSRL ERRERMEPTY QLSRWSPVIK DVMEDVVEDR LDRKLWPFVS
510 520 530 540 550
DPAPVPSSQA AVSARFGHWH KNKAGVEARA GPRLIVYIVG GVAMSEMRAA
560 570 580 590
YEVTRATEGK WEVLIGSSHI LTPTRFLDDL KTLDQKLEGV ALP
Length:593
Mass (Da):66,357
Last modified:November 1, 1996 - v1
Checksum:i1A7735C0566BDC8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19520 mRNA. Translation: AAA69912.1.
D42068 mRNA. Translation: BAA07666.1.
BC008102 mRNA. Translation: AAH08102.1.
CCDSiCCDS22067.1.
PIRiA55931.
RefSeqiNP_035633.1. NM_011503.4.
UniGeneiMm.7247.

Genome annotation databases

EnsembliENSMUST00000160708; ENSMUSP00000125405; ENSMUSG00000004626.
GeneIDi20911.
KEGGimmu:20911.
UCSCiuc009kse.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19520 mRNA. Translation: AAA69912.1.
D42068 mRNA. Translation: BAA07666.1.
BC008102 mRNA. Translation: AAH08102.1.
CCDSiCCDS22067.1.
PIRiA55931.
RefSeqiNP_035633.1. NM_011503.4.
UniGeneiMm.7247.

3D structure databases

ProteinModelPortaliQ64324.
SMRiQ64324. Positions 5-593.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203565. 4 interactions.

PTM databases

PhosphoSiteiQ64324.

Proteomic databases

MaxQBiQ64324.
PaxDbiQ64324.
PRIDEiQ64324.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000160708; ENSMUSP00000125405; ENSMUSG00000004626.
GeneIDi20911.
KEGGimmu:20911.
UCSCiuc009kse.1. mouse.

Organism-specific databases

CTDi6813.
MGIiMGI:107370. Stxbp2.

Phylogenomic databases

eggNOGiCOG5158.
GeneTreeiENSGT00390000005206.
HOVERGENiHBG052710.
InParanoidiQ64324.
KOiK15300.
OrthoDBiEOG78PV8M.
PhylomeDBiQ64324.
TreeFamiTF313242.

Miscellaneous databases

ChiTaRSiStxbp2. mouse.
NextBioi299801.
PROiQ64324.
SOURCEiSearch...

Gene expression databases

BgeeiQ64324.
CleanExiMM_STXBP2.
ExpressionAtlasiQ64324. baseline and differential.
GenevestigatoriQ64324.

Family and domain databases

Gene3Di3.40.50.1910. 2 hits.
InterProiIPR027482. Sec-1-like_dom2.
IPR001619. Sec1-like.
[Graphical view]
PANTHERiPTHR11679. PTHR11679. 1 hit.
PfamiPF00995. Sec1. 1 hit.
[Graphical view]
PIRSFiPIRSF005715. VPS45_Sec1. 1 hit.
SUPFAMiSSF56815. SSF56815. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular identification of two novel Munc-18 isoforms expressed in non-neuronal tissues."
    Tellam J.T., McIntosh S., James D.E.
    J. Biol. Chem. 270:5857-5863(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "A novel isoform of syntaxin-binding protein homologous to yeast Sec1 expressed ubiquitously in mammalian cells."
    Katagiri H., Terasaki J., Murata T., Ishihara H., Ogihara T., Inukai K., Fukushima Y., Anai M., Kikuchi M., Miyazaki J., Yazaki Y., Oka Y.
    J. Biol. Chem. 270:4963-4966(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Pancreatic islet.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiSTXB2_MOUSE
AccessioniPrimary (citable) accession number: Q64324
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: March 4, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.