Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neutral and basic amino acid transport protein rBAT

Gene

Slc3a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the high-affinity sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). May function as an activator of SLC7A9 and be involved in the high-affinity reabsorption of cystine in the kidney proximal tubule.2 Publications

GO - Molecular functioni

  • catalytic activity Source: InterPro
  • protein heterodimerization activity Source: RGD

GO - Biological processi

  • amino acid transport Source: RGD
  • carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-352230. Amino acid transport across the plasma membrane.

Protein family/group databases

CAZyiGH13. Glycoside Hydrolase Family 13.

Names & Taxonomyi

Protein namesi
Recommended name:
Neutral and basic amino acid transport protein rBAT
Alternative name(s):
D2
Solute carrier family 3 member 1
b(0,+)-type amino acid transport protein
Short name:
NAA-TR
Gene namesi
Name:Slc3a1
Synonyms:Nbat
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi3709. Slc3a1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 86CytoplasmicSequence analysisAdd BLAST86
Transmembranei87 – 107Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini108 – 683ExtracellularSequence analysisAdd BLAST576

GO - Cellular componenti

  • brush border membrane Source: Ensembl
  • extracellular exosome Source: Ensembl
  • integral component of plasma membrane Source: RGD
  • mitochondrial inner membrane Source: Ensembl
  • plasma membrane Source: RGD
  • vacuolar membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000719511 – 683Neutral and basic amino acid transport protein rBATAdd BLAST683

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineCombined sources1
Glycosylationi211N-linked (GlcNAc...)Sequence analysis1
Glycosylationi238N-linked (GlcNAc...)Sequence analysis1
Glycosylationi258N-linked (GlcNAc...)Sequence analysis1
Glycosylationi329N-linked (GlcNAc...)Sequence analysis1
Modified residuei383PhosphoserineCombined sources1
Glycosylationi510N-linked (GlcNAc...)Sequence analysis1
Glycosylationi520N-linked (GlcNAc...)Sequence analysis1
Glycosylationi574N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ64319.
PRIDEiQ64319.

PTM databases

iPTMnetiQ64319.
PhosphoSitePlusiQ64319.

Expressioni

Tissue specificityi

Predominantly expressed in kidney and intestine. In kidney localized to the apical membrane of the proximal tubules.3 Publications

Gene expression databases

BgeeiENSRNOG00000007006.
GenevisibleiQ64319. RN.

Interactioni

Subunit structurei

Disulfide-linked heterodimer with the amino acid transporter SLC7A9.1 Publication

GO - Molecular functioni

  • protein heterodimerization activity Source: RGD

Protein-protein interaction databases

MINTiMINT-4997373.
STRINGi10116.ENSRNOP00000009581.

Structurei

3D structure databases

ProteinModelPortaliQ64319.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0471. Eukaryota.
COG0366. LUCA.
GeneTreeiENSGT00860000133838.
HOGENOMiHOG000220640.
HOVERGENiHBG053002.
InParanoidiQ64319.
KOiK14210.
OMAiEYATDPR.
OrthoDBiEOG091G03FE.
PhylomeDBiQ64319.
TreeFamiTF314498.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR015902. Glyco_hydro_13.
IPR006047. Glyco_hydro_13_cat_dom.
IPR013780. Glyco_hydro_b.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 2 hits.
PfamiPF00128. Alpha-amylase. 1 hit.
[Graphical view]
SMARTiSM00642. Aamy. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Q64319-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEDKDKRDS IQMSMKGCRT NNGFVQNEDI QEQDPDSRDT PQSNAVSIPA
60 70 80 90 100
PEEPQLKVVR PYAGMPKEVL FQFSGQARYR VPREILFWLT VVSVFLLIGA
110 120 130 140 150
TIAIIIISPK CLDWWQAGPM YQIYPRSFKD SDKDGNGDLK GIQEKLDYIT
160 170 180 190 200
ALNIKTIWIT SFYKSPLKDF RYAVEDFKEI DPIFGTMKDF ENLVAAVHDK
210 220 230 240 250
GLKLIIDFIP NHTSDKHPWF QSSRTRSGKY TDYYIWHNCT HANGVTTPPN
260 270 280 290 300
NWLSVYGNSS WQFDEERKQC YFHQFLKEQP DLNFRNPAVQ EEIKEIIKFW
310 320 330 340 350
LSKGVDGFSF DAVKFLLEAK DLRNEIQVNT SQIPDTVTRY SELYHDFTTT
360 370 380 390 400
QVGMHDLVRD FRQTMNQFSR EPGRYRFMGT EVSAESTERT MVYYGLSFIQ
410 420 430 440 450
EADFPFNKYL ATLDTLSGHT VYEAITSWME NMPEGKWPNW MIGGPETSRL
460 470 480 490 500
TSRVGSEYVN AMNMLLFTLP GTPITYYGEE IGMGDISITN LNERYDTNAL
510 520 530 540 550
LSKSPMQWDN SSNAGFTEAN HTWLPTNSDY HTVNVDVQKT QPSSALRLYQ
560 570 580 590 600
DLSLLHAREL LLSRGWFCLL RDDNHSVVYT RELDGIDKVF LVVLNFGESS
610 620 630 640 650
TVLNLQETIS DVPTKLRIRL STNPASKGSD VDTHAVSLEK GEGLILEHSM
660 670 680
KTLLHHQKAF RDKCFISNRA CYSSVLDLLY SSC
Length:683
Mass (Da):78,507
Last modified:November 1, 1996 - v1
Checksum:i201C1F2A2F404311
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80804 mRNA. Translation: AAA73144.1.
M77345 mRNA. Translation: AAA41544.1.
BC078852 mRNA. Translation: AAH78852.1.
U10110 Unassigned DNA. Translation: AAA20394.1.
PIRiA41785.
RefSeqiNP_058912.1. NM_017216.1.
UniGeneiRn.11196.

Genome annotation databases

EnsembliENSRNOT00000009581; ENSRNOP00000009581; ENSRNOG00000007006.
GeneIDi29484.
KEGGirno:29484.
UCSCiRGD:3709. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80804 mRNA. Translation: AAA73144.1.
M77345 mRNA. Translation: AAA41544.1.
BC078852 mRNA. Translation: AAH78852.1.
U10110 Unassigned DNA. Translation: AAA20394.1.
PIRiA41785.
RefSeqiNP_058912.1. NM_017216.1.
UniGeneiRn.11196.

3D structure databases

ProteinModelPortaliQ64319.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4997373.
STRINGi10116.ENSRNOP00000009581.

Protein family/group databases

CAZyiGH13. Glycoside Hydrolase Family 13.

PTM databases

iPTMnetiQ64319.
PhosphoSitePlusiQ64319.

Proteomic databases

PaxDbiQ64319.
PRIDEiQ64319.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009581; ENSRNOP00000009581; ENSRNOG00000007006.
GeneIDi29484.
KEGGirno:29484.
UCSCiRGD:3709. rat.

Organism-specific databases

CTDi6519.
RGDi3709. Slc3a1.

Phylogenomic databases

eggNOGiKOG0471. Eukaryota.
COG0366. LUCA.
GeneTreeiENSGT00860000133838.
HOGENOMiHOG000220640.
HOVERGENiHBG053002.
InParanoidiQ64319.
KOiK14210.
OMAiEYATDPR.
OrthoDBiEOG091G03FE.
PhylomeDBiQ64319.
TreeFamiTF314498.

Enzyme and pathway databases

ReactomeiR-RNO-352230. Amino acid transport across the plasma membrane.

Miscellaneous databases

PROiQ64319.

Gene expression databases

BgeeiENSRNOG00000007006.
GenevisibleiQ64319. RN.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR015902. Glyco_hydro_13.
IPR006047. Glyco_hydro_13_cat_dom.
IPR013780. Glyco_hydro_b.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 2 hits.
PfamiPF00128. Alpha-amylase. 1 hit.
[Graphical view]
SMARTiSM00642. Aamy. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSLC31_RAT
AccessioniPrimary (citable) accession number: Q64319
Secondary accession number(s): Q62672
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.