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Protein

Homeobox protein DLX-1

Gene

Dlx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi128 – 18760HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. DNA binding Source: MGI
  3. RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
  4. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: NTNU_SB

GO - Biological processi

  1. cell differentiation Source: MGI
  2. cerebral cortex GABAergic interneuron differentiation Source: MGI
  3. cerebral cortex GABAergic interneuron fate commitment Source: MGI
  4. embryonic skeletal system development Source: MGI
  5. forebrain neuron differentiation Source: MGI
  6. hippocampus development Source: MGI
  7. negative regulation of neuron apoptotic process Source: MGI
  8. negative regulation of Notch signaling pathway Source: MGI
  9. negative regulation of oligodendrocyte differentiation Source: MGI
  10. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  11. odontogenesis of dentin-containing tooth Source: MGI
  12. proximal/distal pattern formation Source: MGI
  13. regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  14. regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment Source: MGI
  15. subpallium development Source: MGI
  16. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein DLX-1
Gene namesi
Name:Dlx1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:94901. Dlx1.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 255255Homeobox protein DLX-1PRO_0000049021Add
BLAST

Proteomic databases

PRIDEiQ64317.

Expressioni

Tissue specificityi

Expressed in a restricted region of the developing brain, within the diencephalon and the adjacent telencephalic regions.

Developmental stagei

Has a segmental expression in the developing forebrain.

Gene expression databases

BgeeiQ64317.
CleanExiMM_DLX1.
ExpressionAtlasiQ64317. baseline and differential.
GenevestigatoriQ64317.

Interactioni

Protein-protein interaction databases

BioGridi199234. 10 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ64317.
SMRiQ64317. Positions 125-185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the distal-less homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG263092.
GeneTreeiENSGT00780000121835.
HOGENOMiHOG000231941.
HOVERGENiHBG005493.
InParanoidiQ64317.
KOiK09314.
OMAiSMSHGHY.
OrthoDBiEOG70W3F8.
PhylomeDBiQ64317.
TreeFamiTF315720.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64317-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMTTMPESL NSPVSGKAVF MEFGPPNQQM SPSPMSHGHY SMHCLHSAGH
60 70 80 90 100
SQPDGAYSSA SSFSRPLGYP YVNSVSSHAS SPYISSVQSY PGSASLAQSR
110 120 130 140 150
LEDPGADSEK STVVEGGEVR FNGKGKKIRK PRTIYSSLQL QALNRRFQQT
160 170 180 190 200
QYLALPERAE LAASLGLTQT QVKIWFQNKR SKFKKLMKQG GAALEGSALA
210 220 230 240 250
NGRALSAGSP PVPPGWNPNS SSGKGSGSSA GSYVPSYTSW YPSAHQEAMQ

QPQLM
Length:255
Mass (Da):27,309
Last modified:November 1, 1996 - v1
Checksum:i99B474F5D3FD8B6D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti98 – 1036QSRLED → PEPPGG (PubMed:1676488).Curated
Sequence conflicti123 – 1231G → GQ (PubMed:1676488).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51001 mRNA. Translation: AAB40900.1.
U51000 Genomic DNA. Translation: AAB40899.1.
BC079609 mRNA. Translation: AAH79609.1.
X57552 Genomic DNA. Translation: CAB37647.1.
CCDSiCCDS16116.1.
RefSeqiNP_034183.1. NM_010053.1.
XP_006498734.1. XM_006498671.1.
XP_006498735.1. XM_006498672.1.
XP_006498736.1. XM_006498673.1.
UniGeneiMm.4543.
Mm.475101.

Genome annotation databases

EnsembliENSMUST00000037119; ENSMUSP00000042413; ENSMUSG00000041911.
GeneIDi13390.
KEGGimmu:13390.
UCSCiuc008kau.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51001 mRNA. Translation: AAB40900.1.
U51000 Genomic DNA. Translation: AAB40899.1.
BC079609 mRNA. Translation: AAH79609.1.
X57552 Genomic DNA. Translation: CAB37647.1.
CCDSiCCDS16116.1.
RefSeqiNP_034183.1. NM_010053.1.
XP_006498734.1. XM_006498671.1.
XP_006498735.1. XM_006498672.1.
XP_006498736.1. XM_006498673.1.
UniGeneiMm.4543.
Mm.475101.

3D structure databases

ProteinModelPortaliQ64317.
SMRiQ64317. Positions 125-185.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199234. 10 interactions.

Proteomic databases

PRIDEiQ64317.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037119; ENSMUSP00000042413; ENSMUSG00000041911.
GeneIDi13390.
KEGGimmu:13390.
UCSCiuc008kau.1. mouse.

Organism-specific databases

CTDi1745.
MGIiMGI:94901. Dlx1.

Phylogenomic databases

eggNOGiNOG263092.
GeneTreeiENSGT00780000121835.
HOGENOMiHOG000231941.
HOVERGENiHBG005493.
InParanoidiQ64317.
KOiK09314.
OMAiSMSHGHY.
OrthoDBiEOG70W3F8.
PhylomeDBiQ64317.
TreeFamiTF315720.

Miscellaneous databases

NextBioi283756.
PROiQ64317.
SOURCEiSearch...

Gene expression databases

BgeeiQ64317.
CleanExiMM_DLX1.
ExpressionAtlasiQ64317. baseline and differential.
GenevestigatoriQ64317.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence, organization, and transcription of the Dlx-1 and Dlx-2 locus."
    McGuinness T., Porteus M.H., Smiga S., Bulfone A., Kingsley C., Qiu M., Liu J.K., Long J.E., Xu D., Rubenstein J.L.R.
    Genomics 35:473-485(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: 129.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. "A mouse gene related to Distal-less shows a restricted expression in the developing forebrain."
    Price M., Lemaistre M., Pischetola M., di Lauro R., Duboule D.
    Nature 351:748-751(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 98-255.
    Tissue: Brain.

Entry informationi

Entry nameiDLX1_MOUSE
AccessioniPrimary (citable) accession number: Q64317
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: February 4, 2015
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.