Q64317 (DLX1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein DLX-1

Gene names

Name:

Dlx1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions.
Subcellular location	Nucleus Potential.
Tissue specificity	Expressed in a restricted region of the developing brain, within the diencephalon and the adjacent telencephalic regions.
Developmental stage	Has a segmental expression in the developing forebrain.
Sequence similarities	Belongs to the distal-less homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cerebral cortex GABAergic interneuron fate commitment Inferred from genetic interaction PubMed 17678855. Source: MGI embryonic skeletal system development Inferred from mutant phenotype PubMed 9187081. Source: MGI hippocampus development Inferred from genetic interaction PubMed 11163262. Source: MGI negative regulation of neuron apoptotic process Inferred from mutant phenotype PubMed 16007083. Source: MGI negative regulation of oligodendrocyte differentiation Inferred from genetic interaction PubMed 17678855. Source: MGI negative regulation of transcription from RNA polymerase II promoter Inferred from genetic interaction PubMed 17678855. Source: MGI odontogenesis of dentin-containing tooth Inferred from genetic interaction PubMed 9187081. Source: MGI proximal/distal pattern formation Inferred from mutant phenotype PubMed 9187081. Source: MGI regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment Inferred from genetic interaction PubMed 17678855. Source: MGI
Cellular_component	nucleus Inferred from direct assay PubMed 10516593PubMed 12397111PubMed 12724837. Source: MGI
Molecular_function	DNA binding Inferred from direct assay PubMed 14769946PubMed 9415433. Source: MGI chromatin binding Inferred from direct assay PubMed 14769946. Source: MGI sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro transcription regulatory region sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	Homeobox protein DLX-1		PRO_0000049021
Regions
	DNA binding	128 – 187	60	Homeobox
Experimental info
	Sequence conflict	98 – 103	6	QSRLED → PEPPGG Ref.3
	Sequence conflict	123	1	G → GQ Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q64317 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 99B474F5D3FD8B6D	FASTA	255	27,309
	10 20 30 40 50 60 MTMTTMPESL NSPVSGKAVF MEFGPPNQQM SPSPMSHGHY SMHCLHSAGH SQPDGAYSSA 70 80 90 100 110 120 SSFSRPLGYP YVNSVSSHAS SPYISSVQSY PGSASLAQSR LEDPGADSEK STVVEGGEVR 130 140 150 160 170 180 FNGKGKKIRK PRTIYSSLQL QALNRRFQQT QYLALPERAE LAASLGLTQT QVKIWFQNKR 190 200 210 220 230 240 SKFKKLMKQG GAALEGSALA NGRALSAGSP PVPPGWNPNS SSGKGSGSSA GSYVPSYTSW 250 YPSAHQEAMQ QPQLM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence, organization, and transcription of the Dlx-1 and Dlx-2 locus." McGuinness T., Porteus M.H., Smiga S., Bulfone A., Kingsley C., Qiu M., Liu J.K., Long J.E., Xu D., Rubenstein J.L.R. Genomics 35:473-485(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Strain: 129.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Brain.
[3]	"A mouse gene related to Distal-less shows a restricted expression in the developing forebrain." Price M., Lemaistre M., Pischetola M., di Lauro R., Duboule D. Nature 351:748-751(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 98-255. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U51001 mRNA. Translation: AAB40900.1. U51000 Genomic DNA. Translation: AAB40899.1. BC079609 mRNA. Translation: AAH79609.1. X57552 Genomic DNA. Translation: CAB37647.1.
IPI	IPI00133259.
RefSeq	NP_034183.1. NM_010053.1.
UniGene	Mm.4543. Mm.475101.
3D structure databases
ProteinModelPortal	Q64317.
SMR	Q64317. Positions 125-185.
ModBase	Search...
Proteomic databases
PRIDE	Q64317.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000037119; ENSMUSP00000042413; ENSMUSG00000041911.
GeneID	13390.
KEGG	mmu:13390.
Organism-specific databases
CTD	1745.
MGI	MGI:94901. Dlx1.
Phylogenomic databases
eggNOG	NOG263092.
GeneTree	ENSGT00700000104129.
HOGENOM	HOG000231941.
HOVERGEN	HBG005493.
InParanoid	Q64317.
KO	K09314.
OMA	MQQSQLM.
OrthoDB	EOG4M0F2M.
Gene expression databases
ArrayExpress	Q64317.
Bgee	Q64317.
CleanEx	MM_DLX1.
Genevestigator	Q64317.
GermOnline	ENSMUSG00000041911. Mus musculus.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. IPR000047. HTH_motif. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX. PR00031. HTHREPRESSR.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	283756.
SOURCE	Search...

Entry information

Entry name

DLX1_MOUSE

Accession

Primary (citable) accession number: Q64317

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 103 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program