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Q64317 (DLX1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein DLX-1
Gene names
Name:Dlx1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length255 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions.

Subcellular location

Nucleus Potential.

Tissue specificity

Expressed in a restricted region of the developing brain, within the diencephalon and the adjacent telencephalic regions.

Developmental stage

Has a segmental expression in the developing forebrain.

Sequence similarities

Belongs to the distal-less homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell differentiation

Inferred from mutant phenotype PubMed 12397111. Source: MGI

cerebral cortex GABAergic interneuron differentiation

Inferred from genetic interaction PubMed 15028753. Source: MGI

cerebral cortex GABAergic interneuron fate commitment

Inferred from genetic interaction PubMed 17678855. Source: MGI

embryonic skeletal system development

Inferred from mutant phenotype PubMed 9187081. Source: MGI

forebrain neuron differentiation

Inferred from genetic interaction PubMed 11163262. Source: MGI

hippocampus development

Inferred from genetic interaction PubMed 11163262. Source: MGI

negative regulation of Notch signaling pathway

Inferred from genetic interaction PubMed 23042297. Source: MGI

negative regulation of neuron apoptotic process

Inferred from mutant phenotype PubMed 16007083. Source: MGI

negative regulation of oligodendrocyte differentiation

Inferred from genetic interaction PubMed 17678855PubMed 23042297. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from genetic interaction PubMed 17678855. Source: MGI

odontogenesis of dentin-containing tooth

Inferred from genetic interaction PubMed 9187081. Source: MGI

proximal/distal pattern formation

Inferred from mutant phenotype PubMed 9187081. Source: MGI

regulation of transcription from RNA polymerase II promoter

Inferred from genetic interaction PubMed 22920256. Source: MGI

regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment

Inferred from genetic interaction PubMed 17678855. Source: MGI

subpallium development

Inferred from genetic interaction PubMed 23042297. Source: MGI

   Cellular_componentnucleus

Inferred from direct assay PubMed 10516593PubMed 12397111PubMed 12724837. Source: MGI

   Molecular_functionDNA binding

Inferred from direct assay PubMed 14769946PubMed 9415433. Source: MGI

chromatin binding

Inferred from direct assay PubMed 14769946. Source: MGI

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

transcription regulatory region sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 255255Homeobox protein DLX-1
PRO_0000049021

Regions

DNA binding128 – 18760Homeobox

Experimental info

Sequence conflict98 – 1036QSRLED → PEPPGG Ref.3
Sequence conflict1231G → GQ Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q64317 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 99B474F5D3FD8B6D

FASTA25527,309
        10         20         30         40         50         60 
MTMTTMPESL NSPVSGKAVF MEFGPPNQQM SPSPMSHGHY SMHCLHSAGH SQPDGAYSSA 

        70         80         90        100        110        120 
SSFSRPLGYP YVNSVSSHAS SPYISSVQSY PGSASLAQSR LEDPGADSEK STVVEGGEVR 

       130        140        150        160        170        180 
FNGKGKKIRK PRTIYSSLQL QALNRRFQQT QYLALPERAE LAASLGLTQT QVKIWFQNKR 

       190        200        210        220        230        240 
SKFKKLMKQG GAALEGSALA NGRALSAGSP PVPPGWNPNS SSGKGSGSSA GSYVPSYTSW 

       250 
YPSAHQEAMQ QPQLM 

« Hide

References

« Hide 'large scale' references
[1]"Sequence, organization, and transcription of the Dlx-1 and Dlx-2 locus."
McGuinness T., Porteus M.H., Smiga S., Bulfone A., Kingsley C., Qiu M., Liu J.K., Long J.E., Xu D., Rubenstein J.L.R.
Genomics 35:473-485(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: 129.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[3]"A mouse gene related to Distal-less shows a restricted expression in the developing forebrain."
Price M., Lemaistre M., Pischetola M., di Lauro R., Duboule D.
Nature 351:748-751(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 98-255.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U51001 mRNA. Translation: AAB40900.1.
U51000 Genomic DNA. Translation: AAB40899.1.
BC079609 mRNA. Translation: AAH79609.1.
X57552 Genomic DNA. Translation: CAB37647.1.
CCDSCCDS16116.1.
RefSeqNP_034183.1. NM_010053.1.
XP_006498734.1. XM_006498671.1.
XP_006498735.1. XM_006498672.1.
XP_006498736.1. XM_006498673.1.
UniGeneMm.4543.
Mm.475101.

3D structure databases

ProteinModelPortalQ64317.
SMRQ64317. Positions 125-185.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid199234. 10 interactions.

Proteomic databases

PRIDEQ64317.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000037119; ENSMUSP00000042413; ENSMUSG00000041911.
GeneID13390.
KEGGmmu:13390.
UCSCuc008kau.1. mouse.

Organism-specific databases

CTD1745.
MGIMGI:94901. Dlx1.

Phylogenomic databases

eggNOGNOG263092.
GeneTreeENSGT00720000108450.
HOGENOMHOG000231941.
HOVERGENHBG005493.
InParanoidQ64317.
KOK09314.
OMAMQQSQLM.
OrthoDBEOG70W3F8.
PhylomeDBQ64317.
TreeFamTF315720.

Gene expression databases

BgeeQ64317.
CleanExMM_DLX1.
GenevestigatorQ64317.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio283756.
PROQ64317.
SOURCESearch...

Entry information

Entry nameDLX1_MOUSE
AccessionPrimary (citable) accession number: Q64317
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot