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Q64317

- DLX1_MOUSE

UniProt

Q64317 - DLX1_MOUSE

Protein

Homeobox protein DLX-1

Gene

Dlx1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi128 – 18760HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. DNA binding Source: MGI
    3. sequence-specific DNA binding transcription factor activity Source: InterPro
    4. transcription regulatory region sequence-specific DNA binding Source: InterPro

    GO - Biological processi

    1. cell differentiation Source: MGI
    2. cerebral cortex GABAergic interneuron differentiation Source: MGI
    3. cerebral cortex GABAergic interneuron fate commitment Source: MGI
    4. embryonic skeletal system development Source: MGI
    5. forebrain neuron differentiation Source: MGI
    6. hippocampus development Source: MGI
    7. negative regulation of neuron apoptotic process Source: MGI
    8. negative regulation of Notch signaling pathway Source: MGI
    9. negative regulation of oligodendrocyte differentiation Source: MGI
    10. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    11. odontogenesis of dentin-containing tooth Source: MGI
    12. proximal/distal pattern formation Source: MGI
    13. regulation of transcription from RNA polymerase II promoter Source: MGI
    14. regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment Source: MGI
    15. subpallium development Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein DLX-1
    Gene namesi
    Name:Dlx1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:94901. Dlx1.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 255255Homeobox protein DLX-1PRO_0000049021Add
    BLAST

    Proteomic databases

    PRIDEiQ64317.

    Expressioni

    Tissue specificityi

    Expressed in a restricted region of the developing brain, within the diencephalon and the adjacent telencephalic regions.

    Developmental stagei

    Has a segmental expression in the developing forebrain.

    Gene expression databases

    BgeeiQ64317.
    CleanExiMM_DLX1.
    GenevestigatoriQ64317.

    Interactioni

    Protein-protein interaction databases

    BioGridi199234. 10 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64317.
    SMRiQ64317. Positions 125-185.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the distal-less homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG263092.
    GeneTreeiENSGT00720000108450.
    HOGENOMiHOG000231941.
    HOVERGENiHBG005493.
    InParanoidiQ64317.
    KOiK09314.
    OMAiMQQSQLM.
    OrthoDBiEOG70W3F8.
    PhylomeDBiQ64317.
    TreeFamiTF315720.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q64317-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTMTTMPESL NSPVSGKAVF MEFGPPNQQM SPSPMSHGHY SMHCLHSAGH    50
    SQPDGAYSSA SSFSRPLGYP YVNSVSSHAS SPYISSVQSY PGSASLAQSR 100
    LEDPGADSEK STVVEGGEVR FNGKGKKIRK PRTIYSSLQL QALNRRFQQT 150
    QYLALPERAE LAASLGLTQT QVKIWFQNKR SKFKKLMKQG GAALEGSALA 200
    NGRALSAGSP PVPPGWNPNS SSGKGSGSSA GSYVPSYTSW YPSAHQEAMQ 250
    QPQLM 255
    Length:255
    Mass (Da):27,309
    Last modified:November 1, 1996 - v1
    Checksum:i99B474F5D3FD8B6D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti98 – 1036QSRLED → PEPPGG(PubMed:1676488)Curated
    Sequence conflicti123 – 1231G → GQ(PubMed:1676488)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U51001 mRNA. Translation: AAB40900.1.
    U51000 Genomic DNA. Translation: AAB40899.1.
    BC079609 mRNA. Translation: AAH79609.1.
    X57552 Genomic DNA. Translation: CAB37647.1.
    CCDSiCCDS16116.1.
    RefSeqiNP_034183.1. NM_010053.1.
    XP_006498734.1. XM_006498671.1.
    XP_006498735.1. XM_006498672.1.
    XP_006498736.1. XM_006498673.1.
    UniGeneiMm.4543.
    Mm.475101.

    Genome annotation databases

    EnsembliENSMUST00000037119; ENSMUSP00000042413; ENSMUSG00000041911.
    GeneIDi13390.
    KEGGimmu:13390.
    UCSCiuc008kau.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U51001 mRNA. Translation: AAB40900.1 .
    U51000 Genomic DNA. Translation: AAB40899.1 .
    BC079609 mRNA. Translation: AAH79609.1 .
    X57552 Genomic DNA. Translation: CAB37647.1 .
    CCDSi CCDS16116.1.
    RefSeqi NP_034183.1. NM_010053.1.
    XP_006498734.1. XM_006498671.1.
    XP_006498735.1. XM_006498672.1.
    XP_006498736.1. XM_006498673.1.
    UniGenei Mm.4543.
    Mm.475101.

    3D structure databases

    ProteinModelPortali Q64317.
    SMRi Q64317. Positions 125-185.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199234. 10 interactions.

    Proteomic databases

    PRIDEi Q64317.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000037119 ; ENSMUSP00000042413 ; ENSMUSG00000041911 .
    GeneIDi 13390.
    KEGGi mmu:13390.
    UCSCi uc008kau.1. mouse.

    Organism-specific databases

    CTDi 1745.
    MGIi MGI:94901. Dlx1.

    Phylogenomic databases

    eggNOGi NOG263092.
    GeneTreei ENSGT00720000108450.
    HOGENOMi HOG000231941.
    HOVERGENi HBG005493.
    InParanoidi Q64317.
    KOi K09314.
    OMAi MQQSQLM.
    OrthoDBi EOG70W3F8.
    PhylomeDBi Q64317.
    TreeFami TF315720.

    Miscellaneous databases

    NextBioi 283756.
    PROi Q64317.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q64317.
    CleanExi MM_DLX1.
    Genevestigatori Q64317.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence, organization, and transcription of the Dlx-1 and Dlx-2 locus."
      McGuinness T., Porteus M.H., Smiga S., Bulfone A., Kingsley C., Qiu M., Liu J.K., Long J.E., Xu D., Rubenstein J.L.R.
      Genomics 35:473-485(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: 129.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    3. "A mouse gene related to Distal-less shows a restricted expression in the developing forebrain."
      Price M., Lemaistre M., Pischetola M., di Lauro R., Duboule D.
      Nature 351:748-751(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 98-255.
      Tissue: Brain.

    Entry informationi

    Entry nameiDLX1_MOUSE
    AccessioniPrimary (citable) accession number: Q64317
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3