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Protein

Homeobox protein DLX-1

Gene

Dlx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role as a transcriptional activator or repressor (PubMed:21875655). Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation (By similarity). Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina (PubMed:21875655). Likely to play a regulatory role in the development of the ventral forebrain (PubMed:1676488). May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (PubMed:1676488).By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi128 – 187HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • chromatin binding Source: MGI
  • DNA binding Source: MGI
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

  • cell differentiation Source: MGI
  • cellular response to BMP stimulus Source: UniProtKB
  • cellular response to transforming growth factor beta stimulus Source: UniProtKB
  • cerebral cortex GABAergic interneuron differentiation Source: MGI
  • cerebral cortex GABAergic interneuron fate commitment Source: MGI
  • embryonic skeletal system development Source: MGI
  • forebrain neuron differentiation Source: MGI
  • hippocampus development Source: MGI
  • negative regulation of BMP signaling pathway Source: UniProtKB
  • negative regulation of cellular response to transforming growth factor beta stimulus Source: UniProtKB
  • negative regulation of neuron apoptotic process Source: MGI
  • negative regulation of Notch signaling pathway Source: MGI
  • negative regulation of oligodendrocyte differentiation Source: MGI
  • negative regulation of photoreceptor cell differentiation Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • odontogenesis of dentin-containing tooth Source: MGI
  • positive regulation of amacrine cell differentiation Source: UniProtKB
  • positive regulation of cell differentiation Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • proximal/distal pattern formation Source: MGI
  • regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment Source: MGI
  • subpallium development Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding, Repressor
Biological processDifferentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein DLX-1
Gene namesi
Name:Dlx1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:94901. Dlx1.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

  • nucleus Source: MGI

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000490211 – 255Homeobox protein DLX-1Add BLAST255

Proteomic databases

PaxDbiQ64317.
PeptideAtlasiQ64317.
PRIDEiQ64317.

PTM databases

PhosphoSitePlusiQ64317.

Expressioni

Tissue specificityi

Expressed in a restricted region of the developing brain, within the diencephalon and the adjacent telencephalic regions.1 Publication

Developmental stagei

Expressed in developing retinal progenitor cells at 12 dpc (PubMed:21875655). Has a segmental expression in the developing forebrain (PubMed:1676488).2 Publications

Gene expression databases

BgeeiENSMUSG00000041911.
CleanExiMM_DLX1.
ExpressionAtlasiQ64317. baseline and differential.
GenevisibleiQ64317. MM.

Interactioni

Subunit structurei

Interacts with SMAD4 (via homeobox DNA-binding domain) (By similarity). Interacts (via homeobox DNA-binding domain) with POU4F2; this interaction suppresses DLX1-mediated transcriptional activity in postnatal retina and enhances retinal ganglion cell (RGC) differentiation (PubMed:21875655).By similarity1 Publication

Protein-protein interaction databases

BioGridi199234. 10 interactors.
STRINGi10090.ENSMUSP00000042413.

Structurei

3D structure databases

ProteinModelPortaliQ64317.
SMRiQ64317.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The homeobox DNA-binding domain is necessary for its nuclear localization, transcriptional and erythroid differentiation activities.By similarity

Sequence similaritiesi

Belongs to the distal-less homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0850. Eukaryota.
ENOG410ZHZR. LUCA.
GeneTreeiENSGT00880000137844.
HOGENOMiHOG000231941.
HOVERGENiHBG005493.
InParanoidiQ64317.
KOiK09314.
OMAiEMTMTTI.
OrthoDBiEOG091G0P17.
PhylomeDBiQ64317.
TreeFamiTF315720.

Family and domain databases

InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR000047. HTH_motif.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q64317-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMTTMPESL NSPVSGKAVF MEFGPPNQQM SPSPMSHGHY SMHCLHSAGH
60 70 80 90 100
SQPDGAYSSA SSFSRPLGYP YVNSVSSHAS SPYISSVQSY PGSASLAQSR
110 120 130 140 150
LEDPGADSEK STVVEGGEVR FNGKGKKIRK PRTIYSSLQL QALNRRFQQT
160 170 180 190 200
QYLALPERAE LAASLGLTQT QVKIWFQNKR SKFKKLMKQG GAALEGSALA
210 220 230 240 250
NGRALSAGSP PVPPGWNPNS SSGKGSGSSA GSYVPSYTSW YPSAHQEAMQ

QPQLM
Length:255
Mass (Da):27,309
Last modified:November 1, 1996 - v1
Checksum:i99B474F5D3FD8B6D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti98 – 103QSRLED → PEPPGG (PubMed:1676488).Curated6
Sequence conflicti123G → GQ (PubMed:1676488).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51001 mRNA. Translation: AAB40900.1.
U51000 Genomic DNA. Translation: AAB40899.1.
BC079609 mRNA. Translation: AAH79609.1.
X57552 Genomic DNA. Translation: CAB37647.1.
CCDSiCCDS16116.1.
RefSeqiNP_034183.1. NM_010053.2.
XP_006498734.1. XM_006498671.3.
XP_006498735.1. XM_006498672.3.
XP_006498736.1. XM_006498673.3.
XP_017170794.1. XM_017315305.1.
XP_017170796.1. XM_017315307.1.
XP_017170800.1. XM_017315311.1.
UniGeneiMm.475101.

Genome annotation databases

EnsembliENSMUST00000037119; ENSMUSP00000042413; ENSMUSG00000041911.
GeneIDi13390.
KEGGimmu:13390.
UCSCiuc008kau.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51001 mRNA. Translation: AAB40900.1.
U51000 Genomic DNA. Translation: AAB40899.1.
BC079609 mRNA. Translation: AAH79609.1.
X57552 Genomic DNA. Translation: CAB37647.1.
CCDSiCCDS16116.1.
RefSeqiNP_034183.1. NM_010053.2.
XP_006498734.1. XM_006498671.3.
XP_006498735.1. XM_006498672.3.
XP_006498736.1. XM_006498673.3.
XP_017170794.1. XM_017315305.1.
XP_017170796.1. XM_017315307.1.
XP_017170800.1. XM_017315311.1.
UniGeneiMm.475101.

3D structure databases

ProteinModelPortaliQ64317.
SMRiQ64317.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199234. 10 interactors.
STRINGi10090.ENSMUSP00000042413.

PTM databases

PhosphoSitePlusiQ64317.

Proteomic databases

PaxDbiQ64317.
PeptideAtlasiQ64317.
PRIDEiQ64317.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037119; ENSMUSP00000042413; ENSMUSG00000041911.
GeneIDi13390.
KEGGimmu:13390.
UCSCiuc008kau.1. mouse.

Organism-specific databases

CTDi1745.
MGIiMGI:94901. Dlx1.

Phylogenomic databases

eggNOGiKOG0850. Eukaryota.
ENOG410ZHZR. LUCA.
GeneTreeiENSGT00880000137844.
HOGENOMiHOG000231941.
HOVERGENiHBG005493.
InParanoidiQ64317.
KOiK09314.
OMAiEMTMTTI.
OrthoDBiEOG091G0P17.
PhylomeDBiQ64317.
TreeFamiTF315720.

Miscellaneous databases

PROiPR:Q64317.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041911.
CleanExiMM_DLX1.
ExpressionAtlasiQ64317. baseline and differential.
GenevisibleiQ64317. MM.

Family and domain databases

InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR000047. HTH_motif.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDLX1_MOUSE
AccessioniPrimary (citable) accession number: Q64317
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 7, 2017
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.