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Protein

Surfeit locus protein 4

Gene

Surf4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.
R-MMU-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Surfeit locus protein 4
Gene namesi
Name:Surf4
Synonyms:Surf-4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:98445. Surf4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001276652 – 269Surfeit locus protein 4Add BLAST268

Proteomic databases

EPDiQ64310.
MaxQBiQ64310.
PaxDbiQ64310.
PRIDEiQ64310.

PTM databases

iPTMnetiQ64310.
PhosphoSitePlusiQ64310.
SwissPalmiQ64310.

Expressioni

Gene expression databases

BgeeiENSMUSG00000014867.
CleanExiMM_SURF4.
ExpressionAtlasiQ64310. baseline and differential.
GenevisibleiQ64310. MM.

Interactioni

Subunit structurei

Found in a complex composed at least of SURF4, TMED2 and TMED10. May interact with LMAN1 (By similarity). Interacts with ZFYVE27 and with KIF5A in a ZFYVE27-dependent manner (PubMed:21976701).By similarity1 Publication

Protein-protein interaction databases

BioGridi203581. 1 interactor.
IntActiQ64310. 1 interactor.
MINTiMINT-1862523.
STRINGi10090.ENSMUSP00000015011.

Structurei

3D structure databases

ProteinModelPortaliQ64310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi266 – 269Di-lysine motifBy similarity4

Domaini

The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.By similarity

Sequence similaritiesi

Belongs to the SURF4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3998. Eukaryota.
COG2259. LUCA.
GeneTreeiENSGT00530000064123.
HOGENOMiHOG000206959.
HOVERGENiHBG054238.
InParanoidiQ64310.
KOiK20369.
OMAiDQLWYLQ.
OrthoDBiEOG091G0H3P.
PhylomeDBiQ64310.
TreeFamiTF300001.

Family and domain databases

InterProiIPR002995. Surf4.
[Graphical view]
PfamiPF02077. SURF4. 1 hit.
[Graphical view]
PROSITEiPS01339. SURF4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64310-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQNDLMGTA EDFADQFLRV TKQYLPHVAR LCLISTFLED GIRMWFQWSE
60 70 80 90 100
QRDYIDTTWS CGYLLASSFV FLNLLGQLTG CVLVLSRNFV QYACFGLFGI
110 120 130 140 150
IALQTIAYSI LWDLKFLMRN LALGGGLLLL LAESRSEGKS MFAGVPTMRE
160 170 180 190 200
SSPKQYMQLG GRVLLVLMFM TLLHFDASFF SIIQNIVGTA LMILVAIGFK
210 220 230 240 250
TKLAALTLVV WLFAINVYFN AFWTIPVYKP MHDFLKYDFF QTMSVIGGLL
260
LVVALGPGGV SMDEKKKEW
Length:269
Mass (Da):30,381
Last modified:November 1, 1996 - v1
Checksum:iCC1F5219400E52F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62606
, M62601, M62602, M62603, M62605 Genomic DNA. Translation: AAA40155.1.
M63114 mRNA. Translation: AAA40156.1.
BC003280 mRNA. Translation: AAH03280.1.
BC027352 mRNA. Translation: AAH27352.1.
CCDSiCCDS15817.1.
PIRiA34727.
RefSeqiNP_035642.1. NM_011512.3.
UniGeneiMm.300594.

Genome annotation databases

EnsembliENSMUST00000015011; ENSMUSP00000015011; ENSMUSG00000014867.
GeneIDi20932.
KEGGimmu:20932.
UCSCiuc008iwl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62606
, M62601, M62602, M62603, M62605 Genomic DNA. Translation: AAA40155.1.
M63114 mRNA. Translation: AAA40156.1.
BC003280 mRNA. Translation: AAH03280.1.
BC027352 mRNA. Translation: AAH27352.1.
CCDSiCCDS15817.1.
PIRiA34727.
RefSeqiNP_035642.1. NM_011512.3.
UniGeneiMm.300594.

3D structure databases

ProteinModelPortaliQ64310.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203581. 1 interactor.
IntActiQ64310. 1 interactor.
MINTiMINT-1862523.
STRINGi10090.ENSMUSP00000015011.

PTM databases

iPTMnetiQ64310.
PhosphoSitePlusiQ64310.
SwissPalmiQ64310.

Proteomic databases

EPDiQ64310.
MaxQBiQ64310.
PaxDbiQ64310.
PRIDEiQ64310.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015011; ENSMUSP00000015011; ENSMUSG00000014867.
GeneIDi20932.
KEGGimmu:20932.
UCSCiuc008iwl.2. mouse.

Organism-specific databases

CTDi6836.
MGIiMGI:98445. Surf4.

Phylogenomic databases

eggNOGiKOG3998. Eukaryota.
COG2259. LUCA.
GeneTreeiENSGT00530000064123.
HOGENOMiHOG000206959.
HOVERGENiHBG054238.
InParanoidiQ64310.
KOiK20369.
OMAiDQLWYLQ.
OrthoDBiEOG091G0H3P.
PhylomeDBiQ64310.
TreeFamiTF300001.

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.
R-MMU-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Miscellaneous databases

ChiTaRSiSurf4. mouse.
PROiQ64310.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000014867.
CleanExiMM_SURF4.
ExpressionAtlasiQ64310. baseline and differential.
GenevisibleiQ64310. MM.

Family and domain databases

InterProiIPR002995. Surf4.
[Graphical view]
PfamiPF02077. SURF4. 1 hit.
[Graphical view]
PROSITEiPS01339. SURF4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSURF4_MOUSE
AccessioniPrimary (citable) accession number: Q64310
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.