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Protein

Surfeit locus protein 4

Gene

Surf4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Surfeit locus protein 4
Gene namesi
Name:Surf4
Synonyms:Surf-4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:98445. Surf4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei65 – 8521HelicalSequence analysisAdd
BLAST
Transmembranei92 – 11221HelicalSequence analysisAdd
BLAST
Transmembranei179 – 19921HelicalSequence analysisAdd
BLAST
Transmembranei203 – 22321HelicalSequence analysisAdd
BLAST
Transmembranei242 – 26221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 269268Surfeit locus protein 4PRO_0000127665Add
BLAST

Proteomic databases

EPDiQ64310.
MaxQBiQ64310.
PaxDbiQ64310.
PRIDEiQ64310.

PTM databases

iPTMnetiQ64310.
PhosphoSiteiQ64310.
SwissPalmiQ64310.

Expressioni

Gene expression databases

BgeeiQ64310.
CleanExiMM_SURF4.
ExpressionAtlasiQ64310. baseline and differential.
GenevisibleiQ64310. MM.

Interactioni

Subunit structurei

Found in a complex composed at least of SURF4, TMED2 and TMED10. May interact with LMAN1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi203581. 1 interaction.
IntActiQ64310. 1 interaction.
MINTiMINT-1862523.
STRINGi10090.ENSMUSP00000015011.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi266 – 2694Di-lysine motifSequence analysis

Domaini

The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.By similarity

Sequence similaritiesi

Belongs to the SURF4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3998. Eukaryota.
COG2259. LUCA.
GeneTreeiENSGT00530000064123.
HOGENOMiHOG000206959.
HOVERGENiHBG054238.
InParanoidiQ64310.
OMAiDQLWYLQ.
OrthoDBiEOG7GTT4K.
PhylomeDBiQ64310.
TreeFamiTF300001.

Family and domain databases

InterProiIPR002995. Surf4.
[Graphical view]
PfamiPF02077. SURF4. 1 hit.
[Graphical view]
PROSITEiPS01339. SURF4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64310-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQNDLMGTA EDFADQFLRV TKQYLPHVAR LCLISTFLED GIRMWFQWSE
60 70 80 90 100
QRDYIDTTWS CGYLLASSFV FLNLLGQLTG CVLVLSRNFV QYACFGLFGI
110 120 130 140 150
IALQTIAYSI LWDLKFLMRN LALGGGLLLL LAESRSEGKS MFAGVPTMRE
160 170 180 190 200
SSPKQYMQLG GRVLLVLMFM TLLHFDASFF SIIQNIVGTA LMILVAIGFK
210 220 230 240 250
TKLAALTLVV WLFAINVYFN AFWTIPVYKP MHDFLKYDFF QTMSVIGGLL
260
LVVALGPGGV SMDEKKKEW
Length:269
Mass (Da):30,381
Last modified:November 1, 1996 - v1
Checksum:iCC1F5219400E52F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62606
, M62601, M62602, M62603, M62605 Genomic DNA. Translation: AAA40155.1.
M63114 mRNA. Translation: AAA40156.1.
BC003280 mRNA. Translation: AAH03280.1.
BC027352 mRNA. Translation: AAH27352.1.
CCDSiCCDS15817.1.
PIRiA34727.
RefSeqiNP_035642.1. NM_011512.3.
UniGeneiMm.300594.

Genome annotation databases

EnsembliENSMUST00000015011; ENSMUSP00000015011; ENSMUSG00000014867.
GeneIDi20932.
KEGGimmu:20932.
UCSCiuc008iwl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62606
, M62601, M62602, M62603, M62605 Genomic DNA. Translation: AAA40155.1.
M63114 mRNA. Translation: AAA40156.1.
BC003280 mRNA. Translation: AAH03280.1.
BC027352 mRNA. Translation: AAH27352.1.
CCDSiCCDS15817.1.
PIRiA34727.
RefSeqiNP_035642.1. NM_011512.3.
UniGeneiMm.300594.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203581. 1 interaction.
IntActiQ64310. 1 interaction.
MINTiMINT-1862523.
STRINGi10090.ENSMUSP00000015011.

PTM databases

iPTMnetiQ64310.
PhosphoSiteiQ64310.
SwissPalmiQ64310.

Proteomic databases

EPDiQ64310.
MaxQBiQ64310.
PaxDbiQ64310.
PRIDEiQ64310.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015011; ENSMUSP00000015011; ENSMUSG00000014867.
GeneIDi20932.
KEGGimmu:20932.
UCSCiuc008iwl.2. mouse.

Organism-specific databases

CTDi6836.
MGIiMGI:98445. Surf4.

Phylogenomic databases

eggNOGiKOG3998. Eukaryota.
COG2259. LUCA.
GeneTreeiENSGT00530000064123.
HOGENOMiHOG000206959.
HOVERGENiHBG054238.
InParanoidiQ64310.
OMAiDQLWYLQ.
OrthoDBiEOG7GTT4K.
PhylomeDBiQ64310.
TreeFamiTF300001.

Enzyme and pathway databases

ReactomeiR-MMU-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Miscellaneous databases

ChiTaRSiSurf4. mouse.
PROiQ64310.
SOURCEiSearch...

Gene expression databases

BgeeiQ64310.
CleanExiMM_SURF4.
ExpressionAtlasiQ64310. baseline and differential.
GenevisibleiQ64310. MM.

Family and domain databases

InterProiIPR002995. Surf4.
[Graphical view]
PfamiPF02077. SURF4. 1 hit.
[Graphical view]
PROSITEiPS01339. SURF4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse surfeit locus contains a cluster of six genes associated with four CpG-rich islands in 32 kilobases of genomic DNA."
    Huxley C., Fried M.
    Mol. Cell. Biol. 10:605-614(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/cJ.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  3. "The surf-4 gene encodes a novel 30 kDa integral membrane protein."
    Reeves J.E., Fried M.
    Mol. Membr. Biol. 12:201-208(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiSURF4_MOUSE
AccessioniPrimary (citable) accession number: Q64310
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.