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Protein

Transmembrane 4 L6 family member 1

Gene

Tm4sf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane 4 L6 family member 1
Alternative name(s):
Membrane component chromosome 3 surface marker 1 homolog
Tumor-associated antigen L6
Gene namesi
Name:Tm4sf1
Synonyms:M3s1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:104678 Tm4sf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9Cytoplasmic1 Publication9
Transmembranei10 – 30HelicalCuratedAdd BLAST21
Topological domaini31 – 49Extracellular1 PublicationAdd BLAST19
Transmembranei50 – 70HelicalCuratedAdd BLAST21
Topological domaini71 – 93Cytoplasmic1 PublicationAdd BLAST23
Transmembranei94 – 114HelicalCuratedAdd BLAST21
Topological domaini115 – 161Extracellular1 PublicationAdd BLAST47
Transmembranei162 – 182HelicalCuratedAdd BLAST21
Topological domaini183 – 202Cytoplasmic1 PublicationAdd BLAST20

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192971 – 202Transmembrane 4 L6 family member 1Add BLAST202

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi129N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi142N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ64302
PRIDEiQ64302

PTM databases

iPTMnetiQ64302

Expressioni

Tissue specificityi

Highly expressed in skin and lung. Moderately expressed in lymph nodes and kidneys. Also present in thymic stroma and fibroblasts.1 Publication

Gene expression databases

BgeeiENSMUSG00000027800
CleanExiMM_TM4SF1
ExpressionAtlasiQ64302 baseline and differential
GenevisibleiQ64302 MM

Interactioni

Subunit structurei

Present in high molecular weight complexes in tumor cells. Interacts with SDCBP2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi201262, 1 interactor
IntActiQ64302, 1 interactor
STRINGi10090.ENSMUSP00000029376

Family & Domainsi

Sequence similaritiesi

Belongs to the L6 tetraspanin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE1N Eukaryota
ENOG410YCUU LUCA
GeneTreeiENSGT00390000010992
HOGENOMiHOG000030899
HOVERGENiHBG000076
InParanoidiQ64302
OMAiCYGRCAR
OrthoDBiEOG091G0L2Q
PhylomeDBiQ64302
TreeFamiTF331371

Family and domain databases

InterProiView protein in InterPro
IPR008661 L6_membrane
PANTHERiPTHR14198 PTHR14198, 1 hit
PfamiView protein in Pfam
PF05805 L6_membrane, 1 hit

Sequencei

Sequence statusi: Complete.

Q64302-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCYVKCARYI GYSLVWAAVF CIVANALLYF PNGETKYATE DHLSRFVWYF
60 70 80 90 100
AGIVGGGLLM LLPAFVFIGM DEEDCCGCCG YENYGKRCSM LSSVLAALIG
110 120 130 140 150
IVGSAYCVIV ASLGLAEGPK CSDAHGVWNY TFASTEGQYL LNSSMWSKCY
160 170 180 190 200
EPKHIVEWHV TLFSILLAFA AVEFILCLIQ VINGMLGGLC GYCCSRQQQY

NC
Length:202
Mass (Da):22,243
Last modified:November 1, 1996 - v1
Checksum:i93838E707D85FF02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15443 mRNA Translation: AAA39403.1
L15429 mRNA Translation: AAA17873.1
AK077326 mRNA Translation: BAC36752.1
AK164718 mRNA Translation: BAE37888.1
BC083073 mRNA Translation: AAH83073.1
CCDSiCCDS38433.1
PIRiA53399
RefSeqiNP_032562.1, NM_008536.3
XP_006501143.1, XM_006501080.1
UniGeneiMm.856

Genome annotation databases

EnsembliENSMUST00000029376; ENSMUSP00000029376; ENSMUSG00000027800
ENSMUST00000171384; ENSMUSP00000130999; ENSMUSG00000027800
ENSMUST00000196979; ENSMUSP00000143652; ENSMUSG00000027800
GeneIDi17112
KEGGimmu:17112
UCSCiuc008pgy.1 mouse

Similar proteinsi

Entry informationi

Entry nameiT4S1_MOUSE
AccessioniPrimary (citable) accession number: Q64302
Secondary accession number(s): Q3TP49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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