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Protein

Transmembrane 4 L6 family member 1

Gene

Tm4sf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane 4 L6 family member 1
Alternative name(s):
Membrane component chromosome 3 surface marker 1 homolog
Tumor-associated antigen L6
Gene namesi
Name:Tm4sf1
Synonyms:M3s1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:104678. Tm4sf1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9Cytoplasmic1 Publication9
Transmembranei10 – 30HelicalCuratedAdd BLAST21
Topological domaini31 – 49Extracellular1 PublicationAdd BLAST19
Transmembranei50 – 70HelicalCuratedAdd BLAST21
Topological domaini71 – 93Cytoplasmic1 PublicationAdd BLAST23
Transmembranei94 – 114HelicalCuratedAdd BLAST21
Topological domaini115 – 161Extracellular1 PublicationAdd BLAST47
Transmembranei162 – 182HelicalCuratedAdd BLAST21
Topological domaini183 – 202Cytoplasmic1 PublicationAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192971 – 202Transmembrane 4 L6 family member 1Add BLAST202

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi129N-linked (GlcNAc...)Sequence analysis1
Glycosylationi142N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ64302.
PRIDEiQ64302.

Expressioni

Tissue specificityi

Highly expressed in skin and lung. Moderately expressed in lymph nodes and kidneys. Also present in thymic stroma and fibroblasts.1 Publication

Gene expression databases

BgeeiENSMUSG00000027800.
CleanExiMM_TM4SF1.
ExpressionAtlasiQ64302. baseline and differential.
GenevisibleiQ64302. MM.

Interactioni

Protein-protein interaction databases

IntActiQ64302. 1 interactor.
STRINGi10090.ENSMUSP00000029376.

Structurei

3D structure databases

ProteinModelPortaliQ64302.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L6 tetraspanin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE1N. Eukaryota.
ENOG410YCUU. LUCA.
GeneTreeiENSGT00390000010992.
HOGENOMiHOG000030899.
HOVERGENiHBG000076.
InParanoidiQ64302.
OMAiCYGRCAR.
OrthoDBiEOG091G0L2Q.
PhylomeDBiQ64302.
TreeFamiTF331371.

Family and domain databases

InterProiIPR008661. L6_membrane.
[Graphical view]
PfamiPF05805. L6_membrane. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64302-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCYVKCARYI GYSLVWAAVF CIVANALLYF PNGETKYATE DHLSRFVWYF
60 70 80 90 100
AGIVGGGLLM LLPAFVFIGM DEEDCCGCCG YENYGKRCSM LSSVLAALIG
110 120 130 140 150
IVGSAYCVIV ASLGLAEGPK CSDAHGVWNY TFASTEGQYL LNSSMWSKCY
160 170 180 190 200
EPKHIVEWHV TLFSILLAFA AVEFILCLIQ VINGMLGGLC GYCCSRQQQY

NC
Length:202
Mass (Da):22,243
Last modified:November 1, 1996 - v1
Checksum:i93838E707D85FF02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15443 mRNA. Translation: AAA39403.1.
L15429 mRNA. Translation: AAA17873.1.
AK077326 mRNA. Translation: BAC36752.1.
AK164718 mRNA. Translation: BAE37888.1.
BC083073 mRNA. Translation: AAH83073.1.
CCDSiCCDS38433.1.
PIRiA53399.
RefSeqiNP_032562.1. NM_008536.3.
XP_006501143.1. XM_006501080.1.
UniGeneiMm.856.

Genome annotation databases

EnsembliENSMUST00000029376; ENSMUSP00000029376; ENSMUSG00000027800.
ENSMUST00000171384; ENSMUSP00000130999; ENSMUSG00000027800.
ENSMUST00000196979; ENSMUSP00000143652; ENSMUSG00000027800.
GeneIDi17112.
KEGGimmu:17112.
UCSCiuc008pgy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15443 mRNA. Translation: AAA39403.1.
L15429 mRNA. Translation: AAA17873.1.
AK077326 mRNA. Translation: BAC36752.1.
AK164718 mRNA. Translation: BAE37888.1.
BC083073 mRNA. Translation: AAH83073.1.
CCDSiCCDS38433.1.
PIRiA53399.
RefSeqiNP_032562.1. NM_008536.3.
XP_006501143.1. XM_006501080.1.
UniGeneiMm.856.

3D structure databases

ProteinModelPortaliQ64302.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ64302. 1 interactor.
STRINGi10090.ENSMUSP00000029376.

Proteomic databases

PaxDbiQ64302.
PRIDEiQ64302.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029376; ENSMUSP00000029376; ENSMUSG00000027800.
ENSMUST00000171384; ENSMUSP00000130999; ENSMUSG00000027800.
ENSMUST00000196979; ENSMUSP00000143652; ENSMUSG00000027800.
GeneIDi17112.
KEGGimmu:17112.
UCSCiuc008pgy.1. mouse.

Organism-specific databases

CTDi4071.
MGIiMGI:104678. Tm4sf1.

Phylogenomic databases

eggNOGiENOG410IE1N. Eukaryota.
ENOG410YCUU. LUCA.
GeneTreeiENSGT00390000010992.
HOGENOMiHOG000030899.
HOVERGENiHBG000076.
InParanoidiQ64302.
OMAiCYGRCAR.
OrthoDBiEOG091G0L2Q.
PhylomeDBiQ64302.
TreeFamiTF331371.

Miscellaneous databases

PROiQ64302.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027800.
CleanExiMM_TM4SF1.
ExpressionAtlasiQ64302. baseline and differential.
GenevisibleiQ64302. MM.

Family and domain databases

InterProiIPR008661. L6_membrane.
[Graphical view]
PfamiPF05805. L6_membrane. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiT4S1_MOUSE
AccessioniPrimary (citable) accession number: Q64302
Secondary accession number(s): Q3TP49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.