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Protein

Transmembrane 4 L6 family member 1

Gene

Tm4sf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane 4 L6 family member 1
Alternative name(s):
Membrane component chromosome 3 surface marker 1 homolog
Tumor-associated antigen L6
Gene namesi
Name:Tm4sf1
Synonyms:M3s1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:104678. Tm4sf1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99Cytoplasmic1 Publication
Transmembranei10 – 3021HelicalCuratedAdd
BLAST
Topological domaini31 – 4919Extracellular1 PublicationAdd
BLAST
Transmembranei50 – 7021HelicalCuratedAdd
BLAST
Topological domaini71 – 9323Cytoplasmic1 PublicationAdd
BLAST
Transmembranei94 – 11421HelicalCuratedAdd
BLAST
Topological domaini115 – 16147Extracellular1 PublicationAdd
BLAST
Transmembranei162 – 18221HelicalCuratedAdd
BLAST
Topological domaini183 – 20220Cytoplasmic1 PublicationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 202202Transmembrane 4 L6 family member 1PRO_0000219297Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi129 – 1291N-linked (GlcNAc...)Sequence analysis
Glycosylationi142 – 1421N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ64302.
PRIDEiQ64302.

Expressioni

Tissue specificityi

Highly expressed in skin and lung. Moderately expressed in lymph nodes and kidneys. Also present in thymic stroma and fibroblasts.1 Publication

Gene expression databases

BgeeiQ64302.
CleanExiMM_TM4SF1.
ExpressionAtlasiQ64302. baseline and differential.
GenevisibleiQ64302. MM.

Interactioni

Protein-protein interaction databases

IntActiQ64302. 1 interaction.
STRINGi10090.ENSMUSP00000029376.

Family & Domainsi

Sequence similaritiesi

Belongs to the L6 tetraspanin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE1N. Eukaryota.
ENOG410YCUU. LUCA.
GeneTreeiENSGT00390000010992.
HOGENOMiHOG000030899.
HOVERGENiHBG000076.
InParanoidiQ64302.
OMAiCYGRCAR.
OrthoDBiEOG7SN8DH.
PhylomeDBiQ64302.
TreeFamiTF331371.

Family and domain databases

InterProiIPR008661. L6_membrane.
[Graphical view]
PfamiPF05805. L6_membrane. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64302-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCYVKCARYI GYSLVWAAVF CIVANALLYF PNGETKYATE DHLSRFVWYF
60 70 80 90 100
AGIVGGGLLM LLPAFVFIGM DEEDCCGCCG YENYGKRCSM LSSVLAALIG
110 120 130 140 150
IVGSAYCVIV ASLGLAEGPK CSDAHGVWNY TFASTEGQYL LNSSMWSKCY
160 170 180 190 200
EPKHIVEWHV TLFSILLAFA AVEFILCLIQ VINGMLGGLC GYCCSRQQQY

NC
Length:202
Mass (Da):22,243
Last modified:November 1, 1996 - v1
Checksum:i93838E707D85FF02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15443 mRNA. Translation: AAA39403.1.
L15429 mRNA. Translation: AAA17873.1.
AK077326 mRNA. Translation: BAC36752.1.
AK164718 mRNA. Translation: BAE37888.1.
BC083073 mRNA. Translation: AAH83073.1.
CCDSiCCDS38433.1.
PIRiA53399.
RefSeqiNP_032562.1. NM_008536.3.
XP_006501143.1. XM_006501080.1.
XP_011238332.1. XM_011240030.1.
UniGeneiMm.856.

Genome annotation databases

EnsembliENSMUST00000029376; ENSMUSP00000029376; ENSMUSG00000027800.
ENSMUST00000171384; ENSMUSP00000130999; ENSMUSG00000027800.
ENSMUST00000196979; ENSMUSP00000143652; ENSMUSG00000027800.
GeneIDi17112.
KEGGimmu:17112.
UCSCiuc008pgy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15443 mRNA. Translation: AAA39403.1.
L15429 mRNA. Translation: AAA17873.1.
AK077326 mRNA. Translation: BAC36752.1.
AK164718 mRNA. Translation: BAE37888.1.
BC083073 mRNA. Translation: AAH83073.1.
CCDSiCCDS38433.1.
PIRiA53399.
RefSeqiNP_032562.1. NM_008536.3.
XP_006501143.1. XM_006501080.1.
XP_011238332.1. XM_011240030.1.
UniGeneiMm.856.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ64302. 1 interaction.
STRINGi10090.ENSMUSP00000029376.

Proteomic databases

PaxDbiQ64302.
PRIDEiQ64302.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029376; ENSMUSP00000029376; ENSMUSG00000027800.
ENSMUST00000171384; ENSMUSP00000130999; ENSMUSG00000027800.
ENSMUST00000196979; ENSMUSP00000143652; ENSMUSG00000027800.
GeneIDi17112.
KEGGimmu:17112.
UCSCiuc008pgy.1. mouse.

Organism-specific databases

CTDi4071.
MGIiMGI:104678. Tm4sf1.

Phylogenomic databases

eggNOGiENOG410IE1N. Eukaryota.
ENOG410YCUU. LUCA.
GeneTreeiENSGT00390000010992.
HOGENOMiHOG000030899.
HOVERGENiHBG000076.
InParanoidiQ64302.
OMAiCYGRCAR.
OrthoDBiEOG7SN8DH.
PhylomeDBiQ64302.
TreeFamiTF331371.

Miscellaneous databases

NextBioi291260.
PROiQ64302.
SOURCEiSearch...

Gene expression databases

BgeeiQ64302.
CleanExiMM_TM4SF1.
ExpressionAtlasiQ64302. baseline and differential.
GenevisibleiQ64302. MM.

Family and domain databases

InterProiIPR008661. L6_membrane.
[Graphical view]
PfamiPF05805. L6_membrane. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Membrane topology of the L6 antigen and identification of the protein epitope recognized by the L6 monoclonal antibody."
    Marken J.S., Bajorath J., Edwards C.P., Farr A.G., Schieven G.L., Hellstroem I., Hellstroem K.E., Aruffo A.
    J. Biol. Chem. 269:7397-7401(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, TOPOLOGY.
    Strain: BALB/cJ.
    Tissue: Thymic epithelium.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney and Pituitary.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.
  4. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
    Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
    Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-142.
    Tissue: Myoblast.

Entry informationi

Entry nameiT4S1_MOUSE
AccessioniPrimary (citable) accession number: Q64302
Secondary accession number(s): Q3TP49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.