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Q642M9 (DHDH_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
EC=1.3.1.20
Alternative name(s):
D-xylose 1-dehydrogenase
D-xylose-NADP dehydrogenase
EC=1.1.1.179
Dimeric dihydrodiol dehydrogenase
Gene names
Name:dhdh
ORF Names:ch211-203b17.3, zgc:101723
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH.

D-xylose + NADP+ = D-xylono-1,5-lactone + NADPH.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the Gfo/Idh/MocA family.

Sequence caution

The sequence CAP09380.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 334334Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
PRO_0000315368

Sites

Site711May play an important role in coenzyme binding By similarity
Site791May play an important role in coenzyme binding By similarity
Site971May play an important role in coenzyme binding By similarity
Site1761May play an important role for the adaptation of the alcohol substrate into the binding site By similarity
Site1801May play an important role in catalytic activity By similarity

Experimental info

Sequence conflict251P → Q in AAH81393. Ref.1
Sequence conflict2451G → A in AAH81393. Ref.1
Sequence conflict2581S → T in AAH81393. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q642M9 [UniParc].

Last modified January 15, 2008. Version 2.
Checksum: C246A390F506702C

FASTA33436,566
        10         20         30         40         50         60 
MALRWGICSA GKISHDFTVA LRTLPAEQHQ VVAVAARELA HAQEFAQKHS IPRAYGSYEE 

        70         80         90        100        110        120 
LAEDPEIDVV YVGTIHPHHL RVGLLFMNAK KNVLCEKPLA MNLKEVQQMI SAARRSDVFL 

       130        140        150        160        170        180 
MEAVWTRFFP ASLEISRLLS QNAVGQVKLV RADFGAALLG VPRAVQKHLG GGALLDIGIY 

       190        200        210        220        230        240 
CIQFVLMVFN GEKPEQIQAS GVCLDTGVDE AMVVTLKFSG HRLAVCTCTV AAELPNEALI 

       250        260        270        280        290        300 
VGTEGTIKVP AHMWCPTSLL VNGVETQFPV PDPHLPLNFI NSTGMRYEAE EVRRCVLAGL 

       310        320        330 
KESSRMSHAD SALLADIMDE ARRQVGVVYS QDSQ

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Olfactory epithelium.
[2]The Danio rerio sequencing project at the Sanger Institute
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-299.
Strain: Tuebingen.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC081393 mRNA. Translation: AAH81393.1.
BX119923 Genomic DNA. Translation: CAP09380.1. Different initiation.
IPIIPI00493991.
RefSeqNP_001005600.1. NM_001005600.1.
UniGeneDr.13011.

3D structure databases

ProteinModelPortalQ642M9.
SMRQ642M9. Positions 2-332.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000134144; ENSDARP00000115782; ENSDARG00000019081.
GeneID449558.
KEGGdre:449558.

Organism-specific databases

ZFINZDB-GENE-040927-25. zgc:101723.

Phylogenomic databases

eggNOGCOG0673.
GeneTreeENSGT00390000007946.
HOVERGENHBG105348.
InParanoidQ642M9.
KOK00078.
OMAAGRLFME.
OrthoDBEOG46144D.

Gene expression databases

ArrayExpressQ642M9.
BgeeQ642M9.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
IPR004104. OxRdtase_C.
[Graphical view]
PfamPF01408. GFO_IDH_MocA. 1 hit.
PF02894. GFO_IDH_MocA_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20832676.

Entry information

Entry nameDHDH_DANRE
AccessionPrimary (citable) accession number: Q642M9
Secondary accession number(s): A8E7G1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: April 3, 2013
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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