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Reviewed, UniProtKB/Swiss-Prot Q642M9 (DHDH_DANRE)

Last modified July 28, 2009. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
    EC=1.3.1.20
Alternative name(s):
    Dimeric dihydrodiol dehydrogenase
    D-xylose-NADP dehydrogenase
    EC=1.1.1.179
    D-xylose 1-dehydrogenase
Gene names
Name: dhdh
ORF Names: ch211-203b17.3, zgc:101723
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

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Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

Trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH.

D-xylose + NADP+ = D-xylono-1,5-lactone + NADPH.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the gfo/idh/mocA family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 334334Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
PRO_0000315368

Sites

Site711May play an important role in coenzyme binding By similarity
Site791May play an important role in coenzyme binding By similarity
Site971May play an important role in coenzyme binding By similarity
Site1761May play an important role for the adaptation of the alcohol substrate into the binding site By similarity
Site1801May play an important role in catalytic activity By similarity

Experimental info

Sequence conflict251P → Q in AAH81393. Ref.1
Sequence conflict2451G → A in AAH81393. Ref.1
Sequence conflict2581S → T in AAH81393. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
Q642M9-1 [UniParc].

Last modified January 15, 2008. Version 2.
Checksum: C246A390F506702C

FASTA33436,566
        10         20         30         40         50         60 
MALRWGICSA GKISHDFTVA LRTLPAEQHQ VVAVAARELA HAQEFAQKHS IPRAYGSYEE 

        70         80         90        100        110        120 
LAEDPEIDVV YVGTIHPHHL RVGLLFMNAK KNVLCEKPLA MNLKEVQQMI SAARRSDVFL 

       130        140        150        160        170        180 
MEAVWTRFFP ASLEISRLLS QNAVGQVKLV RADFGAALLG VPRAVQKHLG GGALLDIGIY 

       190        200        210        220        230        240 
CIQFVLMVFN GEKPEQIQAS GVCLDTGVDE AMVVTLKFSG HRLAVCTCTV AAELPNEALI 

       250        260        270        280        290        300 
VGTEGTIKVP AHMWCPTSLL VNGVETQFPV PDPHLPLNFI NSTGMRYEAE EVRRCVLAGL 

       310        320        330 
KESSRMSHAD SALLADIMDE ARRQVGVVYS QDSQ

« Hide

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References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Olfactory epithelium.
[2]The Danio rerio sequencing project at the Sanger Institute
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-299.
Strain: Tuebingen.

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Cross-references

Sequence databases

BC081393 mRNA. Translation: AAH81393.1.
BX119923 Genomic DNA. Translation: CAP09380.1. Different initiation.
IPIIPI00493991.
RefSeqNP_001005600.1.
UniGeneDr.13011

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSDART00000016394; ENSDARP00000012198; ENSDARG00000019081; Danio rerio. [Genome view]
GeneID449558.
KEGGdre:449558.

Organism-specific databases

ZFINZDB-GENE-040927-25. zgc:101723.

Phylogenomic databases

HOGENOMQ642M9.
HOVERGENQ642M9.

Enzyme and pathway databases

BRENDA1.1.1.179. 96826.
1.3.1.20. 96826.

Gene expression databases

ArrayExpressQ642M9.
BgeeQ642M9.

Family and domain databases

InterProIPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
IPR004104. OxRdtase_C.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PfamPF01408. GFO_IDH_MocA. 1 hit.
PF02894. GFO_IDH_MocA_C. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameDHDH_DANRE
AccessionPrimary (citable) accession number: Q642M9
Secondary accession number(s): A8E7G1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: July 28, 2009
This is version 33 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectZebrafish annotation project

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents