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Protein

Peroxisomal membrane protein PEX14

Gene

Pex14

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein PEX14
Alternative name(s):
PTS1 receptor-docking protein
Peroxin-14
Peroxisomal membrane anchor protein PEX14
Gene namesi
Name:Pex14
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi68336. Pex14.

Subcellular locationi

  • Peroxisome membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

GO - Cellular componenti

  • integral component of membrane Source: RGD
  • nucleolus Source: Ensembl
  • peroxisomal membrane Source: HGNC
  • peroxisome Source: UniProtKB
  • protein complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 376375Peroxisomal membrane protein PEX14PRO_0000371415Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei34 – 341N6-acetyllysineBy similarity
Modified residuei282 – 2821PhosphoserineCombined sources
Modified residuei334 – 3341PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ642G4.
PRIDEiQ642G4.

PTM databases

iPTMnetiQ642G4.
PhosphoSiteiQ642G4.

Expressioni

Gene expression databases

GenevisibleiQ642G4. RN.

Interactioni

Subunit structurei

Interacts with PEX5, PEX13 and PEX19. Interacts with tubulin.By similarity

Protein-protein interaction databases

DIPiDIP-58546N.
STRINGi10116.ENSRNOP00000018167.

Structurei

Secondary structure

1
376
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi25 – 3713Combined sources
Helixi41 – 433Combined sources
Helixi46 – 5510Combined sources
Helixi60 – 6910Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3FF5X-ray1.80A/B25-70[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ642G4.

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxin-14 family.Curated

Phylogenomic databases

eggNOGiKOG2629. Eukaryota.
ENOG4111P8A. LUCA.
GeneTreeiENSGT00390000015047.
HOGENOMiHOG000220930.
InParanoidiQ642G4.
KOiK13343.
OMAiWQIPVKP.
OrthoDBiEOG7DFXD4.
PhylomeDBiQ642G4.
TreeFamiTF323535.

Family and domain databases

InterProiIPR025655. PEX14.
IPR006785. Pex14_N.
[Graphical view]
PANTHERiPTHR23058. PTHR23058. 1 hit.
PfamiPF04695. Pex14_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q642G4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSEQAEQP NQPSSSPGSE NVVPREPLIA TAVKFLQNSR VRQSPLATRR
60 70 80 90 100
AFLKKKGLTD EEIDLAFQQS GTASDEPSPV GPATPVVPVQ PPHLISQPYS
110 120 130 140 150
PGGSRWRDYG ALAIILAGIA FGFHQLYKKY LLPLILGGRE DRKQLERMAA
160 170 180 190 200
SLSELSGSVA QTVTQVQTTL ASVQELLRQQ QQKVQELAHE LAAAKATTST
210 220 230 240 250
NWILESQNIN ELKSEINSLK GLLLNRRQFP PSPSAPKIPS WQIPVKSPSP
260 270 280 290 300
SSPAAVNHHS SSDISPVSNE SPSSSPGKDG HSPEGSTATY RLLGPQEEGE
310 320 330 340 350
GVVDVKGQVR MEVQGEEEKR EDEEGEEDED DDVSHVDEED VLGVQREDRR
360 370
GGDGQINEQV EKLRRPEGAS NESERD
Length:376
Mass (Da):40,936
Last modified:October 25, 2004 - v1
Checksum:iC9DFFC0DD4DD45C8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti303 – 3031V → M in BAA36835 (PubMed:10212238).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017544 mRNA. Translation: BAA36835.1.
BC081708 mRNA. Translation: AAH81708.1.
RefSeqiNP_742060.1. NM_172063.1.
UniGeneiRn.7844.

Genome annotation databases

EnsembliENSRNOT00000018167; ENSRNOP00000018167; ENSRNOG00000013498.
GeneIDi64460.
KEGGirno:64460.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017544 mRNA. Translation: BAA36835.1.
BC081708 mRNA. Translation: AAH81708.1.
RefSeqiNP_742060.1. NM_172063.1.
UniGeneiRn.7844.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3FF5X-ray1.80A/B25-70[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-58546N.
STRINGi10116.ENSRNOP00000018167.

PTM databases

iPTMnetiQ642G4.
PhosphoSiteiQ642G4.

Proteomic databases

PaxDbiQ642G4.
PRIDEiQ642G4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018167; ENSRNOP00000018167; ENSRNOG00000013498.
GeneIDi64460.
KEGGirno:64460.

Organism-specific databases

CTDi5195.
RGDi68336. Pex14.

Phylogenomic databases

eggNOGiKOG2629. Eukaryota.
ENOG4111P8A. LUCA.
GeneTreeiENSGT00390000015047.
HOGENOMiHOG000220930.
InParanoidiQ642G4.
KOiK13343.
OMAiWQIPVKP.
OrthoDBiEOG7DFXD4.
PhylomeDBiQ642G4.
TreeFamiTF323535.

Miscellaneous databases

EvolutionaryTraceiQ642G4.
PROiQ642G4.

Gene expression databases

GenevisibleiQ642G4. RN.

Family and domain databases

InterProiIPR025655. PEX14.
IPR006785. Pex14_N.
[Graphical view]
PANTHERiPTHR23058. PTHR23058. 1 hit.
PfamiPF04695. Pex14_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The peroxin Pex14p. cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant, characterization, and functional analysis."
    Shimizu N., Itoh R., Hirono Y., Otera H., Ghaedi K., Tateishi K., Tamura S., Okumoto K., Harano T., Mukai S., Fujiki Y.
    J. Biol. Chem. 274:12593-12604(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-282 AND SER-334, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPEX14_RAT
AccessioniPrimary (citable) accession number: Q642G4
Secondary accession number(s): Q9Z2Z4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: October 25, 2004
Last modified: June 8, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.