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Protein

Peroxisomal membrane protein PEX14

Gene

Pex14

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-RNO-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-RNO-9033241 Peroxisomal protein import

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein PEX14
Alternative name(s):
PTS1 receptor-docking protein
Peroxin-14
Peroxisomal membrane anchor protein PEX14
Gene namesi
Name:Pex14
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi68336 Pex14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003714152 – 376Peroxisomal membrane protein PEX14Add BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei34N6-acetyllysineBy similarity1
Modified residuei232PhosphoserineBy similarity1
Modified residuei282PhosphoserineCombined sources1
Modified residuei334PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ642G4
PRIDEiQ642G4

PTM databases

iPTMnetiQ642G4
PhosphoSitePlusiQ642G4

Expressioni

Gene expression databases

BgeeiENSRNOG00000013498
GenevisibleiQ642G4 RN

Interactioni

Subunit structurei

Interacts with PEX5, PEX13 and PEX19. Interacts with tubulin.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi249075, 1 interactor
DIPiDIP-58546N
IntActiQ642G4, 1 interactor
STRINGi10116.ENSRNOP00000018167

Structurei

Secondary structure

1376
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi25 – 37Combined sources13
Helixi41 – 43Combined sources3
Helixi46 – 55Combined sources10
Helixi60 – 69Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FF5X-ray1.80A/B25-70[»]
SMRiQ642G4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ642G4

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxin-14 family.Curated

Phylogenomic databases

eggNOGiKOG2629 Eukaryota
ENOG4111P8A LUCA
GeneTreeiENSGT00390000015047
HOGENOMiHOG000220930
InParanoidiQ642G4
KOiK13343
OMAiASIPAWQ
OrthoDBiEOG091G0LT7
PhylomeDBiQ642G4
TreeFamiTF323535

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR025655 PEX14
IPR006785 Pex14_N
IPR036388 WH-like_DNA-bd_sf
PANTHERiPTHR23058 PTHR23058, 1 hit
PfamiView protein in Pfam
PF04695 Pex14_N, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q642G4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSEQAEQP NQPSSSPGSE NVVPREPLIA TAVKFLQNSR VRQSPLATRR
60 70 80 90 100
AFLKKKGLTD EEIDLAFQQS GTASDEPSPV GPATPVVPVQ PPHLISQPYS
110 120 130 140 150
PGGSRWRDYG ALAIILAGIA FGFHQLYKKY LLPLILGGRE DRKQLERMAA
160 170 180 190 200
SLSELSGSVA QTVTQVQTTL ASVQELLRQQ QQKVQELAHE LAAAKATTST
210 220 230 240 250
NWILESQNIN ELKSEINSLK GLLLNRRQFP PSPSAPKIPS WQIPVKSPSP
260 270 280 290 300
SSPAAVNHHS SSDISPVSNE SPSSSPGKDG HSPEGSTATY RLLGPQEEGE
310 320 330 340 350
GVVDVKGQVR MEVQGEEEKR EDEEGEEDED DDVSHVDEED VLGVQREDRR
360 370
GGDGQINEQV EKLRRPEGAS NESERD
Length:376
Mass (Da):40,936
Last modified:October 25, 2004 - v1
Checksum:iC9DFFC0DD4DD45C8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti303V → M in BAA36835 (PubMed:10212238).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017544 mRNA Translation: BAA36835.1
BC081708 mRNA Translation: AAH81708.1
RefSeqiNP_742060.1, NM_172063.1
UniGeneiRn.7844

Genome annotation databases

EnsembliENSRNOT00000018167; ENSRNOP00000018167; ENSRNOG00000013498
GeneIDi64460
KEGGirno:64460

Similar proteinsi

Entry informationi

Entry nameiPEX14_RAT
AccessioniPrimary (citable) accession number: Q642G4
Secondary accession number(s): Q9Z2Z4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: October 25, 2004
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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