Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sclerostin domain-containing protein 1

Gene

Sostdc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner (By similarity). May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling.By similarity2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Sclerostin domain-containing protein 1
Alternative name(s):
Uterine sensitization-associated gene 1 protein
Short name:
USAG-1
Wnt-signaling modulator
Gene namesi
Name:Sostdc1
Synonyms:Usag1, Wise
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi628877. Sostdc1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 206183Sclerostin domain-containing protein 1PRO_0000033183Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi47 – 471N-linked (GlcNAc...)Sequence analysis
Disulfide bondi75 ↔ 133PROSITE-ProRule annotation
Disulfide bondi89 ↔ 147PROSITE-ProRule annotation
Disulfide bondi100 ↔ 163PROSITE-ProRule annotation
Disulfide bondi104 ↔ 165PROSITE-ProRule annotation
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ642G2.

Expressioni

Tissue specificityi

Highly expressed within the maximally sensitized/receptive endometrium. Weakly expressed in brain, kidney and the female reproductive tract. Expressed in the dermal papilla (DP) and at high level in the precortex of both anagen vibrissae and pelage follicles. Dynymic expression during the hair cycle.2 Publications

Developmental stagei

Highly expressed in epidermis, dermis and the outermost periderm layer in the 17 day post-coitum (dpc).1 Publication

Inductioni

Up-regulated at day 5 pregnant or pseudopregnant of the uterine glandular epithelial cells, at time of maximal sensitization for the decidual cell reaction. Down-regulated at day 6 refractory uterus.1 Publication

Gene expression databases

GenevisibleiQ642G2. RN.

Interactioni

Subunit structurei

Interacts with BMP2, BMP4, BMP6 and BMP7 with high affinity.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008106.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini75 – 17096CTCKPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the sclerostin family.Curated
Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIVA. Eukaryota.
ENOG410YEMP. LUCA.
GeneTreeiENSGT00390000014900.
HOGENOMiHOG000252934.
HOVERGENiHBG003729.
InParanoidiQ642G2.
OMAiAKPAQHH.
OrthoDBiEOG7CVPZN.
PhylomeDBiQ642G2.
TreeFamiTF353019.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR008835. Sclerostin/SOSTDC1.
[Graphical view]
PANTHERiPTHR14903. PTHR14903. 1 hit.
PfamiPF05463. Sclerostin. 1 hit.
[Graphical view]
PROSITEiPS01225. CTCK_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q642G2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPPAIHLSL IPLLCILMKN CLAFKNDATE ILYSHVVKPV SAHPSSNSTL
60 70 80 90 100
NQARNGGRHF SSTGLDRNSR VQVGCRELRS TKYISDGQCT SISPLKELVC
110 120 130 140 150
AGECLPLPVL PNWIGGGYGT KYWSRRSSQE WRCVNDKTRT QRIQLQCQDG
160 170 180 190 200
STRTYKITVV TACKCKRYTR QHNESSHNFE SVSPAKPAQH HRERKRASKS

SKHSLS
Length:206
Mass (Da):23,136
Last modified:October 25, 2004 - v1
Checksum:i52BD602431C6DD15
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti187 – 1871P → L in AAN45848 (PubMed:12390898).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411056 mRNA. Translation: AAN45848.1.
BC081710 mRNA. Translation: AAH81710.1.
RefSeqiNP_714959.1. NM_153737.1.
UniGeneiRn.2415.

Genome annotation databases

EnsembliENSRNOT00000008106; ENSRNOP00000008106; ENSRNOG00000005770.
GeneIDi266803.
KEGGirno:266803.
UCSCiRGD:628877. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411056 mRNA. Translation: AAN45848.1.
BC081710 mRNA. Translation: AAH81710.1.
RefSeqiNP_714959.1. NM_153737.1.
UniGeneiRn.2415.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008106.

Proteomic databases

PaxDbiQ642G2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000008106; ENSRNOP00000008106; ENSRNOG00000005770.
GeneIDi266803.
KEGGirno:266803.
UCSCiRGD:628877. rat.

Organism-specific databases

CTDi25928.
RGDi628877. Sostdc1.

Phylogenomic databases

eggNOGiENOG410IIVA. Eukaryota.
ENOG410YEMP. LUCA.
GeneTreeiENSGT00390000014900.
HOGENOMiHOG000252934.
HOVERGENiHBG003729.
InParanoidiQ642G2.
OMAiAKPAQHH.
OrthoDBiEOG7CVPZN.
PhylomeDBiQ642G2.
TreeFamiTF353019.

Miscellaneous databases

PROiQ642G2.

Gene expression databases

GenevisibleiQ642G2. RN.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR008835. Sclerostin/SOSTDC1.
[Graphical view]
PANTHERiPTHR14903. PTHR14903. 1 hit.
PfamiPF05463. Sclerostin. 1 hit.
[Graphical view]
PROSITEiPS01225. CTCK_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Uterine sensitization-associated gene-1: a novel gene induced within the rat endometrium at the time of uterine receptivity/sensitization for the decidual cell reaction."
    Simmons D.G., Kennedy T.G.
    Biol. Reprod. 67:1638-1645(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INDUCTION.
    Strain: Sprague-Dawley.
    Tissue: Uterus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  3. "The WNT signalling modulator, Wise, is expressed in an interaction-dependent manner during hair-follicle cycling."
    O'Shaughnessy R.F.L., Yeo W., Gautier J., Jahoda C.A.B., Christiano A.M.
    J. Invest. Dermatol. 123:613-621(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiSOSD1_RAT
AccessioniPrimary (citable) accession number: Q642G2
Secondary accession number(s): Q8CJA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: October 25, 2004
Last modified: June 8, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.