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Protein

Vesicle-trafficking protein SEC22a

Gene

Sec22a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in vesicle transport between the ER and the Golgi complex.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-204005 COPII-mediated vesicle transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle-trafficking protein SEC22a
Alternative name(s):
SEC22 vesicle-trafficking protein homolog A
SEC22 vesicle-trafficking protein-like 2
Short name:
rSec22a
Gene namesi
Name:Sec22a
Synonyms:Sec22l2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi621659 Sec22a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 187CytoplasmicSequence analysisAdd BLAST186
Transmembranei188 – 208HelicalSequence analysisAdd BLAST21
Topological domaini209 – 226LumenalSequence analysisAdd BLAST18
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21
Topological domaini248 – 253CytoplasmicSequence analysis6
Transmembranei254 – 271HelicalSequence analysisAdd BLAST18
Topological domaini272 – 274LumenalSequence analysis3
Transmembranei275 – 295HelicalSequence analysisAdd BLAST21
Topological domaini296 – 307CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002530462 – 307Vesicle-trafficking protein SEC22aAdd BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei6PhosphoserineBy similarity1
Modified residuei8PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ642F4
PRIDEiQ642F4

Expressioni

Gene expression databases

BgeeiENSRNOG00000043069
GenevisibleiQ642F4 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061258

Structurei

3D structure databases

ProteinModelPortaliQ642F4
SMRiQ642F4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 119LonginPROSITE-ProRule annotationAdd BLAST112

Sequence similaritiesi

Belongs to the synaptobrevin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0862 Eukaryota
COG5143 LUCA
GeneTreeiENSGT00510000046833
HOVERGENiHBG053258
InParanoidiQ642F4
KOiK08520
OMAiVQECRKY
OrthoDBiEOG091G0MPE
PhylomeDBiQ642F4

Family and domain databases

InterProiView protein in InterPro
IPR011012 Longin-like_dom_sf
IPR010908 Longin_dom
IPR027152 Sec22a
PANTHERiPTHR21136:SF68 PTHR21136:SF68, 1 hit
PfamiView protein in Pfam
PF13774 Longin, 1 hit
SMARTiView protein in SMART
SM01270 Longin, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS50859 LONGIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q642F4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSMILSASVV RVRDGLPLSA STDCEQSAGV QECRKYFKML SRKLAQFPDR
60 70 80 90 100
CTLKTGRHNI NFISSLGVSY MMLCTENYPN VLAFSFLDEL QKEFITTYNM
110 120 130 140 150
MKTNTAVRPY CFIEFDNFIQ RTKQRYNNPR SLSTKINLSD MQMEIKLRPP
160 170 180 190 200
YQIPMCELGS ANGVTSAFSV DCKGAGKISS AHQRLEPATL SGIVAFILSL
210 220 230 240 250
LCGALNLIRG FHAIESLLQS DGEDFSYMIA FFLGTAACLY QCYLLVYYTS
260 270 280 290 300
WRNVKSFLTF GLICLCNMYL YELRNLWQLF FHVTVGAFVT LQIWLRQAQG

KAPDHDV
Length:307
Mass (Da):34,902
Last modified:October 25, 2004 - v1
Checksum:i6476E49A735794E9
GO
Isoform 21 Publication (identifier: Q642F4-2) [UniParc]FASTAAdd to basket
Also known as: rsec22a1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     242-307: CYLLVYYTSW...AQGKAPDHDV → MICLCLQGRKERT

Show »
Length:254
Mass (Da):28,544
Checksum:i5660A25B16C4D2D6
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_020996242 – 307CYLLV…PDHDV → MICLCLQGRKERT in isoform 2. 1 PublicationAdd BLAST66

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U42209 mRNA Translation: AAB03367.1
BC081746 mRNA Translation: AAH81746.1
RefSeqiNP_476488.2, NM_057147.2 [Q642F4-1]
XP_006248481.1, XM_006248419.3 [Q642F4-1]
XP_006248482.1, XM_006248420.3 [Q642F4-1]
XP_008766915.2, XM_008768693.2 [Q642F4-2]
UniGeneiRn.34191

Genome annotation databases

EnsembliENSRNOT00000063795; ENSRNOP00000061258; ENSRNOG00000043069 [Q642F4-1]
GeneIDi117513
KEGGirno:117513
UCSCiRGD:621659 rat [Q642F4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSC22A_RAT
AccessioniPrimary (citable) accession number: Q642F4
Secondary accession number(s): Q62891
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 25, 2004
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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