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Protein

Vesicle-trafficking protein SEC22a

Gene

Sec22a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in vesicle transport between the ER and the Golgi complex.1 Publication

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: RGD
  • protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle-trafficking protein SEC22a
Alternative name(s):
SEC22 vesicle-trafficking protein homolog A
SEC22 vesicle-trafficking protein-like 2
Short name:
rSec22a
Gene namesi
Name:Sec22a
Synonyms:Sec22l2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi621659. Sec22a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 187186CytoplasmicSequence analysisAdd
BLAST
Transmembranei188 – 20821HelicalSequence analysisAdd
BLAST
Topological domaini209 – 22618LumenalSequence analysisAdd
BLAST
Transmembranei227 – 24721HelicalSequence analysisAdd
BLAST
Topological domaini248 – 2536CytoplasmicSequence analysis
Transmembranei254 – 27118HelicalSequence analysisAdd
BLAST
Topological domaini272 – 2743LumenalSequence analysis
Transmembranei275 – 29521HelicalSequence analysisAdd
BLAST
Topological domaini296 – 30712CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 307306Vesicle-trafficking protein SEC22aPRO_0000253046Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei6 – 61PhosphoserineBy similarity
Modified residuei8 – 81PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ642F4.
PRIDEiQ642F4.

Expressioni

Gene expression databases

GenevisibleiQ642F4. RN.

Interactioni

Protein-protein interaction databases

MINTiMINT-4570018.
STRINGi10116.ENSRNOP00000061258.

Structurei

3D structure databases

ProteinModelPortaliQ642F4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 119112LonginPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the synaptobrevin family.Curated
Contains 1 longin domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0862. Eukaryota.
COG5143. LUCA.
GeneTreeiENSGT00510000046833.
HOVERGENiHBG053258.
InParanoidiQ642F4.
KOiK08520.
OMAiVQECRKY.
OrthoDBiEOG7TBC2D.
PhylomeDBiQ642F4.

Family and domain databases

Gene3Di3.30.450.50. 1 hit.
InterProiIPR011012. Longin-like_dom.
IPR010908. Longin_dom.
IPR027152. Sec22a.
[Graphical view]
PANTHERiPTHR21136:SF68. PTHR21136:SF68. 1 hit.
PfamiPF13774. Longin. 1 hit.
[Graphical view]
SMARTiSM01270. Longin. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS50859. LONGIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q642F4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSMILSASVV RVRDGLPLSA STDCEQSAGV QECRKYFKML SRKLAQFPDR
60 70 80 90 100
CTLKTGRHNI NFISSLGVSY MMLCTENYPN VLAFSFLDEL QKEFITTYNM
110 120 130 140 150
MKTNTAVRPY CFIEFDNFIQ RTKQRYNNPR SLSTKINLSD MQMEIKLRPP
160 170 180 190 200
YQIPMCELGS ANGVTSAFSV DCKGAGKISS AHQRLEPATL SGIVAFILSL
210 220 230 240 250
LCGALNLIRG FHAIESLLQS DGEDFSYMIA FFLGTAACLY QCYLLVYYTS
260 270 280 290 300
WRNVKSFLTF GLICLCNMYL YELRNLWQLF FHVTVGAFVT LQIWLRQAQG

KAPDHDV
Length:307
Mass (Da):34,902
Last modified:October 25, 2004 - v1
Checksum:i6476E49A735794E9
GO
Isoform 21 Publication (identifier: Q642F4-2) [UniParc]FASTAAdd to basket

Also known as: rsec22a1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     242-307: CYLLVYYTSW...AQGKAPDHDV → MICLCLQGRKERT

Show »
Length:254
Mass (Da):28,544
Checksum:i5660A25B16C4D2D6
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei242 – 30766CYLLV…PDHDV → MICLCLQGRKERT in isoform 2. 1 PublicationVSP_020996Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U42209 mRNA. Translation: AAB03367.1.
BC081746 mRNA. Translation: AAH81746.1.
RefSeqiNP_476488.2. NM_057147.2. [Q642F4-1]
XP_006248481.1. XM_006248419.2. [Q642F4-1]
XP_006248482.1. XM_006248420.2. [Q642F4-1]
UniGeneiRn.34191.

Genome annotation databases

EnsembliENSRNOT00000063795; ENSRNOP00000061258; ENSRNOG00000043069. [Q642F4-1]
GeneIDi117513.
KEGGirno:117513.
UCSCiRGD:621659. rat. [Q642F4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U42209 mRNA. Translation: AAB03367.1.
BC081746 mRNA. Translation: AAH81746.1.
RefSeqiNP_476488.2. NM_057147.2. [Q642F4-1]
XP_006248481.1. XM_006248419.2. [Q642F4-1]
XP_006248482.1. XM_006248420.2. [Q642F4-1]
UniGeneiRn.34191.

3D structure databases

ProteinModelPortaliQ642F4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4570018.
STRINGi10116.ENSRNOP00000061258.

Proteomic databases

PaxDbiQ642F4.
PRIDEiQ642F4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000063795; ENSRNOP00000061258; ENSRNOG00000043069. [Q642F4-1]
GeneIDi117513.
KEGGirno:117513.
UCSCiRGD:621659. rat. [Q642F4-1]

Organism-specific databases

CTDi26984.
RGDi621659. Sec22a.

Phylogenomic databases

eggNOGiKOG0862. Eukaryota.
COG5143. LUCA.
GeneTreeiENSGT00510000046833.
HOVERGENiHBG053258.
InParanoidiQ642F4.
KOiK08520.
OMAiVQECRKY.
OrthoDBiEOG7TBC2D.
PhylomeDBiQ642F4.

Miscellaneous databases

PROiQ642F4.

Gene expression databases

GenevisibleiQ642F4. RN.

Family and domain databases

Gene3Di3.30.450.50. 1 hit.
InterProiIPR011012. Longin-like_dom.
IPR010908. Longin_dom.
IPR027152. Sec22a.
[Graphical view]
PANTHERiPTHR21136:SF68. PTHR21136:SF68. 1 hit.
PfamiPF13774. Longin. 1 hit.
[Graphical view]
SMARTiSM01270. Longin. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS50859. LONGIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mammalian vesicle trafficking proteins of the endoplasmic reticulum and Golgi apparatus."
    Hay J.C., Hirling H., Scheller R.H.
    J. Biol. Chem. 271:5671-5679(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, SUBCELLULAR LOCATION.
    Strain: Sprague-DawleyImported.
    Tissue: Liver1 Publication.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.

Entry informationi

Entry nameiSC22A_RAT
AccessioniPrimary (citable) accession number: Q642F4
Secondary accession number(s): Q62891
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 25, 2004
Last modified: June 8, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.