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Protein

Zinc finger protein 18

Gene

Znf18

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri415 – 43723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri443 – 46523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri471 – 49323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri499 – 52123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri527 – 54923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 18
Alternative name(s):
Zinc finger protein 535
Gene namesi
Name:Znf18
Synonyms:Zfp18, Zfp535
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1305130. Zfp18.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Zinc finger protein 18PRO_0000047342Add
BLAST

Proteomic databases

PaxDbiQ642B9.
PRIDEiQ642B9.

Expressioni

Gene expression databases

GenevisibleiQ642B9. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005518.

Structurei

3D structure databases

ProteinModelPortaliQ642B9.
SMRiQ642B9. Positions 36-125, 440-549.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 12383SCAN boxPROSITE-ProRule annotationAdd
BLAST
Domaini218 – 29174KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri415 – 43723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri443 – 46523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri471 – 49323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri499 – 52123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri527 – 54923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129746.
HOGENOMiHOG000234619.
HOVERGENiHBG102043.
InParanoidiQ642B9.
KOiK09229.
OMAiSHIVKEE.
OrthoDBiEOG7FNC71.
PhylomeDBiQ642B9.
TreeFamiTF337489.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR027764. Zfp18.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PTHR10032:SF11. PTHR10032:SF11. 1 hit.
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q642B9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVNLGQALG LLPFLAKAED ATFSGSDVIQ QRELANPETA RQLFRQFRYQ
60 70 80 90 100
VMSGPQETLR QLRKLCFQWL RPEVHTKEQI LEILMLEQFL TILPGEIQMW
110 120 130 140 150
VRKQCPGSGE EAVTLVESLK GDPQKLWQWI SIQVLGQEIP FEKENSARCR
160 170 180 190 200
GDKVEPALEA EPTVEVVPQD LPLQNTSSAP GELLSHGVKE ESDLEPELAL
210 220 230 240 250
AASQLPARPE ERPTRDQEVG TALLPSLQEE QWRHLDSTQK EQYWDLMLET
260 270 280 290 300
YGKMVSGVAG ISNSKPDLTN MAEYGEELVG LHLHSAEKMA RAPCKEDRQE
310 320 330 340 350
NDKENLNLEN HRDQGCLDVF DQAPGEAPPQ TALSDFFGES EPHHFGGESV
360 370 380 390 400
PEALENLQGE GTGAHLFPHE RGSGKQLGQH IQSSSSGELS ALWLEEKREA
410 420 430 440 450
SQKGQARAPM AQKLPTCREC GKTFYRNSQL VFHQRTHTGE TYFHCRICKK
460 470 480 490 500
AFLRSSDFVK HQRTHTGEKP CKCDYCGKGF SDFSGLRHHE KIHTGEKPYK
510 520 530 540 550
CPICEKSFIQ RSNFNRHQRV HTGEKPYKCT HCGKRFSWSS SLDKHQRSHL

GKKPCP
Length:556
Mass (Da):62,947
Last modified:October 25, 2004 - v1
Checksum:i81BE49E124CC8200
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081874 mRNA. Translation: AAH81874.1.
RefSeqiNP_001012008.1. NM_001012008.1.
XP_006246757.1. XM_006246695.2.
UniGeneiRn.93963.

Genome annotation databases

EnsembliENSRNOT00000005518; ENSRNOP00000005518; ENSRNOG00000003981.
GeneIDi303226.
KEGGirno:303226.
UCSCiRGD:1305130. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081874 mRNA. Translation: AAH81874.1.
RefSeqiNP_001012008.1. NM_001012008.1.
XP_006246757.1. XM_006246695.2.
UniGeneiRn.93963.

3D structure databases

ProteinModelPortaliQ642B9.
SMRiQ642B9. Positions 36-125, 440-549.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005518.

Proteomic databases

PaxDbiQ642B9.
PRIDEiQ642B9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005518; ENSRNOP00000005518; ENSRNOG00000003981.
GeneIDi303226.
KEGGirno:303226.
UCSCiRGD:1305130. rat.

Organism-specific databases

CTDi303226.
RGDi1305130. Zfp18.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129746.
HOGENOMiHOG000234619.
HOVERGENiHBG102043.
InParanoidiQ642B9.
KOiK09229.
OMAiSHIVKEE.
OrthoDBiEOG7FNC71.
PhylomeDBiQ642B9.
TreeFamiTF337489.

Miscellaneous databases

PROiQ642B9.

Gene expression databases

GenevisibleiQ642B9. RN.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR027764. Zfp18.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PTHR10032:SF11. PTHR10032:SF11. 1 hit.
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiZNF18_RAT
AccessioniPrimary (citable) accession number: Q642B9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 25, 2004
Last modified: June 8, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.