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Protein

Zinc finger protein 18

Gene

Znf18

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri415 – 437C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri443 – 465C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri471 – 493C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri499 – 521C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri527 – 549C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 18
Alternative name(s):
Zinc finger protein 535
Gene namesi
Name:Znf18
Synonyms:Zfp18, Zfp535
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1305130 Zfp18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473421 – 556Zinc finger protein 18Add BLAST556

Proteomic databases

PaxDbiQ642B9
PRIDEiQ642B9

Expressioni

Gene expression databases

BgeeiENSRNOG00000003981
GenevisibleiQ642B9 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005518

Structurei

3D structure databases

ProteinModelPortaliQ642B9
SMRiQ642B9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 123SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini218 – 291KRABPROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri415 – 437C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri443 – 465C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri471 – 493C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri499 – 521C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri527 – 549C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144000
HOGENOMiHOG000234619
HOVERGENiHBG102043
InParanoidiQ642B9
KOiK09229
OMAiVMSGPHE
OrthoDBiEOG091G04IJ
PhylomeDBiQ642B9
TreeFamiTF337489

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR027764 Zfp18/Zfp446
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR45403 PTHR45403, 1 hit
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequencei

Sequence statusi: Complete.

Q642B9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVNLGQALG LLPFLAKAED ATFSGSDVIQ QRELANPETA RQLFRQFRYQ
60 70 80 90 100
VMSGPQETLR QLRKLCFQWL RPEVHTKEQI LEILMLEQFL TILPGEIQMW
110 120 130 140 150
VRKQCPGSGE EAVTLVESLK GDPQKLWQWI SIQVLGQEIP FEKENSARCR
160 170 180 190 200
GDKVEPALEA EPTVEVVPQD LPLQNTSSAP GELLSHGVKE ESDLEPELAL
210 220 230 240 250
AASQLPARPE ERPTRDQEVG TALLPSLQEE QWRHLDSTQK EQYWDLMLET
260 270 280 290 300
YGKMVSGVAG ISNSKPDLTN MAEYGEELVG LHLHSAEKMA RAPCKEDRQE
310 320 330 340 350
NDKENLNLEN HRDQGCLDVF DQAPGEAPPQ TALSDFFGES EPHHFGGESV
360 370 380 390 400
PEALENLQGE GTGAHLFPHE RGSGKQLGQH IQSSSSGELS ALWLEEKREA
410 420 430 440 450
SQKGQARAPM AQKLPTCREC GKTFYRNSQL VFHQRTHTGE TYFHCRICKK
460 470 480 490 500
AFLRSSDFVK HQRTHTGEKP CKCDYCGKGF SDFSGLRHHE KIHTGEKPYK
510 520 530 540 550
CPICEKSFIQ RSNFNRHQRV HTGEKPYKCT HCGKRFSWSS SLDKHQRSHL

GKKPCP
Length:556
Mass (Da):62,947
Last modified:October 25, 2004 - v1
Checksum:i81BE49E124CC8200
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081874 mRNA Translation: AAH81874.1
RefSeqiNP_001012008.1, NM_001012008.1
XP_006246757.1, XM_006246695.3
UniGeneiRn.93963

Genome annotation databases

EnsembliENSRNOT00000005518; ENSRNOP00000005518; ENSRNOG00000003981
GeneIDi303226
KEGGirno:303226
UCSCiRGD:1305130 rat

Similar proteinsi

Entry informationi

Entry nameiZNF18_RAT
AccessioniPrimary (citable) accession number: Q642B9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 25, 2004
Last modified: March 28, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health