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Q642A5

- DPOE3_RAT

UniProt

Q642A5 - DPOE3_RAT

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Protein

DNA polymerase epsilon subunit 3

Gene
Pole3
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Forms a complex with DNA polymerase epsilon subunit CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 By similarity.

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

  1. DNA-directed DNA polymerase activity Source: UniProtKB-KW
  2. sequence-specific DNA binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase epsilon subunit 3 (EC:2.7.7.7)
Alternative name(s):
DNA polymerase II subunit 3
DNA polymerase epsilon subunit p17
Gene namesi
Name:Pole3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 5, UP000002494: Chromosome 7

Organism-specific databases

RGDi1359475. Pole3.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. epsilon DNA polymerase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 145144DNA polymerase epsilon subunit 3PRO_0000208344Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei83 – 831Phosphothreonine By similarity
Modified residuei121 – 1211Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ642A5.

Expressioni

Gene expression databases

GenevestigatoriQ642A5.

Interactioni

Subunit structurei

Component of the epsilon DNA polymerase complex consisting of four subunits: POLE, POLE2, POLE3 and POLE4. Interaction with POLE4 is a prerequisite for further binding with POLE and POLE2. Interacts with CHRAC1. Together with CHRAC1, ACF1 and ISWI/SNF2H proteins, it forms the ISWI chromatin-remodeling complex, CHRAC By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020722.

Structurei

3D structure databases

ProteinModelPortaliQ642A5.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili85 – 14460 Reviewed predictionAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG2036.
GeneTreeiENSGT00550000074689.
HOGENOMiHOG000007701.
HOVERGENiHBG060262.
InParanoidiQ642A5.
KOiK02326.
OMAiKSREDDN.
OrthoDBiEOG7RNK2W.
PhylomeDBiQ642A5.
TreeFamiTF103008.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR003958. CBFA_NFYB_domain.
IPR009072. Histone-fold.
[Graphical view]
PfamiPF00808. CBFD_NFYB_HMF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q642A5-1 [UniParc]FASTAAdd to Basket

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MAERPEDLNL PNAVITRIIK EALPDGVNIS KEARSAISRA ASVFVLYATS    50
CANNFAMKGK RKTLNASDVL SAMEEMEFQR FVTPLKEALE AYRREQKGKK 100
EASEQKKKDK DKKDCEEQDK SREEEDEDEE RLDEEEQNEE EEVDN 145
Length:145
Mass (Da):16,674
Last modified:October 25, 2004 - v1
Checksum:i6CB14ED20FE15EC1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC081988 mRNA. Translation: AAH81988.1.
BC083800 mRNA. Translation: AAH83800.1.
RefSeqiNP_001007653.1. NM_001007652.2.
XP_002726991.1. XM_002726945.3.
XP_002729875.1. XM_002729829.3.
UniGeneiRn.3290.

Genome annotation databases

EnsembliENSRNOT00000006416; ENSRNOP00000006416; ENSRNOG00000004843.
ENSRNOT00000020722; ENSRNOP00000020722; ENSRNOG00000015392.
GeneIDi100362333.
298098.
KEGGirno:100362333.
rno:298098.
UCSCiRGD:1359475. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC081988 mRNA. Translation: AAH81988.1 .
BC083800 mRNA. Translation: AAH83800.1 .
RefSeqi NP_001007653.1. NM_001007652.2.
XP_002726991.1. XM_002726945.3.
XP_002729875.1. XM_002729829.3.
UniGenei Rn.3290.

3D structure databases

ProteinModelPortali Q642A5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000020722.

Proteomic databases

PRIDEi Q642A5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000006416 ; ENSRNOP00000006416 ; ENSRNOG00000004843 .
ENSRNOT00000020722 ; ENSRNOP00000020722 ; ENSRNOG00000015392 .
GeneIDi 100362333.
298098.
KEGGi rno:100362333.
rno:298098.
UCSCi RGD:1359475. rat.

Organism-specific databases

CTDi 54107.
RGDi 1359475. Pole3.

Phylogenomic databases

eggNOGi COG2036.
GeneTreei ENSGT00550000074689.
HOGENOMi HOG000007701.
HOVERGENi HBG060262.
InParanoidi Q642A5.
KOi K02326.
OMAi KSREDDN.
OrthoDBi EOG7RNK2W.
PhylomeDBi Q642A5.
TreeFami TF103008.

Miscellaneous databases

NextBioi 643156.
PROi Q642A5.

Gene expression databases

Genevestigatori Q642A5.

Family and domain databases

Gene3Di 1.10.20.10. 1 hit.
InterProi IPR003958. CBFA_NFYB_domain.
IPR009072. Histone-fold.
[Graphical view ]
Pfami PF00808. CBFD_NFYB_HMF. 1 hit.
[Graphical view ]
SUPFAMi SSF47113. SSF47113. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiDPOE3_RAT
AccessioniPrimary (citable) accession number: Q642A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: October 25, 2004
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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