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Q642A5

- DPOE3_RAT

UniProt

Q642A5 - DPOE3_RAT

Protein

DNA polymerase epsilon subunit 3

Gene

Pole3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Forms a complex with DNA polymerase epsilon subunit CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1.By similarity

    Catalytic activityi

    Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

    GO - Molecular functioni

    1. DNA-directed DNA polymerase activity Source: UniProtKB-KW
    2. sequence-specific DNA binding Source: InterPro

    Keywords - Molecular functioni

    DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA polymerase epsilon subunit 3 (EC:2.7.7.7)
    Alternative name(s):
    DNA polymerase II subunit 3
    DNA polymerase epsilon subunit p17
    Gene namesi
    Name:Pole3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 5, UP000002494: Chromosome 7

    Organism-specific databases

    RGDi1359475. Pole3.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. epsilon DNA polymerase complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 145144DNA polymerase epsilon subunit 3PRO_0000208344Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei83 – 831PhosphothreonineBy similarity
    Modified residuei121 – 1211PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PRIDEiQ642A5.

    Expressioni

    Gene expression databases

    GenevestigatoriQ642A5.

    Interactioni

    Subunit structurei

    Component of the epsilon DNA polymerase complex consisting of four subunits: POLE, POLE2, POLE3 and POLE4. Interaction with POLE4 is a prerequisite for further binding with POLE and POLE2. Interacts with CHRAC1. Together with CHRAC1, ACF1 and ISWI/SNF2H proteins, it forms the ISWI chromatin-remodeling complex, CHRAC By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000020722.

    Structurei

    3D structure databases

    ProteinModelPortaliQ642A5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili85 – 14460Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG2036.
    GeneTreeiENSGT00550000074689.
    HOGENOMiHOG000007701.
    HOVERGENiHBG060262.
    InParanoidiQ642A5.
    KOiK02326.
    OMAiKSREDDN.
    OrthoDBiEOG7RNK2W.
    PhylomeDBiQ642A5.
    TreeFamiTF103008.

    Family and domain databases

    Gene3Di1.10.20.10. 1 hit.
    InterProiIPR003958. CBFA_NFYB_domain.
    IPR009072. Histone-fold.
    [Graphical view]
    PfamiPF00808. CBFD_NFYB_HMF. 1 hit.
    [Graphical view]
    SUPFAMiSSF47113. SSF47113. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q642A5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAERPEDLNL PNAVITRIIK EALPDGVNIS KEARSAISRA ASVFVLYATS    50
    CANNFAMKGK RKTLNASDVL SAMEEMEFQR FVTPLKEALE AYRREQKGKK 100
    EASEQKKKDK DKKDCEEQDK SREEEDEDEE RLDEEEQNEE EEVDN 145
    Length:145
    Mass (Da):16,674
    Last modified:October 25, 2004 - v1
    Checksum:i6CB14ED20FE15EC1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC081988 mRNA. Translation: AAH81988.1.
    BC083800 mRNA. Translation: AAH83800.1.
    RefSeqiNP_001007653.1. NM_001007652.2.
    XP_002726991.1. XM_002726945.3.
    XP_002729875.1. XM_002729829.3.
    UniGeneiRn.3290.

    Genome annotation databases

    EnsembliENSRNOT00000006416; ENSRNOP00000006416; ENSRNOG00000004843.
    ENSRNOT00000020722; ENSRNOP00000020722; ENSRNOG00000015392.
    GeneIDi100362333.
    298098.
    KEGGirno:100362333.
    rno:298098.
    UCSCiRGD:1359475. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC081988 mRNA. Translation: AAH81988.1 .
    BC083800 mRNA. Translation: AAH83800.1 .
    RefSeqi NP_001007653.1. NM_001007652.2.
    XP_002726991.1. XM_002726945.3.
    XP_002729875.1. XM_002729829.3.
    UniGenei Rn.3290.

    3D structure databases

    ProteinModelPortali Q642A5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000020722.

    Proteomic databases

    PRIDEi Q642A5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000006416 ; ENSRNOP00000006416 ; ENSRNOG00000004843 .
    ENSRNOT00000020722 ; ENSRNOP00000020722 ; ENSRNOG00000015392 .
    GeneIDi 100362333.
    298098.
    KEGGi rno:100362333.
    rno:298098.
    UCSCi RGD:1359475. rat.

    Organism-specific databases

    CTDi 54107.
    RGDi 1359475. Pole3.

    Phylogenomic databases

    eggNOGi COG2036.
    GeneTreei ENSGT00550000074689.
    HOGENOMi HOG000007701.
    HOVERGENi HBG060262.
    InParanoidi Q642A5.
    KOi K02326.
    OMAi KSREDDN.
    OrthoDBi EOG7RNK2W.
    PhylomeDBi Q642A5.
    TreeFami TF103008.

    Miscellaneous databases

    NextBioi 643156.
    PROi Q642A5.

    Gene expression databases

    Genevestigatori Q642A5.

    Family and domain databases

    Gene3Di 1.10.20.10. 1 hit.
    InterProi IPR003958. CBFA_NFYB_domain.
    IPR009072. Histone-fold.
    [Graphical view ]
    Pfami PF00808. CBFD_NFYB_HMF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47113. SSF47113. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiDPOE3_RAT
    AccessioniPrimary (citable) accession number: Q642A5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3