Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q642A5 (DPOE3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
DNA polymerase epsilon subunit 3

EC=2.7.7.7
Alternative name(s):
DNA polymerase II subunit 3
DNA polymerase epsilon subunit p17
Gene names
Name:Pole3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length145 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Forms a complex with DNA polymerase epsilon subunit CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 By similarity.

Catalytic activity

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Subunit structure

Component of the epsilon DNA polymerase complex consisting of four subunits: POLE, POLE2, POLE3 and POLE4. Interaction with POLE4 is a prerequisite for further binding with POLE and POLE2. Interacts with CHRAC1. Together with CHRAC1, ACF1 and ISWI/SNF2H proteins, it forms the ISWI chromatin-remodeling complex, CHRAC By similarity.

Subcellular location

Nucleus Potential.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 145144DNA polymerase epsilon subunit 3
PRO_0000208344

Regions

Coiled coil85 – 14460 Potential

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue831Phosphothreonine By similarity
Modified residue1211Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q642A5 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: 6CB14ED20FE15EC1

FASTA14516,674
        10         20         30         40         50         60 
MAERPEDLNL PNAVITRIIK EALPDGVNIS KEARSAISRA ASVFVLYATS CANNFAMKGK 

        70         80         90        100        110        120 
RKTLNASDVL SAMEEMEFQR FVTPLKEALE AYRREQKGKK EASEQKKKDK DKKDCEEQDK 

       130        140 
SREEEDEDEE RLDEEEQNEE EEVDN 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC081988 mRNA. Translation: AAH81988.1.
BC083800 mRNA. Translation: AAH83800.1.
RefSeqNP_001007653.1. NM_001007652.2.
XP_002726991.1. XM_002726945.3.
XP_002729875.1. XM_002729829.3.
UniGeneRn.3290.

3D structure databases

ProteinModelPortalQ642A5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000020722.

Proteomic databases

PRIDEQ642A5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000006416; ENSRNOP00000006416; ENSRNOG00000004843.
ENSRNOT00000020722; ENSRNOP00000020722; ENSRNOG00000015392.
GeneID100362333.
298098.
KEGGrno:100362333.
rno:298098.
UCSCRGD:1359475. rat.

Organism-specific databases

CTD54107.
RGD1359475. Pole3.

Phylogenomic databases

eggNOGCOG2036.
GeneTreeENSGT00550000074689.
HOGENOMHOG000007701.
HOVERGENHBG060262.
InParanoidQ642A5.
KOK02326.
OMAKSREDDN.
OrthoDBEOG7RNK2W.
PhylomeDBQ642A5.
TreeFamTF103008.

Gene expression databases

GenevestigatorQ642A5.

Family and domain databases

Gene3D1.10.20.10. 1 hit.
InterProIPR003958. CBFA_NFYB_domain.
IPR009072. Histone-fold.
[Graphical view]
PfamPF00808. CBFD_NFYB_HMF. 1 hit.
[Graphical view]
SUPFAMSSF47113. SSF47113. 1 hit.
ProtoNetSearch...

Other

NextBio643156.
PROQ642A5.

Entry information

Entry nameDPOE3_RAT
AccessionPrimary (citable) accession number: Q642A5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: October 25, 2004
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program