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Q642A2

- ATRAP_RAT

UniProt

Q642A2 - ATRAP_RAT

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Protein

Type-1 angiotensin II receptor-associated protein

Gene
Agtrap, Atrap
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. May play a role of negative regulator in cardiomyocyte hypertrophy induced by angiotensin II through an inhibition of p38 mitogen-activated protein kinase pathway. Attenuates type-1 angiotensin II receptor growth promoting effect and angiotensin II-induced phosphorylation of protein kinase AKT and of STAT3.1 Publication

GO - Molecular functioni

  1. angiotensin type II receptor activity Source: Ensembl

GO - Biological processi

  1. regulation of blood pressure Source: Ensembl
  2. response to hypoxia Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Type-1 angiotensin II receptor-associated protein
Alternative name(s):
AT1 receptor-associated protein
Gene namesi
Name:Agtrap
Synonyms:Atrap
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 5

Organism-specific databases

RGDi1359346. Agtrap.

Subcellular locationi

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity. Golgi apparatus membrane; Multi-pass membrane protein By similarity. Cytoplasmic vesicle membrane; Multi-pass membrane protein By similarity
Note: Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99Extracellular Reviewed prediction
Transmembranei10 – 3021Helical; Reviewed predictionAdd
BLAST
Topological domaini31 – 5323Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei54 – 7421Helical; Reviewed predictionAdd
BLAST
Topological domaini75 – 8612Extracellular Reviewed predictionAdd
BLAST
Transmembranei87 – 10721Helical; Reviewed predictionAdd
BLAST
Topological domaini108 – 16053Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell cortex Source: Ensembl
  2. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  3. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  4. Golgi membrane Source: UniProtKB-SubCell
  5. integral component of membrane Source: UniProtKB-KW
  6. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 160160Type-1 angiotensin II receptor-associated proteinPRO_0000064738Add
BLAST

Proteomic databases

PRIDEiQ642A2.

Expressioni

Gene expression databases

GenevestigatoriQ642A2.

Interactioni

Subunit structurei

Interacts with GNB2L1/RACK1, and with the carboxy-terminal region of AGTR1 By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011747.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni110 – 12213Interaction with AGTR1 By similarityAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45277.
GeneTreeiENSGT00390000017402.
HOGENOMiHOG000034218.
HOVERGENiHBG080881.
InParanoidiQ642A2.
OMAiVHISIFY.
OrthoDBiEOG7S4X7K.
PhylomeDBiQ642A2.
TreeFamiTF324477.

Family and domain databases

InterProiIPR009436. Angiotensin_II_typ1_rcpt-assoc.
[Graphical view]
PfamiPF06396. AGTRAP. 1 hit.
[Graphical view]
ProDomiPD357679. PD357679. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00805. AGTRAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q642A2-1 [UniParc]FASTAAdd to Basket

« Hide

MELPAVNLKV ILLVHWLLTT WGCLAFSGSY AWGNFTILAL GVWAVAQRDS    50
VDAIGMFLGG LVATIFLDII YISIFYSSVA VGDTGRFSAG MAIFSLLLKP 100
FSCCLVYHMH RERGGELPLR SDFFGPSQEH SAYQTIDSSD SPADPLASLE 150
NKGQAAPRGY 160
Length:160
Mass (Da):17,398
Last modified:October 25, 2004 - v1
Checksum:iDEBD34E6F62CBB5A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC082019 mRNA. Translation: AAH82019.1.
RefSeqiNP_001007655.1. NM_001007654.1.
UniGeneiRn.8471.

Genome annotation databases

EnsembliENSRNOT00000011747; ENSRNOP00000011747; ENSRNOG00000008619.
GeneIDi298646.
KEGGirno:298646.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC082019 mRNA. Translation: AAH82019.1 .
RefSeqi NP_001007655.1. NM_001007654.1.
UniGenei Rn.8471.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000011747.

Proteomic databases

PRIDEi Q642A2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000011747 ; ENSRNOP00000011747 ; ENSRNOG00000008619 .
GeneIDi 298646.
KEGGi rno:298646.

Organism-specific databases

CTDi 57085.
RGDi 1359346. Agtrap.

Phylogenomic databases

eggNOGi NOG45277.
GeneTreei ENSGT00390000017402.
HOGENOMi HOG000034218.
HOVERGENi HBG080881.
InParanoidi Q642A2.
OMAi VHISIFY.
OrthoDBi EOG7S4X7K.
PhylomeDBi Q642A2.
TreeFami TF324477.

Miscellaneous databases

NextBioi 644104.
PROi Q642A2.

Gene expression databases

Genevestigatori Q642A2.

Family and domain databases

InterProi IPR009436. Angiotensin_II_typ1_rcpt-assoc.
[Graphical view ]
Pfami PF06396. AGTRAP. 1 hit.
[Graphical view ]
ProDomi PD357679. PD357679. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00805. AGTRAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  2. "ATRAP, novel AT1 receptor associated protein, enhances internalization of AT1 receptor and inhibits vascular smooth muscle cell growth."
    Cui T., Nakagami H., Iwai M., Takeda Y., Shiuchi T., Tamura K., Daviet L., Horiuchi M.
    Biochem. Biophys. Res. Commun. 279:938-941(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiATRAP_RAT
AccessioniPrimary (citable) accession number: Q642A2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 25, 2004
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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