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Protein

Type-1 angiotensin II receptor-associated protein

Gene

Agtrap

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. May play a role of negative regulator in cardiomyocyte hypertrophy induced by angiotensin II through an inhibition of p38 mitogen-activated protein kinase pathway. Attenuates type-1 angiotensin II receptor growth promoting effect and angiotensin II-induced phosphorylation of protein kinase AKT and of STAT3.1 Publication

GO - Molecular functioni

GO - Biological processi

  • regulation of blood pressure Source: Ensembl
  • response to hypoxia Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Type-1 angiotensin II receptor-associated protein
Alternative name(s):
AT1 receptor-associated protein
Gene namesi
Name:Agtrap
Synonyms:Atrap
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1359346. Agtrap.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99ExtracellularSequence Analysis
Transmembranei10 – 3021HelicalSequence AnalysisAdd
BLAST
Topological domaini31 – 5323CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei54 – 7421HelicalSequence AnalysisAdd
BLAST
Topological domaini75 – 8612ExtracellularSequence AnalysisAdd
BLAST
Transmembranei87 – 10721HelicalSequence AnalysisAdd
BLAST
Topological domaini108 – 16053CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 160160Type-1 angiotensin II receptor-associated proteinPRO_0000064738Add
BLAST

Proteomic databases

PRIDEiQ642A2.

Expressioni

Gene expression databases

GenevisibleiQ642A2. RN.

Interactioni

Subunit structurei

Interacts with GNB2L1/RACK1, and with the carboxy-terminal region of AGTR1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011747.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni110 – 12213Interaction with AGTR1By similarityAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45277.
GeneTreeiENSGT00390000017402.
HOGENOMiHOG000034218.
HOVERGENiHBG080881.
InParanoidiQ642A2.
OMAiWANFTIL.
OrthoDBiEOG7S4X7K.
PhylomeDBiQ642A2.
TreeFamiTF324477.

Family and domain databases

InterProiIPR009436. Angiotensin_II_typ1_rcpt-assoc.
[Graphical view]
PfamiPF06396. AGTRAP. 1 hit.
[Graphical view]
ProDomiPD357679. PD357679. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00805. AGTRAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q642A2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELPAVNLKV ILLVHWLLTT WGCLAFSGSY AWGNFTILAL GVWAVAQRDS
60 70 80 90 100
VDAIGMFLGG LVATIFLDII YISIFYSSVA VGDTGRFSAG MAIFSLLLKP
110 120 130 140 150
FSCCLVYHMH RERGGELPLR SDFFGPSQEH SAYQTIDSSD SPADPLASLE
160
NKGQAAPRGY
Length:160
Mass (Da):17,398
Last modified:October 25, 2004 - v1
Checksum:iDEBD34E6F62CBB5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082019 mRNA. Translation: AAH82019.1.
RefSeqiNP_001007655.1. NM_001007654.1.
UniGeneiRn.8471.

Genome annotation databases

EnsembliENSRNOT00000011747; ENSRNOP00000011747; ENSRNOG00000008619.
GeneIDi298646.
KEGGirno:298646.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082019 mRNA. Translation: AAH82019.1.
RefSeqiNP_001007655.1. NM_001007654.1.
UniGeneiRn.8471.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011747.

Proteomic databases

PRIDEiQ642A2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000011747; ENSRNOP00000011747; ENSRNOG00000008619.
GeneIDi298646.
KEGGirno:298646.

Organism-specific databases

CTDi57085.
RGDi1359346. Agtrap.

Phylogenomic databases

eggNOGiNOG45277.
GeneTreeiENSGT00390000017402.
HOGENOMiHOG000034218.
HOVERGENiHBG080881.
InParanoidiQ642A2.
OMAiWANFTIL.
OrthoDBiEOG7S4X7K.
PhylomeDBiQ642A2.
TreeFamiTF324477.

Miscellaneous databases

NextBioi644104.
PROiQ642A2.

Gene expression databases

GenevisibleiQ642A2. RN.

Family and domain databases

InterProiIPR009436. Angiotensin_II_typ1_rcpt-assoc.
[Graphical view]
PfamiPF06396. AGTRAP. 1 hit.
[Graphical view]
ProDomiPD357679. PD357679. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00805. AGTRAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  2. "ATRAP, novel AT1 receptor associated protein, enhances internalization of AT1 receptor and inhibits vascular smooth muscle cell growth."
    Cui T., Nakagami H., Iwai M., Takeda Y., Shiuchi T., Tamura K., Daviet L., Horiuchi M.
    Biochem. Biophys. Res. Commun. 279:938-941(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiATRAP_RAT
AccessioniPrimary (citable) accession number: Q642A2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 25, 2004
Last modified: June 24, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.