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Q642A2 (ATRAP_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Type-1 angiotensin II receptor-associated protein
Alternative name(s):
AT1 receptor-associated protein
Gene names
Name:Agtrap
Synonyms:Atrap
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length160 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. May play a role of negative regulator in cardiomyocyte hypertrophy induced by angiotensin II through an inhibition of p38 mitogen-activated protein kinase pathway. Attenuates type-1 angiotensin II receptor growth promoting effect and angiotensin II-induced phosphorylation of protein kinase AKT and of STAT3. Ref.2

Subunit structure

Interacts with GNB2L1/RACK1, and with the carboxy-terminal region of AGTR1 By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity. Golgi apparatus membrane; Multi-pass membrane protein By similarity. Cytoplasmic vesicle membrane; Multi-pass membrane protein By similarity. Note: Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles By similarity.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 160160Type-1 angiotensin II receptor-associated protein
PRO_0000064738

Regions

Topological domain1 – 99Extracellular Potential
Transmembrane10 – 3021Helical; Potential
Topological domain31 – 5323Cytoplasmic Potential
Transmembrane54 – 7421Helical; Potential
Topological domain75 – 8612Extracellular Potential
Transmembrane87 – 10721Helical; Potential
Topological domain108 – 16053Cytoplasmic Potential
Region110 – 12213Interaction with AGTR1 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q642A2 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: DEBD34E6F62CBB5A

FASTA16017,398
        10         20         30         40         50         60 
MELPAVNLKV ILLVHWLLTT WGCLAFSGSY AWGNFTILAL GVWAVAQRDS VDAIGMFLGG 

        70         80         90        100        110        120 
LVATIFLDII YISIFYSSVA VGDTGRFSAG MAIFSLLLKP FSCCLVYHMH RERGGELPLR 

       130        140        150        160 
SDFFGPSQEH SAYQTIDSSD SPADPLASLE NKGQAAPRGY 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[2]"ATRAP, novel AT1 receptor associated protein, enhances internalization of AT1 receptor and inhibits vascular smooth muscle cell growth."
Cui T., Nakagami H., Iwai M., Takeda Y., Shiuchi T., Tamura K., Daviet L., Horiuchi M.
Biochem. Biophys. Res. Commun. 279:938-941(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC082019 mRNA. Translation: AAH82019.1.
RefSeqNP_001007655.1. NM_001007654.1.
UniGeneRn.8471.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000011747.

Proteomic databases

PRIDEQ642A2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000011747; ENSRNOP00000011747; ENSRNOG00000008619.
GeneID298646.
KEGGrno:298646.

Organism-specific databases

CTD57085.
RGD1359346. Agtrap.

Phylogenomic databases

eggNOGNOG45277.
GeneTreeENSGT00390000017402.
HOGENOMHOG000034218.
HOVERGENHBG080881.
InParanoidQ642A2.
OMAVHISIFY.
OrthoDBEOG7S4X7K.
PhylomeDBQ642A2.
TreeFamTF324477.

Gene expression databases

GenevestigatorQ642A2.

Family and domain databases

InterProIPR009436. Angiotensin_II_typ1_rcpt-assoc.
[Graphical view]
PfamPF06396. AGTRAP. 1 hit.
[Graphical view]
ProDomPD357679. PD357679. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00805. AGTRAP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio644104.
PROQ642A2.

Entry information

Entry nameATRAP_RAT
AccessionPrimary (citable) accession number: Q642A2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 25, 2004
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program