Q642A2 (ATRAP_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Type-1 angiotensin II receptor-associated protein

Alternative name(s):
AT1 receptor-associated protein

Gene names

Name:	Agtrap
Synonyms:	Atrap

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	160 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. May play a role of negative regulator in cardiomyocyte hypertrophy induced by angiotensin II through an inhibition of p38 mitogen-activated protein kinase pathway. Attenuates type-1 angiotensin II receptor growth promoting effect and angiotensin II-induced phosphorylation of protein kinase AKT and of STAT3. Ref.2
Subunit structure	Interacts with GNB2L1/RACK1, and with the carboxy-terminal region of AGTR1 By similarity.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity. Golgi apparatus membrane; Multi-pass membrane protein By similarity. Cytoplasmic vesicle membrane; Multi-pass membrane protein By similarity. Note: Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles By similarity.

Ontologies

Keywords
Cellular component	Cytoplasmic vesicle Endoplasmic reticulum Golgi apparatus Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of blood pressure Inferred from electronic annotation. Source: Compara response to hypoxia Inferred from expression pattern PubMed 17033689. Source: RGD
Cellular_component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell cell cortex Inferred from electronic annotation. Source: Compara cytoplasmic vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: Compara
Molecular_function	angiotensin type II receptor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 160	160	Type-1 angiotensin II receptor-associated protein		PRO_0000064738
Regions
	Topological domain	1 – 9	9	Extracellular Potential
	Transmembrane	10 – 30	21	Helical; Potential
	Topological domain	31 – 53	23	Cytoplasmic Potential
	Transmembrane	54 – 74	21	Helical; Potential
	Topological domain	75 – 86	12	Extracellular Potential
	Transmembrane	87 – 107	21	Helical; Potential
	Topological domain	108 – 160	53	Cytoplasmic Potential
	Region	110 – 122	13	Interaction with AGTR1 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q642A2 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: DEBD34E6F62CBB5A	FASTA	160	17,398
	10 20 30 40 50 60 MELPAVNLKV ILLVHWLLTT WGCLAFSGSY AWGNFTILAL GVWAVAQRDS VDAIGMFLGG 70 80 90 100 110 120 LVATIFLDII YISIFYSSVA VGDTGRFSAG MAIFSLLLKP FSCCLVYHMH RERGGELPLR 130 140 150 160 SDFFGPSQEH SAYQTIDSSD SPADPLASLE NKGQAAPRGY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[2]	"ATRAP, novel AT1 receptor associated protein, enhances internalization of AT1 receptor and inhibits vascular smooth muscle cell growth." Cui T., Nakagami H., Iwai M., Takeda Y., Shiuchi T., Tamura K., Daviet L., Horiuchi M. Biochem. Biophys. Res. Commun. 279:938-941(2000) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC082019 mRNA. Translation: AAH82019.1.
IPI	IPI00365307.
RefSeq	NP_001007655.1. NM_001007654.1.
UniGene	Rn.8471.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000011747.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000011747; ENSRNOP00000011747; ENSRNOG00000008619.
GeneID	298646.
KEGG	rno:298646.
Organism-specific databases
CTD	57085.
RGD	1359346. Agtrap.
Phylogenomic databases
eggNOG	NOG45277.
GeneTree	ENSGT00390000017402.
HOGENOM	HOG000034218.
HOVERGEN	HBG080881.
InParanoid	Q642A2.
OMA	WAVAQRD.
OrthoDB	EOG4R7VC7.
Gene expression databases
Genevestigator	Q642A2.
GermOnline	ENSRNOG00000008619. Rattus norvegicus.
Family and domain databases
InterPro	IPR009436. Angiotensin_II_typ1_rcpt-assoc. [Graphical view]
Pfam	PF06396. AGTRAP. 1 hit. [Graphical view]
ProDom	PD357679. PD357679. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00805. AGTRAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	644104.

Entry information

Entry name

ATRAP_RAT

Accession

Primary (citable) accession number: Q642A2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	October 25, 2004
Last modified:	April 3, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program