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Q642A2

- ATRAP_RAT

UniProt

Q642A2 - ATRAP_RAT

Protein

Type-1 angiotensin II receptor-associated protein

Gene

Agtrap

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    Functioni

    Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. May play a role of negative regulator in cardiomyocyte hypertrophy induced by angiotensin II through an inhibition of p38 mitogen-activated protein kinase pathway. Attenuates type-1 angiotensin II receptor growth promoting effect and angiotensin II-induced phosphorylation of protein kinase AKT and of STAT3.1 Publication

    GO - Molecular functioni

    1. angiotensin type II receptor activity Source: Ensembl

    GO - Biological processi

    1. regulation of blood pressure Source: Ensembl
    2. response to hypoxia Source: RGD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type-1 angiotensin II receptor-associated protein
    Alternative name(s):
    AT1 receptor-associated protein
    Gene namesi
    Name:Agtrap
    Synonyms:Atrap
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 5

    Organism-specific databases

    RGDi1359346. Agtrap.

    Subcellular locationi

    Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity. Golgi apparatus membrane By similarity; Multi-pass membrane protein By similarity. Cytoplasmic vesicle membrane By similarity; Multi-pass membrane protein By similarity
    Note: Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.By similarity

    GO - Cellular componenti

    1. cell cortex Source: Ensembl
    2. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
    3. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    4. Golgi membrane Source: UniProtKB-SubCell
    5. integral component of membrane Source: UniProtKB-KW
    6. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 160160Type-1 angiotensin II receptor-associated proteinPRO_0000064738Add
    BLAST

    Proteomic databases

    PRIDEiQ642A2.

    Expressioni

    Gene expression databases

    GenevestigatoriQ642A2.

    Interactioni

    Subunit structurei

    Interacts with GNB2L1/RACK1, and with the carboxy-terminal region of AGTR1.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000011747.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 99ExtracellularSequence Analysis
    Topological domaini31 – 5323CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini75 – 8612ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini108 – 16053CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei54 – 7421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei87 – 10721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni110 – 12213Interaction with AGTR1By similarityAdd
    BLAST

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45277.
    GeneTreeiENSGT00390000017402.
    HOGENOMiHOG000034218.
    HOVERGENiHBG080881.
    InParanoidiQ642A2.
    OMAiVHISIFY.
    OrthoDBiEOG7S4X7K.
    PhylomeDBiQ642A2.
    TreeFamiTF324477.

    Family and domain databases

    InterProiIPR009436. Angiotensin_II_typ1_rcpt-assoc.
    [Graphical view]
    PfamiPF06396. AGTRAP. 1 hit.
    [Graphical view]
    ProDomiPD357679. PD357679. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00805. AGTRAP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q642A2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELPAVNLKV ILLVHWLLTT WGCLAFSGSY AWGNFTILAL GVWAVAQRDS    50
    VDAIGMFLGG LVATIFLDII YISIFYSSVA VGDTGRFSAG MAIFSLLLKP 100
    FSCCLVYHMH RERGGELPLR SDFFGPSQEH SAYQTIDSSD SPADPLASLE 150
    NKGQAAPRGY 160
    Length:160
    Mass (Da):17,398
    Last modified:October 25, 2004 - v1
    Checksum:iDEBD34E6F62CBB5A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC082019 mRNA. Translation: AAH82019.1.
    RefSeqiNP_001007655.1. NM_001007654.1.
    UniGeneiRn.8471.

    Genome annotation databases

    EnsembliENSRNOT00000011747; ENSRNOP00000011747; ENSRNOG00000008619.
    GeneIDi298646.
    KEGGirno:298646.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC082019 mRNA. Translation: AAH82019.1 .
    RefSeqi NP_001007655.1. NM_001007654.1.
    UniGenei Rn.8471.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000011747.

    Proteomic databases

    PRIDEi Q642A2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000011747 ; ENSRNOP00000011747 ; ENSRNOG00000008619 .
    GeneIDi 298646.
    KEGGi rno:298646.

    Organism-specific databases

    CTDi 57085.
    RGDi 1359346. Agtrap.

    Phylogenomic databases

    eggNOGi NOG45277.
    GeneTreei ENSGT00390000017402.
    HOGENOMi HOG000034218.
    HOVERGENi HBG080881.
    InParanoidi Q642A2.
    OMAi VHISIFY.
    OrthoDBi EOG7S4X7K.
    PhylomeDBi Q642A2.
    TreeFami TF324477.

    Miscellaneous databases

    NextBioi 644104.
    PROi Q642A2.

    Gene expression databases

    Genevestigatori Q642A2.

    Family and domain databases

    InterProi IPR009436. Angiotensin_II_typ1_rcpt-assoc.
    [Graphical view ]
    Pfami PF06396. AGTRAP. 1 hit.
    [Graphical view ]
    ProDomi PD357679. PD357679. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00805. AGTRAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    2. "ATRAP, novel AT1 receptor associated protein, enhances internalization of AT1 receptor and inhibits vascular smooth muscle cell growth."
      Cui T., Nakagami H., Iwai M., Takeda Y., Shiuchi T., Tamura K., Daviet L., Horiuchi M.
      Biochem. Biophys. Res. Commun. 279:938-941(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiATRAP_RAT
    AccessioniPrimary (citable) accession number: Q642A2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3