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Q64299

- NOV_MOUSE

UniProt

Q64299 - NOV_MOUSE

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Protein
Protein NOV homolog
Gene
Nov, Ccn3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Immediate-early protein likely to play a role in cell growth regulation By similarity.

GO - Biological processi

  1. regulation of cell growth Source: InterPro
  2. regulation of gene expression Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NOV homolog
Short name:
NovH
Alternative name(s):
CCN family member 3
Nephroblastoma-overexpressed gene protein homolog
Gene namesi
Name:Nov
Synonyms:Ccn3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:109185. Nov.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: Ensembl
  2. dendrite Source: Ensembl
  3. extracellular matrix Source: Ensembl
  4. extracellular region Source: UniProtKB-SubCell
  5. intracellular membrane-bounded organelle Source: Ensembl
  6. neuronal cell body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 354333Protein NOV homolog
PRO_0000014416Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi91 – 911N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi261 ↔ 298 By similarity
Glycosylationi277 – 2771N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi278 ↔ 312 By similarity
Disulfide bondi289 ↔ 328 By similarity
Disulfide bondi292 ↔ 330 By similarity
Disulfide bondi297 ↔ 334 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ64299.
PRIDEiQ64299.

Expressioni

Gene expression databases

BgeeiQ64299.
CleanExiMM_NOV.
GenevestigatoriQ64299.

Interactioni

Subunit structurei

Interacts with FBLN1 By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054389.

Structurei

3D structure databases

ProteinModelPortaliQ64299.
SMRiQ64299. Positions 270-335.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 9975IGFBP N-terminal
Add
BLAST
Domaini102 – 16867VWFC
Add
BLAST
Domaini202 – 24746TSP type-1
Add
BLAST
Domaini261 – 33575CTCK
Add
BLAST

Sequence similaritiesi

Belongs to the CCN family.
Contains 1 TSP type-1 domain.
Contains 1 VWFC domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG72934.
GeneTreeiENSGT00750000117442.
HOGENOMiHOG000231462.
HOVERGENiHBG000635.
InParanoidiQ64299.
OMAiCCTPHNT.
OrthoDBiEOG7N8ZXB.
PhylomeDBiQ64299.
TreeFamiTF326070.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamiPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTiSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64299-1 [UniParc]FASTAAdd to Basket

« Hide

MSLFLRKRCL CLGFLLFHLL SQVSASLRCP SRCPPKCPSI SPTCAPGVRS    50
VLDGCSCCPV CARQRGESCS EMRPCDQSSG LYCDRSADPN NQTGICMVPE 100
GDNCVFDGVI YRNGEKFEPN CQYFCTCRDG QIGCLPRCQL DVLLPGPDCP 150
APRKVAVPGE CCEKWTCGSD EQGTQGTLGG LALPAYRPEA TVGVEVSDSS 200
INCIEQTTEW SACSKSCGMG VSTRVTNRNR QCEMVKQTRL CIVRPCEQEP 250
EEVTDKKGKK CLRTKKSLKA IHLQFENCTS LYTYKPRFCG VCSDGRCCTP 300
HNTKTIQVEF QCLPGEIIKK PVMVIGTCTC YSNCPQNNEA FLQDLELKTS 350
RGEI 354
Length:354
Mass (Da):38,928
Last modified:November 1, 1996 - v1
Checksum:i08ECE8CFC67829DE
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61R → G in BAC30363. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X97863 Genomic DNA. Translation: CAA66457.1.
Y09257 mRNA. Translation: CAA70454.1.
X96585 mRNA. Translation: CAA65404.1.
AK039481 mRNA. Translation: BAC30363.1.
AK081944 mRNA. Translation: BAC38378.1.
BC003774 mRNA. Translation: AAH03774.1.
CCDSiCCDS27471.1.
RefSeqiNP_035060.1. NM_010930.4.
UniGeneiMm.5167.

Genome annotation databases

EnsembliENSMUST00000050027; ENSMUSP00000054389; ENSMUSG00000037362.
GeneIDi18133.
KEGGimmu:18133.
UCSCiuc007vrn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X97863 Genomic DNA. Translation: CAA66457.1 .
Y09257 mRNA. Translation: CAA70454.1 .
X96585 mRNA. Translation: CAA65404.1 .
AK039481 mRNA. Translation: BAC30363.1 .
AK081944 mRNA. Translation: BAC38378.1 .
BC003774 mRNA. Translation: AAH03774.1 .
CCDSi CCDS27471.1.
RefSeqi NP_035060.1. NM_010930.4.
UniGenei Mm.5167.

3D structure databases

ProteinModelPortali Q64299.
SMRi Q64299. Positions 270-335.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000054389.

Proteomic databases

PaxDbi Q64299.
PRIDEi Q64299.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000050027 ; ENSMUSP00000054389 ; ENSMUSG00000037362 .
GeneIDi 18133.
KEGGi mmu:18133.
UCSCi uc007vrn.1. mouse.

Organism-specific databases

CTDi 4856.
MGIi MGI:109185. Nov.

Phylogenomic databases

eggNOGi NOG72934.
GeneTreei ENSGT00750000117442.
HOGENOMi HOG000231462.
HOVERGENi HBG000635.
InParanoidi Q64299.
OMAi CCTPHNT.
OrthoDBi EOG7N8ZXB.
PhylomeDBi Q64299.
TreeFami TF326070.

Miscellaneous databases

NextBioi 293376.
PROi Q64299.
SOURCEi Search...

Gene expression databases

Bgeei Q64299.
CleanExi MM_NOV.
Genevestigatori Q64299.

Family and domain databases

InterProi IPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view ]
PIRSFi PIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTi SM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEi PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: 129/Sv and ICR.
    Tissue: Brain.
  2. "Regulation of nov by WT1: a potential role for nov in nephrogenesis."
    Martinerie C., Chevalier G., Rauscher F.J. III, Perbal B.
    Oncogene 12:1479-1492(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryonic head and Spinal cord.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiNOV_MOUSE
AccessioniPrimary (citable) accession number: Q64299
Secondary accession number(s): Q8CA67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi