Q64299 (NOV_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein NOV homolog
Short name=NovH

Alternative name(s):
CCN family member 3
Nephroblastoma-overexpressed gene protein homolog

Gene names

Name:	Nov
Synonyms:	Ccn3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Immediate-early protein likely to play a role in cell growth regulation By similarity.
Subunit structure	Interacts with FBLN1 By similarity.
Subcellular location	Secreted.
Sequence similarities	Belongs to the CCN family. Contains 1 CTCK (C-terminal cystine knot-like) domain. Contains 1 IGFBP N-terminal domain. Contains 1 TSP type-1 domain. Contains 1 VWFC domain.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Growth factor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of cell growth Inferred from electronic annotation. Source: InterPro regulation of gene expression Inferred from sequence orthology PubMed 18597638. Source: MGI
Cellular_component	axon Inferred from electronic annotation. Source: Compara dendrite Inferred from electronic annotation. Source: Compara extracellular matrix Inferred from electronic annotation. Source: Compara extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell intracellular membrane-bounded organelle Inferred from electronic annotation. Source: Compara neuronal cell body Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 354	333	Protein NOV homolog		PRO_0000014416
Regions
	Domain	25 – 99	75	IGFBP N-terminal
	Domain	102 – 168	67	VWFC
	Domain	202 – 247	46	TSP type-1
	Domain	261 – 335	75	CTCK
Amino acid modifications
	Glycosylation	91	1	N-linked (GlcNAc...) Potential
	Glycosylation	277	1	N-linked (GlcNAc...) Potential
	Disulfide bond	261 ↔ 298		By similarity
	Disulfide bond	278 ↔ 312		By similarity
	Disulfide bond	289 ↔ 328		By similarity
	Disulfide bond	292 ↔ 330		By similarity
	Disulfide bond	297 ↔ 334		By similarity
Experimental info
	Sequence conflict	6	1	R → G in BAC30363. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q64299 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 08ECE8CFC67829DE	FASTA	354	38,928
	10 20 30 40 50 60 MSLFLRKRCL CLGFLLFHLL SQVSASLRCP SRCPPKCPSI SPTCAPGVRS VLDGCSCCPV 70 80 90 100 110 120 CARQRGESCS EMRPCDQSSG LYCDRSADPN NQTGICMVPE GDNCVFDGVI YRNGEKFEPN 130 140 150 160 170 180 CQYFCTCRDG QIGCLPRCQL DVLLPGPDCP APRKVAVPGE CCEKWTCGSD EQGTQGTLGG 190 200 210 220 230 240 LALPAYRPEA TVGVEVSDSS INCIEQTTEW SACSKSCGMG VSTRVTNRNR QCEMVKQTRL 250 260 270 280 290 300 CIVRPCEQEP EEVTDKKGKK CLRTKKSLKA IHLQFENCTS LYTYKPRFCG VCSDGRCCTP 310 320 330 340 350 HNTKTIQVEF QCLPGEIIKK PVMVIGTCTC YSNCPQNNEA FLQDLELKTS RGEI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic structure and chromosomal mapping of the mouse nov gene." Snaith M.R., Natarajan D., Taylor L.B., Choi C.P., Martinerie C., Perbal B., Schofield P.N., Boulter C.A. Genomics 38:425-428(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Strain: 129/Sv and ICR. Tissue: Brain.
[2]	"Regulation of nov by WT1: a potential role for nov in nephrogenesis." Martinerie C., Chevalier G., Rauscher F.J. III, Perbal B. Oncogene 12:1479-1492(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6.
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Embryonic head and Spinal cord.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Czech II. Tissue: Mammary tumor.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X97863 Genomic DNA. Translation: CAA66457.1. Y09257 mRNA. Translation: CAA70454.1. X96585 mRNA. Translation: CAA65404.1. AK039481 mRNA. Translation: BAC30363.1. AK081944 mRNA. Translation: BAC38378.1. BC003774 mRNA. Translation: AAH03774.1.
IPI	IPI00132307.
RefSeq	NP_035060.1. NM_010930.4.
UniGene	Mm.5167.
3D structure databases
ProteinModelPortal	Q64299.
SMR	Q64299. Positions 207-250.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000054389.
Proteomic databases
PaxDb	Q64299.
PRIDE	Q64299.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000050027; ENSMUSP00000054389; ENSMUSG00000037362.
GeneID	18133.
KEGG	mmu:18133.
UCSC	uc007vrn.1. mouse.
Organism-specific databases
CTD	4856.
MGI	MGI:109185. Nov.
Phylogenomic databases
eggNOG	NOG72934.
GeneTree	ENSGT00550000074368.
HOGENOM	HOG000231462.
HOVERGEN	HBG000635.
InParanoid	Q64299.
OMA	CCTPHNT.
OrthoDB	EOG4QZ7M8.
Gene expression databases
Bgee	Q64299.
CleanEx	MM_NOV.
Genevestigator	Q64299.
GermOnline	ENSMUSG00000037362. Mus musculus.
Family and domain databases
InterPro	IPR006208. Cys_knot. IPR006207. Cys_knot_C. IPR000867. IGFBP-like. IPR012395. IGFBP_CNN. IPR017891. Insulin_GF-bd_Cys-rich_CS. IPR000884. Thrombospondin_1_rpt. IPR001007. VWF_C. [Graphical view]
Pfam	PF00007. Cys_knot. 1 hit. PF00219. IGFBP. 1 hit. PF00090. TSP_1. 1 hit. PF00093. VWC. 1 hit. [Graphical view]
PIRSF	PIRSF036495. IGFBP_rP_CNN. 1 hit.
SMART	SM00041. CT. 1 hit. SM00121. IB. 1 hit. SM00209. TSP1. 1 hit. SM00214. VWC. 1 hit. [Graphical view]
SUPFAM	SSF82895. TSP1. 1 hit.
PROSITE	PS01185. CTCK_1. 1 hit. PS01225. CTCK_2. 1 hit. PS00222. IGFBP_N_1. 1 hit. PS51323. IGFBP_N_2. 1 hit. PS50092. TSP1. 1 hit. PS01208. VWFC_1. 1 hit. PS50184. VWFC_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	293376.
SOURCE	Search...

Entry information

Entry name

NOV_MOUSE

Accession

Primary (citable) accession number: Q64299
Secondary accession number(s): Q8CA67

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program