ID   OMP_MOUSE               Reviewed;         163 AA.
AC   Q64288;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   16-JUN-2009, entry version 64.
DE   RecName: Full=Olfactory marker protein;
GN   Name=Omp;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=94154378; PubMed=8111122; DOI=10.1007/BF00360561;
RA   Brown K.A., Sutcliffe M.J., Steele K., Brown S.D.;
RT   "Sequencing of the olfactory marker protein gene in normal and shaker-
RT   1 mutant mice.";
RL   Mamm. Genome 5:11-14(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=129;
RX   MEDLINE=94307732; PubMed=8034318; DOI=10.1006/geno.1994.1200;
RA   Buiakova O.I., Rama Krishna N.S., Getchell T.V., Margolis F.L.;
RT   "Human and rodent OMP genes: conservation of structural and regulatory
RT   motifs and cellular localization.";
RL   Genomics 20:452-462(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Olfactory epithelium;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   INTERACTION WITH BEX1 AND BEX2.
RX   PubMed=12911636;
RA   Behrens M., Margolis J.W., Margolis F.L.;
RT   "Identification of members of the Bex gene family as olfactory marker
RT   protein (OMP) binding partners.";
RL   J. Neurochem. 86:1289-1296(2003).
RN   [5]
RP   INTERACTION WITH BEX1 AND BEX2.
RX   PubMed=15198671; DOI=10.1111/j.1471-4159.2004.02463.x;
RA   Koo J.H., Gill S., Pannell L.K., Menco B.P.M., Margolis J.W.,
RA   Margolis F.L.;
RT   "The interaction of Bex and OMP reveals a dimer of OMP with a short
RT   half-life.";
RL   J. Neurochem. 90:102-116(2004).
RN   [6]
RP   X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
RX   PubMed=12054872; DOI=10.1016/S0022-2836(02)00242-5;
RA   Smith P.C., Firestein S., Hunt J.F.;
RT   "The crystal structure of the olfactory marker protein at 2.3 A
RT   resolution.";
RL   J. Mol. Biol. 319:807-821(2002).
CC   -!- FUNCTION: May act as a modulator of the olfactory signal-
CC       transduction cascade.
CC   -!- SUBUNIT: Interacts with BEX1 and BEX2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- TISSUE SPECIFICITY: Uniquely associated with mature olfactory
CC       receptor neurons.
CC   -!- SIMILARITY: Belongs to the olfactory marker protein family.
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DR   EMBL; U02557; AAA18415.1; -; Unassigned_DNA.
DR   EMBL; U01213; AAA20486.1; -; Genomic_DNA.
DR   EMBL; BC046600; AAH46600.1; -; mRNA.
DR   IPI; IPI00132300; -.
DR   PIR; B54261; B54261.
DR   RefSeq; NP_035140.1; -.
DR   UniGene; Mm.440368; -.
DR   PDB; 1F35; X-ray; 2.30 A; A/B=2-163.
DR   PDB; 1JOB; X-ray; 2.40 A; A=2-163.
DR   PDB; 1JOD; X-ray; 3.20 A; A/B=2-163.
DR   PDBsum; 1F35; -.
DR   PDBsum; 1JOB; -.
DR   PDBsum; 1JOD; -.
DR   PRIDE; Q64288; -.
DR   Ensembl; ENSMUSG00000074006; Mus musculus.
DR   GeneID; 18378; -.
DR   KEGG; mmu:18378; -.
DR   MGI; MGI:97436; Omp.
DR   HOGENOM; Q64288; -.
DR   HOVERGEN; Q64288; -.
DR   OMA; Q64288; ALTEMMR.
DR   NextBio; 293958; -.
DR   ArrayExpress; Q64288; -.
DR   Bgee; Q64288; -.
DR   CleanEx; MM_OMP; -.
DR   GermOnline; ENSMUSG00000074006; Mus musculus.
DR   GO; GO:0030424; C:axon; IDA:MGI.
DR   GO; GO:0043025; C:cell soma; IDA:MGI.
DR   GO; GO:0005829; C:cytosol; IDA:MGI.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0005515; F:protein binding; IEA:InterPro.
DR   GO; GO:0004871; F:signal transducer activity; IMP:MGI.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007608; P:sensory perception of smell; IMP:MGI.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   InterPro; IPR009103; Olfactory_marker.
DR   Gene3D; G3DSA:2.60.120.390; Olfactory_marker; 1.
DR   PANTHER; PTHR15357; Olfactory_marker; 1.
DR   Pfam; PF06554; Olfactory_mark; 1.
DR   ProDom; PD022055; Olfactory_marker; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Acetylation; Cytoplasm; Olfaction; Sensory transduction.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    163       Olfactory marker protein.
FT                                /FTId=PRO_0000058045.
FT   MOD_RES       2      2       N-acetylalanine (By similarity).
FT   STRAND       10     14
FT   HELIX        19     34
FT   STRAND       50     56
FT   STRAND       61     83
FT   TURN         89     91
FT   HELIX        96     98
FT   STRAND      104    108
FT   STRAND      115    117
FT   HELIX       119    135
FT   STRAND      137    145
FT   HELIX       151    153
FT   STRAND      154    162
SQ   SEQUENCE   163 AA;  18867 MW;  D50EA5937D7EAE16 CRC64;
     MAEDGPQKQQ LEMPLVLDQD LTQQMRLRVE SLKQRGEKKQ DGEKLIRPAE SVYRLDFIQQ
     QKLQFDHWNV VLDKPGKVTI TGTSQNWTPD LTNLMTRQLL DPAAIFWRKE DSDAMDWNEA
     DALEFGERLS DLAKIRKVMY FLITFGEGVE PANLKASVVF NQL
//