Olfactory marker protein - Mus musculus (Mouse)

Contribute

Send feedback

Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q64288 (OMP_MOUSE)

Last modified December 15, 2009. Version 71. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data |

Customize display

text xml rdf/xml gff fasta

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein names

Recommended name:
Olfactory marker protein

Gene names

Name:

Omp

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Hide | Top

Protein attributes

Sequence length	163 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

Hide | Top

General annotation (Comments)

Function	May act as a modulator of the olfactory signal-transduction cascade.
Subunit structure	Interacts with BEX1 and BEX2. Ref.4 Ref.5
Subcellular location	Cytoplasm By similarity.
Tissue specificity	Uniquely associated with mature olfactory receptor neurons.
Sequence similarities	Belongs to the olfactory marker protein family.

Hide | Top

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cytoplasm
PTM	Acetylation
Technical term	3D-structure
Gene Ontology (GO)
Biological process	response to stimulus Inferred from electronic annotation. Source: UniProtKB-KW sensory perception of smell Inferred from mutant phenotype. Source: MGI signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	axon Inferred from direct assay. Source: MGI cell soma Inferred from direct assay. Source: MGI cytosol Inferred from direct assay. Source: MGI nucleus Ref.4 Inferred from direct assay. Source: MGI
Molecular function	protein binding Inferred from electronic annotation. Source: InterPro signal transducer activity Inferred from mutant phenotype. Source: MGI
Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed By similarity

Chain

2 – 163

162

Olfactory marker protein

PRO_0000058045

Amino acid modifications

Modified residue

N-acetylalanine By similarity

Secondary structure

163

Helix Strand Turn

Details...

Hide | Top

Sequences

Sequence

Length

Mass (Da)

Tools

Q64288-1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: D50EA5937D7EAE16
Show »

FASTA

163

18,867

        10         20         30         40         50         60 
MAEDGPQKQQ LEMPLVLDQD LTQQMRLRVE SLKQRGEKKQ DGEKLIRPAE SVYRLDFIQQ 

        70         80         90        100        110        120 
QKLQFDHWNV VLDKPGKVTI TGTSQNWTPD LTNLMTRQLL DPAAIFWRKE DSDAMDWNEA 

       130        140        150        160 
DALEFGERLS DLAKIRKVMY FLITFGEGVE PANLKASVVF NQL

« Hide

Hide | Top

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequencing of the olfactory marker protein gene in normal and shaker-1 mutant mice." Brown K.A., Sutcliffe M.J., Steele K., Brown S.D. Mamm. Genome 5:11-14(1994) [PubMed: 8111122] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Human and rodent OMP genes: conservation of structural and regulatory motifs and cellular localization." Buiakova O.I., Rama Krishna N.S., Getchell T.V., Margolis F.L. Genomics 20:452-462(1994) [PubMed: 8034318] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Olfactory epithelium.
[4]	"Identification of members of the Bex gene family as olfactory marker protein (OMP) binding partners." Behrens M., Margolis J.W., Margolis F.L. J. Neurochem. 86:1289-1296(2003) [PubMed: 12911636] [Abstract] Cited for: INTERACTION WITH BEX1 AND BEX2.
[5]	"The interaction of Bex and OMP reveals a dimer of OMP with a short half-life." Koo J.H., Gill S., Pannell L.K., Menco B.P.M., Margolis J.W., Margolis F.L. J. Neurochem. 90:102-116(2004) [PubMed: 15198671] [Abstract] Cited for: INTERACTION WITH BEX1 AND BEX2.
[6]	"The crystal structure of the olfactory marker protein at 2.3 A resolution." Smith P.C., Firestein S., Hunt J.F. J. Mol. Biol. 319:807-821(2002) [PubMed: 12054872] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
+	Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U02557 Unassigned DNA. Translation: AAA18415.1.
U01213 Genomic DNA. Translation: AAA20486.1.
BC046600 mRNA. Translation: AAH46600.1.

IPI

IPI00132300.

PIR

B54261.

RefSeq

NP_035140.1.

UniGene

Mm.440368

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1F35	X-ray	2.30	A/B	2-163	[»]
1JOB	X-ray	2.40	A	2-163	[»]
1JOD	X-ray	3.20	A/B	2-163	[»]

ModBase

Search...

Protein-protein interaction databases

STRING

Q64288.

Proteomic databases

PRIDE

Q64288.

Genome annotation databases

Ensembl

ENSMUST00000098281; ENSMUSP00000095882; ENSMUSG00000074006; Mus musculus. [Genome view]

GeneID

18378.

KEGG

mmu:18378.

UCSC

uc009ike.1. mouse.

Organism-specific databases

CTD

18378.

MGI

MGI:97436. Omp.

Phylogenomic databases

HOGENOM

HBG269098.

HOVERGEN

Q64288.

InParanoid

Q64288.

OMA

HWTPDLT.

OrthoDB

EOG9NGK97.

Gene expression databases

ArrayExpress

Q64288.

Bgee

Q64288.

CleanEx

MM_OMP.

Genevestigator

Q64288.

GermOnline

ENSMUSG00000074006. Mus musculus.

Family and domain databases

InterPro

IPR009103. Olfactory_marker.
[Graphical view]

Gene3D

G3DSA:2.60.120.390. Olfactory_marker. 1 hit.

PANTHER

PTHR15357. Olfactory_marker. 1 hit.

Pfam

PF06554. Olfactory_mark. 1 hit.
[Graphical view]

ProDom

PD022055. Olfactory_marker. 1 hit.
[Graphical view] [Entries sharing at least one domain]

ProtoNet

Search...

Other Resources

NextBio

293958.

SOURCE

Search...

Hide | Top

Entry information

Entry name

OMP_MOUSE

Accession

Primary (citable) accession number: Q64288

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	January 23, 2007
Last modified:	December 15, 2009
This is version 71 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Hide | Top

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families