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Q64285 (CEL_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bile salt-activated lipase

Short name=BAL
EC=3.1.1.13
EC=3.1.1.3
Alternative name(s):
Bile salt-stimulated lipase
Short name=BSSL
Carboxyl ester lipase
Cholesterol esterase
Pancreatic lysophospholipase
Sterol esterase
Gene names
Name:Cel
Synonyms:Lip1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length599 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides By similarity.

Catalytic activity

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

A steryl ester + H2O = a sterol + a fatty acid.

Subunit structure

Interacts with CLC. Ref.3

Subcellular location

Secreted By similarity.

Tissue specificity

EXpressed by eosinophils. Ref.3

Sequence similarities

Belongs to the type-B carboxylesterase/lipase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 By similarity
Chain21 – 599579Bile salt-activated lipase
PRO_0000008632

Regions

Repeat559 – 569111
Repeat570 – 580112
Repeat581 – 58883
Region559 – 588304 X 11 AA tandem repeats, O-glycosylated region

Sites

Active site2141Acyl-ester intermediate By similarity
Active site3401Charge relay system By similarity
Active site4551Charge relay system By similarity

Amino acid modifications

Glycosylation2071N-linked (GlcNAc...) Potential
Glycosylation3251N-linked (GlcNAc...) Potential
Disulfide bond84 ↔ 100 By similarity
Disulfide bond266 ↔ 277 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q64285 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 9E4428FDFCA8602E

FASTA59965,813
        10         20         30         40         50         60 
MGRLEVLFLG LTCCLAAACA AKLGAVYTEG GFVEGVNKKL SLLGGDSVDI FKGIPFATAK 

        70         80         90        100        110        120 
TLENPQRHPG WQGTLKATNF KKRCLQATIT QDNTYGQEDC LYLNIWVPQG RKQVSHNLPV 

       130        140        150        160        170        180 
MVWIYGGAFL MGSGQGANFL KNYLYDGEEI ATRGNVIVVT FNYRVGPLGF LSTGDANLPG 

       190        200        210        220        230        240 
NFGLRDQHMA IAWVKRNIAA FGGDPDNITI FGESAGAASV SLQTLSPYNK GLIRRAISQS 

       250        260        270        280        290        300 
GMALSPWAIQ KNPLFWAKTI AKKVGCPTED TGKMAACLKI TDPRALTLAY KLPVKKQEYP 

       310        320        330        340        350        360 
VVHYLAFIPV IDGDFIPDDP INLYNNTADI DYIAGINNMD GHLFATIDVP AVDKTKQTVT 

       370        380        390        400        410        420 
EEDFYRLVSG HTVAKGLKGA QATFDIYTES WAQDPSQENM KKTVVAFETD VLFLIPTEIA 

       430        440        450        460        470        480 
LAQHKAHAKS AKTYSYLFSH PSRMPIYPKW MGADHADDLQ YVFGKPFATP LGYRPQDRAV 

       490        500        510        520        530        540 
SKAMIAYWTN FARSGDPNMG NSPVPTHWYP YTLENGNYLD ITKTITSASM KEHLREKFLK 

       550        560        570        580        590 
FWAVTFEVLP TVTGDQDTLT PPEDDSEVAP DPPSDDSQVV PVPPTDDSVE AQMPATIGF 

« Hide

References

[1]"Characterization of the mouse pancreatic/mammary gland cholesterol esterase-encoding cDNA and gene."
Mackay K., Lawn R.M.
Gene 165:255-259(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Mammary gland.
[2]"Molecular cloning and characterization of the mouse carboxyl ester lipase gene and evidence for expression in the lactating mammary gland."
Lidmer A.S., Kannius M., Lundberg L., Bjursell G., Nilsson J.
Genomics 29:115-122(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Lactating mammary gland.
[3]"Charcot-Leyden crystal protein (galectin-10) is not a dual function galectin with lysophospholipase activity but binds a lysophospholipase inhibitor in a novel structural fashion."
Ackerman S.J., Liu L., Kwatia M.A., Savage M.P., Leonidas D.D., Swaminathan G.J., Acharya K.R.
J. Biol. Chem. 277:14859-14868(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CLC, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U33169 mRNA. Translation: AAA92088.1.
U37386 mRNA. Translation: AAC52279.1.
PIRA57701.
RefSeqNP_034015.1. NM_009885.1.
UniGeneMm.236017.

3D structure databases

ProteinModelPortalQ64285.
SMRQ64285. Positions 21-553.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS09.985.

PTM databases

PhosphoSiteQ64285.

2D gel databases

SWISS-2DPAGEQ64285.

Proteomic databases

PaxDbQ64285.
PRIDEQ64285.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000028161; ENSMUSP00000028161; ENSMUSG00000026818.
GeneID12613.
KEGGmmu:12613.
UCSCuc008iyr.1. mouse.

Organism-specific databases

CTD1056.
MGIMGI:88374. Cel.

Phylogenomic databases

eggNOGCOG2272.
GeneTreeENSGT00740000115241.
HOGENOMHOG000091866.
HOVERGENHBG008839.
InParanoidQ64285.
KOK12298.
OMAHESTRTR.
OrthoDBEOG7034GN.
PhylomeDBQ64285.
TreeFamTF315470.

Gene expression databases

BgeeQ64285.
CleanExMM_CEL.
GenevestigatorQ64285.

Family and domain databases

InterProIPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
[Graphical view]
PfamPF00135. COesterase. 1 hit.
[Graphical view]
PROSITEPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCEL. mouse.
NextBio281770.
PROQ64285.
SOURCESearch...

Entry information

Entry nameCEL_MOUSE
AccessionPrimary (citable) accession number: Q64285
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot