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Q64285

- CEL_MOUSE

UniProt

Q64285 - CEL_MOUSE

Protein

Bile salt-activated lipase

Gene

Cel

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides By similarity.By similarity

    Catalytic activityi

    Triacylglycerol + H2O = diacylglycerol + a carboxylate.
    A steryl ester + H2O = a sterol + a fatty acid.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei214 – 2141Acyl-ester intermediatePROSITE-ProRule annotation
    Active sitei340 – 3401Charge relay systemBy similarity
    Active sitei455 – 4551Charge relay systemBy similarity

    GO - Molecular functioni

    1. acylglycerol lipase activity Source: RefGenome
    2. carboxylic ester hydrolase activity Source: RefGenome
    3. sterol esterase activity Source: UniProtKB-EC
    4. triglyceride lipase activity Source: UniProtKB-EC

    GO - Biological processi

    1. ceramide catabolic process Source: MGI
    2. cholesterol catabolic process Source: Ensembl
    3. pancreatic juice secretion Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase, Serine esterase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Enzyme and pathway databases

    ReactomeiREACT_204917. Digestion of dietary lipid.

    Protein family/group databases

    MEROPSiS09.985.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bile salt-activated lipase (EC:3.1.1.13, EC:3.1.1.3)
    Short name:
    BAL
    Alternative name(s):
    Bile salt-stimulated lipase
    Short name:
    BSSL
    Carboxyl ester lipase
    Cholesterol esterase
    Pancreatic lysophospholipase
    Sterol esterase
    Gene namesi
    Name:Cel
    Synonyms:Lip1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:88374. Cel.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosol Source: RefGenome
    3. extracellular space Source: RefGenome

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020By similarityAdd
    BLAST
    Chaini21 – 599579Bile salt-activated lipasePRO_0000008632Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi84 ↔ 100By similarity
    Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi266 ↔ 277By similarity
    Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ64285.
    PaxDbiQ64285.
    PRIDEiQ64285.

    2D gel databases

    SWISS-2DPAGEQ64285.

    PTM databases

    PhosphoSiteiQ64285.

    Expressioni

    Tissue specificityi

    EXpressed by eosinophils.1 Publication

    Gene expression databases

    BgeeiQ64285.
    CleanExiMM_CEL.
    GenevestigatoriQ64285.

    Interactioni

    Subunit structurei

    Interacts with CLC.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ64285.
    SMRiQ64285. Positions 21-553.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati559 – 569111Add
    BLAST
    Repeati570 – 580112Add
    BLAST
    Repeati581 – 58883

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni559 – 588304 X 11 AA tandem repeats, O-glycosylated regionAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG2272.
    GeneTreeiENSGT00740000115241.
    HOGENOMiHOG000091866.
    HOVERGENiHBG008839.
    InParanoidiQ64285.
    KOiK12298.
    OMAiARISTWS.
    OrthoDBiEOG7034GN.
    PhylomeDBiQ64285.
    TreeFamiTF315470.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR002018. CarbesteraseB.
    IPR019826. Carboxylesterase_B_AS.
    IPR019819. Carboxylesterase_B_CS.
    [Graphical view]
    PfamiPF00135. COesterase. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
    PS00941. CARBOXYLESTERASE_B_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q64285-1 [UniParc]FASTAAdd to Basket

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    MGRLEVLFLG LTCCLAAACA AKLGAVYTEG GFVEGVNKKL SLLGGDSVDI    50
    FKGIPFATAK TLENPQRHPG WQGTLKATNF KKRCLQATIT QDNTYGQEDC 100
    LYLNIWVPQG RKQVSHNLPV MVWIYGGAFL MGSGQGANFL KNYLYDGEEI 150
    ATRGNVIVVT FNYRVGPLGF LSTGDANLPG NFGLRDQHMA IAWVKRNIAA 200
    FGGDPDNITI FGESAGAASV SLQTLSPYNK GLIRRAISQS GMALSPWAIQ 250
    KNPLFWAKTI AKKVGCPTED TGKMAACLKI TDPRALTLAY KLPVKKQEYP 300
    VVHYLAFIPV IDGDFIPDDP INLYNNTADI DYIAGINNMD GHLFATIDVP 350
    AVDKTKQTVT EEDFYRLVSG HTVAKGLKGA QATFDIYTES WAQDPSQENM 400
    KKTVVAFETD VLFLIPTEIA LAQHKAHAKS AKTYSYLFSH PSRMPIYPKW 450
    MGADHADDLQ YVFGKPFATP LGYRPQDRAV SKAMIAYWTN FARSGDPNMG 500
    NSPVPTHWYP YTLENGNYLD ITKTITSASM KEHLREKFLK FWAVTFEVLP 550
    TVTGDQDTLT PPEDDSEVAP DPPSDDSQVV PVPPTDDSVE AQMPATIGF 599
    Length:599
    Mass (Da):65,813
    Last modified:November 1, 1996 - v1
    Checksum:i9E4428FDFCA8602E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U33169 mRNA. Translation: AAA92088.1.
    U37386 mRNA. Translation: AAC52279.1.
    CCDSiCCDS15841.1.
    PIRiA57701.
    RefSeqiNP_034015.1. NM_009885.1.
    UniGeneiMm.236017.

    Genome annotation databases

    EnsembliENSMUST00000028161; ENSMUSP00000028161; ENSMUSG00000026818.
    GeneIDi12613.
    KEGGimmu:12613.
    UCSCiuc008iyr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U33169 mRNA. Translation: AAA92088.1 .
    U37386 mRNA. Translation: AAC52279.1 .
    CCDSi CCDS15841.1.
    PIRi A57701.
    RefSeqi NP_034015.1. NM_009885.1.
    UniGenei Mm.236017.

    3D structure databases

    ProteinModelPortali Q64285.
    SMRi Q64285. Positions 21-553.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S09.985.

    PTM databases

    PhosphoSitei Q64285.

    2D gel databases

    SWISS-2DPAGE Q64285.

    Proteomic databases

    MaxQBi Q64285.
    PaxDbi Q64285.
    PRIDEi Q64285.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028161 ; ENSMUSP00000028161 ; ENSMUSG00000026818 .
    GeneIDi 12613.
    KEGGi mmu:12613.
    UCSCi uc008iyr.1. mouse.

    Organism-specific databases

    CTDi 1056.
    MGIi MGI:88374. Cel.

    Phylogenomic databases

    eggNOGi COG2272.
    GeneTreei ENSGT00740000115241.
    HOGENOMi HOG000091866.
    HOVERGENi HBG008839.
    InParanoidi Q64285.
    KOi K12298.
    OMAi ARISTWS.
    OrthoDBi EOG7034GN.
    PhylomeDBi Q64285.
    TreeFami TF315470.

    Enzyme and pathway databases

    Reactomei REACT_204917. Digestion of dietary lipid.

    Miscellaneous databases

    ChiTaRSi CEL. mouse.
    NextBioi 281770.
    PROi Q64285.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q64285.
    CleanExi MM_CEL.
    Genevestigatori Q64285.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR002018. CarbesteraseB.
    IPR019826. Carboxylesterase_B_AS.
    IPR019819. Carboxylesterase_B_CS.
    [Graphical view ]
    Pfami PF00135. COesterase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00122. CARBOXYLESTERASE_B_1. 1 hit.
    PS00941. CARBOXYLESTERASE_B_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the mouse pancreatic/mammary gland cholesterol esterase-encoding cDNA and gene."
      Mackay K., Lawn R.M.
      Gene 165:255-259(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Mammary gland.
    2. "Molecular cloning and characterization of the mouse carboxyl ester lipase gene and evidence for expression in the lactating mammary gland."
      Lidmer A.S., Kannius M., Lundberg L., Bjursell G., Nilsson J.
      Genomics 29:115-122(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Lactating mammary gland.
    3. "Charcot-Leyden crystal protein (galectin-10) is not a dual function galectin with lysophospholipase activity but binds a lysophospholipase inhibitor in a novel structural fashion."
      Ackerman S.J., Liu L., Kwatia M.A., Savage M.P., Leonidas D.D., Swaminathan G.J., Acharya K.R.
      J. Biol. Chem. 277:14859-14868(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CLC, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiCEL_MOUSE
    AccessioniPrimary (citable) accession number: Q64285
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3