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Protein

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2

Gene

Bst1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.

Catalytic activityi

NAD+ + H2O = ADP-D-ribose + nicotinamide.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Ligandi

NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 (EC:3.2.2.6)
Alternative name(s):
ADP-ribosyl cyclase 2
Antigen BP3
BP-3 alloantigen
Bone marrow stromal antigen 1
Short name:
BST-1
Cyclic ADP-ribose hydrolase 2
Short name:
cADPr hydrolase 2
Leukocyte antigen 65
Short name:
Ly-65
CD_antigen: CD157
Gene namesi
Name:Bst1
Synonyms:Bp-3, Bp3, Ly65
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:105370. Bst1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000000403425 – 286ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2Add BLAST262
PropeptideiPRO_0000004035287 – 311Sequence analysisAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 60By similarity
Glycosylationi59N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi76 ↔ 156By similarity
Glycosylationi88N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi137 ↔ 150By similarity
Glycosylationi141N-linked (GlcNAc...)Sequence analysis1
Glycosylationi185N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi231 ↔ 252By similarity
Disulfide bondi264 ↔ 273By similarity
Lipidationi286GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiQ64277.
MaxQBiQ64277.
PaxDbiQ64277.
PeptideAtlasiQ64277.
PRIDEiQ64277.

PTM databases

PhosphoSitePlusiQ64277.

Expressioni

Tissue specificityi

Expressed in the bone marrow, spleen and thymus in lymphoid organs, and the lung, kidney and heart in non-lymphoid organs.

Gene expression databases

BgeeiENSMUSG00000029082.
CleanExiMM_BST1.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ64277. 1 interactor.
MINTiMINT-4089430.
STRINGi10090.ENSMUSP00000098796.

Structurei

3D structure databases

ProteinModelPortaliQ64277.
SMRiQ64277.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ADP-ribosyl cyclase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IP4Q. Eukaryota.
ENOG4111W33. LUCA.
HOGENOMiHOG000293141.
HOVERGENiHBG097049.
InParanoidiQ64277.
KOiK18152.
PhylomeDBiQ64277.
TreeFamiTF332530.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR003193. ADP-ribosyl_cyclase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR10912. PTHR10912. 1 hit.
PfamiPF02267. Rib_hydrolayse. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64277-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVQGGLLSL WLWLWLSLLT VLLGARARWR GEGTTPHLQS IFLGRCAEYT
60 70 80 90 100
TLLSLGNKNC TAIWEAFKGV LDKDPCSVLP SDYDLFINLS RHPIPRDKSL
110 120 130 140 150
FWENNHLLVM SYGENTRRLV ALCDVLYGKV GDFLSWCRQE NASGLDYQSC
160 170 180 190 200
PTSEDCENNA VDSYWKSASM QYSRDSSGVI NVMLNGSEPK GAYPTRGFFA
210 220 230 240 250
DFEIPYLQKD KVTRIEIWVM HDVGGPNVES CGEGSVKILE DRLEALGFQH
260 270 280 290 300
SCINDYRPVK FLMCVDHSTH PDCIMNSASA SMRRESASLH AIGDASLLIS
310
LLVALASSSQ A
Length:311
Mass (Da):34,616
Last modified:November 1, 1996 - v1
Checksum:i5663D3427E460AD7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30R → T in BAC30804 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L32812 mRNA. Translation: AAA67046.1.
D31788 mRNA. Translation: BAA06597.1.
AK041059 mRNA. Translation: BAC30804.1.
CCDSiCCDS19264.1.
PIRiJC2541.
RefSeqiNP_033893.2. NM_009763.3.
UniGeneiMm.246332.

Genome annotation databases

GeneIDi12182.
KEGGimmu:12182.
UCSCiuc008xia.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L32812 mRNA. Translation: AAA67046.1.
D31788 mRNA. Translation: BAA06597.1.
AK041059 mRNA. Translation: BAC30804.1.
CCDSiCCDS19264.1.
PIRiJC2541.
RefSeqiNP_033893.2. NM_009763.3.
UniGeneiMm.246332.

3D structure databases

ProteinModelPortaliQ64277.
SMRiQ64277.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ64277. 1 interactor.
MINTiMINT-4089430.
STRINGi10090.ENSMUSP00000098796.

PTM databases

PhosphoSitePlusiQ64277.

Proteomic databases

EPDiQ64277.
MaxQBiQ64277.
PaxDbiQ64277.
PeptideAtlasiQ64277.
PRIDEiQ64277.

Protocols and materials databases

DNASUi12182.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi12182.
KEGGimmu:12182.
UCSCiuc008xia.1. mouse.

Organism-specific databases

CTDi683.
MGIiMGI:105370. Bst1.

Phylogenomic databases

eggNOGiENOG410IP4Q. Eukaryota.
ENOG4111W33. LUCA.
HOGENOMiHOG000293141.
HOVERGENiHBG097049.
InParanoidiQ64277.
KOiK18152.
PhylomeDBiQ64277.
TreeFamiTF332530.

Miscellaneous databases

PROiQ64277.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029082.
CleanExiMM_BST1.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR003193. ADP-ribosyl_cyclase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR10912. PTHR10912. 1 hit.
PfamiPF02267. Rib_hydrolayse. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBST1_MOUSE
AccessioniPrimary (citable) accession number: Q64277
Secondary accession number(s): Q8BRY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.