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Q64277

- BST1_MOUSE

UniProt

Q64277 - BST1_MOUSE

Protein

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2

Gene

Bst1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.

    Catalytic activityi

    NAD+ + H2O = ADP-D-ribose + nicotinamide.

    GO - Molecular functioni

    1. NAD(P)+ nucleosidase activity Source: UniProtKB-EC
    2. NAD+ nucleosidase activity Source: InterPro
    3. transferase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Ligandi

    NAD, NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 (EC:3.2.2.6)
    Alternative name(s):
    ADP-ribosyl cyclase 2
    Antigen BP3
    BP-3 alloantigen
    Bone marrow stromal antigen 1
    Short name:
    BST-1
    Cyclic ADP-ribose hydrolase 2
    Short name:
    cADPr hydrolase 2
    Leukocyte antigen 65
    Short name:
    Ly-65
    CD_antigen: CD157
    Gene namesi
    Name:Bst1
    Synonyms:Bp-3, Bp3, Ly65
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:105370. Bst1.

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 24241 PublicationAdd
    BLAST
    Chaini25 – 286262ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2PRO_0000004034Add
    BLAST
    Propeptidei287 – 31125Sequence AnalysisPRO_0000004035Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi46 ↔ 60By similarity
    Glycosylationi59 – 591N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi76 ↔ 156By similarity
    Glycosylationi88 – 881N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi137 ↔ 150By similarity
    Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi231 ↔ 252By similarity
    Disulfide bondi264 ↔ 273By similarity
    Lipidationi286 – 2861GPI-anchor amidated serineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    MaxQBiQ64277.
    PaxDbiQ64277.
    PRIDEiQ64277.

    PTM databases

    PhosphoSiteiQ64277.

    Expressioni

    Tissue specificityi

    Expressed in the bone marrow, spleen and thymus in lymphoid organs, and the lung, kidney and heart in non-lymphoid organs.

    Gene expression databases

    ArrayExpressiQ64277.
    BgeeiQ64277.
    CleanExiMM_BST1.
    GenevestigatoriQ64277.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    IntActiQ64277. 1 interaction.
    MINTiMINT-4089430.
    STRINGi10090.ENSMUSP00000098796.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64277.
    SMRiQ64277. Positions 29-275.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ADP-ribosyl cyclase family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42584.
    GeneTreeiENSGT00390000017291.
    HOGENOMiHOG000293141.
    HOVERGENiHBG097049.
    InParanoidiQ64277.
    KOiK18152.
    OrthoDBiEOG7RBZ9B.
    PhylomeDBiQ64277.
    TreeFamiTF332530.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR003193. ADP-ribosyl_cyclase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR10912. PTHR10912. 1 hit.
    PfamiPF02267. Rib_hydrolayse. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q64277-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVQGGLLSL WLWLWLSLLT VLLGARARWR GEGTTPHLQS IFLGRCAEYT    50
    TLLSLGNKNC TAIWEAFKGV LDKDPCSVLP SDYDLFINLS RHPIPRDKSL 100
    FWENNHLLVM SYGENTRRLV ALCDVLYGKV GDFLSWCRQE NASGLDYQSC 150
    PTSEDCENNA VDSYWKSASM QYSRDSSGVI NVMLNGSEPK GAYPTRGFFA 200
    DFEIPYLQKD KVTRIEIWVM HDVGGPNVES CGEGSVKILE DRLEALGFQH 250
    SCINDYRPVK FLMCVDHSTH PDCIMNSASA SMRRESASLH AIGDASLLIS 300
    LLVALASSSQ A 311
    Length:311
    Mass (Da):34,616
    Last modified:November 1, 1996 - v1
    Checksum:i5663D3427E460AD7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti30 – 301R → T in BAC30804. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L32812 mRNA. Translation: AAA67046.1.
    D31788 mRNA. Translation: BAA06597.1.
    AK041059 mRNA. Translation: BAC30804.1.
    CCDSiCCDS19264.1.
    PIRiJC2541.
    RefSeqiNP_033893.2. NM_009763.3.
    UniGeneiMm.246332.

    Genome annotation databases

    EnsembliENSMUST00000101237; ENSMUSP00000098796; ENSMUSG00000029082.
    GeneIDi12182.
    KEGGimmu:12182.
    UCSCiuc008xia.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L32812 mRNA. Translation: AAA67046.1 .
    D31788 mRNA. Translation: BAA06597.1 .
    AK041059 mRNA. Translation: BAC30804.1 .
    CCDSi CCDS19264.1.
    PIRi JC2541.
    RefSeqi NP_033893.2. NM_009763.3.
    UniGenei Mm.246332.

    3D structure databases

    ProteinModelPortali Q64277.
    SMRi Q64277. Positions 29-275.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q64277. 1 interaction.
    MINTi MINT-4089430.
    STRINGi 10090.ENSMUSP00000098796.

    PTM databases

    PhosphoSitei Q64277.

    Proteomic databases

    MaxQBi Q64277.
    PaxDbi Q64277.
    PRIDEi Q64277.

    Protocols and materials databases

    DNASUi 12182.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000101237 ; ENSMUSP00000098796 ; ENSMUSG00000029082 .
    GeneIDi 12182.
    KEGGi mmu:12182.
    UCSCi uc008xia.1. mouse.

    Organism-specific databases

    CTDi 683.
    MGIi MGI:105370. Bst1.

    Phylogenomic databases

    eggNOGi NOG42584.
    GeneTreei ENSGT00390000017291.
    HOGENOMi HOG000293141.
    HOVERGENi HBG097049.
    InParanoidi Q64277.
    KOi K18152.
    OrthoDBi EOG7RBZ9B.
    PhylomeDBi Q64277.
    TreeFami TF332530.

    Miscellaneous databases

    NextBioi 280573.
    PROi Q64277.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q64277.
    Bgeei Q64277.
    CleanExi MM_BST1.
    Genevestigatori Q64277.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR003193. ADP-ribosyl_cyclase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR10912. PTHR10912. 1 hit.
    Pfami PF02267. Rib_hydrolayse. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The murine BP-3 gene encodes a relative of the CD38/NAD glycohydrolase family."
      Dong C., Wang J., Neame P., Cooper M.D.
      Int. Immunol. 6:1353-1360(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 25-44; 168-180 AND 261-274.
      Strain: BALB/c.
      Tissue: Lymphoma.
    2. "Molecular cloning of murine BST-1 having homology with CD38 and Aplysia ADP-ribosyl cyclase."
      Itoh M., Ishihara K., Tomizawa H., Tanaka H., Kobune Y., Ishikawa J., Kaisho T., Hirano T.
      Biochem. Biophys. Res. Commun. 203:1309-1317(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Aorta.

    Entry informationi

    Entry nameiBST1_MOUSE
    AccessioniPrimary (citable) accession number: Q64277
    Secondary accession number(s): Q8BRY3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3