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Q64277 (BST1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ADP-ribosyl cyclase 2
EC=3.2.2.5
Alternative name(s):
Antigen BP3
BP-3 alloantigen
Bone marrow stromal antigen 1
Short name=BST-1
Cyclic ADP-ribose hydrolase 2
Short name=cADPr hydrolase 2
Leukocyte antigen 65
Short name=Ly-65
CD_antigen=CD157
Gene names
Name:Bst1
Synonyms:Bp-3, Bp3, Ly65
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.

Catalytic activity

NAD+ + H2O = ADP-ribose + nicotinamide.

Subunit structure

Homodimer By similarity.

Subcellular location

Cell membrane; Lipid-anchor › GPI-anchor.

Tissue specificity

Expressed in the bone marrow, spleen and thymus in lymphoid organs, and the lung, kidney and heart in non-lymphoid organs.

Sequence similarities

Belongs to the ADP-ribosyl cyclase family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainSignal
   LigandNAD
   Molecular functionHydrolase
   PTMDisulfide bond
GPI-anchor
Glycoprotein
Lipoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Cellular_componentanchored to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionNAD+ nucleosidase activity

Inferred from electronic annotation. Source: EC

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Ref.1
Chain25 – 286262ADP-ribosyl cyclase 2
PRO_0000004034
Propeptide287 – 31125 Potential
PRO_0000004035

Amino acid modifications

Lipidation2861GPI-anchor amidated serine Potential
Glycosylation591N-linked (GlcNAc...) Potential
Glycosylation881N-linked (GlcNAc...) Potential
Glycosylation1411N-linked (GlcNAc...) Potential
Glycosylation1851N-linked (GlcNAc...) Potential
Disulfide bond46 ↔ 60 By similarity
Disulfide bond76 ↔ 156 By similarity
Disulfide bond137 ↔ 150 By similarity
Disulfide bond231 ↔ 252 By similarity
Disulfide bond264 ↔ 273 By similarity

Experimental info

Sequence conflict301R → T in BAC30804. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q64277 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 5663D3427E460AD7

FASTA31134,616
        10         20         30         40         50         60 
MAVQGGLLSL WLWLWLSLLT VLLGARARWR GEGTTPHLQS IFLGRCAEYT TLLSLGNKNC 

        70         80         90        100        110        120 
TAIWEAFKGV LDKDPCSVLP SDYDLFINLS RHPIPRDKSL FWENNHLLVM SYGENTRRLV 

       130        140        150        160        170        180 
ALCDVLYGKV GDFLSWCRQE NASGLDYQSC PTSEDCENNA VDSYWKSASM QYSRDSSGVI 

       190        200        210        220        230        240 
NVMLNGSEPK GAYPTRGFFA DFEIPYLQKD KVTRIEIWVM HDVGGPNVES CGEGSVKILE 

       250        260        270        280        290        300 
DRLEALGFQH SCINDYRPVK FLMCVDHSTH PDCIMNSASA SMRRESASLH AIGDASLLIS 

       310 
LLVALASSSQ A

« Hide

References

« Hide 'large scale' references
[1]"The murine BP-3 gene encodes a relative of the CD38/NAD glycohydrolase family."
Dong C., Wang J., Neame P., Cooper M.D.
Int. Immunol. 6:1353-1360(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 25-44; 168-180 AND 261-274.
Strain: BALB/c.
Tissue: Lymphoma.
[2]"Molecular cloning of murine BST-1 having homology with CD38 and Aplysia ADP-ribosyl cyclase."
Itoh M., Ishihara K., Tomizawa H., Tanaka H., Kobune Y., Ishikawa J., Kaisho T., Hirano T.
Biochem. Biophys. Res. Commun. 203:1309-1317(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Aorta.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L32812 mRNA. Translation: AAA67046.1.
D31788 mRNA. Translation: BAA06597.1.
AK041059 mRNA. Translation: BAC30804.1.
IPIIPI00132279.
PIRJC2541.
RefSeqNP_033893.2. NM_009763.3.
UniGeneMm.246332.

3D structure databases

ProteinModelPortalQ64277.
SMRQ64277. Positions 29-275.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000098796.

PTM databases

PhosphoSiteQ64277.

Proteomic databases

PaxDbQ64277.
PRIDEQ64277.

Protocols and materials databases

DNASU12182.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000101237; ENSMUSP00000098796; ENSMUSG00000029082.
GeneID12182.
KEGGmmu:12182.
UCSCuc008xia.1. mouse.

Organism-specific databases

CTD683.
MGIMGI:105370. Bst1.

Phylogenomic databases

eggNOGNOG42584.
GeneTreeENSGT00390000017291.
HOGENOMHOG000293141.
HOVERGENHBG097049.
InParanoidQ64277.
KOK01242.
OrthoDBEOG4X97HZ.

Gene expression databases

ArrayExpressQ64277.
BgeeQ64277.
CleanExMM_BST1.
GenevestigatorQ64277.
GermOnlineENSMUSG00000029082. Mus musculus.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR003193. ADP-ribosyl_cyclase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR10912. PTHR10912. 1 hit.
PfamPF02267. Rib_hydrolayse. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio280573.
SOURCESearch...

Entry information

Entry nameBST1_MOUSE
AccessionPrimary (citable) accession number: Q64277
Secondary accession number(s): Q8BRY3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 3, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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