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Protein

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2

Gene

Bst1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.

Catalytic activityi

NAD+ + H2O = ADP-D-ribose + nicotinamide.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Transferase
LigandNAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 (EC:3.2.2.6)
Alternative name(s):
ADP-ribosyl cyclase 2
Antigen BP3
BP-3 alloantigen
Bone marrow stromal antigen 1
Short name:
BST-1
Cyclic ADP-ribose hydrolase 2
Short name:
cADPr hydrolase 2
Leukocyte antigen 65
Short name:
Ly-65
CD_antigen: CD157
Gene namesi
Name:Bst1
Synonyms:Bp-3, Bp3, Ly65
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:105370 Bst1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000000403425 – 286ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2Add BLAST262
PropeptideiPRO_0000004035287 – 311Sequence analysisAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 60By similarity
Glycosylationi59N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi76 ↔ 156By similarity
Glycosylationi88N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi137 ↔ 150By similarity
Glycosylationi141N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi185N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi231 ↔ 252By similarity
Disulfide bondi264 ↔ 273By similarity
Lipidationi286GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiQ64277
MaxQBiQ64277
PaxDbiQ64277
PeptideAtlasiQ64277
PRIDEiQ64277

PTM databases

iPTMnetiQ64277
PhosphoSitePlusiQ64277
SwissPalmiQ64277

Expressioni

Tissue specificityi

Expressed in the bone marrow, spleen and thymus in lymphoid organs, and the lung, kidney and heart in non-lymphoid organs.

Gene expression databases

CleanExiMM_BST1

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ64277, 1 interactor
MINTiQ64277
STRINGi10090.ENSMUSP00000098796

Structurei

3D structure databases

ProteinModelPortaliQ64277
SMRiQ64277
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ADP-ribosyl cyclase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IP4Q Eukaryota
ENOG4111W33 LUCA
HOGENOMiHOG000293141
HOVERGENiHBG097049
InParanoidiQ64277
KOiK18152
PhylomeDBiQ64277
TreeFamiTF332530

Family and domain databases

CDDicd04759 Rib_hydrolase, 1 hit
InterProiView protein in InterPro
IPR003193 ADP-ribosyl_cyclase
PANTHERiPTHR10912 PTHR10912, 1 hit
PfamiView protein in Pfam
PF02267 Rib_hydrolayse, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64277-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVQGGLLSL WLWLWLSLLT VLLGARARWR GEGTTPHLQS IFLGRCAEYT
60 70 80 90 100
TLLSLGNKNC TAIWEAFKGV LDKDPCSVLP SDYDLFINLS RHPIPRDKSL
110 120 130 140 150
FWENNHLLVM SYGENTRRLV ALCDVLYGKV GDFLSWCRQE NASGLDYQSC
160 170 180 190 200
PTSEDCENNA VDSYWKSASM QYSRDSSGVI NVMLNGSEPK GAYPTRGFFA
210 220 230 240 250
DFEIPYLQKD KVTRIEIWVM HDVGGPNVES CGEGSVKILE DRLEALGFQH
260 270 280 290 300
SCINDYRPVK FLMCVDHSTH PDCIMNSASA SMRRESASLH AIGDASLLIS
310
LLVALASSSQ A
Length:311
Mass (Da):34,616
Last modified:November 1, 1996 - v1
Checksum:i5663D3427E460AD7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30R → T in BAC30804 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L32812 mRNA Translation: AAA67046.1
D31788 mRNA Translation: BAA06597.1
AK041059 mRNA Translation: BAC30804.1
CCDSiCCDS19264.1
PIRiJC2541
RefSeqiNP_033893.2, NM_009763.3
UniGeneiMm.246332

Genome annotation databases

GeneIDi12182
KEGGimmu:12182
UCSCiuc008xia.1 mouse

Similar proteinsi

Entry informationi

Entry nameiBST1_MOUSE
AccessioniPrimary (citable) accession number: Q64277
Secondary accession number(s): Q8BRY3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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