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Protein

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2

Gene

Bst1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.

Catalytic activityi

NAD+ + H2O = ADP-D-ribose + nicotinamide.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Ligandi

NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 (EC:3.2.2.6)
Alternative name(s):
ADP-ribosyl cyclase 2
Antigen BP3
BP-3 alloantigen
Bone marrow stromal antigen 1
Short name:
BST-1
Cyclic ADP-ribose hydrolase 2
Short name:
cADPr hydrolase 2
Leukocyte antigen 65
Short name:
Ly-65
CD_antigen: CD157
Gene namesi
Name:Bst1
Synonyms:Bp-3, Bp3, Ly65
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:105370. Bst1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24241 PublicationAdd
BLAST
Chaini25 – 286262ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2PRO_0000004034Add
BLAST
Propeptidei287 – 31125Sequence AnalysisPRO_0000004035Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi46 ↔ 60By similarity
Glycosylationi59 – 591N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi76 ↔ 156By similarity
Glycosylationi88 – 881N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi137 ↔ 150By similarity
Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi231 ↔ 252By similarity
Disulfide bondi264 ↔ 273By similarity
Lipidationi286 – 2861GPI-anchor amidated serineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ64277.
PaxDbiQ64277.
PRIDEiQ64277.

PTM databases

PhosphoSiteiQ64277.

Expressioni

Tissue specificityi

Expressed in the bone marrow, spleen and thymus in lymphoid organs, and the lung, kidney and heart in non-lymphoid organs.

Gene expression databases

BgeeiQ64277.
CleanExiMM_BST1.
ExpressionAtlasiQ64277. baseline and differential.
GenevisibleiQ64277. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ64277. 1 interaction.
MINTiMINT-4089430.
STRINGi10090.ENSMUSP00000098796.

Structurei

3D structure databases

ProteinModelPortaliQ64277.
SMRiQ64277. Positions 29-275.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ADP-ribosyl cyclase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42584.
HOGENOMiHOG000293141.
HOVERGENiHBG097049.
InParanoidiQ64277.
KOiK18152.
OrthoDBiEOG7RBZ9B.
PhylomeDBiQ64277.
TreeFamiTF332530.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR003193. ADP-ribosyl_cyclase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR10912. PTHR10912. 1 hit.
PfamiPF02267. Rib_hydrolayse. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64277-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVQGGLLSL WLWLWLSLLT VLLGARARWR GEGTTPHLQS IFLGRCAEYT
60 70 80 90 100
TLLSLGNKNC TAIWEAFKGV LDKDPCSVLP SDYDLFINLS RHPIPRDKSL
110 120 130 140 150
FWENNHLLVM SYGENTRRLV ALCDVLYGKV GDFLSWCRQE NASGLDYQSC
160 170 180 190 200
PTSEDCENNA VDSYWKSASM QYSRDSSGVI NVMLNGSEPK GAYPTRGFFA
210 220 230 240 250
DFEIPYLQKD KVTRIEIWVM HDVGGPNVES CGEGSVKILE DRLEALGFQH
260 270 280 290 300
SCINDYRPVK FLMCVDHSTH PDCIMNSASA SMRRESASLH AIGDASLLIS
310
LLVALASSSQ A
Length:311
Mass (Da):34,616
Last modified:November 1, 1996 - v1
Checksum:i5663D3427E460AD7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti30 – 301R → T in BAC30804 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L32812 mRNA. Translation: AAA67046.1.
D31788 mRNA. Translation: BAA06597.1.
AK041059 mRNA. Translation: BAC30804.1.
CCDSiCCDS19264.1.
PIRiJC2541.
RefSeqiNP_033893.2. NM_009763.3.
UniGeneiMm.246332.

Genome annotation databases

GeneIDi12182.
KEGGimmu:12182.
UCSCiuc008xia.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L32812 mRNA. Translation: AAA67046.1.
D31788 mRNA. Translation: BAA06597.1.
AK041059 mRNA. Translation: BAC30804.1.
CCDSiCCDS19264.1.
PIRiJC2541.
RefSeqiNP_033893.2. NM_009763.3.
UniGeneiMm.246332.

3D structure databases

ProteinModelPortaliQ64277.
SMRiQ64277. Positions 29-275.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ64277. 1 interaction.
MINTiMINT-4089430.
STRINGi10090.ENSMUSP00000098796.

PTM databases

PhosphoSiteiQ64277.

Proteomic databases

MaxQBiQ64277.
PaxDbiQ64277.
PRIDEiQ64277.

Protocols and materials databases

DNASUi12182.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi12182.
KEGGimmu:12182.
UCSCiuc008xia.1. mouse.

Organism-specific databases

CTDi683.
MGIiMGI:105370. Bst1.

Phylogenomic databases

eggNOGiNOG42584.
HOGENOMiHOG000293141.
HOVERGENiHBG097049.
InParanoidiQ64277.
KOiK18152.
OrthoDBiEOG7RBZ9B.
PhylomeDBiQ64277.
TreeFamiTF332530.

Miscellaneous databases

NextBioi280573.
PROiQ64277.
SOURCEiSearch...

Gene expression databases

BgeeiQ64277.
CleanExiMM_BST1.
ExpressionAtlasiQ64277. baseline and differential.
GenevisibleiQ64277. MM.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR003193. ADP-ribosyl_cyclase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR10912. PTHR10912. 1 hit.
PfamiPF02267. Rib_hydrolayse. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The murine BP-3 gene encodes a relative of the CD38/NAD glycohydrolase family."
    Dong C., Wang J., Neame P., Cooper M.D.
    Int. Immunol. 6:1353-1360(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 25-44; 168-180 AND 261-274.
    Strain: BALB/c.
    Tissue: Lymphoma.
  2. "Molecular cloning of murine BST-1 having homology with CD38 and Aplysia ADP-ribosyl cyclase."
    Itoh M., Ishihara K., Tomizawa H., Tanaka H., Kobune Y., Ishikawa J., Kaisho T., Hirano T.
    Biochem. Biophys. Res. Commun. 203:1309-1317(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Aorta.

Entry informationi

Entry nameiBST1_MOUSE
AccessioniPrimary (citable) accession number: Q64277
Secondary accession number(s): Q8BRY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 24, 2015
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.