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Protein

Translation initiation factor eIF-2B subunit alpha

Gene

Eif2b1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.

GO - Molecular functioni

  • GDP binding Source: RGD
  • GTP binding Source: RGD
  • translation initiation factor activity Source: RGD

GO - Biological processi

  • cellular response to stimulus Source: UniProtKB
  • oligodendrocyte development Source: UniProtKB
  • positive regulation of GTPase activity Source: GOC
  • response to amino acid starvation Source: RGD
  • response to glucose Source: UniProtKB
  • response to heat Source: UniProtKB
  • response to peptide hormone Source: UniProtKB
  • translation Source: RGD
  • translational initiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

ReactomeiR-RNO-72731. Recycling of eIF2:GDP.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor eIF-2B subunit alpha
Alternative name(s):
eIF-2B GDP-GTP exchange factor subunit alpha
Gene namesi
Name:Eif2b1
Synonyms:Eif2ba
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi620819. Eif2b1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Translation initiation factor eIF-2B subunit alphaPRO_0000156057Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ64270.
PRIDEiQ64270.

Expressioni

Gene expression databases

ExpressionAtlasiQ64270. baseline and differential.
GenevisibleiQ64270. RN.

Interactioni

Subunit structurei

Complex of five different subunits; alpha, beta, gamma, delta and epsilon.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001373.

Structurei

3D structure databases

ProteinModelPortaliQ64270.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1466. Eukaryota.
COG1184. LUCA.
GeneTreeiENSGT00550000074853.
HOGENOMiHOG000175731.
HOVERGENiHBG051457.
InParanoidiQ64270.
KOiK03239.
OMAiVRFRVIY.
OrthoDBiEOG7VHSZ3.
PhylomeDBiQ64270.
TreeFamiTF101505.

Family and domain databases

InterProiIPR000649. IF-2B-related.
[Graphical view]
PfamiPF01008. IF-2B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64270-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDGELIKYF KSQMKGDPNM ASAVAAIQTL LEFLKRDKGE TIQGLRAHLT
60 70 80 90 100
KAIETLCAVD SSVAVSSGGE LFLRFISLTS LEYSDYSKCK KIMIERGELF
110 120 130 140 150
LSRISLSRTK IASLCHAFIK DGARILTHAY SRVVLRVLEE AVAAKKRFSV
160 170 180 190 200
YITESQPDLS GKKMAKALCH LNVPVTVVLD AAVGYIMEKV DLVIVGAEGV
210 220 230 240 250
VENGGIINKI GTNQMAVCAK AQNKPFYVVA ESFKFVRLFP LNQQDVPDKF
260 270 280 290 300
KYKADTLKSV QAGQDLKEEH PWVDYTSPSL ITLLFTDLGV LTPSAVSDEL

IKLYL
Length:305
Mass (Da):33,678
Last modified:November 1, 1997 - v1
Checksum:iE0ACC1756E118101
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05821 mRNA. Translation: AAC52196.1.
L41679 Genomic DNA. Translation: AAA91276.1.
BC081709 mRNA. Translation: AAH81709.1.
PIRiI59376.
RefSeqiNP_742026.1. NM_172029.2.
UniGeneiRn.9181.

Genome annotation databases

EnsembliENSRNOT00000001373; ENSRNOP00000001373; ENSRNOG00000001039.
GeneIDi64514.
KEGGirno:64514.
UCSCiRGD:620819. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05821 mRNA. Translation: AAC52196.1.
L41679 Genomic DNA. Translation: AAA91276.1.
BC081709 mRNA. Translation: AAH81709.1.
PIRiI59376.
RefSeqiNP_742026.1. NM_172029.2.
UniGeneiRn.9181.

3D structure databases

ProteinModelPortaliQ64270.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001373.

Proteomic databases

PaxDbiQ64270.
PRIDEiQ64270.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001373; ENSRNOP00000001373; ENSRNOG00000001039.
GeneIDi64514.
KEGGirno:64514.
UCSCiRGD:620819. rat.

Organism-specific databases

CTDi1967.
RGDi620819. Eif2b1.

Phylogenomic databases

eggNOGiKOG1466. Eukaryota.
COG1184. LUCA.
GeneTreeiENSGT00550000074853.
HOGENOMiHOG000175731.
HOVERGENiHBG051457.
InParanoidiQ64270.
KOiK03239.
OMAiVRFRVIY.
OrthoDBiEOG7VHSZ3.
PhylomeDBiQ64270.
TreeFamiTF101505.

Enzyme and pathway databases

ReactomeiR-RNO-72731. Recycling of eIF2:GDP.

Miscellaneous databases

PROiQ64270.

Gene expression databases

ExpressionAtlasiQ64270. baseline and differential.
GenevisibleiQ64270. RN.

Family and domain databases

InterProiIPR000649. IF-2B-related.
[Graphical view]
PfamiPF01008. IF-2B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of cDNA encoding the alpha subunit of the rat protein synthesis initiation factor eIF-2B."
    Flowers K.M., Kimball S.R., Feldhoff R.C., Hinnebusch A.G., Jefferson L.S.
    Proc. Natl. Acad. Sci. U.S.A. 92:4274-4278(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. "Structure and sequence of the gene encoding the alpha-subunit of rat translation initiation factor-2B."
    Flowers K.M., Mellor H., Kimball S.R., Jefferson L.S.
    Biochim. Biophys. Acta 1264:163-167(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiEI2BA_RAT
AccessioniPrimary (citable) accession number: Q64270
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 8, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.