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Q64268

- HEP2_RAT

UniProt

Q64268 - HEP2_RAT

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Protein

Heparin cofactor 2

Gene

Serpind1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT) (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei443 – 4442Reactive bondBy similarity

GO - Molecular functioni

  1. heparin binding Source: UniProtKB-KW
  2. serine-type endopeptidase inhibitor activity Source: RefGenome

GO - Biological processi

  1. blood coagulation Source: UniProtKB-KW
  2. negative regulation of endopeptidase activity Source: RefGenome
  3. regulation of proteolysis Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Biological processi

Blood coagulation, Hemostasis

Keywords - Ligandi

Heparin-binding

Protein family/group databases

MEROPSiI04.019.

Names & Taxonomyi

Protein namesi
Recommended name:
Heparin cofactor 2
Alternative name(s):
Heparin cofactor II
Short name:
HC-II
Protease inhibitor leuserpin-2
Serpin D1
Gene namesi
Name:Serpind1
Synonyms:Hcf2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 11

Organism-specific databases

RGDi619854. Serpind1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: InterPro
  2. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 479456Heparin cofactor 2PRO_0000032497Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi31 – 311N-linked (GlcNAc...)Sequence Analysis
Modified residuei61 – 611SulfotyrosineBy similarity
Modified residuei74 – 741SulfotyrosineBy similarity
Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi367 – 3671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi403 – 4031N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Different composition of the N-linked oligosaccharides appears to yield a 68-kDa and a 72-kDa form.By similarity

Keywords - PTMi

Glycoprotein, Sulfation

Proteomic databases

PaxDbiQ64268.
PRIDEiQ64268.

PTM databases

PhosphoSiteiQ64268.

Expressioni

Gene expression databases

GenevestigatoriQ64268.

Structurei

3D structure databases

ProteinModelPortaliQ64268.
SMRiQ64268. Positions 55-479.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati55 – 65111Add
BLAST
Repeati69 – 79112Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni55 – 79252 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)Add
BLAST
Regioni172 – 19221Glycosaminoglycan-binding siteBy similarityAdd
BLAST

Domaini

The N-terminal acidic repeat region mediates, in part, the glycosaminoglycan-accelerated thrombin inhibition.By similarity

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118839.
HOGENOMiHOG000294159.
HOVERGENiHBG101242.
InParanoidiQ64268.
KOiK03912.
OMAiHIMKLTK.
OrthoDBiEOG7327PB.
PhylomeDBiQ64268.
TreeFamiTF343094.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64268-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKHPAYTLLL SLIMSMCAGS KGLAEQLTKE NLTVSLLPPN FHKENTVTND
60 70 80 90 100
WIPEGEEDDD YLDLEKLLSE DDDYIYVVDA VSPTDSESSA GNILQLFQGK
110 120 130 140 150
SRIQRLNILN AKFAFNLYRV LKDQATSSDN IFIAPVGIST AMGMISLGLR
160 170 180 190 200
GETHEEVHSV LHFKDFVNAS SKYEVTTIHN LFRKLTHRLF RRNFGYTLQS
210 220 230 240 250
VNDLYIQKQF PIREDFKAAM REFYFAEAQE ADFSDPAFIS KANSHILKLT
260 270 280 290 300
KGLIKEALEN TDSATQMMIL NCIYFKGAWM NKFPVEMTHN HNFRLNEREV
310 320 330 340 350
VKVSMMQTKG NFLAANDQEL DCDILQLEYV GGISMLIVIP RKLSGMKTLE
360 370 380 390 400
AQLTPQVVER WQKSMTNRTR EVLLPKFKLE KNYNLVEVLK SMGITKLFNK
410 420 430 440 450
NGNMSGISDQ RIIIDLFKHQ STITVNEEGT QAAAVTTVGF MPLSTQVRFT
460 470
VDRPFLFLVY EHRTSCLLFM GRVANPAKS
Length:479
Mass (Da):54,552
Last modified:November 1, 1997 - v1
Checksum:i4F736C2F8459E514
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X74550 mRNA. Translation: CAA52644.1.
X74549 mRNA. Translation: CAA52643.1.
BC091145 mRNA. Translation: AAH91145.1.
PIRiS41066.
RefSeqiNP_077358.1. NM_024382.1.
XP_006248771.1. XM_006248709.2.
UniGeneiRn.10553.

Genome annotation databases

EnsembliENSRNOT00000031819; ENSRNOP00000031829; ENSRNOG00000001865.
GeneIDi79224.
KEGGirno:79224.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X74550 mRNA. Translation: CAA52644.1 .
X74549 mRNA. Translation: CAA52643.1 .
BC091145 mRNA. Translation: AAH91145.1 .
PIRi S41066.
RefSeqi NP_077358.1. NM_024382.1.
XP_006248771.1. XM_006248709.2.
UniGenei Rn.10553.

3D structure databases

ProteinModelPortali Q64268.
SMRi Q64268. Positions 55-479.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi I04.019.

PTM databases

PhosphoSitei Q64268.

Proteomic databases

PaxDbi Q64268.
PRIDEi Q64268.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000031819 ; ENSRNOP00000031829 ; ENSRNOG00000001865 .
GeneIDi 79224.
KEGGi rno:79224.

Organism-specific databases

CTDi 3053.
RGDi 619854. Serpind1.

Phylogenomic databases

eggNOGi COG4826.
GeneTreei ENSGT00760000118839.
HOGENOMi HOG000294159.
HOVERGENi HBG101242.
InParanoidi Q64268.
KOi K03912.
OMAi HIMKLTK.
OrthoDBi EOG7327PB.
PhylomeDBi Q64268.
TreeFami TF343094.

Miscellaneous databases

NextBioi 614652.
PROi Q64268.

Gene expression databases

Genevestigatori Q64268.

Family and domain databases

InterProi IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
PROSITEi PS00284. SERPIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Secondary thrombin-binding site, glycosaminoglycan binding domain and reactive center region of leuserpin-2 are strongly conserved in mammalian species."
    Westrup D., Ragg H.
    Biochim. Biophys. Acta 1217:93-96(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiHEP2_RAT
AccessioniPrimary (citable) accession number: Q64268
Secondary accession number(s): Q5BKA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3