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Q64268

- HEP2_RAT

UniProt

Q64268 - HEP2_RAT

Protein

Heparin cofactor 2

Gene

Serpind1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT) By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei443 – 4442Reactive bondBy similarity

    GO - Molecular functioni

    1. heparin binding Source: UniProtKB-KW
    2. serine-type endopeptidase inhibitor activity Source: RefGenome

    GO - Biological processi

    1. blood coagulation Source: UniProtKB-KW
    2. negative regulation of endopeptidase activity Source: RefGenome
    3. regulation of proteolysis Source: RefGenome

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Keywords - Biological processi

    Blood coagulation, Hemostasis

    Keywords - Ligandi

    Heparin-binding

    Protein family/group databases

    MEROPSiI04.019.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heparin cofactor 2
    Alternative name(s):
    Heparin cofactor II
    Short name:
    HC-II
    Protease inhibitor leuserpin-2
    Serpin D1
    Gene namesi
    Name:Serpind1
    Synonyms:Hcf2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 11

    Organism-specific databases

    RGDi619854. Serpind1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 479456Heparin cofactor 2PRO_0000032497Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi31 – 311N-linked (GlcNAc...)Sequence Analysis
    Modified residuei61 – 611SulfotyrosineBy similarity
    Modified residuei74 – 741SulfotyrosineBy similarity
    Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi367 – 3671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi403 – 4031N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Different composition of the N-linked oligosaccharides appears to yield a 68-kDa and a 72-kDa form.By similarity

    Keywords - PTMi

    Glycoprotein, Sulfation

    Proteomic databases

    PaxDbiQ64268.
    PRIDEiQ64268.

    PTM databases

    PhosphoSiteiQ64268.

    Expressioni

    Gene expression databases

    GenevestigatoriQ64268.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64268.
    SMRiQ64268. Positions 55-479.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati55 – 65111Add
    BLAST
    Repeati69 – 79112Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni55 – 79252 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)Add
    BLAST
    Regioni172 – 19221Glycosaminoglycan-binding siteBy similarityAdd
    BLAST

    Domaini

    The N-terminal acidic repeat region mediates, in part, the glycosaminoglycan-accelerated thrombin inhibition.By similarity

    Sequence similaritiesi

    Belongs to the serpin family.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG4826.
    GeneTreeiENSGT00750000117478.
    HOGENOMiHOG000294159.
    HOVERGENiHBG101242.
    InParanoidiQ64268.
    KOiK03912.
    OMAiHIMKLTK.
    OrthoDBiEOG7327PB.
    PhylomeDBiQ64268.
    TreeFamiTF343094.

    Family and domain databases

    InterProiIPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q64268-1 [UniParc]FASTAAdd to Basket

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    MKHPAYTLLL SLIMSMCAGS KGLAEQLTKE NLTVSLLPPN FHKENTVTND    50
    WIPEGEEDDD YLDLEKLLSE DDDYIYVVDA VSPTDSESSA GNILQLFQGK 100
    SRIQRLNILN AKFAFNLYRV LKDQATSSDN IFIAPVGIST AMGMISLGLR 150
    GETHEEVHSV LHFKDFVNAS SKYEVTTIHN LFRKLTHRLF RRNFGYTLQS 200
    VNDLYIQKQF PIREDFKAAM REFYFAEAQE ADFSDPAFIS KANSHILKLT 250
    KGLIKEALEN TDSATQMMIL NCIYFKGAWM NKFPVEMTHN HNFRLNEREV 300
    VKVSMMQTKG NFLAANDQEL DCDILQLEYV GGISMLIVIP RKLSGMKTLE 350
    AQLTPQVVER WQKSMTNRTR EVLLPKFKLE KNYNLVEVLK SMGITKLFNK 400
    NGNMSGISDQ RIIIDLFKHQ STITVNEEGT QAAAVTTVGF MPLSTQVRFT 450
    VDRPFLFLVY EHRTSCLLFM GRVANPAKS 479
    Length:479
    Mass (Da):54,552
    Last modified:November 1, 1997 - v1
    Checksum:i4F736C2F8459E514
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X74550 mRNA. Translation: CAA52644.1.
    X74549 mRNA. Translation: CAA52643.1.
    BC091145 mRNA. Translation: AAH91145.1.
    PIRiS41066.
    RefSeqiNP_077358.1. NM_024382.1.
    XP_006248771.1. XM_006248709.1.
    UniGeneiRn.10553.

    Genome annotation databases

    EnsembliENSRNOT00000031819; ENSRNOP00000031829; ENSRNOG00000001865.
    GeneIDi79224.
    KEGGirno:79224.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X74550 mRNA. Translation: CAA52644.1 .
    X74549 mRNA. Translation: CAA52643.1 .
    BC091145 mRNA. Translation: AAH91145.1 .
    PIRi S41066.
    RefSeqi NP_077358.1. NM_024382.1.
    XP_006248771.1. XM_006248709.1.
    UniGenei Rn.10553.

    3D structure databases

    ProteinModelPortali Q64268.
    SMRi Q64268. Positions 55-479.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I04.019.

    PTM databases

    PhosphoSitei Q64268.

    Proteomic databases

    PaxDbi Q64268.
    PRIDEi Q64268.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000031819 ; ENSRNOP00000031829 ; ENSRNOG00000001865 .
    GeneIDi 79224.
    KEGGi rno:79224.

    Organism-specific databases

    CTDi 3053.
    RGDi 619854. Serpind1.

    Phylogenomic databases

    eggNOGi COG4826.
    GeneTreei ENSGT00750000117478.
    HOGENOMi HOG000294159.
    HOVERGENi HBG101242.
    InParanoidi Q64268.
    KOi K03912.
    OMAi HIMKLTK.
    OrthoDBi EOG7327PB.
    PhylomeDBi Q64268.
    TreeFami TF343094.

    Miscellaneous databases

    NextBioi 614652.
    PROi Q64268.

    Gene expression databases

    Genevestigatori Q64268.

    Family and domain databases

    InterProi IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Secondary thrombin-binding site, glycosaminoglycan binding domain and reactive center region of leuserpin-2 are strongly conserved in mammalian species."
      Westrup D., Ragg H.
      Biochim. Biophys. Acta 1217:93-96(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiHEP2_RAT
    AccessioniPrimary (citable) accession number: Q64268
    Secondary accession number(s): Q5BKA6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3