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Q64268

- HEP2_RAT

UniProt

Q64268 - HEP2_RAT

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Protein

Heparin cofactor 2

Gene
Serpind1, Hcf2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT) By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei443 – 4442Reactive bond By similarity

GO - Molecular functioni

  1. heparin binding Source: UniProtKB-KW
  2. serine-type endopeptidase inhibitor activity Source: RefGenome

GO - Biological processi

  1. blood coagulation Source: UniProtKB-KW
  2. negative regulation of endopeptidase activity Source: RefGenome
  3. regulation of proteolysis Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Biological processi

Blood coagulation, Hemostasis

Keywords - Ligandi

Heparin-binding

Protein family/group databases

MEROPSiI04.019.

Names & Taxonomyi

Protein namesi
Recommended name:
Heparin cofactor 2
Alternative name(s):
Heparin cofactor II
Short name:
HC-II
Protease inhibitor leuserpin-2
Serpin D1
Gene namesi
Name:Serpind1
Synonyms:Hcf2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 11

Organism-specific databases

RGDi619854. Serpind1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Chaini24 – 479456Heparin cofactor 2PRO_0000032497Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi31 – 311N-linked (GlcNAc...) Reviewed prediction
Modified residuei61 – 611Sulfotyrosine By similarity
Modified residuei74 – 741Sulfotyrosine By similarity
Glycosylationi168 – 1681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi367 – 3671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi403 – 4031N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Different composition of the N-linked oligosaccharides appears to yield a 68-kDa and a 72-kDa form By similarity.

Keywords - PTMi

Glycoprotein, Sulfation

Proteomic databases

PaxDbiQ64268.
PRIDEiQ64268.

PTM databases

PhosphoSiteiQ64268.

Expressioni

Gene expression databases

GenevestigatoriQ64268.

Structurei

3D structure databases

ProteinModelPortaliQ64268.
SMRiQ64268. Positions 55-479.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati55 – 65111Add
BLAST
Repeati69 – 79112Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni55 – 79252 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)Add
BLAST
Regioni172 – 19221Glycosaminoglycan-binding site By similarityAdd
BLAST

Domaini

The N-terminal acidic repeat region mediates, in part, the glycosaminoglycan-accelerated thrombin inhibition By similarity.

Sequence similaritiesi

Belongs to the serpin family.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00750000117478.
HOGENOMiHOG000294159.
HOVERGENiHBG101242.
InParanoidiQ64268.
KOiK03912.
OMAiHIMKLTK.
OrthoDBiEOG7327PB.
PhylomeDBiQ64268.
TreeFamiTF343094.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64268-1 [UniParc]FASTAAdd to Basket

« Hide

MKHPAYTLLL SLIMSMCAGS KGLAEQLTKE NLTVSLLPPN FHKENTVTND    50
WIPEGEEDDD YLDLEKLLSE DDDYIYVVDA VSPTDSESSA GNILQLFQGK 100
SRIQRLNILN AKFAFNLYRV LKDQATSSDN IFIAPVGIST AMGMISLGLR 150
GETHEEVHSV LHFKDFVNAS SKYEVTTIHN LFRKLTHRLF RRNFGYTLQS 200
VNDLYIQKQF PIREDFKAAM REFYFAEAQE ADFSDPAFIS KANSHILKLT 250
KGLIKEALEN TDSATQMMIL NCIYFKGAWM NKFPVEMTHN HNFRLNEREV 300
VKVSMMQTKG NFLAANDQEL DCDILQLEYV GGISMLIVIP RKLSGMKTLE 350
AQLTPQVVER WQKSMTNRTR EVLLPKFKLE KNYNLVEVLK SMGITKLFNK 400
NGNMSGISDQ RIIIDLFKHQ STITVNEEGT QAAAVTTVGF MPLSTQVRFT 450
VDRPFLFLVY EHRTSCLLFM GRVANPAKS 479
Length:479
Mass (Da):54,552
Last modified:November 1, 1997 - v1
Checksum:i4F736C2F8459E514
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X74550 mRNA. Translation: CAA52644.1.
X74549 mRNA. Translation: CAA52643.1.
BC091145 mRNA. Translation: AAH91145.1.
PIRiS41066.
RefSeqiNP_077358.1. NM_024382.1.
XP_006248771.1. XM_006248709.1.
UniGeneiRn.10553.

Genome annotation databases

EnsembliENSRNOT00000031819; ENSRNOP00000031829; ENSRNOG00000001865.
GeneIDi79224.
KEGGirno:79224.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X74550 mRNA. Translation: CAA52644.1 .
X74549 mRNA. Translation: CAA52643.1 .
BC091145 mRNA. Translation: AAH91145.1 .
PIRi S41066.
RefSeqi NP_077358.1. NM_024382.1.
XP_006248771.1. XM_006248709.1.
UniGenei Rn.10553.

3D structure databases

ProteinModelPortali Q64268.
SMRi Q64268. Positions 55-479.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi I04.019.

PTM databases

PhosphoSitei Q64268.

Proteomic databases

PaxDbi Q64268.
PRIDEi Q64268.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000031819 ; ENSRNOP00000031829 ; ENSRNOG00000001865 .
GeneIDi 79224.
KEGGi rno:79224.

Organism-specific databases

CTDi 3053.
RGDi 619854. Serpind1.

Phylogenomic databases

eggNOGi COG4826.
GeneTreei ENSGT00750000117478.
HOGENOMi HOG000294159.
HOVERGENi HBG101242.
InParanoidi Q64268.
KOi K03912.
OMAi HIMKLTK.
OrthoDBi EOG7327PB.
PhylomeDBi Q64268.
TreeFami TF343094.

Miscellaneous databases

NextBioi 614652.
PROi Q64268.

Gene expression databases

Genevestigatori Q64268.

Family and domain databases

InterProi IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
PROSITEi PS00284. SERPIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Secondary thrombin-binding site, glycosaminoglycan binding domain and reactive center region of leuserpin-2 are strongly conserved in mammalian species."
    Westrup D., Ragg H.
    Biochim. Biophys. Acta 1217:93-96(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiHEP2_RAT
AccessioniPrimary (citable) accession number: Q64268
Secondary accession number(s): Q5BKA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 14, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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