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Protein

Heparin cofactor 2

Gene

Serpind1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT) (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei443 – 444Reactive bondBy similarity2

GO - Molecular functioni

  • heparin binding Source: UniProtKB-KW
  • serine-type endopeptidase inhibitor activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding, Protease inhibitor, Serine protease inhibitor
Biological processBlood coagulation, Hemostasis

Enzyme and pathway databases

ReactomeiR-RNO-140837 Intrinsic Pathway of Fibrin Clot Formation
R-RNO-140875 Common Pathway of Fibrin Clot Formation
R-RNO-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-RNO-8957275 Post-translational protein phosphorylation

Protein family/group databases

MEROPSiI04.019

Names & Taxonomyi

Protein namesi
Recommended name:
Heparin cofactor 2
Alternative name(s):
Heparin cofactor II
Short name:
HC-II
Protease inhibitor leuserpin-2
Serpin D1
Gene namesi
Name:Serpind1
Synonyms:Hcf2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi619854 Serpind1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000003249724 – 479Heparin cofactor 2Add BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi31N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei61SulfotyrosineBy similarity1
Modified residuei74SulfotyrosineBy similarity1
Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi367N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi403N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Different composition of the N-linked oligosaccharides appears to yield a 68-kDa and a 72-kDa form.By similarity

Keywords - PTMi

Glycoprotein, Sulfation

Proteomic databases

PaxDbiQ64268
PRIDEiQ64268

PTM databases

iPTMnetiQ64268
PhosphoSitePlusiQ64268

Expressioni

Gene expression databases

BgeeiENSRNOG00000001865
ExpressionAtlasiQ64268 baseline and differential
GenevisibleiQ64268 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031829

Structurei

3D structure databases

ProteinModelPortaliQ64268
SMRiQ64268
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati55 – 651Add BLAST11
Repeati69 – 792Add BLAST11

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni55 – 792 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)Add BLAST25
Regioni172 – 192Glycosaminoglycan-binding siteBy similarityAdd BLAST21

Domaini

The N-terminal acidic repeat region mediates, in part, the glycosaminoglycan-accelerated thrombin inhibition.By similarity

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118839
HOGENOMiHOG000294159
HOVERGENiHBG101242
InParanoidiQ64268
KOiK03912
PhylomeDBiQ64268
TreeFamiTF343094

Family and domain databases

CDDicd02047 HCII, 1 hit
InterProiView protein in InterPro
IPR033831 HCII
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64268-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHPAYTLLL SLIMSMCAGS KGLAEQLTKE NLTVSLLPPN FHKENTVTND
60 70 80 90 100
WIPEGEEDDD YLDLEKLLSE DDDYIYVVDA VSPTDSESSA GNILQLFQGK
110 120 130 140 150
SRIQRLNILN AKFAFNLYRV LKDQATSSDN IFIAPVGIST AMGMISLGLR
160 170 180 190 200
GETHEEVHSV LHFKDFVNAS SKYEVTTIHN LFRKLTHRLF RRNFGYTLQS
210 220 230 240 250
VNDLYIQKQF PIREDFKAAM REFYFAEAQE ADFSDPAFIS KANSHILKLT
260 270 280 290 300
KGLIKEALEN TDSATQMMIL NCIYFKGAWM NKFPVEMTHN HNFRLNEREV
310 320 330 340 350
VKVSMMQTKG NFLAANDQEL DCDILQLEYV GGISMLIVIP RKLSGMKTLE
360 370 380 390 400
AQLTPQVVER WQKSMTNRTR EVLLPKFKLE KNYNLVEVLK SMGITKLFNK
410 420 430 440 450
NGNMSGISDQ RIIIDLFKHQ STITVNEEGT QAAAVTTVGF MPLSTQVRFT
460 470
VDRPFLFLVY EHRTSCLLFM GRVANPAKS
Length:479
Mass (Da):54,552
Last modified:November 1, 1997 - v1
Checksum:i4F736C2F8459E514
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74550 mRNA Translation: CAA52644.1
X74549 mRNA Translation: CAA52643.1
BC091145 mRNA Translation: AAH91145.1
PIRiS41066
RefSeqiNP_077358.1, NM_024382.1
XP_006248771.1, XM_006248709.2
UniGeneiRn.10553

Genome annotation databases

EnsembliENSRNOT00000031819; ENSRNOP00000031829; ENSRNOG00000001865
GeneIDi79224
KEGGirno:79224

Similar proteinsi

Entry informationi

Entry nameiHEP2_RAT
AccessioniPrimary (citable) accession number: Q64268
Secondary accession number(s): Q5BKA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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