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Q64264 (5HT1A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
5-hydroxytryptamine receptor 1A
Short name=5-HT-1A
Short name=5-HT1A
Alternative name(s):
Serotonin receptor 1A
Gene names
Name:Htr1a
Synonyms:Gpcr18
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length421 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Most abundantly expressed in midbrain and cortex.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4214215-hydroxytryptamine receptor 1A
PRO_0000068904

Regions

Topological domain1 – 3636Extracellular By similarity
Transmembrane37 – 6226Helical; Name=1; By similarity
Topological domain63 – 7311Cytoplasmic By similarity
Transmembrane74 – 9825Helical; Name=2; By similarity
Topological domain99 – 10911Extracellular By similarity
Transmembrane110 – 13223Helical; Name=3; By similarity
Topological domain133 – 15220Cytoplasmic By similarity
Transmembrane153 – 17826Helical; Name=4; By similarity
Topological domain179 – 19113Extracellular By similarity
Transmembrane192 – 21726Helical; Name=5; By similarity
Topological domain218 – 345128Cytoplasmic By similarity
Transmembrane346 – 36722Helical; Name=6; By similarity
Topological domain368 – 37811Extracellular By similarity
Transmembrane379 – 40325Helical; Name=7; By similarity
Topological domain404 – 42118Cytoplasmic By similarity

Amino acid modifications

Glycosylation101N-linked (GlcNAc...) Potential
Glycosylation111N-linked (GlcNAc...) Potential
Glycosylation241N-linked (GlcNAc...) Potential
Glycosylation301N-linked (GlcNAc...) Potential
Disulfide bond109 ↔ 187 By similarity
Cross-link334Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Natural variations

Natural variant17 – 193EPF → DHL in strain: C3H/An.

Experimental info

Sequence conflict1771T → A in AAA81519. Ref.1
Sequence conflict2421F → L in AAA16850. Ref.6
Sequence conflict2471A → V in AAA16850. Ref.6
Sequence conflict2631C → W in AAA16850. Ref.6
Sequence conflict3041H → D in AAA81519. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q64264 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 74F519DF7CC0C7AA

FASTA42146,176
        10         20         30         40         50         60 
MDMFSLGQGN NTTTSLEPFG TGGNDTGLSN VTFSYQVITS LLLGTLIFCA VLGNACVVAA 

        70         80         90        100        110        120 
IALERSLQNV ANYLIGSLAV TDLMVSVLVL PMAALYQVLN KWTLGQVTCD LFIALDVLCC 

       130        140        150        160        170        180 
TSSILHLCAI ALDRYWAITD PIDYVNKRTP RRAAALISLT WLIGFLISIP PMLGWRTPED 

       190        200        210        220        230        240 
RSNPNECTIS KDHGYTIYST FGAFYIPLLL MLVLYGRIFR AARFRIRKTV KKVEKKGAGT 

       250        260        270        280        290        300 
SFGTSSAPPP KKSLNGQPGS GDCRRSAENR AVGTPCANGA VRQGEDDATL EVIEVHRVGN 

       310        320        330        340        350        360 
SKGHLPLPSE SGATSYVPAC LERKNERTAE AKRKMALARE RKTVKTLGII MGTFILCWLP 

       370        380        390        400        410        420 
FFIVALVLPF CESSCHMPEL LGAIINWLGY SNSLLNPVIY AYFNKDFQNA FKKIIKCKFC 


R

« Hide

References

« Hide 'large scale' references
[1]"Cloning and differentiation-induced expression of a murine serotonin 1A receptor in a septal cell line."
Charest A., Wainer B.H., Albert P.R.
J. Neurosci. 13:5164-5171(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: NIH Swiss.
Tissue: Brain.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Brain cortex, Corpora quadrigemina and Hippocampus.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]"The serotonin 1a receptor gene contains a TATA-less promoter that responds to MAZ and Sp1."
Parks C.L., Shenk T.
J. Biol. Chem. 271:4417-4430(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-23.
Strain: C3H/An.
[6]"Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors."
Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I., Copeland N.G., Jenkins N.A.
Genomics 18:175-184(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 136-353.
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U39391 mRNA. Translation: AAA81519.1.
AK043668 mRNA. Translation: BAC31611.1.
AK049814 mRNA. Translation: BAC33931.1.
AK049884 mRNA. Translation: BAC33970.1.
AK140194 mRNA. Translation: BAE24273.1.
CH466568 Genomic DNA. Translation: EDL18479.1.
BC138669 mRNA. Translation: AAI38670.1.
BC138681 mRNA. Translation: AAI38682.1.
U33820 Genomic DNA. Translation: AAC52572.1.
L20339 mRNA. Translation: AAA16850.1.
IPIIPI00132265.
PIRI49375.
RefSeqNP_032334.2. NM_008308.4.
UniGeneMm.4716.

3D structure databases

HSSPHSSP built from PDB template 1HLL based on UniProtKB P08913.
ProteinModelPortalQ64264.
SMRQ64264. Positions 50-416.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000022235.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ64264.

Proteomic databases

PRIDEQ64264.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000022235; ENSMUSP00000022235; ENSMUSG00000021721.
GeneID15550.
KEGGmmu:15550.

Organism-specific databases

CTD3350.
MGIMGI:96273. Htr1a.

Phylogenomic databases

eggNOGNOG249628.
GeneTreeENSGT00650000092921.
HOGENOMHOG000239242.
HOVERGENHBG106962.
InParanoidQ8BGS4.
KOK04153.
OMAPEDRSNP.
OrthoDBEOG4CC41F.

Gene expression databases

BgeeQ64264.
CleanExMM_HTR1A.
GenevestigatorQ64264.
GermOnlineENSMUSG00000021721. Mus musculus.

Family and domain databases

InterProIPR000610. 5HT1A_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00512. 5HT1ARECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

BindingDBQ64264.
ChEMBLCHEMBL3737.
NextBio288480.
SOURCESearch...

Entry information

Entry name5HT1A_MOUSE
AccessionPrimary (citable) accession number: Q64264
Secondary accession number(s): Q60956, Q61617, Q8BGS4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: May 1, 2013
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents