Q64244CD38_RATADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 13.2.2.-3.2.2.62'-phospho-ADP-ribosyl cyclase2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase2.4.99.202'-phospho-cyclic-ADP-ribose transferaseADP-ribosyl cyclase 1ADPRC 1CD38HCyclic ADP-ribose hydrolase 1cADPR hydrolase 1CD38Cd38Rattus norvegicusRatEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattusA cloned rat CD38-homologous protein and its expression in pancreatic islets.NUCLEOTIDE SEQUENCE [MRNA]ERRATUM OF PUBMED:8037769Cloning and characterization of cDNA encoding rat ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase (homologue to human CD38) from islets of Langerhans.NUCLEOTIDE SEQUENCE [MRNA]CD38/ADP-ribosyl cyclase: a new role in the regulation of osteoclastic bone resorption.FUNCTIONSUBCELLULAR LOCATIONTISSUE SPECIFICITYERRATUM OF PUBMED:10477767CD38 is the major enzyme responsible for synthesis of nicotinic acid-adenine dinucleotide phosphate in mammalian tissues.FUNCTION IN SYNTHESIS OF NICOTINIC ACID-ADENINE DINUCLEOTIDE PHOSPHATEACTIVITY REGULATIONSUBCELLULAR LOCATIONSynthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion, the latter a Ca(2+) mobilizer (PubMed:11829748). Also has cADPR hydrolase activity (By similarity).Regulates osteoclastic bone resorption, probably via production of cyclic ADP-ribose and triggering of a cytosolic calcium ion signal through ryanodine receptor activation.NAD(+) = cyclic ADP-beta-D-ribose + H(+) + nicotinamideNADP(+) + nicotinate = nicotinamide + nicotinate-adenine dinucleotide phosphateH2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamideBoth NAADP and cADPR synthesis are inhibited by nicotinic acid.Homodimer.Cell membraneSingle-pass type II membrane proteinSpleen, liver, heart, thymus, thyroid gland, ileum, colon, cerebellum, salivary gland, adrenal gland, jejunum, islets of Langerhans and osteoclasts.Belongs to the ADP-ribosyl cyclase family.Cell membraneDisulfide bondGlycoproteinHydrolaseMembraneNADNADPReference proteomeSignal-anchorTransferaseTransmembraneTransmembrane helixMANYEFSQVSEDRPGCRLTRKAQIGLGVGLLLLVALVVVVVIVLWPRSPLVWKGKPTTKHFADIILGRCLIYTQILRPEMRDQDCKKILSTFKRGFISKNPCNITNEDYAPLVKLVTQTIPCNKTLFWSKSKHLAHQYTWIQGKMFTLEDTLLGYIADDLRWCGDPSTSDMNYDSCPHWSENCPNNPVAVFWNVISQKFAEDACGVVQVMLNGSLSEPFYRNSTFGSVEVFNLDPNKVHKLQAWVMHDIKGTSSNACSSPSINELKSIVNKRNMIFACQDNYRPVRFLQCVKNPEHPSCRLNV
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