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Protein

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

Gene

Cd38

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity.
Regulates osteoclastic bone resorption, probably via production of cyclic ADP-ribose and triggering of a cytosolic calcium ion signal through ryanodine receptor activation.

Catalytic activityi

NAD+ + H2O = ADP-D-ribose + nicotinamide.
NADP+ + nicotinate = nicotinate-adenine dinucleotide phosphate + nicotinamide.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei122By similarity1
Active sitei204By similarity1

GO - Molecular functioni

GO - Biological processi

  • artery smooth muscle contraction Source: RGD
  • B cell receptor signaling pathway Source: Ensembl
  • female pregnancy Source: RGD
  • long term synaptic depression Source: RGD
  • negative regulation of apoptotic process Source: Ensembl
  • negative regulation of bone resorption Source: RGD
  • negative regulation of neuron projection development Source: RGD
  • negative regulation of transcription, DNA-templated Source: Ensembl
  • positive regulation of B cell proliferation Source: GO_Central
  • positive regulation of cell growth Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of insulin secretion Source: RGD
  • positive regulation of transcription, DNA-templated Source: Ensembl
  • positive regulation of vasoconstriction Source: RGD
  • response to cytokine Source: RGD
  • response to estradiol Source: RGD
  • response to hormone Source: RGD
  • response to hydroperoxide Source: RGD
  • response to hypoxia Source: RGD
  • response to interleukin-1 Source: RGD
  • response to progesterone Source: RGD
  • response to retinoic acid Source: RGD

Keywordsi

Molecular functionHydrolase, Transferase
LigandNAD, NADP

Enzyme and pathway databases

BRENDAi2.4.99.20 5301
ReactomeiR-RNO-196807 Nicotinate metabolism
SABIO-RKiQ64244

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC:3.2.2.6)
Alternative name(s):
2'-phospho-ADP-ribosyl cyclase
2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase (EC:2.4.99.20)
2'-phospho-cyclic-ADP-ribose transferase
ADP-ribosyl cyclase 1
Short name:
ADPRC 1
CD38H
Cyclic ADP-ribose hydrolase 1
Short name:
cADPr hydrolase 1
CD_antigen: CD38
Gene namesi
Name:Cd38
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi2303 Cd38

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 21CytoplasmicSequence analysisAdd BLAST21
Transmembranei22 – 44Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
Topological domaini45 – 303ExtracellularSequence analysisAdd BLAST259

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001440701 – 303ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1Add BLAST303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi69 ↔ 85By similarity
Disulfide bondi102 ↔ 183By similarity
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi123N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi163 ↔ 176By similarity
Glycosylationi212N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi222N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi257 ↔ 278By similarity
Disulfide bondi290 ↔ 299By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ64244
PRIDEiQ64244

PTM databases

iPTMnetiQ64244
PhosphoSitePlusiQ64244
SwissPalmiQ64244
UniCarbKBiQ64244

Expressioni

Tissue specificityi

Spleen, liver, heart, thymus, thyroid gland, ileum, colon, cerebellum, salivary gland, adrenal gland, jejunum, islets of Langerhans and osteoclasts.1 Publication

Gene expression databases

BgeeiENSRNOG00000003069
GenevisibleiQ64244 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004121

Structurei

3D structure databases

ProteinModelPortaliQ64244
SMRiQ64244
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ADP-ribosyl cyclase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH8E Eukaryota
ENOG4111W33 LUCA
GeneTreeiENSGT00390000017291
HOGENOMiHOG000293141
HOVERGENiHBG005277
InParanoidiQ64244
KOiK01242
OMAiQCVKNPE
OrthoDBiEOG091G0GI3
PhylomeDBiQ64244
TreeFamiTF332530

Family and domain databases

CDDicd04759 Rib_hydrolase, 1 hit
InterProiView protein in InterPro
IPR003193 ADP-ribosyl_cyclase
IPR033567 CD38
PANTHERiPTHR10912 PTHR10912, 1 hit
PTHR10912:SF5 PTHR10912:SF5, 1 hit
PfamiView protein in Pfam
PF02267 Rib_hydrolayse, 1 hit

Sequencei

Sequence statusi: Complete.

Q64244-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANYEFSQVS EDRPGCRLTR KAQIGLGVGL LLLVALVVVV VIVLWPRSPL
60 70 80 90 100
VWKGKPTTKH FADIILGRCL IYTQILRPEM RDQDCKKILS TFKRGFISKN
110 120 130 140 150
PCNITNEDYA PLVKLVTQTI PCNKTLFWSK SKHLAHQYTW IQGKMFTLED
160 170 180 190 200
TLLGYIADDL RWCGDPSTSD MNYDSCPHWS ENCPNNPVAV FWNVISQKFA
210 220 230 240 250
EDACGVVQVM LNGSLSEPFY RNSTFGSVEV FNLDPNKVHK LQAWVMHDIK
260 270 280 290 300
GTSSNACSSP SINELKSIVN KRNMIFACQD NYRPVRFLQC VKNPEHPSCR

LNV
Length:303
Mass (Da):34,436
Last modified:November 1, 1996 - v1
Checksum:i84F23AD3094871C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D30795 mRNA Translation: BAA06457.1
D29646 mRNA Translation: BAA06129.1
PIRiJC2410
RefSeqiNP_037259.1, NM_013127.1
UniGeneiRn.11414

Genome annotation databases

EnsembliENSRNOT00000004121; ENSRNOP00000004121; ENSRNOG00000003069
GeneIDi25668
KEGGirno:25668

Similar proteinsi

Entry informationi

Entry nameiCD38_RAT
AccessioniPrimary (citable) accession number: Q64244
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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