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Protein

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

Gene

Cd38

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity.
Regulates osteoclastic bone resorption, probably via production of cyclic ADP-ribose and triggering of a cytosolic calcium ion signal through ryanodine receptor activation.

Catalytic activityi

NAD+ + H2O = ADP-D-ribose + nicotinamide.
NADP+ + nicotinate = nicotinate-adenine dinucleotide phosphate + nicotinamide.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei122 – 1221By similarity
Active sitei204 – 2041By similarity

GO - Molecular functioni

  1. NAD(P)+ nucleosidase activity Source: UniProtKB-EC
  2. NAD+ nucleosidase activity Source: RGD
  3. phosphorus-oxygen lyase activity Source: GO_Central
  4. transferase activity Source: UniProtKB-KW

GO - Biological processi

  1. B cell receptor signaling pathway Source: Ensembl
  2. female pregnancy Source: RGD
  3. long term synaptic depression Source: RGD
  4. metabolic process Source: GOC
  5. negative regulation of apoptotic process Source: Ensembl
  6. negative regulation of bone resorption Source: RGD
  7. negative regulation of transcription, DNA-templated Source: Ensembl
  8. positive regulation of B cell proliferation Source: GO_Central
  9. positive regulation of cell growth Source: RGD
  10. positive regulation of cytosolic calcium ion concentration Source: RGD
  11. positive regulation of insulin secretion Source: RGD
  12. positive regulation of transcription, DNA-templated Source: Ensembl
  13. positive regulation of vasoconstriction Source: RGD
  14. response to cytokine Source: RGD
  15. response to drug Source: Ensembl
  16. response to estradiol Source: RGD
  17. response to hormone Source: RGD
  18. response to hydroperoxide Source: RGD
  19. response to hypoxia Source: RGD
  20. response to interleukin-1 Source: RGD
  21. response to progesterone Source: RGD
  22. response to retinoic acid Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

SABIO-RKQ64244.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC:3.2.2.6)
Alternative name(s):
2'-phospho-ADP-ribosyl cyclase
2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase (EC:2.4.99.20)
2'-phospho-cyclic-ADP-ribose transferase
ADP-ribosyl cyclase 1
Short name:
ADPRC 1
CD38H
Cyclic ADP-ribose hydrolase 1
Short name:
cADPr hydrolase 1
CD_antigen: CD38
Gene namesi
Name:Cd38
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 14

Organism-specific databases

RGDi2303. Cd38.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2121CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei22 – 4423Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini45 – 303259ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. intracellular membrane-bounded organelle Source: RGD
  4. nucleus Source: RGD
  5. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1PRO_0000144070Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi69 ↔ 85By similarity
Disulfide bondi102 ↔ 183By similarity
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi123 – 1231N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi163 ↔ 176By similarity
Glycosylationi212 – 2121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi257 ↔ 278By similarity
Disulfide bondi290 ↔ 299By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ64244.

Expressioni

Tissue specificityi

Spleen, liver, heart, thymus, thyroid gland, ileum, colon, cerebellum, salivary gland, adrenal gland, jejunum, islets of Langerhans and osteoclasts.1 Publication

Gene expression databases

GenevestigatoriQ64244.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004121.

Structurei

3D structure databases

ProteinModelPortaliQ64244.
SMRiQ64244. Positions 50-282.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ADP-ribosyl cyclase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42596.
GeneTreeiENSGT00390000017291.
HOGENOMiHOG000293141.
HOVERGENiHBG005277.
InParanoidiQ64244.
KOiK01242.
OMAiKNPCNIT.
OrthoDBiEOG7RBZ9B.
PhylomeDBiQ64244.
TreeFamiTF332530.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR003193. ADP-ribosyl_cyclase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR10912. PTHR10912. 1 hit.
PfamiPF02267. Rib_hydrolayse. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64244-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANYEFSQVS EDRPGCRLTR KAQIGLGVGL LLLVALVVVV VIVLWPRSPL
60 70 80 90 100
VWKGKPTTKH FADIILGRCL IYTQILRPEM RDQDCKKILS TFKRGFISKN
110 120 130 140 150
PCNITNEDYA PLVKLVTQTI PCNKTLFWSK SKHLAHQYTW IQGKMFTLED
160 170 180 190 200
TLLGYIADDL RWCGDPSTSD MNYDSCPHWS ENCPNNPVAV FWNVISQKFA
210 220 230 240 250
EDACGVVQVM LNGSLSEPFY RNSTFGSVEV FNLDPNKVHK LQAWVMHDIK
260 270 280 290 300
GTSSNACSSP SINELKSIVN KRNMIFACQD NYRPVRFLQC VKNPEHPSCR

LNV
Length:303
Mass (Da):34,436
Last modified:November 1, 1996 - v1
Checksum:i84F23AD3094871C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D30795 mRNA. Translation: BAA06457.1.
D29646 mRNA. Translation: BAA06129.1.
PIRiJC2410.
RefSeqiNP_037259.1. NM_013127.1.
UniGeneiRn.11414.

Genome annotation databases

EnsembliENSRNOT00000004121; ENSRNOP00000004121; ENSRNOG00000003069.
GeneIDi25668.
KEGGirno:25668.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D30795 mRNA. Translation: BAA06457.1.
D29646 mRNA. Translation: BAA06129.1.
PIRiJC2410.
RefSeqiNP_037259.1. NM_013127.1.
UniGeneiRn.11414.

3D structure databases

ProteinModelPortaliQ64244.
SMRiQ64244. Positions 50-282.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004121.

Proteomic databases

PRIDEiQ64244.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004121; ENSRNOP00000004121; ENSRNOG00000003069.
GeneIDi25668.
KEGGirno:25668.

Organism-specific databases

CTDi952.
RGDi2303. Cd38.

Phylogenomic databases

eggNOGiNOG42596.
GeneTreeiENSGT00390000017291.
HOGENOMiHOG000293141.
HOVERGENiHBG005277.
InParanoidiQ64244.
KOiK01242.
OMAiKNPCNIT.
OrthoDBiEOG7RBZ9B.
PhylomeDBiQ64244.
TreeFamiTF332530.

Enzyme and pathway databases

SABIO-RKQ64244.

Miscellaneous databases

NextBioi607593.
PROiQ64244.

Gene expression databases

GenevestigatoriQ64244.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR003193. ADP-ribosyl_cyclase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR10912. PTHR10912. 1 hit.
PfamiPF02267. Rib_hydrolayse. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Brain.
  2. Erratum
    Li Q., Yamada Y., Yasuda K., Ihara Y., Okamoto Y., Kaisaki P.J., Watanabe R., Ikeda H., Tsuda K., Seino Y.
    Biochem. Biophys. Res. Commun. 204:1001-1001(1994)
  3. "Cloning and characterization of cDNA encoding rat ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase (homologue to human CD38) from islets of Langerhans."
    Koguma T., Takasawa S., Tohgo A., Karasawa T., Furuya Y., Yonekura H., Okamoto H.
    Biochim. Biophys. Acta 1223:160-162(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Pancreatic islet.
  4. Cited for: FUNCTION, TISSUE SPECIFICITY.
  5. "CD38 is the major enzyme responsible for synthesis of nicotinic acid-adenine dinucleotide phosphate in mammalian tissues."
    Chini E.N., Chini C.C., Kato I., Takasawa S., Okamoto H.
    Biochem. J. 362:125-130(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN SYNTHESIS OF NICOTINIC ACID-ADENINE DINUCLEOTIDE PHOSPHATE.

Entry informationi

Entry nameiCD38_RAT
AccessioniPrimary (citable) accession number: Q64244
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: February 4, 2015
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.