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Q64244

- CD38_RAT

UniProt

Q64244 - CD38_RAT

Protein

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

Gene

Cd38

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity.
    Regulates osteoclastic bone resorption, probably via production of cyclic ADP-ribose and triggering of a cytosolic calcium ion signal through ryanodine receptor activation.

    Catalytic activityi

    NAD+ + H2O = ADP-D-ribose + nicotinamide.
    NADP+ + nicotinate = nicotinate-adenine dinucleotide phosphate + nicotinamide.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei122 – 1221By similarity
    Active sitei204 – 2041By similarity

    GO - Molecular functioni

    1. NAD(P)+ nucleosidase activity Source: UniProtKB-EC
    2. NAD+ nucleosidase activity Source: RGD
    3. phosphorus-oxygen lyase activity Source: Ensembl
    4. transferase activity Source: UniProtKB-KW

    GO - Biological processi

    1. B cell receptor signaling pathway Source: Ensembl
    2. female pregnancy Source: RGD
    3. long term synaptic depression Source: RGD
    4. metabolic process Source: GOC
    5. negative regulation of apoptotic process Source: Ensembl
    6. negative regulation of bone resorption Source: RGD
    7. negative regulation of transcription, DNA-templated Source: Ensembl
    8. positive regulation of B cell proliferation Source: Ensembl
    9. positive regulation of cell growth Source: RGD
    10. positive regulation of cytosolic calcium ion concentration Source: RGD
    11. positive regulation of insulin secretion Source: RGD
    12. positive regulation of transcription, DNA-templated Source: Ensembl
    13. positive regulation of vasoconstriction Source: RGD
    14. response to cytokine Source: RGD
    15. response to drug Source: Ensembl
    16. response to estradiol Source: RGD
    17. response to hormone Source: RGD
    18. response to hydroperoxide Source: RGD
    19. response to hypoxia Source: RGD
    20. response to interleukin-1 Source: RGD
    21. response to progesterone Source: RGD
    22. response to retinoic acid Source: RGD

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Ligandi

    NAD, NADP

    Enzyme and pathway databases

    SABIO-RKQ64244.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC:3.2.2.6)
    Alternative name(s):
    2'-phospho-ADP-ribosyl cyclase
    2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase (EC:2.4.99.20)
    2'-phospho-cyclic-ADP-ribose transferase
    ADP-ribosyl cyclase 1
    Short name:
    ADPRC 1
    CD38H
    Cyclic ADP-ribose hydrolase 1
    Short name:
    cADPr hydrolase 1
    CD_antigen: CD38
    Gene namesi
    Name:Cd38
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 14

    Organism-specific databases

    RGDi2303. Cd38.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. intracellular membrane-bounded organelle Source: RGD
    4. nucleus Source: RGD
    5. plasma membrane Source: RGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 303303ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1PRO_0000144070Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi69 ↔ 85By similarity
    Disulfide bondi102 ↔ 183By similarity
    Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi123 – 1231N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi163 ↔ 176By similarity
    Glycosylationi212 – 2121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi257 ↔ 278By similarity
    Disulfide bondi290 ↔ 299By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ64244.

    Expressioni

    Tissue specificityi

    Spleen, liver, heart, thymus, thyroid gland, ileum, colon, cerebellum, salivary gland, adrenal gland, jejunum, islets of Langerhans and osteoclasts.1 Publication

    Gene expression databases

    GenevestigatoriQ64244.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000004121.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64244.
    SMRiQ64244. Positions 50-282.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2121CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini45 – 303259ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei22 – 4423Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ADP-ribosyl cyclase family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG42596.
    GeneTreeiENSGT00390000017291.
    HOGENOMiHOG000293141.
    HOVERGENiHBG005277.
    InParanoidiQ64244.
    KOiK01242.
    OMAiKNPCNIT.
    OrthoDBiEOG7RBZ9B.
    PhylomeDBiQ64244.
    TreeFamiTF332530.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR003193. ADP-ribosyl_cyclase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR10912. PTHR10912. 1 hit.
    PfamiPF02267. Rib_hydrolayse. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q64244-1 [UniParc]FASTAAdd to Basket

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    MANYEFSQVS EDRPGCRLTR KAQIGLGVGL LLLVALVVVV VIVLWPRSPL    50
    VWKGKPTTKH FADIILGRCL IYTQILRPEM RDQDCKKILS TFKRGFISKN 100
    PCNITNEDYA PLVKLVTQTI PCNKTLFWSK SKHLAHQYTW IQGKMFTLED 150
    TLLGYIADDL RWCGDPSTSD MNYDSCPHWS ENCPNNPVAV FWNVISQKFA 200
    EDACGVVQVM LNGSLSEPFY RNSTFGSVEV FNLDPNKVHK LQAWVMHDIK 250
    GTSSNACSSP SINELKSIVN KRNMIFACQD NYRPVRFLQC VKNPEHPSCR 300
    LNV 303
    Length:303
    Mass (Da):34,436
    Last modified:November 1, 1996 - v1
    Checksum:i84F23AD3094871C5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D30795 mRNA. Translation: BAA06457.1.
    D29646 mRNA. Translation: BAA06129.1.
    PIRiJC2410.
    RefSeqiNP_037259.1. NM_013127.1.
    UniGeneiRn.11414.

    Genome annotation databases

    EnsembliENSRNOT00000004121; ENSRNOP00000004121; ENSRNOG00000003069.
    GeneIDi25668.
    KEGGirno:25668.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D30795 mRNA. Translation: BAA06457.1 .
    D29646 mRNA. Translation: BAA06129.1 .
    PIRi JC2410.
    RefSeqi NP_037259.1. NM_013127.1.
    UniGenei Rn.11414.

    3D structure databases

    ProteinModelPortali Q64244.
    SMRi Q64244. Positions 50-282.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000004121.

    Proteomic databases

    PRIDEi Q64244.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000004121 ; ENSRNOP00000004121 ; ENSRNOG00000003069 .
    GeneIDi 25668.
    KEGGi rno:25668.

    Organism-specific databases

    CTDi 952.
    RGDi 2303. Cd38.

    Phylogenomic databases

    eggNOGi NOG42596.
    GeneTreei ENSGT00390000017291.
    HOGENOMi HOG000293141.
    HOVERGENi HBG005277.
    InParanoidi Q64244.
    KOi K01242.
    OMAi KNPCNIT.
    OrthoDBi EOG7RBZ9B.
    PhylomeDBi Q64244.
    TreeFami TF332530.

    Enzyme and pathway databases

    SABIO-RK Q64244.

    Miscellaneous databases

    NextBioi 607593.
    PROi Q64244.

    Gene expression databases

    Genevestigatori Q64244.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR003193. ADP-ribosyl_cyclase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR10912. PTHR10912. 1 hit.
    Pfami PF02267. Rib_hydrolayse. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Brain.
    2. Erratum
      Li Q., Yamada Y., Yasuda K., Ihara Y., Okamoto Y., Kaisaki P.J., Watanabe R., Ikeda H., Tsuda K., Seino Y.
      Biochem. Biophys. Res. Commun. 204:1001-1001(1994)
    3. "Cloning and characterization of cDNA encoding rat ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase (homologue to human CD38) from islets of Langerhans."
      Koguma T., Takasawa S., Tohgo A., Karasawa T., Furuya Y., Yonekura H., Okamoto H.
      Biochim. Biophys. Acta 1223:160-162(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Pancreatic islet.
    4. Cited for: FUNCTION, TISSUE SPECIFICITY.
    5. "CD38 is the major enzyme responsible for synthesis of nicotinic acid-adenine dinucleotide phosphate in mammalian tissues."
      Chini E.N., Chini C.C., Kato I., Takasawa S., Okamoto H.
      Biochem. J. 362:125-130(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN SYNTHESIS OF NICOTINIC ACID-ADENINE DINUCLEOTIDE PHOSPHATE.

    Entry informationi

    Entry nameiCD38_RAT
    AccessioniPrimary (citable) accession number: Q64244
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3