ID   DLX3_MOUSE              Reviewed;         287 AA.
AC   Q64205;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   24-JAN-2024, entry version 165.
DE   RecName: Full=Homeobox protein DLX-3;
GN   Name=Dlx3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC   STRAIN=FVB/N;
RX   PubMed=7893603; DOI=10.1016/0925-4773(94)90060-4;
RA   Robinson G.W., Mahon K.A.;
RT   "Differential and overlapping expression domains of Dlx-2 and Dlx-3 suggest
RT   distinct roles for Distal-less homeobox genes in craniofacial
RT   development.";
RL   Mech. Dev. 48:199-215(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Embryo;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   FUNCTION.
RX   PubMed=23371388; DOI=10.1210/me.2012-1289;
RA   Xie H., Cherrington B.D., Meadows J.D., Witham E.A., Mellon P.L.;
RT   "Msx1 homeodomain protein represses the alphaGSU and GnRH receptor genes
RT   during gonadotrope development.";
RL   Mol. Endocrinol. 27:422-436(2013).
RN   [4]
RP   INTERACTION WITH IPO7, AND SUBCELLULAR LOCATION.
RX   PubMed=35922041; DOI=10.1093/stmcls/sxac055;
RA   Zhang Y., Zhang H., Xiao Z., Yuan G., Yang G.;
RT   "IPO7 Promotes Odontoblastic Differentiation and Inhibits Osteoblastic
RT   Differentiation Through Regulation of RUNX2 Expression and Translocation.";
RL   Stem Cells 40:1020-1030(2022).
CC   -!- FUNCTION: Transcriptional activator (PubMed:23371388). Activates
CC       transcription of GNRHR, via binding to the downstream activin
CC       regulatory element (DARE) in the gene promoter (PubMed:23371388).
CC       {ECO:0000269|PubMed:23371388}.
CC   -!- SUBUNIT: Heterodimer with MEIS1 (By similarity). Interacts with IPO7;
CC       the interaction facilitates nuclear translocation of DLX3 in dental
CC       papilla cells (PubMed:35922041). {ECO:0000250|UniProtKB:O60479,
CC       ECO:0000269|PubMed:35922041}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC       ECO:0000269|PubMed:35922041}. Cytoplasm {ECO:0000269|PubMed:35922041}.
CC   -!- DEVELOPMENTAL STAGE: Not expressed in the central nervous system at
CC       16.5 dpc (PubMed:7893603). Initially expressed in the branchial arches
CC       at 9.5 dpc, expression is confined to the caudal portion of the
CC       mandibular process at 10.5 dpc (PubMed:7893603). Distally expressed in
CC       the posterior regions of the first and second branchial arches at 10.5
CC       dpc (PubMed:7893603). Expressed in the auditory hillocks, ventral
CC       olfactory bulbs, the oral epithelium and the external naris at 12.5 dpc
CC       (PubMed:7893603). Expressed in the area under the first branchial cleft
CC       from which the external ear develops, in cell adjacent to Meckel's
CC       cartilage, in the external naris and mesenchymal cells that enclose the
CC       nasal epithelium at 13.5 dpc (PubMed:7893603). Expressed in the
CC       developing otic vesicle at 11.5 dpc, expression is then restricted to
CC       the vestibular region at 12.5 dpc and further restricted to the
CC       epithelium of the utricle and the semicircular canals at 13.5 dpc
CC       (PubMed:7893603). Expression declines thereafter with no expression
CC       detected in the developing inner ear at 14.5 dpc (PubMed:7893603).
CC       Expressed in the mesenchyme of the dental papilla at 13.5 dpc,
CC       expression remains in ameloblasts and odontoblasts at 16.5 dpc
CC       (PubMed:7893603). Expressed in a patchy pattern in the epithelium of
CC       the upper lip at 12.5 dpc, expression is increased in follicles during
CC       whisker development from 14.5 dpc until birth (PubMed:7893603).
CC       {ECO:0000269|PubMed:7893603}.
CC   -!- SIMILARITY: Belongs to the distal-less homeobox family. {ECO:0000305}.
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DR   EMBL; S81932; AAB33879.1; -; mRNA.
DR   EMBL; BC058852; AAH58852.1; -; mRNA.
DR   CCDS; CCDS25272.1; -.
DR   RefSeq; NP_034185.1; NM_010055.3.
DR   AlphaFoldDB; Q64205; -.
DR   SMR; Q64205; -.
DR   STRING; 10090.ENSMUSP00000090443; -.
DR   iPTMnet; Q64205; -.
DR   PhosphoSitePlus; Q64205; -.
DR   PaxDb; 10090-ENSMUSP00000090443; -.
DR   ProteomicsDB; 279386; -.
DR   Antibodypedia; 17996; 294 antibodies from 32 providers.
DR   DNASU; 13393; -.
DR   Ensembl; ENSMUST00000092768.7; ENSMUSP00000090443.6; ENSMUSG00000001510.9.
DR   GeneID; 13393; -.
DR   KEGG; mmu:13393; -.
DR   UCSC; uc007kzy.2; mouse.
DR   AGR; MGI:94903; -.
DR   CTD; 1747; -.
DR   MGI; MGI:94903; Dlx3.
DR   VEuPathDB; HostDB:ENSMUSG00000001510; -.
DR   eggNOG; KOG0850; Eukaryota.
DR   GeneTree; ENSGT00940000158951; -.
DR   HOGENOM; CLU_074733_1_0_1; -.
DR   InParanoid; Q64205; -.
DR   OMA; SWYHTQN; -.
DR   OrthoDB; 2969529at2759; -.
DR   PhylomeDB; Q64205; -.
DR   TreeFam; TF350606; -.
DR   BioGRID-ORCS; 13393; 3 hits in 79 CRISPR screens.
DR   ChiTaRS; Dlx3; mouse.
DR   PRO; PR:Q64205; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; Q64205; Protein.
DR   Bgee; ENSMUSG00000001510; Expressed in calcareous tooth and 157 other cell types or tissues.
DR   ExpressionAtlas; Q64205; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0003682; F:chromatin binding; IDA:MGI.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:MGI.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:MGI.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:UniProtKB.
DR   GO; GO:0001568; P:blood vessel development; IMP:MGI.
DR   GO; GO:0030509; P:BMP signaling pathway; IMP:MGI.
DR   GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR   GO; GO:0010467; P:gene expression; IMP:MGI.
DR   GO; GO:0035315; P:hair cell differentiation; IMP:MGI.
DR   GO; GO:0042633; P:hair cycle; IMP:MGI.
DR   GO; GO:0071335; P:hair follicle cell proliferation; IMP:MGI.
DR   GO; GO:0001942; P:hair follicle development; IMP:MGI.
DR   GO; GO:0031069; P:hair follicle morphogenesis; IMP:MGI.
DR   GO; GO:0071895; P:odontoblast differentiation; IMP:CACAO.
DR   GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IMP:MGI.
DR   GO; GO:0001890; P:placenta development; IMP:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0016055; P:Wnt signaling pathway; IMP:MGI.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR022135; Distal-less_N.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   PANTHER; PTHR24327; HOMEOBOX PROTEIN; 1.
DR   PANTHER; PTHR24327:SF28; HOMEOBOX PROTEIN DLX-3; 1.
DR   Pfam; PF12413; DLL_N; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   Genevisible; Q64205; MM.
PE   1: Evidence at protein level;
KW   Activator; Cytoplasm; Developmental protein; DNA-binding; Homeobox;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..287
FT                   /note="Homeobox protein DLX-3"
FT                   /id="PRO_0000049027"
FT   DNA_BIND        129..188
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          131..181
FT                   /note="Interaction with DNA"
FT                   /evidence="ECO:0000250|UniProtKB:O60479"
FT   REGION          195..287
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        195..225
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        226..240
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        242..271
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        272..287
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   287 AA;  31791 MW;  1F7DB917FC4C2158 CRC64;
     MSGSFDRKLS SILTDISSSL SCHAGSKDSP TLPESTVTDL GYYSAPQHDY YSGQPYGQTV
     NPYTYHHQFN LNGLAGTGAY SPKSEYTYGG SYRQYGAYRE QPLPAQDPVS VKEEPEAEVR
     MVNGKPKKVR KPRTIYSSYQ LAALQRRFQK AQYLALPERA ELAAQLGLTQ TQVKIWFQNR
     RSKFKKLYKN GEVPLEHSPN NSDSMACNSP PSPALWDTSS HSTPAPARNP LPPPLPYSAS
     PNYLDDPTNS WYHTQNLSGP HLQQQPPQPA TLHHASPGPP PNPGAVY
//