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Protein

Homeobox protein DLX-3

Gene

Dlx3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi129 – 188HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • blood vessel development Source: MGI
  • odontoblast differentiation Source: CACAO
  • odontogenesis of dentin-containing tooth Source: MGI
  • placenta development Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein DLX-3
Gene namesi
Name:Dlx3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:94903. Dlx3.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nucleus Source: MGI

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000490271 – 287Homeobox protein DLX-3Add BLAST287

Proteomic databases

PaxDbiQ64205.
PRIDEiQ64205.

PTM databases

iPTMnetiQ64205.
PhosphoSitePlusiQ64205.

Expressioni

Tissue specificityi

Not expressed in the central nervous system. Expressed in a highly restricted region of the branchial arches. In later development, expressed in the developing middle and inner ear, teeth and whisker follicles.

Gene expression databases

BgeeiENSMUSG00000001510.
CleanExiMM_DLX3.
ExpressionAtlasiQ64205. baseline and differential.
GenevisibleiQ64205. MM.

Interactioni

Protein-protein interaction databases

IntActiQ64205. 1 interactor.
MINTiMINT-4093163.
STRINGi10090.ENSMUSP00000090443.

Structurei

3D structure databases

ProteinModelPortaliQ64205.
SMRiQ64205.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the distal-less homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0850. Eukaryota.
ENOG410ZHZR. LUCA.
GeneTreeiENSGT00880000137844.
HOGENOMiHOG000231940.
HOVERGENiHBG005493.
InParanoidiQ64205.
KOiK09315.
OMAiSWYHTQN.
OrthoDBiEOG091G0P17.
PhylomeDBiQ64205.
TreeFamiTF350606.

Family and domain databases

InterProiView protein in InterPro
IPR022135. Distal-less_N.
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR000047. HTH_motif.
PfamiView protein in Pfam
PF12413. DLL_N. 1 hit.
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q64205-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGSFDRKLS SILTDISSSL SCHAGSKDSP TLPESTVTDL GYYSAPQHDY
60 70 80 90 100
YSGQPYGQTV NPYTYHHQFN LNGLAGTGAY SPKSEYTYGG SYRQYGAYRE
110 120 130 140 150
QPLPAQDPVS VKEEPEAEVR MVNGKPKKVR KPRTIYSSYQ LAALQRRFQK
160 170 180 190 200
AQYLALPERA ELAAQLGLTQ TQVKIWFQNR RSKFKKLYKN GEVPLEHSPN
210 220 230 240 250
NSDSMACNSP PSPALWDTSS HSTPAPARNP LPPPLPYSAS PNYLDDPTNS
260 270 280
WYHTQNLSGP HLQQQPPQPA TLHHASPGPP PNPGAVY
Length:287
Mass (Da):31,791
Last modified:November 1, 1996 - v1
Checksum:i1F7DB917FC4C2158
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S81932 mRNA. Translation: AAB33879.1.
BC058852 mRNA. Translation: AAH58852.1.
CCDSiCCDS25272.1.
RefSeqiNP_034185.1. NM_010055.3.
UniGeneiMm.5194.

Genome annotation databases

EnsembliENSMUST00000092768; ENSMUSP00000090443; ENSMUSG00000001510.
GeneIDi13393.
KEGGimmu:13393.
UCSCiuc007kzy.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiDLX3_MOUSE
AccessioniPrimary (citable) accession number: Q64205
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 7, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families