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Q64205

- DLX3_MOUSE

UniProt

Q64205 - DLX3_MOUSE

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Protein

Homeobox protein DLX-3

Gene

Dlx3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi129 – 18860HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
  3. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. blood vessel development Source: MGI
  2. odontoblast differentiation Source: MGI
  3. odontogenesis of dentin-containing tooth Source: MGI
  4. placenta development Source: MGI
  5. positive regulation of transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein DLX-3
Gene namesi
Name:Dlx3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:94903. Dlx3.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 287287Homeobox protein DLX-3PRO_0000049027Add
BLAST

Proteomic databases

PaxDbiQ64205.
PRIDEiQ64205.

PTM databases

PhosphoSiteiQ64205.

Expressioni

Tissue specificityi

Not expressed in the central nervous system. Expressed in a highly restricted region of the branchial arches. In later development, expressed in the developing middle and inner ear, teeth and whisker follicles.

Gene expression databases

BgeeiQ64205.
CleanExiMM_DLX3.
ExpressionAtlasiQ64205. differential.
GenevestigatoriQ64205.

Interactioni

Protein-protein interaction databases

IntActiQ64205. 1 interaction.
MINTiMINT-4093163.

Structurei

3D structure databases

ProteinModelPortaliQ64205.
SMRiQ64205. Positions 100-190.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the distal-less homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG299102.
HOGENOMiHOG000231940.
HOVERGENiHBG005493.
InParanoidiQ64205.
KOiK09315.
OMAiSWYHTQN.
OrthoDBiEOG70W3F8.
PhylomeDBiQ64205.
TreeFamiTF350606.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR022135. Distal-less_N.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF12413. DLL_N. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64205-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGSFDRKLS SILTDISSSL SCHAGSKDSP TLPESTVTDL GYYSAPQHDY
60 70 80 90 100
YSGQPYGQTV NPYTYHHQFN LNGLAGTGAY SPKSEYTYGG SYRQYGAYRE
110 120 130 140 150
QPLPAQDPVS VKEEPEAEVR MVNGKPKKVR KPRTIYSSYQ LAALQRRFQK
160 170 180 190 200
AQYLALPERA ELAAQLGLTQ TQVKIWFQNR RSKFKKLYKN GEVPLEHSPN
210 220 230 240 250
NSDSMACNSP PSPALWDTSS HSTPAPARNP LPPPLPYSAS PNYLDDPTNS
260 270 280
WYHTQNLSGP HLQQQPPQPA TLHHASPGPP PNPGAVY
Length:287
Mass (Da):31,791
Last modified:November 1, 1996 - v1
Checksum:i1F7DB917FC4C2158
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S81932 mRNA. Translation: AAB33879.1.
BC058852 mRNA. Translation: AAH58852.1.
CCDSiCCDS25272.1.
RefSeqiNP_034185.1. NM_010055.3.
UniGeneiMm.5194.

Genome annotation databases

EnsembliENSMUST00000092768; ENSMUSP00000090443; ENSMUSG00000001510.
GeneIDi13393.
KEGGimmu:13393.
UCSCiuc007kzy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S81932 mRNA. Translation: AAB33879.1 .
BC058852 mRNA. Translation: AAH58852.1 .
CCDSi CCDS25272.1.
RefSeqi NP_034185.1. NM_010055.3.
UniGenei Mm.5194.

3D structure databases

ProteinModelPortali Q64205.
SMRi Q64205. Positions 100-190.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q64205. 1 interaction.
MINTi MINT-4093163.

PTM databases

PhosphoSitei Q64205.

Proteomic databases

PaxDbi Q64205.
PRIDEi Q64205.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000092768 ; ENSMUSP00000090443 ; ENSMUSG00000001510 .
GeneIDi 13393.
KEGGi mmu:13393.
UCSCi uc007kzy.2. mouse.

Organism-specific databases

CTDi 1747.
MGIi MGI:94903. Dlx3.

Phylogenomic databases

eggNOGi NOG299102.
HOGENOMi HOG000231940.
HOVERGENi HBG005493.
InParanoidi Q64205.
KOi K09315.
OMAi SWYHTQN.
OrthoDBi EOG70W3F8.
PhylomeDBi Q64205.
TreeFami TF350606.

Miscellaneous databases

NextBioi 283764.
PROi Q64205.
SOURCEi Search...

Gene expression databases

Bgeei Q64205.
CleanExi MM_DLX3.
ExpressionAtlasi Q64205. differential.
Genevestigatori Q64205.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR022135. Distal-less_N.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view ]
Pfami PF12413. DLL_N. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Differential and overlapping expression domains of Dlx-2 and Dlx-3 suggest distinct roles for Distal-less homeobox genes in craniofacial development."
    Robinson G.W., Mahon K.A.
    Mech. Dev. 48:199-215(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: FVB/N.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.

Entry informationi

Entry nameiDLX3_MOUSE
AccessioniPrimary (citable) accession number: Q64205
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3