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Protein

Homeobox protein DLX-3

Gene

Dlx3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi129 – 18860HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
  3. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. blood vessel development Source: MGI
  2. odontoblast differentiation Source: MGI
  3. odontogenesis of dentin-containing tooth Source: MGI
  4. placenta development Source: MGI
  5. positive regulation of transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein DLX-3
Gene namesi
Name:Dlx3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:94903. Dlx3.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 287287Homeobox protein DLX-3PRO_0000049027Add
BLAST

Proteomic databases

PaxDbiQ64205.
PRIDEiQ64205.

PTM databases

PhosphoSiteiQ64205.

Expressioni

Tissue specificityi

Not expressed in the central nervous system. Expressed in a highly restricted region of the branchial arches. In later development, expressed in the developing middle and inner ear, teeth and whisker follicles.

Gene expression databases

BgeeiQ64205.
CleanExiMM_DLX3.
ExpressionAtlasiQ64205. baseline and differential.
GenevestigatoriQ64205.

Interactioni

Protein-protein interaction databases

IntActiQ64205. 1 interaction.
MINTiMINT-4093163.

Structurei

3D structure databases

ProteinModelPortaliQ64205.
SMRiQ64205. Positions 100-190.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the distal-less homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG299102.
HOGENOMiHOG000231940.
HOVERGENiHBG005493.
InParanoidiQ64205.
KOiK09315.
OMAiSWYHTQN.
OrthoDBiEOG70W3F8.
PhylomeDBiQ64205.
TreeFamiTF350606.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR022135. Distal-less_N.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF12413. DLL_N. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64205-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGSFDRKLS SILTDISSSL SCHAGSKDSP TLPESTVTDL GYYSAPQHDY
60 70 80 90 100
YSGQPYGQTV NPYTYHHQFN LNGLAGTGAY SPKSEYTYGG SYRQYGAYRE
110 120 130 140 150
QPLPAQDPVS VKEEPEAEVR MVNGKPKKVR KPRTIYSSYQ LAALQRRFQK
160 170 180 190 200
AQYLALPERA ELAAQLGLTQ TQVKIWFQNR RSKFKKLYKN GEVPLEHSPN
210 220 230 240 250
NSDSMACNSP PSPALWDTSS HSTPAPARNP LPPPLPYSAS PNYLDDPTNS
260 270 280
WYHTQNLSGP HLQQQPPQPA TLHHASPGPP PNPGAVY
Length:287
Mass (Da):31,791
Last modified:November 1, 1996 - v1
Checksum:i1F7DB917FC4C2158
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S81932 mRNA. Translation: AAB33879.1.
BC058852 mRNA. Translation: AAH58852.1.
CCDSiCCDS25272.1.
RefSeqiNP_034185.1. NM_010055.3.
UniGeneiMm.5194.

Genome annotation databases

EnsembliENSMUST00000092768; ENSMUSP00000090443; ENSMUSG00000001510.
GeneIDi13393.
KEGGimmu:13393.
UCSCiuc007kzy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S81932 mRNA. Translation: AAB33879.1.
BC058852 mRNA. Translation: AAH58852.1.
CCDSiCCDS25272.1.
RefSeqiNP_034185.1. NM_010055.3.
UniGeneiMm.5194.

3D structure databases

ProteinModelPortaliQ64205.
SMRiQ64205. Positions 100-190.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ64205. 1 interaction.
MINTiMINT-4093163.

PTM databases

PhosphoSiteiQ64205.

Proteomic databases

PaxDbiQ64205.
PRIDEiQ64205.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000092768; ENSMUSP00000090443; ENSMUSG00000001510.
GeneIDi13393.
KEGGimmu:13393.
UCSCiuc007kzy.2. mouse.

Organism-specific databases

CTDi1747.
MGIiMGI:94903. Dlx3.

Phylogenomic databases

eggNOGiNOG299102.
HOGENOMiHOG000231940.
HOVERGENiHBG005493.
InParanoidiQ64205.
KOiK09315.
OMAiSWYHTQN.
OrthoDBiEOG70W3F8.
PhylomeDBiQ64205.
TreeFamiTF350606.

Miscellaneous databases

NextBioi283764.
PROiQ64205.
SOURCEiSearch...

Gene expression databases

BgeeiQ64205.
CleanExiMM_DLX3.
ExpressionAtlasiQ64205. baseline and differential.
GenevestigatoriQ64205.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR022135. Distal-less_N.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF12413. DLL_N. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Differential and overlapping expression domains of Dlx-2 and Dlx-3 suggest distinct roles for Distal-less homeobox genes in craniofacial development."
    Robinson G.W., Mahon K.A.
    Mech. Dev. 48:199-215(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: FVB/N.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.

Entry informationi

Entry nameiDLX3_MOUSE
AccessioniPrimary (citable) accession number: Q64205
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: March 4, 2015
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.