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Q64205

- DLX3_MOUSE

UniProt

Q64205 - DLX3_MOUSE

Protein

Homeobox protein DLX-3

Gene

Dlx3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi129 – 18860HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
    3. transcription regulatory region sequence-specific DNA binding Source: InterPro

    GO - Biological processi

    1. blood vessel development Source: MGI
    2. odontoblast differentiation Source: MGI
    3. odontogenesis of dentin-containing tooth Source: MGI
    4. placenta development Source: MGI
    5. positive regulation of transcription from RNA polymerase II promoter Source: GOC

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein DLX-3
    Gene namesi
    Name:Dlx3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:94903. Dlx3.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 287287Homeobox protein DLX-3PRO_0000049027Add
    BLAST

    Proteomic databases

    PaxDbiQ64205.
    PRIDEiQ64205.

    PTM databases

    PhosphoSiteiQ64205.

    Expressioni

    Tissue specificityi

    Not expressed in the central nervous system. Expressed in a highly restricted region of the branchial arches. In later development, expressed in the developing middle and inner ear, teeth and whisker follicles.

    Gene expression databases

    ArrayExpressiQ64205.
    BgeeiQ64205.
    CleanExiMM_DLX3.
    GenevestigatoriQ64205.

    Interactioni

    Protein-protein interaction databases

    IntActiQ64205. 1 interaction.
    MINTiMINT-4093163.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64205.
    SMRiQ64205. Positions 100-190.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the distal-less homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG299102.
    HOGENOMiHOG000231940.
    HOVERGENiHBG005493.
    InParanoidiQ64205.
    KOiK09315.
    OMAiSWYHTQN.
    OrthoDBiEOG70W3F8.
    PhylomeDBiQ64205.
    TreeFamiTF350606.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR022135. Distal-less_N.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view]
    PfamiPF12413. DLL_N. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q64205-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGSFDRKLS SILTDISSSL SCHAGSKDSP TLPESTVTDL GYYSAPQHDY    50
    YSGQPYGQTV NPYTYHHQFN LNGLAGTGAY SPKSEYTYGG SYRQYGAYRE 100
    QPLPAQDPVS VKEEPEAEVR MVNGKPKKVR KPRTIYSSYQ LAALQRRFQK 150
    AQYLALPERA ELAAQLGLTQ TQVKIWFQNR RSKFKKLYKN GEVPLEHSPN 200
    NSDSMACNSP PSPALWDTSS HSTPAPARNP LPPPLPYSAS PNYLDDPTNS 250
    WYHTQNLSGP HLQQQPPQPA TLHHASPGPP PNPGAVY 287
    Length:287
    Mass (Da):31,791
    Last modified:November 1, 1996 - v1
    Checksum:i1F7DB917FC4C2158
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S81932 mRNA. Translation: AAB33879.1.
    BC058852 mRNA. Translation: AAH58852.1.
    CCDSiCCDS25272.1.
    RefSeqiNP_034185.1. NM_010055.3.
    UniGeneiMm.5194.

    Genome annotation databases

    EnsembliENSMUST00000092768; ENSMUSP00000090443; ENSMUSG00000001510.
    GeneIDi13393.
    KEGGimmu:13393.
    UCSCiuc007kzy.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S81932 mRNA. Translation: AAB33879.1 .
    BC058852 mRNA. Translation: AAH58852.1 .
    CCDSi CCDS25272.1.
    RefSeqi NP_034185.1. NM_010055.3.
    UniGenei Mm.5194.

    3D structure databases

    ProteinModelPortali Q64205.
    SMRi Q64205. Positions 100-190.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q64205. 1 interaction.
    MINTi MINT-4093163.

    PTM databases

    PhosphoSitei Q64205.

    Proteomic databases

    PaxDbi Q64205.
    PRIDEi Q64205.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000092768 ; ENSMUSP00000090443 ; ENSMUSG00000001510 .
    GeneIDi 13393.
    KEGGi mmu:13393.
    UCSCi uc007kzy.2. mouse.

    Organism-specific databases

    CTDi 1747.
    MGIi MGI:94903. Dlx3.

    Phylogenomic databases

    eggNOGi NOG299102.
    HOGENOMi HOG000231940.
    HOVERGENi HBG005493.
    InParanoidi Q64205.
    KOi K09315.
    OMAi SWYHTQN.
    OrthoDBi EOG70W3F8.
    PhylomeDBi Q64205.
    TreeFami TF350606.

    Miscellaneous databases

    NextBioi 283764.
    PROi Q64205.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q64205.
    Bgeei Q64205.
    CleanExi MM_DLX3.
    Genevestigatori Q64205.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR022135. Distal-less_N.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view ]
    Pfami PF12413. DLL_N. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differential and overlapping expression domains of Dlx-2 and Dlx-3 suggest distinct roles for Distal-less homeobox genes in craniofacial development."
      Robinson G.W., Mahon K.A.
      Mech. Dev. 48:199-215(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: FVB/N.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo.

    Entry informationi

    Entry nameiDLX3_MOUSE
    AccessioniPrimary (citable) accession number: Q64205
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3