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Q64205 (DLX3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein DLX-3
Gene names
Name:Dlx3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length287 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.

Subcellular location

Nucleus Potential.

Tissue specificity

Not expressed in the central nervous system. Expressed in a highly restricted region of the branchial arches. In later development, expressed in the developing middle and inner ear, teeth and whisker follicles.

Sequence similarities

Belongs to the distal-less homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 287287Homeobox protein DLX-3
PRO_0000049027

Regions

DNA binding129 – 18860Homeobox

Sequences

Sequence LengthMass (Da)Tools
Q64205 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 1F7DB917FC4C2158

FASTA28731,791
        10         20         30         40         50         60 
MSGSFDRKLS SILTDISSSL SCHAGSKDSP TLPESTVTDL GYYSAPQHDY YSGQPYGQTV 

        70         80         90        100        110        120 
NPYTYHHQFN LNGLAGTGAY SPKSEYTYGG SYRQYGAYRE QPLPAQDPVS VKEEPEAEVR 

       130        140        150        160        170        180 
MVNGKPKKVR KPRTIYSSYQ LAALQRRFQK AQYLALPERA ELAAQLGLTQ TQVKIWFQNR 

       190        200        210        220        230        240 
RSKFKKLYKN GEVPLEHSPN NSDSMACNSP PSPALWDTSS HSTPAPARNP LPPPLPYSAS 

       250        260        270        280 
PNYLDDPTNS WYHTQNLSGP HLQQQPPQPA TLHHASPGPP PNPGAVY 

« Hide

References

« Hide 'large scale' references
[1]"Differential and overlapping expression domains of Dlx-2 and Dlx-3 suggest distinct roles for Distal-less homeobox genes in craniofacial development."
Robinson G.W., Mahon K.A.
Mech. Dev. 48:199-215(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: FVB/N.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S81932 mRNA. Translation: AAB33879.1.
BC058852 mRNA. Translation: AAH58852.1.
CCDSCCDS25272.1.
RefSeqNP_034185.1. NM_010055.3.
UniGeneMm.5194.

3D structure databases

ProteinModelPortalQ64205.
SMRQ64205. Positions 100-190.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ64205. 1 interaction.
MINTMINT-4093163.

PTM databases

PhosphoSiteQ64205.

Proteomic databases

PaxDbQ64205.
PRIDEQ64205.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000092768; ENSMUSP00000090443; ENSMUSG00000001510.
GeneID13393.
KEGGmmu:13393.
UCSCuc007kzy.2. mouse.

Organism-specific databases

CTD1747.
MGIMGI:94903. Dlx3.

Phylogenomic databases

eggNOGNOG299102.
HOGENOMHOG000231940.
HOVERGENHBG005493.
InParanoidQ64205.
KOK09315.
OMASWYHTQN.
OrthoDBEOG70W3F8.
PhylomeDBQ64205.
TreeFamTF350606.

Gene expression databases

ArrayExpressQ64205.
BgeeQ64205.
CleanExMM_DLX3.
GenevestigatorQ64205.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR022135. Distal-less_N.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamPF12413. DLL_N. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio283764.
PROQ64205.
SOURCESearch...

Entry information

Entry nameDLX3_MOUSE
AccessionPrimary (citable) accession number: Q64205
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot