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Protein

Peflin

Gene

Pef1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi126 – 137121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi193 – 204122PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peflin
Alternative name(s):
PEF protein with a long N-terminal hydrophobic domain
Penta-EF hand domain-containing protein 1
Gene namesi
Name:Pef1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1359536. Pef1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283PeflinPRO_0000247047Add
BLAST

Proteomic databases

PaxDbiQ641Z8.
PRIDEiQ641Z8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000013972.
GenevisibleiQ641Z8. RN.

Interactioni

Subunit structurei

Heterodimer; heterodimerizes with PDCD6. Dissociates from PDCD6 in presence of Ca2+ (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018742.

Structurei

3D structure databases

ProteinModelPortaliQ641Z8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati21 – 2991
Repeati31 – 3992
Repeati41 – 4883
Repeati49 – 58104
Repeati59 – 6795
Repeati75 – 8396
Repeati84 – 9187
Repeati92 – 9988
Repeati100 – 10899
Domaini113 – 14836EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini149 – 17931EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini180 – 21536EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini216 – 25237EF-hand 4PROSITE-ProRule annotationAdd
BLAST
Domaini253 – 28230EF-hand 5PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 108889 X 9 AA approximate tandem repeat of [AP]-P-G-G-P-Y-G-G-P-PAdd
BLAST
Regioni203 – 28381Required for interaction with PDCD6By similarityAdd
BLAST

Sequence similaritiesi

Contains 5 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0037. Eukaryota.
ENOG410YKQK. LUCA.
GeneTreeiENSGT00620000087734.
HOGENOMiHOG000231983.
HOVERGENiHBG004492.
InParanoidiQ641Z8.
OMAiPSMQLDR.
OrthoDBiEOG091G0ISY.
PhylomeDBiQ641Z8.
TreeFamiTF314682.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13202. EF-hand_5. 1 hit.
PF13405. EF-hand_6. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q641Z8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASYPDGQSY PGAAGQVPGP HPGGYYPGPP HGGGQYGSGF PPGGYGAPAP
60 70 80 90 100
GGPYGYPSAG GTPSGTPGGP YGGGPPGGPY GGGPPGGPYG QAHPSPYGTQ
110 120 130 140 150
PPGPYGQGGV PPNVDPEAYS WFQSVDADHS GYISLKELKQ ALVNSNWSSF
160 170 180 190 200
NDETCLMMIN MFDKTKTGRI DVVGFSALWK FLQQWKNLFQ QYDRDHSGSI
210 220 230 240 250
SSTELQQALS QMGYNLSPQF TQLLVSRYCT RSAIPAMQLD CFIKVCTQLQ
260 270 280
VLTEAFREKD TAVQGNIRLS FEDFVTMTAS RML
Length:283
Mass (Da):30,012
Last modified:October 25, 2004 - v1
Checksum:i2454D005C02C595D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082028 mRNA. Translation: AAH82028.1.
RefSeqiNP_001007652.1. NM_001007651.1.
UniGeneiRn.96097.

Genome annotation databases

EnsembliENSRNOT00000018742; ENSRNOP00000018742; ENSRNOG00000013972.
GeneIDi297900.
KEGGirno:297900.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082028 mRNA. Translation: AAH82028.1.
RefSeqiNP_001007652.1. NM_001007651.1.
UniGeneiRn.96097.

3D structure databases

ProteinModelPortaliQ641Z8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018742.

Proteomic databases

PaxDbiQ641Z8.
PRIDEiQ641Z8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018742; ENSRNOP00000018742; ENSRNOG00000013972.
GeneIDi297900.
KEGGirno:297900.

Organism-specific databases

CTDi553115.
RGDi1359536. Pef1.

Phylogenomic databases

eggNOGiKOG0037. Eukaryota.
ENOG410YKQK. LUCA.
GeneTreeiENSGT00620000087734.
HOGENOMiHOG000231983.
HOVERGENiHBG004492.
InParanoidiQ641Z8.
OMAiPSMQLDR.
OrthoDBiEOG091G0ISY.
PhylomeDBiQ641Z8.
TreeFamiTF314682.

Miscellaneous databases

PROiQ641Z8.

Gene expression databases

BgeeiENSRNOG00000013972.
GenevisibleiQ641Z8. RN.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13202. EF-hand_5. 1 hit.
PF13405. EF-hand_6. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPEF1_RAT
AccessioniPrimary (citable) accession number: Q641Z8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 25, 2004
Last modified: September 7, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.