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Protein

Acid sphingomyelinase-like phosphodiesterase 3a

Gene

Smpdl3a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP. Has in vitro activity with p-nitrophenyl-TMP. Has lower activity with nucleoside diphosphates, and no activity with nucleoside monophosphates. Has in vitro activity with CDP-choline, giving rise to CMP and phosphocholine. Has in vitro activity with CDP-ethanolamine. Does not have sphingomyelin phosphodiesterase activity.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi42Zinc 1By similarity1
Metal bindingi44Zinc 1By similarity1
Metal bindingi107Zinc 1By similarity1
Metal bindingi107Zinc 2By similarity1
Binding sitei111SubstrateBy similarity1
Metal bindingi148Zinc 2By similarity1
Binding sitei148SubstrateBy similarity1
Binding sitei149SubstrateBy similarity1
Metal bindingi249Zinc 2By similarity1
Metal bindingi290Zinc 2By similarity1
Metal bindingi292Zinc 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Acid sphingomyelinase-like phosphodiesterase 3a (EC:3.1.4.-)
Short name:
ASM-like phosphodiesterase 3a
Gene namesi
Name:Smpdl3a
Synonyms:Asml3a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1359277 Smpdl3a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000233023 – 445Acid sphingomyelinase-like phosphodiesterase 3aAdd BLAST423

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi59 ↔ 78By similarity
Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi219N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi235N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi353N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi364N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi417 ↔ 421Sequence analysis
Disulfide bondi427 ↔ 440By similarity

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ641Z7
PRIDEiQ641Z7

Expressioni

Gene expression databases

BgeeiENSRNOG00000000815
GenevisibleiQ641Z7 RN

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001081

Structurei

3D structure databases

ProteinModelPortaliQ641Z7
SMRiQ641Z7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acid sphingomyelinase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3770 Eukaryota
ENOG410YYPB LUCA
GeneTreeiENSGT00530000063095
HOGENOMiHOG000294197
HOVERGENiHBG050594
InParanoidiQ641Z7
KOiK01128
OMAiDLWKPWL
OrthoDBiEOG091G080M
PhylomeDBiQ641Z7
TreeFamiTF313674

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR017064 ASM-like_Pdiesterase_prd
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PIRSFiPIRSF036767 ASM-like_PDE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q641Z7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPGNFLCC LLVAWLCDPG LGVPLAPAYG APAVGQFWHV TDLHLDPTYH
60 70 80 90 100
ITDDHTKVCA SSKGANVSNP GPFGDVLCDS PYQLILSAFD FIKNSGQEAS
110 120 130 140 150
FMIWTGDSPP HVPVRELSTG SVIEVITNMT VTVQNLFPNL QVFPALGNHD
160 170 180 190 200
YWPQDQLPIA TSKVYSAVSD LWKPWLDEEA ISTLRKGGFY SQKVASNPDL
210 220 230 240 250
RIISLNTNLY YGPNIMTLNK TDPANQFEWL ENTLNSSLRN KEKVYVIAHV
260 270 280 290 300
PVGYLPYATK TPAMRQYYNE KLVDIFRRYS SVIAGQFYGH THRDSLMVLS
310 320 330 340 350
DKNGNPINSV FVAPAVTPVK GVLEKETNNP GVRLFQYKPG DYTLLDMLQY
360 370 380 390 400
YLNLTEANLK GESNWTLEYT LTQAYGVADL QPKSLHGLAQ QLATIDSKQF
410 420 430 440
LKYYHYFFVS YDSSAPCDQR CKTLQICAIM NLDLVSYEDC LKRHL
Length:445
Mass (Da):49,896
Last modified:October 25, 2004 - v1
Checksum:iF85CDFFE1063B323
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082029 mRNA Translation: AAH82029.1
RefSeqiNP_001005539.1, NM_001005539.1
UniGeneiRn.8142

Genome annotation databases

EnsembliENSRNOT00000001081; ENSRNOP00000001081; ENSRNOG00000000815
GeneIDi294422
KEGGirno:294422
UCSCiRGD:1359277 rat

Similar proteinsi

Entry informationi

Entry nameiASM3A_RAT
AccessioniPrimary (citable) accession number: Q641Z7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 25, 2004
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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